Identifying the molecular basis of Jinhong tablets against chronic superficial gastritis via chemical profile identification and symptom-guided network pharmacology analysis

Chronic superficial gastritis(CSG)is a common disease of the digestive system that possesses a serious pathogenesis.Jinhong tablet(JHT),a traditional Chinese medicine(TCM)prescription,exerts therapeutic effects against CSG.However,the molecular basis of its therapeutic effect has not been clarified.Herein,we employed ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q/TOF-MS)based chemical profile identification to determine the chemical components in JHT.Further,we applied network pharmacology to illustrate its molecular mechanisms.A total of 96 chemical constituents were identified in JHT,31 of which were confirmed using reference standards.Based on the bioinformatics analysis using the symptom-guided pharmacological networks of“chi,”“blood,”“pain,”and“inflammation,”and target screening through the interaction probabilities between compounds and targets,matrix metalloproteinase 2(MMP2),dopamine d2 receptor(DRD2),and Aldo-keto reductase family 1 member B1(AKR1B1)were identified as key targets in the therapeutic effect exhibited by JHT against CSG.Moreover,according to the inhibitory activities presented in the literature and binding mode analysis,the structural types of alkaloids,flavonoids,organic acids,including chlorogenic acid(10),caffeic acid(13),(-)-corydalmine(33),(-)-isocorypalmine(36),isochlorogenic acid C(38),isochlorogenic acid A(41),quercetin-3-O-a-L-rhamnoside(42),isochlorogenic acid B(47),quercetin(63),and kaempferol(70)tended to show remarkable activities against CSG.Owing to the above findings,we systematically identified the chemical components of JHT and revealed its molecular mechanisms based on the symptoms associated with CSG.

Evaluation of the Gastric Microbiome in Patients with Chronic Superficial Gastritis and Intestinal Metaplasia

Objective To evaluate the gastric microbiome in patients with chronic superficial gastritis(CSG)and intestinal metaplasia(IM)and investigate the influence of Helicobacter pylori(H.pylori)on the gastric microbiome.Methods Gastric mucosa tissue samples were collected from 54 patients with CSG and IM,and the patients were classified into the following four groups based on the state of H.pylori infection and histology:H.pylori-negative CSG(n=24),H.pylori-positive CSG(n=14),H.pylori-negative IM(n=11),and H.pylori-positive IM(n=5).The gastric microbiome was analyzed by 16S rRNA gene sequencing.Results H.pylori strongly influenced the bacterial abundance and diversity regardless of CSG and IM.In H.pylori-positive subjects,the bacterial abundance and diversity were significantly lower than in H.pylori-negative subjects.The H.pylori-negative groups had similar bacterial composition and bacterial abundance.The H.pylori-positive groups also had similar bacterial composition but different bacterial relative abundance.The relative abundance of Neisseria,Streptococcus,Rothia,and Veillonella were richer in the I-HP group than in G-HP group,especially Neisseria(t=175.1,P<0.001).Conclusions The gastric microbial abundance and diversity are lower in H.pylori-infected patients regardless of CSG and IM.Compared to H.pylori-positive CSG group and H.pylori-positive IM,the relative abundance of Neisseria,Streptococcus,Rothia,and Veillonella is higher in H.pylori-positive patients with IM than in H.pylori-positive patients with CSG,especially Neisseria.

Serum protein profiles suggest a possible link between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To identify potential serum protein candidates involved in linking the traditional Chinese medicine(TCM)-defined qi deficiency constitution(QDC)to Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Using participants with the TCM-defined balanced constitution as a control population,labelfree quantitative proteomics was adopted to identify differentially expressed proteins(DEPs)in serum samples from two case populations:case population 1(participants with QDC)and case population 2(patients with PQDS of CSG).The DEPs discovered in both case populations were analyzed to identify common DEPs as potential candidates for proteins involved in the link between QDC and PQDS.Based on Kyoto Encyclopedia of Genes and Genomes pathway(KEGG)and Gene Ontology(GO)enrichment analysis and analysis of proteineprotein interaction networks,we evaluated the possible functions of these potential serum candidates.Results:We discovered 24 and 28 proteins that were differentially expressed in case populations 1 and 2,respectively,compared with the control population.Hierarchical clustering analysis showed that the expression profile of DEPs of individuals from the same population clustered well,while those from different populations were segregated.Furthermore,GO analysis revealed the 10 DEPs that were common to both case populations to be mainly associated with negative regulation of cellular metabolic and immune system processes while KEGG analysis indicated these proteins to be associated with complement and coagulation cascades and peroxisome proliferator-activated receptor signaling.Notably,serum levels of C4b-binding protein beta chain,glycosylphosphatidylinositol-specific phospholipase D1 and MS-F1 light chain variable region proteins were notably higher in the two case populations compared with the control,particularly in the case of CSG with PQDS.Conclusion:The results presented here provide new insights into the molecular mechanisms underlying development of PQDS of CSG from QDC,and suggest candidate serum biomarkers for future application in integrative medicine.

