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The Application of Bilayer Artificial Dermis Combined with VSD Technology in Chronic Wounds
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作者 Xianjin Dong Huasong Luo 《Journal of Biosciences and Medicines》 2024年第3期238-244,共7页
Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD... Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD) technology in the treatment of chronic wounds. Method: From June 2021 to December 2023, our hospital treated 24 patients with chronic skin tissue wounds on their limbs using a novel tissue engineering product, the bilayer artificial dermis, in combination with VSD technology to repair the wounds. The bilayer artificial dermis protects subcutaneous tissue, blood vessels, nerves, muscles, and tendons, and also promotes the growth of granulation tissue and blood vessels to aid in wound healing when used in conjunction with VSD technology for wound dressing changes in chronic wounds. Results: In this study, 24 cases of chronic wounds with exposed bone or tendon larger than 1.0 cm2 were treated with a bilayer artificial skin combined with VSD dressing after wound debridement. The wounds were not suitable for immediate skin grafting. At 2 - 3 weeks post-treatment, good granulation tissue growth was observed. Subsequent procedures included thick skin grafting or wound dressing changes until complete wound healing. Patients were followed up on average for 3 months (range: 1 - 12 months) post-surgery. Comparative analysis of the appearance, function, skin color, elasticity, and sensation of the healed chronic wounds revealed superior outcomes compared to traditional skin fl repairs, resulting in significantly higher satisfaction levels among patients and their families. Conclusion: The application of bilayer artificial dermis combined with VSD technology for the repair of chronic wounds proves to be a viable method, yielding satisfactory therapeutic effects compared to traditional skin flap procedures. 展开更多
关键词 Bilayer Artificial Dermis Vacuum Sealing Drainage (VSD) chronic wounds wound Healing APPLICATION
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Empowerment in chronic wound care——exploring the scope for patient contribution
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作者 Benedikt Hackert Ewa Klara Stürmer Ulrich Weger 《Frontiers of Nursing》 2024年第1期1-16,共16页
Objective:In this study,we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom(DOF):that is,shaping of everyday wound care tasks ... Objective:In this study,we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom(DOF):that is,shaping of everyday wound care tasks initiated by patients and based on their wishes,mostly in terms of patients executing treatment steps,requesting or directing health care professionals to under take changes,or modifications of internal states.Methods:As a first step,we conducted a systematic literature search,followed by an inductive form of qualitative content analysis,which resulted in the identification of 5 dimensions as main elements of empowerment:education and shared decision making,adherence to self-care behaviors,responsibility and control,general call for empowerment,and DOF.However,the latter are noticeably absent in the literature.To investigate patients'freedom in shaping the wound care process,we conducted a second literature search.Results:A number of possibilities for patients to influence the wound care process could be identified,but experimental or clinical evidence about their effects is missing,their variety is limited,and they are only inadequately described.Conclusions:However,DOF should be an indispensable aspect of genuine empowerment,since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling empowered.Thus,in the third part,we develop a research proposal on how to investigate and include DOF in the clinical practice of wound care.Finally,limitations about implementations are discussed(e.g.,patients being reluctant to overcome their passive role,resulting in frustration for health care professionals). 展开更多
关键词 ADHERENCE chronic wounds control degrees of freedom EMPOWERMENT shared decision making
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Efficacy of lidocaine wet compress combined with red-light irradiation for chronic wounds
