大量流行病学和动物实验研究显示,发育早期不利因素,特别是宫内营养失衡(包括营养不良及营养过剩),导致机体生理和代谢发生永久改变,引发子代肥胖、2型糖尿病、高血压、冠心病等成年慢性疾病的发生发展。这一过程发生在胎儿发育的窗口期...大量流行病学和动物实验研究显示,发育早期不利因素,特别是宫内营养失衡(包括营养不良及营养过剩),导致机体生理和代谢发生永久改变,引发子代肥胖、2型糖尿病、高血压、冠心病等成年慢性疾病的发生发展。这一过程发生在胎儿发育的窗口期,即健康和疾病的发育起源(developmental origins of health and disease,DOHaD)。目前,其具体机制引发了国内外学者的广泛关注,特别是代谢调节关键基因在转录水平的改变及表观遗传学在引发成年代谢表型中的作用。深入了解并进一步探讨其机制以寻求有效的干预方式对控制心血管疾病及2型糖尿病的流行意义重大,对于经济快速转型的发展中国家更是意义深远。展开更多
Chronic lung diseases have been recognized as one of the world's leading causes of death in recent decades. Lacking effective treatments brings the patients not only bad quality of life but also higher risk for lu...Chronic lung diseases have been recognized as one of the world's leading causes of death in recent decades. Lacking effective treatments brings the patients not only bad quality of life but also higher risk for lung cancer development. By increasing the understanding of deeper mechanism of how lung develops and regenerates, researchers now focus on studying lung regenerative medicine, aiming to apply different and more efficient therapies to treat chronic lung diseases. This review will provide a wide picture of both basic lung developmental, regeneration mechanism and different designed strategies for treating chronic lung diseases in the future decades.展开更多
文摘大量流行病学和动物实验研究显示,发育早期不利因素,特别是宫内营养失衡(包括营养不良及营养过剩),导致机体生理和代谢发生永久改变,引发子代肥胖、2型糖尿病、高血压、冠心病等成年慢性疾病的发生发展。这一过程发生在胎儿发育的窗口期,即健康和疾病的发育起源(developmental origins of health and disease,DOHaD)。目前,其具体机制引发了国内外学者的广泛关注,特别是代谢调节关键基因在转录水平的改变及表观遗传学在引发成年代谢表型中的作用。深入了解并进一步探讨其机制以寻求有效的干预方式对控制心血管疾病及2型糖尿病的流行意义重大,对于经济快速转型的发展中国家更是意义深远。
文摘Chronic lung diseases have been recognized as one of the world's leading causes of death in recent decades. Lacking effective treatments brings the patients not only bad quality of life but also higher risk for lung cancer development. By increasing the understanding of deeper mechanism of how lung develops and regenerates, researchers now focus on studying lung regenerative medicine, aiming to apply different and more efficient therapies to treat chronic lung diseases. This review will provide a wide picture of both basic lung developmental, regeneration mechanism and different designed strategies for treating chronic lung diseases in the future decades.