Systematic evaluation and Meta-analysis of the efficacy of Xiaochaihu Decoction in the treatment of chronic superficial gastritis

Objective:To compare the effectiveness of Xiaochaihu Decoction(XCHD)or the modified XCHD combined with western medicine in the treatment of superficial gastritis.Methods:We collected the studies about XCHD or the modified XCHD combined with western medicine for superficial gastritis in China Biology Medicine(CBM)Database(2010-2018),China National Knowledge Infrastructure(CNKI)Database(2010-2018),VIP Database(2010-2018),Wanfang Database(2010-2018)and the Back Issues Database of Hebei University.The randomized controlled trials(RCTs)were included in this study.The literatures were independently extracted by two researchers and the Cochrane Review Handbook(version 5.1.0)was applied to assess the quality of included trials.Statistical analysis was performed with RevMan(version 5.3).Results:A total of 8 RCTs,including 732 cases,were included finally.Meta-analysis results showed that compared with the western medicine treatment group,XCHD or the modified XCHD combined with western medicine could improve the total effective rate[OR=4.67,95%CI(2.90,7.55),P<0.00001],physiological function[MD=10,95%CI(8.78,11.23),P<0.00001],role physical[MD=13.85,95%CI(11.19,16.51),P<0.00001],physical pain[MD=11.64,95%CI(9.05,14.23),P<0.00001],general health[MD=11.20,95%CI(9.52,12.88),P<0.00001],vitality[MD=13.46,95%CI(12.30,14.62),P<0.00001],social function[MD=19.20,95%CI(17.32,21.09),P<0.00001],affection function[MD=30.3,95%CI(28.99,31.62),P<0.00001],mental health[MD=9.80,95%CI(8.44,11.16),P<0.00001].Conclusion:XCHD or the modified XCHD combined with western medicine in the treatment of superficial gastritis has good performance in clinical efficacy and the improvement of quality of life.However,with several methodology problems existing in the included RCTs,the effectiveness of XCHD or the modified XCHD is still need more high-quality randomized,double-blind,placebo-controlled trials to further confirmed.

Screening for blood leukocyte microRNA biomarkers responsible for association between qi deficiency constitution and Pi-qi-deficiency syndrome of chronic superficial gastritis

Objective:To screen for blood leukocyte microRNA(miRNA)biomarkers responsible for the association between the traditional Chinese medicine(TCM)qi deficiency constitution(QDC)and the Pi-qi-deficiency syndrome(PQDS)of chronic superficial gastritis(CSG).Methods:Peripheral blood leukocytes were separated from people of two TCM constitutions(balance and qi deficiency)and from CSG patients with PQDS.Total RNA was isolated from the leukocytes and subjected to subsequent high-throughput miRNA sequencing to identify the miRNAs that are specifically and highly expressed in persons of QDC and CSG patients with PQDS.In addition,the target genes of the associated miRNAs were predicted.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway-based enrichment analyses of these target genes were performed to further evaluate the associated miRNA candidates as potential biomarkers responsible for the association between QDC and PQDS of CSG.Results:Compared with the control group with a balance constitution(P<.05,fold change>1.5 or<0.5),31 and 38 differentially expressed miRNAs were found in persons of QDC and CSG patients with PQDS,respectively.In particular,hsa-miR-145-5p and hsa-miR-146a-3p were highly expressed in both the persons of QDC and CSG patients with PQDS.GO analysis of the target genes of the two common miRNAs showed that they were mainly associated with functions related to synthesis and metabolism,such as cellular nitrogen compound metabolic processes,biosynthetic processes,cellular protein modification processes,and cellular component assembly.KEGG analysis identified the common pathways enriched among the target genes,including the Hippo signaling pathway and the transcriptional misregulation pathway.The common target genes of the two miRNAs seemed to be associated with the spliceosome pathway and the RNA degradation pathway.Conclusion:Hsa-miR-145-5p and hsa-miR-146a-3p may serve as candidate biomarkers responsible for the association between QDC and PQDS of CSG.