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作者 Man-Zhen Bao Lian-Bang Zhou +4 位作者 Ling Zhao Hui Zhang Yuan Li Li Yang An-Ting Tai 《World Journal of Clinical Cases》 SCIE 2023年第30期7277-7283,共7页
BACKGROUND Chronic wounds that fail to progress through normal phases of healing present a significant healthcare burden owing to prolonged treatment and associated costs.Traditional wound care typically involves regu... BACKGROUND Chronic wounds that fail to progress through normal phases of healing present a significant healthcare burden owing to prolonged treatment and associated costs.Traditional wound care typically involves regular dressing changes,which can be painful.Recent approaches have explored the use of lidocaine to manage pain and red-light irradiation(RLI),known for its anti-inflammatory and cell proliferation effects,to potentially enhance wound healing.AIM To investigate the therapeutic efficacy of lidocaine wet compression(LWC)combined with RLI for chronic wounds.METHODS We enrolled 150 patients with chronic wounds from the Wound and Ostomy Outpatient Clinic of the Second Hospital of Anhui Medical University from April to September 2022.The wounds were treated with dressing changes.The patients were randomly assigned to the control and experimental groups using a random number table and given the same first dressing change(2%LWC for 5 min and routine dressing change).From the second dressing change,in addition to 2%LWC for 5 min and routine dressing change,the experimental group received RLI,whereas the control group continued to receive the same LWC and dressing change.The first and second dressing changes were performed on days 1 and 2,respectively.The third dressing change was performed 3 d after the second change.The frequency of subsequent dressing changes was determined based on wound exudation and pain.Pain during the first three dressing changes was evaluated in both groups.The average number of dressing changes within 28 d and the degree of wound healing on day 28 were also recorded.RESULTS During the initial dressing change,no noticeable differences were observed in the pain levels experienced by the two groups,indicating similar pain tolerance.However,during the second and third dressing changes,the experimental group reported significantly less pain than the control group.Furthermore,over 28 d,the experimental group required fewer dressing changes than the control group.CONCLUSION Notably,the effectiveness of wound healing on the 28th day was significantly higher in the experimental group than that of in the control group.The combination of LWC and RLI was effective in reducing early-stage pain,promoting wound healing,decreasing the frequency of dressing changes,and enhancing patients’overall quality of life with chronic wounds. 展开更多
关键词 chronic wound LIDOCAINE Red light PAIN Quality of Life wound exudation
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Antibacterial Properties of Crateva adansonii (Capparidaceae) on Strains Isolated from Chronic Wounds Diagnosed in the Commune of Ouinhi in 2021
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作者 Zinsou Franck Maurille Mignanwandé Hervé Kouessivi Janvier Bokossa +6 位作者 Jules Afle Dagbédji Damien Toffa Carine Zinsou Wilfrid Hinnoutondji Kpètèhoto Rafiatou Ba Esai Gimatal Anagonou Roch Christian Johnson 《Pharmacology & Pharmacy》 2023年第11期449-462,共14页
Plants have always been used by people for therapeutic purposes. They are still the main source of therapeutic substances in developing countries. Crateva adansonii, a member of the Capparidaceae family, is a medicina... Plants have always been used by people for therapeutic purposes. They are still the main source of therapeutic substances in developing countries. Crateva adansonii, a member of the Capparidaceae family, is a medicinal plant with antibacterial properties used in Benin. The aim of this study was to assess the efficacy of an aqueous extract of C. adansonii on bacterial strains isolated from chronic wounds in the Ouinhi population. To achieve this, the bacterial flora present in chronic wounds was identified using the Ikram method (2014) coupled with the API Remoel One method. The