Clinical Efficacy of Chaihu Shugan Powder Classical Formula in Treating Chronic Superficial Gastritis with Liver-Stomach Disharmony

[Objectives] To investigate the clinical efficacy of Chaihu Shugan Powder on chronic superficial gastritis with liver-stomach disharmony syndrome.[Methods] A total of 72 patients diagnosed with chronic superficial gastritis characterized by liver-stomach disharmony syndrome between September 2023 and August 2024 were randomly assigned into two groups. The control group received treatment with western medicine, and the treatment group was administered both western medicine and Chaihu Shugan Powder. The therapeutic effects, TCM syndrome scores, adverse reactions, and recurrence rate were compared between the two groups.[Results] The total effective rate was 88.89% in the treatment group and 80.56% in the control group. The differences between the two groups were statistically significant ( P <0.05), indicating that the improvement observed in the treatment group was significantly greater than that in the control group ( P <0.05). In comparison to pre-treatment levels, the TCM syndrome scores for both patient groups exhibited a reduction following treatment. Notably, the extent of this reduction in the treatment group was significantly greater than that observed in the control group ( P <0.05). Neither group of patients experienced serious adverse reactions during treatment. Furthermore, the recurrence rate among patients in the control group was found to be higher than that in the treatment group.[Conclusions] The clinical efficacy of Chaihu Shugan Powder in the treatment of chronic superficial gastritis with liver-stomach disharmony syndrome is significant, demonstrating a notable reduction in the recurrence rate of the condition.

Bioinformatics Research on Chronic Superficial Gastritis of Pi-deficiency Syndrome by Gene Arrays

Objective： To determine the bioinformatical characteristics of differential gene expression in patients with chronic superficial gastritis （CSG） with the Pi-deficiency syndrome （PDS） and those of the non- Pi-deficiency syndrome （non-PDS）, i.e. patients of CSG with Pi （脾）-Wei （胃） dampnese-heat syndrome and healthy persons. Methods： With the BRB-Array Tools software package, original data collection and bioinformatic analysis of gene arrays were conducted in 6 CSG patients of PDS （CSG-PDS）, 6 CSG patients of non-PDS （CSG-nPDS）, and 6 healthy volunteers （Normal）. Results： Compared with non-PDS, the gene expressions in PDS with regards to protein synthesis, energy metabolism, immune reaction and ionic transport tended to be down-regulated, while those concerning secretion, cytoskeleton and ubiquitinization were up-regulated dominantly. Conclusions： The two kinds of samples, CSG-PDS/Normal and CSG-PDS/CSG-nPDS, have their respective gene expression profiles with different characteristics. Gene expression profile has certain referential significance in syndrome classification.

Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(H.pylori)infection and increased risk of gastric cancer.AIM To identify the risk factors associated with H.pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.METHODS We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with H.pylori-induced chronic gastritis,and Group 2–control group.RESULTS Rural area and poor living conditions were significantly associated with H.pylori chronic gastritis(P=0.0042/P<0.0001).Both positive immunoglobulin A anti H.pylori and the rapid urease test were significantly associated with H.pylori infection(P<0.0001).Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with H.pylori chronic gastritis(P=0.111/P=0.284).We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation.

A Long-Term Follow-up Study of Chronic Gastritis with Fibergastroscope

A more than 5 year follow up study about 48 cases of chronic atrophic gastritis(CAG) and 100 cases of chronic superficial gastritis (CSG) is reported in CAG, it is found that 35.5% of the patients were improved, 41.6% stabilized, 12.5% deteriorated, 6.2% recovered, and 4.2% cancerated. In CSG, it is found that 40% of the patients were improved, 48% stabilized, 6% deteriorated, 5% recovered and 1% cancerated. It is concluded that CAG group has a higher rate of cancerization than that of CSG group.