antibacterial properties of the aqueous extract of C. adansonii on the microbial strains isolated were then assessed by determining the Inhibition Diameters (ID), the Minimum Inhibitory Concentrations (MIC) and finally the Minimum Bactericidal Concentrations (MBC). A total of eighty (80) strains were isolated and identified on the basis of morphological, cultural and biochemical characteristics. The species S. Aureus species accounted for the largest proportion (67.5%). Other species such as Listeria sp, Pseudomonas proteus, S. epidermidis and Bacillus cereus, Citrobacter freundii, Steno maltophila;Axin calcoaceticus, E. coli, K. pneumonia, Lem. richardii, Salmonella paratyphi A, Salmonella sp, Shigella sp were determined in variable proportions. At a concentration of 10 mg/ml, only S. aureus was sensitive to contact with the extract. However, at 20 mg/ml, 89% of strains were sensitive and 11% very sensitive. The highly sensitive strains are Salmonella sp and E. coli. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) are 20 mg/ml and 40 mg/ml respectively. The MBC/MIC ratio of the aqueous mixture of Crateva adansonii (Capparidaceae) varied from 1.2 to 2, with a bactericidal effect on 100% of the strains tested. 展开更多
关键词 Crateva adansonii Antimicrobial Activities chronic wound Strains BENIN
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Discussion on the Application Effect of Simplified Vacuum Sealing Drainage(VSD)in the Treatment of Chronic Refractory Wounds
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作者 Xiaohong Rong Jing Deng +2 位作者 Qingrong Du Xiaoli Zheng Xiaoying Zhang 《Journal of Clinical and Nursing Research》 2023年第5期78-83,共6页
Objective:To analyze the effect of simplified vacuum sealing drainage(VSD)in the treatment of chronic refractory wounds.Methods:A total of 90 patients with chronic refractory wounds treated from May 2022 to May 2023 w... Objective:To analyze the effect of simplified vacuum sealing drainage(VSD)in the treatment of chronic refractory wounds.Methods:A total of 90 patients with chronic refractory wounds treated from May 2022 to May 2023 were randomly divided into groups.The simplified VSD treatment was employed in group A,and conventional treatment was employed in group B,and the wound healing of both groups were compared.Results:Group A showed better wound healing compared to group B,P<0.05;the wound healing rate,wound healing duration,visual analog scale(VAS)score,wound dressing times and other indicators in group A were better than those in group B,P<0.05.The SF-36 score of group A was higher than that of group B,P<0.05;the complication rate of chronic refractory wounds in group A was no different from that in group B,P>0.05.Conclusion:Simplified VSD treatment is effective in treating patients with chronic refractory wounds,and it reduces the number of wound dressing changes and promote wound healing. 展开更多
关键词 chronic refractory wound Simplified VSD Curative effect
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Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds:A case report 被引量:5
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作者 Po Liu Yang Liu +3 位作者 Chang-Neng Ke Wei-Shan Li Yue-Ming Liu Shi Xu 《World Journal of Clinical Cases》 SCIE 2021年第18期4797-4802,共6页
BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic... BACKGROUND Management of chronic refractory wounds is one of the toughest clinical challenges for surgeons.Because of poor blood supply,less tissue coverage,and easy exposure,the lower leg is a common site for chronic refractory wounds.The current therapeutic regimens often lead to prolonged hospital stay and higher healthcare costs.Concentrated growth factor(CGF)is a novel blood extract that contains various growth factors,platelets,and fibrins to promote wound healing process.However,there has been little research reported on the treatment of lower extremity wounds with CGF.CASE SUMMARY A 37-year-old man,without any past medical history,presented an ulcerated chronic wound on his right lower leg.The skin defect exhibited clear boundaries,with a size of 2.0 cm×3.5 cm.The depth of wound was up to the layer of deep fascia.Staphylococcus aureus was detected by bacterial culture.The final diagnosis was right lower extremity ulcers with infection.Cefathiamidine,silver sulfadiazine,and mupirocin cream were applied to control the infection.CGF gel was prepared from the patient’s blood sample,and was used to cover the wound after thorough debridement.The skin wound was successfully healed after three times of CGF treatment.CONCLUSION CGF displays an excellent wound healing promoting effect in patients with lowerextremity chronic refractory wounds. 展开更多