HP阳性慢性浅表性胃炎患者采用益生菌联合铋剂四联治疗价值探讨

目的探究幽门螺旋杆菌阳性慢性浅表性胃炎患者应用益生菌联合铋剂四联治疗的效果。方法将福建省福清市医院自2021年2月至2023年10月收治的120例HP阳性慢性浅表性胃炎患者纳入研究。采用完全随机分组法均分为试验组及对照组,每组均为60例。对照组采用铋剂四联治疗,试验组加用益生菌治疗。比较两组的治疗效果、HP转阴率、临床症状改善情况、胃肠功能水平、炎性因子水平及安全性。结果试验组治疗效果高于对照组(P<0.05);试验组HP转阴率高于对照组(P<0.05);试验组临床症状改善情况中腹胀、恶心呕吐、反酸嗳气及上腹痛症状消失时间均少于对照组(P<0.05);试验组胃肠功能中PGⅠ、PGⅡ水平均低于对照组(P<0.05);试验组胃肠功能中GAS水平高于对照组(P<0.05);试验组不良反应率低于对照组(P<0.05)。结论对比单独应用铋剂四联治疗,益生菌联合治疗能够提高HP阳性慢性浅表性胃炎患者的疗效,改善临床症状及胃肠功能,降低炎性因子水平,且不良反应较少,安全性较好。

基于网络药理学和分子对接探讨胃复春治疗慢性浅表性胃炎作用机制

目的:基于网络药理学探讨胃复春(WFC)治疗慢性浅表性胃炎(CSG)的分子机制。方法:采用中药系统药理学数据库与分析平台(TCMSP)、中药综合资源数据库(TCMID)及SwissTargetPrediction网站检索WFC的相关化学成分及其对应的作用靶点;利用GeneCard数据库、OMIM数据库筛选CSG的作用靶点,通过韦恩在线网站获取WFC与CSG的交集靶点,并通过Cytoscape 3.7.2软件构建蛋白互作网络图;根据拓扑学参数查找WFC治疗CSG的核心靶点,运用Cytoscape 3.7.2软件构建成分-核心靶点网络图筛选WFC作用于CSG的关键成分。利用David网站对交集靶点进行基因本体论(GO)和京都基因与基因组百科全书数据库(KEGG)通路富集分析,采用R软件绘制可视化气泡图。通过SYBYL-X2.1.1软件对WFC治疗CSG的主要活性成分及关键靶点进行分子对接。结果:WFC治疗CSG的关键成分为人参皂苷Rh2、柚皮素、14-乙酰基-耐阴午茶菜素b、β-谷甾醇等,关键靶点有白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、苏氨酸蛋白激酶1(AKT1)、血管内皮生长因子A(VEGFA)、抑癌基因53(TP53)等。WFC治疗CSG主要作用于癌症信号通路、脂质与动脉粥样硬化信号通路、卡波西肉瘤相关疱疹病毒感染等信号通路,其功能主要有参与RNA聚合酶Ⅱ启动子转录的正调控、信号转导及细胞凋亡过程的负调控,在蛋白质结合、ATP结合方面起重要作用等。分子对接结果显示,WFC中的关键成分14-乙酰基-耐阴午茶菜素b、人参皂苷Rh2、川陈皮素与关键靶点IL-6、AKT1、VEGFA的结合活性较强。结论:WFC可能通过调节IL-6、TNF、AKT1等靶点治疗CSG,其作用机制与癌症信号通路,脂质与动脉粥样硬化信号通路密切相关。

奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的临床效果

目的观察奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的效果。方法选取经胃镜诊断均为慢性浅表性胃炎的患者,均在福清市中医院于2021年8月至2023年1月期间收治,总计100例,采用随机数字表方法分组,对照组(50例,奥美拉唑治疗)和观察组(50例,奥美拉唑+阿莫西林治疗)。结果观察组慢性浅表性胃炎患者临床治疗总有效率高于对照组(P<0.05);观察组慢性浅表性胃炎患者纳差消失时间、恶心呕吐消失时间、腹胀消失时间均短于对照组(均P<0.05);治疗后,观察组慢性浅表性胃炎患者肿瘤坏死因子α、白细胞介素6、核转录因子水平、临床病理积分、疼痛评分均低于对照组(均P<0.05);治疗后,观察组慢性浅表性胃炎患者胃泌素水平低于对照组,胃动素水平高于对照组(均P<0.05);观察组慢性浅表性胃炎患者恶心、呕吐、头晕总不良反应发生率与对照组相近,对比结果差异不显著(P>0.05)。结论奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的效果显著优于奥美拉唑。

王有鹏教授运用“分消走泄”法论治小儿慢性胃炎

王有鹏教授认为慢性胃炎的病机是脾为湿困,气机壅滞,他常运用“分消走泄”法治疗慢性胃炎,针对初期、后期不同病机灵活变通,在宣通气机、分消湿邪的基础上,分别运用祛湿运脾、消导和胃、疏肝理气、活血止血之法,标本兼治,疗效显著。