关键词 Concentrated growth factors chronic refractory wounds Lower extremity ULCER wound healing Case report
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Comparison of Chronic Wound Inpatients and Outpatients’ Diets and Meals Nutrient Content in Taabo Wound Management Unit, Côte d’Ivoire
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作者 Didier Y. Koffi Amoin Georgette Konan +1 位作者 Evans Ehouman Bassirou Bonfoh 《Food and Nutrition Sciences》 CAS 2023年第3期156-174,共19页
Chronic and potential non-healing wounds are a great challenge for patients, physicians, and wound care professionals and the health system. A balanced nutrition intake is essential for health as well as a speedy reco... Chronic and potential non-healing wounds are a great challenge for patients, physicians, and wound care professionals and the health system. A balanced nutrition intake is essential for health as well as a speedy recovery of such wounds. The study objective was to compare chronic wound inpatients supplemented with food nutrient content with outpatients with their usual intake in a cross-sectional study. Patients’ food samples were taken for chemical analyses. The protein, beta-carotene, sodium, magnesium, manganese, and potassium content prove statistically significant differences. Outpatients’ diets are more diversified than inpatients’ diets, and supplementation diet richest in beta-carotene and in protein. Outpatients have better dietary diversity than those who were hospitalized. The result provides insights of supplementary food as critical issues pertaining to chronic wounds management. However, analyzing bioavailability of nutrient on patients’ blood may provide more knowledge in the appropriate integrated wound management. 展开更多
关键词 chronic wound BIOCHEMISTRY Nutrient Content wound Management te d’Ivoire
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Role of stem cell therapies in treating chronic wounds:A systematic review 被引量:7
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作者 Anjali C Raghuram Roy P Yu +4 位作者 Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong 《World Journal of Stem Cells》 SCIE CAS 2020年第7期659-675,共17页
BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for ... BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. 展开更多
关键词 Mesenchymal stem cells Adult stem cells Embryonic stem cells Erythroid precursor cells Stem cell therapies chronic wounds
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Research progress of compound Baiyu powder in treatment of chronic refractory wounds
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作者 LI Doudou LIU Xiaorong +4 位作者 GE Yunxia YAO Xiaoming YE Juan PANG Zhonghua YU Zhongxiang 《中西医结合护理(中英文)》 2018年第12期1-5,共5页
Chronic refractory w ounds are common and frequently-seen diseases in surgery.Due to their long course of disease and complex pathogeneses,chronic refractory w ounds arouse high attention in clinic.With the preliminar... Chronic refractory w ounds are common and frequently-seen diseases in surgery.Due to their long course of disease and complex pathogeneses,chronic refractory w ounds arouse high attention in clinic.With the preliminary results of clinical research of their pathogeneses and new treatments achieved,traditional Chinese medicine(TCM),w ith its unique concept,breaks the limitation commonly existing in the methods of w estern medicine,especially obtaining certain achievements in chronic refractory w ounds.This paper review ed the therapeutic effects of compound Baiyu pow der in the treatment of chronic refractory w ounds to prove to be effective,convenient to use and save medical costs. 展开更多
关键词 COMPOUND Baiyu POWDER chronic refractory wounds oral ULCER ABSCESS diabetic foot empirical formula bacterial BIOFILM pathogeneses
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The mechanism of Jiuyi powder and its effective components in inhibiting the M1 phenotype polarization of macrophages on chronic and refractory wounds infected by MRSA
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作者 Yu-Lian Yin Tian Meng +4 位作者 Li-Na Ma Yi-Wei Fan Yi-Fan Cheng Yuan-Yuan Zhong Hong-Feng Chen 《Journal of Hainan Medical University》 2022年第5期5-10,共6页
Objective:To observe the effect of Jiuyi powder and its active components on the bacterial culture and macrophage phenotypic factors of the chronic refractory wound rat model,and to explore its mechanism of removing d... Objective:To observe the effect of Jiuyi powder and its active components on the bacterial culture and macrophage phenotypic factors of the chronic refractory wound rat model,and to explore its mechanism of removing decay and promoting muscle growth.Methods:SD rats were divided into control group,Jiuyi powder group,Shengdan group,and calcined gypsum group,with 8 rats in each group.MRSA-infected skin lesions and wounds were used to build a model of chronic and difficult-to-heal wounds in rats.After the model was formed,the control group was treated with daily routine nitrofural disinfection and replaced with sterile gauze.On the basis of the control group,quantitative Jiuyi powder,Shengdan powder,and calcined gypsum powder were used for dressing change,once a day for 7 consecutive days.Before and after the last administration,collect rat wound secretions for bacterial culture,inducible monoxide nitrogen synthase content.At the same time,after the last administration,the rat wound tissue was excised for histopathology and immunofluorescence double staining to label macrophages and their M1 phenotype.Results:After the last dressing change,the wound healing of Jiuyi powder group was better than the other groups,and the wound healing rate of each group had significant difference(P<0.05).The histomology showed that the inflammation of Jiuyi powder group was controlled and had a healing trend.After the last drug change,the contents of TNF-α,IL-6 and iNOS in serum of all groups decreased,and the contents of IL-6,TNF-αand iNOS in serum of Jiuyi powder group decreased significantly before and after medication(P<0.05).There was statistical significance in serum IL-6 content between calcined gypsum group and Shengdan group before and after medication(P<0.05).In addition,the results showed that the contents of IL-6 and iNOS in serum of Jiuyi powder group were statistically different from those of the control group(P<0.05).Tissue immunofluorescence double staining showed that the positive rate of M1 macrophages in Jiuyi powder group and Shengdan group was significantly lower than that in control group(P<0.05).The MRSA negative conversion rate of Jiuyi powder group and Shengdan group was better than that of the control group and calcined gypsum group(P<0.05).Conclusion:Jiuyi powder can improve the inflammation of chronic refractory wounds,and has antibacterial,anti-corrosion and myogenic effects.Its mechanism may be related to the inhibition of macrophage M1 phenotype polarization. 展开更多
关键词 chronic refractory wound Jiuyi powder Macrophage Phenotypic polarization Rats
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Combined debridement in chronic wounds:A literature review
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作者 Wan-Lin Liu Yun-Lan Jiang +2 位作者 Yan-Qiao Wang Ying-Xin Li Yi-Xian Liu 《Chinese Nursing Research》 CAS 2017年第1期5-8,共4页
Wounds debridement is important for healing of chronic wounds. Combined debridement is a new technique to deal with the complex chronic wounds. This review introduces several topical methods of combined debridement ac... Wounds debridement is important for healing of chronic wounds. Combined debridement is a new technique to deal with the complex chronic wounds. This review introduces several topical methods of combined debridement according to the various color classifications. Methods include combined sharp and hydrogel debridement, combined ultrasonic and enzymatic debridement, ultrasonic debridement combined with surgical debridement and vacuum aspiration on debridement, and other types of debridement. This article also explores why each combined debridement mentioned above can achieve a good effect. 展开更多