基于数据挖掘探讨中医治疗脾胃湿热型慢性非萎缩性胃炎的用药规律

目的:探索分析中医药治疗脾胃湿热型慢性非萎缩性胃炎的用药规律。方法:收集中国知网数据库、万方数据库建库至2022年9月1日关于中医药治疗脾胃湿热证慢性非萎缩性胃炎的处方,筛选后导入中医传承计算平台V3.0,对录入处方中药物的使用频次、四气-五味、归经、功效进行分析,采用关联规则、k-means聚类算法进行演算进行分析。结果:共收集91首有效方剂,涉及中药112味。单味药用药频次以黄连最高,半夏次之;药性以寒性、温性为主,平性次之;药味以苦味、辛味最多,辅以甘味;归经中以脾经、胃经为主、肺经次之。功效主要为清热类药、补虚类药、化湿类药、理气类药。常用药物组合频次排前6位的分别为“黄连、半夏”“黄连、陈皮”“半夏、厚朴”“半夏、黄芩”“黄连、黄芩”“半夏、陈皮”;通过k-means聚类得到3对核心药物组合,分别为“黄连、半夏、陈皮、黄芩、厚朴”“厚朴、半夏、黄连、黄芩、甘草”“黄连、半夏、生姜、厚朴、苍术”。结论:中医药治疗脾胃湿热型慢性非萎缩性胃炎以清热燥湿、理气调中为治疗原则,以辛开苦降为重要指导思想,以恢复脾胃气机升降为主要目的,以半夏泻心汤及王氏连朴饮为治疗基础方。此方能通过降低机体炎症水平、抑制胃酸分泌、从而达到促进胃黏膜修复的作用,同时还能改善胃肠道动力,从而减轻患者临床症状,改善预后。

穴位贴敷联合艾灸治疗慢性浅表性胃炎疗效观察及对胃肠激素水平的影响

目的:观察穴位贴敷联合艾灸治疗慢性浅表性胃炎(CSG)的临床疗效以及对胃肠激素水平的影响。方法:选取100例CSG患者,按随机数字表法分为观察组和对照组各50例。对照组采用奥美拉唑肠溶胶囊联合艾灸治疗,观察组在对照组基础上加用穴位敷贴治疗。比较2组临床疗效、中医证候评分、胃肠激素[胃泌素(GAS)、生长抑素(SS)、胃动素(MLT)]水平以及不良反应。结果:观察组总有效率为86.00%,对照组为68.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组胃痛、饮食减少、恶心呕吐、善太息、嗳气吞酸等中医证候评分比较,差异均无统计学意义(P>0.05);治疗后,2组上述各项评分均较治疗前降低(P<0.05),且观察组各项评分均低于对照组(P<0.05)。治疗前,2组血清GAS、SS、MLT水平比较,差异无统计学意义(P>0.05)。治疗后,2组GAS水平均较治疗前降低(P<0.05),SS、MLT水平均较治疗前升高(P<0.05);且观察组GAS水平低于对照组(P<0.05),SS、MLT水平高于对照组(P<0.05)。治疗过程中,2组均未出现明显不良反应。结论:穴位贴敷联合艾灸治疗CSG疗效确切,可有效改善中医证候及胃肠激素水平,且治疗安全性良好。

香砂六君子汤治疗慢性浅表性胃炎Meta分析和试验序贯分析

目的系统评价香砂六君子汤治疗慢性浅表性胃炎的临床有效率和安全性。方法通过检索中国知网(CNKI)、维普、万方、中国生物医学文献(CBM)中有关香砂六君子汤治疗慢性浅表性胃炎的临床随机对照试验(RCT),使用Cochrane手册进行风险偏倚评估和质量评价,通过Revman 5.4软件进行Meta分析,利用TSA 0.9软件进行序贯分析。结果纳入14项研究,共1388例患者,Meta分析显示,总有效率、中医证候积分、不良反应差异均有统计学意义(P<0.00001),临床疗效累积Z值曲线穿过了传统界值、TSA界值以及期望信息值RIS,进一步验证香砂六君子汤的有效性。结论香砂六君子汤治疗慢性浅表性胃炎更为安全有效,但由于此次纳入文献质量均不高,后续仍需高质量的随机双盲对照试验加以证实。

温中健脾养胃汤治疗老年脾胃虚寒型慢性浅表性胃炎临床观察

目的 探究自拟温中健脾养胃汤治疗老年脾胃虚寒型慢性浅表性胃炎(CSG)的效果。方法 选取2018年3月—2021年3月蕲春县人民医院收治的脾胃虚寒型CSG患者100例,随机分为观察组(50例)、对照组(50例);对照组接受常规疗法,观察组在此基础上联合自拟温中健脾养胃汤。比较两组疗效,临床症状中医证候积分、幽门螺杆菌(Hp)转阴时间、胃黏膜病理学评分、白细胞计数(WBC)、白细胞介素-6(IL-6)以及肿瘤坏死因子-α(TNF-α)水平。结果 观察组治疗总有效率92.00%(46/50)显著高于对照组的74.00%(37/50)(P<0.05);观察组Hp转阴时间低于对照组(P<0.05),且中医证候积分、胃黏膜病理学评分、WBC计数、IL-6以及TNF-α水平亦低于对照组(P<0.05),差异有统计学意义。结论 温中健脾养胃汤辅助能提高CSG治疗总有效率、同时能缓解胃黏膜病理学和炎性反应。

无缝隙护理结合饮食干预在小儿慢性胃炎中的应用效果

目的 观察无缝隙护理结合饮食干预在小儿慢性胃炎中的应用效果。方法 选取2022年10月至2023年6月滨州医学院附属医院收治的60例慢性胃炎患儿,按照随机数字表法分为两组,每组30例。参照组应用常规护理,试验组在常规护理基础上应用无缝隙护理结合饮食干预,比较两组临床症状改善时间、住院时间、生活质量及心理状态。结果 试验组恶心呕吐、反酸、腹痛改善时间以及住院时间均短于参照组(P<0.05);试验组生活质量评分高于参照组(P<0.05);试验组焦虑自评量表、抑郁自评量表评分均低于参照组(P<0.05)。结论 无缝隙护理结合饮食干预在小儿慢性胃炎中的应用效果显著,能缓解临床症状,提高生活质量,调节心理状态,值得推广。

以家庭为中心的护理模式在慢性胃炎患儿中的应用效果

目的评价以家庭为中心的护理模式在慢性胃炎患儿中的实施效果和价值。方法回顾分析徐州儿童医院于2021年1月至2022年6月收治的共计98例慢性胃炎患儿的病例资料,按护理方法的不同分入对照组(n=50,给予常规护理)和观察组(n=48,实施以家庭为中心的护理)。比较2组的治疗依从性、症状改善时间、血清指标水平以及免疫功能。结果观察组的治疗总依从率为97.92%,明显较对照组的86.00%更高(P<0.05)。与对照组相比,观察组的腹部疼痛等各项症状改善时间均更早(P均<0.05)。出院时及出院3个月后,2组的血清胃泌素(Gastrin)和丙二醛(MDA)水平均较入院时降低(P均<0.05);观察组的Gastrin和MDA水平均较同期对照组更低(P均<0.05)。出院时及出院3个月后,2组的外周血T淋巴细胞亚群CD3^(+)和CD4^(+)均较入院时升高,CD8^(+)均较入院时降低(P均<0.05);观察组的CD3^(+)和CD4^(+)均较同期对照组更高,CD8^(+)均较同期对照组更低(P均<0.05)。结论在慢性胃炎患儿中采用以家庭为中心的护理进行干预,对其治疗依从性提升、症状改善时间缩短、血清相关指标以及免疫功能指标改善均可产生积极作用。

心理护理干预在慢性浅表性胃炎患者中的应用效果

目的:分析心理护理干预在慢性浅表性胃炎患者中的应用效果。方法:选取2023年1—12月威海市中心医院收治的慢性浅表性胃炎患者120例作为临床资料,随机分为研究组和对照组,各60例。对照组采用常规护理干预,研究组采用心理护理干预。比较两组心理状态评分、生活质量评分、服药依从性及护理满意度。结果:护理前,两组焦虑自评量表(SAS)和抑郁自评量表(SDS)评分比较,差异无统计学意义(P>0.05);护理后,两组SDS、SAS评分均低于护理前,且研究组低于对照组(P<0.05)。护理前,两组社会功能、生理功能、活力状态评分比较,差异无统计学意义(P>0.05);护理后,两组社会功能、生理功能、活力状态评分均高于护理前,且研究组高于对照组(P<0.05)。研究组服药依从性高于对照组(P<0.05)。研究组护理满意度略高于对照组,但差异无统计学意义(P=0.093)。结论:心理护理干预在慢性浅表性胃炎患者中的应用效果较好,能够改善患者的负面情绪,提高其生活质量、护理满意度和治疗依从性。