关键词 Combined debridement chronic wounds Review Necrotic tissue Ulcer
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Value of Zhuang medicine choerospondias axillaris bark for evaluating the expression of PTEN,VEGF in chronic wounds rats
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作者 Xiao-Wei He Xin Huang +2 位作者 Jia-Qi Di Bing Wang Xing Yin 《Journal of Hainan Medical University》 2019年第11期1-4,共4页
Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 gr... Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups: normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN、VEGF mRNA after 12 d.Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1 d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing. 展开更多
关键词 chronic wounds Choerospondias axillaris BARK Cell ULTRASTRUCTURE PTEN VEGF
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To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds
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作者 Zhihui Hou Mingjuan Gu 《Discussion of Clinical Cases》 2019年第1期11-14,共4页
Objective:To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds.Methods:During March of 2015 to... Objective:To investigate the clinical effect of modified closed negative pressure suction technique combined with flap transplantation on the treatment of deep chronic refractory wounds.Methods:During March of 2015 to April of 2018,52 cases of patients with deep chronic refractory wounds were selected as research objects.They were divided into the control group and the treatment group by use of the random number table method,with 26 cases in each group.Among them,the control group was given conventional debridement combined with flap reconstruction,and the treatment group was treated with modified closed negative pressure suction technique combined with flap transplantation to observe the clinical effect.Results:(1)According to the analysis on the effect of flap transplantation,the excellent and good rate of the treatment group was 92.3%,and in the control group,it was 76.9%(p<0.05).(2)According to the statistics,the incidence of complications in the treatment group was lower than that in the control group(p<0.05).Conclusions:Modified closed negative pressure suction technique combined with flap transplantation has a good effect on the treatment of deep chronic refractory wounds with fewer complications. 展开更多
关键词 Modified closed negative pressure suction technique Flap transplantation Deep chronic refractory wounds
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Recent advances on the association of apoptosis in chronic non healing diabetic wound 被引量:13
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作者 Awadhesh K Arya Richik Tripathi +1 位作者 Santosh Kumar Kamlakar Tripathi 《World Journal of Diabetes》 SCIE CAS 2014年第6期756-762,共7页
Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and ... Generally, wounds are of two categories, such as chronic and acute. Chronic wounds takes time to heal when compared to the acute wounds. Chronic wounds include vasculitis, non healing ulcer, pyoderma gangrenosum, and diseases that cause ischemia. Chronic wounds are rapidly increasing among the elderly population with dysfunctional valves in their lower extremity deep veins, ulcer, neuropathic foot and pressure ulcers. The process of the healing of wounds has several steps with the involvement of immune cells and several other cell types. There are many evidences supporting the hypothesis that apoptosis of immune cells is involved in the wound healing process by ending inflammatory condition. It is also involved in the resolution of various phases of tissue repair. During final steps of wound healing most of the endothelial cells, macrophagesand myofibroblasts undergo apoptosis or exit from the wound, leaving a mass that contains few cells and consists mostly of collagen and other extracellular matrix proteins to provide strength to the healing tissue. This review discusses the various phases of wound healing both in the chronic and acute wounds especially during diabetes mellitus and thus support the hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus and gives proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients. 展开更多
关键词 HEALING wound repair MODALITIES EXTREMITY eventually CASPASE oxidative advances COLLAGEN
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Effects of platelet-rich plasma on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue 被引量:1
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作者 Tie-ning Zhang Quan Li +3 位作者 Te Ba Tian-xi Shao Fang Li Ling-feng Wang 《Discussion of Clinical Cases》 2021年第1期24-28,共5页
Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human ... Objective:To observe the effects of platelet-rich plasma(PRP)on in vitro proliferation and migration of fibroblasts from human chronic refractory wound granulation tissue.Methods:Fibroblasts were separated from human chronic refractory wound granulation tissue and then were identified.The obtained fibroblasts were divided into fetal bovine serum(FBS)group,hydrogel group and PRP group,and the three groups were cultured with culture mediums containing FBS,hydrogel and PRP respectively,in order to observe the growth of fibroblasts.The wound scratch assay was used to observe the migration of fibroblasts.Results:PRP group had more fibroblasts than FBS group and hydrogel group since Day 5 of culture,and exhibited greater fibroblast scratch migration area than FBS group on 48 h and 72 h of wound scratch assay(all p<.05).Conclusions:Compared with FBS,human fibroblasts cultured by PRP can more effectively promote the proliferation and migration of fibroblasts. 展开更多
关键词 FIBROBLAST chronic refractory wound Granulation tissue Platelet-rich plasma Cell proliferation Cell migration In vitro
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Case Report of a Chronic Wound Due to Venous Insufficiency Following a Traumatic Arteriovenous Fistula
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作者 Jialiang Chen Louis Chebli 《Open Journal of Clinical Diagnostics》 2021年第2期47-51,共5页
Chronic lower limb wounds are common. They can be of arterial or venous origin. In this article, we will present a clinical case of a 30-year-old patient with a chronic injury to the right medial malleolus. In his his... Chronic lower limb wounds are common. They can be of arterial or venous origin. In this article, we will present a clinical case of a 30-year-old patient with a chronic injury to the right medial malleolus. In his history, we can note a gunshot wound to the right leg. Ultrasonography and CT angiography helped in the diagnosis of traumatic arteriovenous fistula. The patient underwent a fistula embolization which allowed the wound to heal. The clinical presentation, additional examinations and the latest treatment recommendations will be discussed in this article. 展开更多
关键词 Arteriovenous Fistula chronic wound TRAUMA Venous Insufficiency
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Experimental Study of Moist Exposed Burn Therapy/Moist Exposed Burn Ointment Combined with Zhuang Medicine Detoxification for Chronic Refractory Wound Healing
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作者 Xing Yin Xin Huang +2 位作者 Qi Zhang Jianye Dai Xiaowei He 《Journal of Biosciences and Medicines》 2021年第11期21-29,共9页
<strong>Background: </strong>This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism. At present, there is ... <strong>Background: </strong>This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism. At present, there is still a lack of effective clinical treatment. This study, therefore, aims at exploring moist exposed burn therapy/moist exposed burn ointment (MEBT/MEBO) combined with Zhuang medicine detoxification in the treatment of chronic refractory wound healing. <strong>Methodology: </strong>100 SPF Wistar rats were randomly divided into blank control group, model control group, MEBO group, Zhuang medicine group and Combined group, with 20 rats in each group. Open wound model was established in blank control group, and chronic refractory wound model was established in other groups. Black control group and model control group were given food and water freely, MEBO group was given dressing change once a day, Zhuang medicine group was given intragastric administration once a day, and combined group was given dressing change and intragastric administration once a day. The effective rate of wound healing was observed after 12 days of continuous intervention. <strong>Conclusion: </strong>Skin regeneration medical technique combined with Zhuang medicine poison theory can effectively reduce the symptoms of bleeding and exudation, reduce the area of wound, shorten the healing time of wound, and achieve physiological healing of wound. It has a good effect on chronic refractory wound. 展开更多
关键词 chronic Refractory wounds wound Repair MEBT/MEBO Zhuang Medicine
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Managament Wound Healing: The Importance of a Wound Clinic in Hospital Centers
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作者 Alfredo Chama Naranjo Cuahutémoc Márquez Espriella +17 位作者 Alberto Ignacio Cahuana Quispe Barbosa Villarreal Fernando Ana Priscila Campollo López Mauricio Gutiérrez Álvarez Carlos Emiliano García Córdova Jesús Ricardo García Corral Cuervo Vergara Marco Antonio Jorge Luis Rosales Becerra Dávila Díaz Rodrigo Edgar Alan Guillen Martínez Marín Canto Miguel Eduardo Luis Arturo Herrera Lozano Ochoa Contreras Erick Cesar Martinez Villalobos Claudia Nallely Cruz Soto Randall Camacho Rodriguez Hayah Ricardo Alberto Pulido López Edwing Michel Jaimes Durán 《Modern Plastic Surgery》 2023年第4期118-125,共8页
Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary... Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary team for wound care and treatment yields favorable clinical outcomes as well as a reduction in economic expenses due to a higher rate of healing, a decrease in hospital stays, and a reduction in the number of readmissions. The establishment of wound clinics enhances the utilization of diagnostic, preventive, and therapeutic resources, improving the quality of life of patients and facilitating their reintegration into their normal lives. The objective is solely to describe the importance of wound clinics in the medical profession. Methods: A retrospective literature search was conducted to include articles no more than 10 years old that reported measures or results of the study in order to perform a literature review and describe the importance of wound clinics in medical practice. Results: A total of 7 articles were obtained with the inclusion criteria, the most recent being from the year 2023 and the oldest from 2013. Conclusion: An important area for improvement in the healthcare industry is the management and treatment of complex wounds. The establishment of wound clinics offers comprehensive and specialized care for both acute and chronic complex wounds with the goal of enhancing secondary illness patients’ prevention, treatment, and rehabilitation. 展开更多
关键词 wound Clinic Pressure Ulcer chronic wound wound Healing Quality of Life
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基于互联网医院医联体慢性伤口云端管理模式的应用研究
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作者 张在萍 张薇 +1 位作者 谢萍 汤雨佳 《现代临床护理》 2024年第3期82-87,共6页
目的探讨基于互联网医院医联体慢性伤口云端管理模式在医联体慢性伤口患者管理中的构建和应用效果。方法采用不同病例前-后对照研究,将2020年4月至2021年4月医联体就诊慢性伤口患者90例设为对照组,将2021年5月至2022年5月医联体就诊慢... 目的探讨基于互联网医院医联体慢性伤口云端管理模式在医联体慢性伤口患者管理中的构建和应用效果。方法采用不同病例前-后对照研究,将2020年4月至2021年4月医联体就诊慢性伤口患者90例设为对照组,将2021年5月至2022年5月医联体就诊慢性伤口患者96例设为观察组。对照组给予常规伤口护理管理,观察组采用构建的互联网医院医联体慢性伤口云端管理模式,对10家医联体医院的患者进行全程同质管理。比较两组患者的伤口愈合率、患者满意度,转诊率和伤口愈合时间。结果观察组患者伤口愈合率、患者满意度均高于对照组,转诊率较对照组低,伤口愈合时间较对照组短,两组比较,差异具有统计学意义(均P<0.05)。结论基于互联网医院医联体慢性伤口云端管理模式的实施能缩短医联体慢性伤口患者伤口愈合时间,提高伤口愈合率、患者满意度,提高医联体医院慢性伤口护理质量,为实现医联体医院慢性伤口同质化护理目标打好基础。 展开更多
关键词 互联网医院 医联体 云会诊 慢性伤口云端管理模式 前-后对照研究
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老年慢性伤口病人家庭照顾者疲劳现状及影响因素分析
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作者 胡燕利 魏晓燕 +6 位作者 郭丹 郭明伟 张云霞 金露 付艳伶 董红静 王艳 《全科护理》 2024年第10期1916-1920,共5页
目的:了解老年慢性伤口病人家庭照顾者疲劳现状及影响因素,为制订干预措施,减轻家庭照顾者的疲劳提供参考依据。方法:采用疲劳自评量表、习得性无助量表对就诊于北京市某三级甲等医院门诊换药室的380名老年慢性伤口病人家庭照顾者进行... 目的:了解老年慢性伤口病人家庭照顾者疲劳现状及影响因素,为制订干预措施,减轻家庭照顾者的疲劳提供参考依据。方法:采用疲劳自评量表、习得性无助量表对就诊于北京市某三级甲等医院门诊换药室的380名老年慢性伤口病人家庭照顾者进行问卷调查。结果:老年慢性伤口病人家庭照顾者总体疲劳状况得分为(73.30±18.20)分;单因素分析结果显示,不同年龄、婚姻状况、与病人关系、平均每年照顾病人时间、照顾者身体状况、照顾者患慢性病数量、照顾者伤口护理技能了解程度、病人日常生活能力的家庭照顾者疲劳状况得分比较差异均有统计学意义(P<0.05);多元线性回归分析结果显示,照顾者身体状况、病人日常生活能力、照顾者习得性无助感是影响老年慢性伤口病人照顾者疲劳的因素。结论:老年慢性伤口病人照顾者疲劳水平较高,建议政府部门加快推进“互联网+护理服务”的开展,制定政策、建立行业标准,保障护患权利,以减轻照顾者疲劳。 展开更多
关键词 老年慢性伤口病人 家庭照顾者 疲劳 影响因素分析
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