Chronic Urticaria Due to Allergy to Wheat Alpha-Amylase Inhibitor Proteins

Chronic spontaneous urticaria (CSU) is defined as the spontaneous appearance of wheals, angioedema, or both, for at least 6 weeks, due to known or unknown causes [1]. In some patients who present a CSU with daily or almost daily symptoms a type I allergy could be the underlying cause. We present one adult patient with chronic urticaria who was finally diagnosed as a non-occupational case of IgE-mediated wheat allergy manifested following exposure by 3 different routes: inhalation (rhinitis and bronchial asthma), dermal absorption (contact urticaria) and ingestion (systemic chronic urticaria). We were able to detect the culprit proteins by immunoblotting. Serum IgE binds mainly to alpha-amylase/trypsin inhibitors and, to a lesser extent, to other proteins associated with food allergy to grains (e.g. beta-glucanase, serpin, peroxidase). In our opinion, skin prick tests with a food standard battery could help in the etiological diagnosis of chronic urticaria. The identification of responsible allergens could be difficult because only a few complex in vitro techniques allow detecting the allergy to several proteins.

Effectiveness and safety of acupoint catgut embedding combined with Chinese herbal medicine in chronic urticaria: A systematic review of randomized controlled trials

Objective:To evaluate the effectiveness and safety of acupoint catgut embedding(ACE)in combination with Chinese herbal medicine(CHM)in treating chronic urticaria(CU).Methods:We thoroughly searched Embase,PubMed,Cochrane Library,Web of Science,China National Knowledge Infrastructure(CNKI),Wangfang database,Chinese Scientific Journal Database(VIP),and Chinese biomedical literature database(SinoMed)for relevant studies from inception until May 2022.Randomized controlled trials(RCTs)on ACE combined with CHM for CU were included.Literature search,data extraction,and risk of bias assessment were independently conducted by two authors.Results:A total of 15 RCTs with 1065 participants were included in this review.Five trials reported that the combined therapy showed a higher total effective rate,and four trials reported that the combined therapy was associated with a lower level of serum immunoglobulin E.Furthermore,two,four,and four trials reported that the combined therapy was more effective in reducing itching degree,size,and number of wheals,respectively.The combined therapy was reported to be associated with a lower recurrence rate in three trials,and with a fewer adverse reaction rate in two trials.Conclusions:ACE in combination with CHM appears to be a safe and effective therapy for patients with CU.Given the relatively low quality of the included trials,these findings should be interpreted cautiously.Further high-quality RCTs are needed to confirm our findings.

Based on data mining,the drug law of clinical treatment of chronic urticaria

Background:Based on clinical data mining,we introduce the medication rule and clinical application of Professor Wang Lifen in the treatment of chronic urticaria,as the reference of clinical treatment of chronic urticaria.Methods:we collected 110 traditional Chinese medicine prescriptions for the treatment of chronic urticaria,and found out tastes,functions and channel tropism of Chinese medicine.After collecting and sorting,we inputted the data into excel 2010 software and established drug electronic database.We calculated the frequency of tastes,functions and channel tropism using the Spss 20.0 and analyzed the potential relationship between the drugs using Weka 3.8.We used Cytoscape 3.6.1 to draw the related network and combine it into a new prescription.Then the clinical data of prescriptions were statistically analyzed.Results:The statistical analysis showed that the high-frequency drugs for the treatment of the disease were Gancao(Glycyrrhizae radix et rhizoma),Huangqin(Radix scutellariae),Desmopeel,Jingjie(Herba schizonepetae),parsnip,etc.,accounting for more than 69.50%of the total frequency.Moreover,the combination and drug pairs with the strongest and most commonly used high-frequency drugs were found.From the point of medicinal properties of these drugs in the treatment of chronic urticaria,the main drugs are cold,followed by warm and smooth,accounting for 70.75%of the total frequency.From the perspective of the efficacy of these drugs in the treatment of chronic urticaria,heat-clearing drugs are the main ones,followed by relieving drugs and Tonic drugs,accounting for 68.25%of the total frequency.From the perspective of medicine taste,sweet taste is the most important,followed by bitter and pungent taste,accounting for 68.00%of the total frequency.From the perspective of drugs channel tropism,the meridian of spleen is the most important,followed by the meridian of lung,liver,heart,stomach,etc.,accounting for 71.62%of the total frequency.Conclusion:According to the data mining results,traditional Chinese medicine treatment of chronic urticaria is mainly based on dispelling wind,clearing heat and removing dampness,cooling blood and detoxifying,supplemented by nourishing blood and nourishing deficiency.This data mining conforms to the law and principle of traditional Chinese medicine treatment of chronic urticaria,which has certain reference and enlightenment significance for clinical treatment of chronic urticaria.

Pricking,Cupping and Qu Feng Tiao Ying Decoction for Treatment of Chronic Urticaria

Chronic urticaria is a commonly encountered skin illness characterized by protracted course and recurrent episodes. The author had treated 26 cases of chronic urticaria by pricking, cupping and Qu Feng Tiao Ying (QFTY) decoction (祛风调营汤the Wind-dispelling and Ying system-regulating Decoction) with satisfactory results. A report is as follows.……

Association of HLA-DRB1, DQB1 Alleles with Chronic Urticaria

In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1*12, *0901 (RR=3.11, χ2=7.579, P=0.006; RR=2.47, χ2=5.684, P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1*05 (RR=0.26, χ2=6.683, P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1*12, *0901 and HLA-DQB1*05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.

Psychiatric comorbidities in children and adolescents with chronic urticaria

Background Chronic urticaria(CU)has been shown to impact patients'quality of life negatively and may coexist with psychiatric disorders.We systematically reviewed the published evidence of comorbid psychiatric disorders in children and adolescents with CU.Methods A systematic review of studies published until February 2022 in PubMed,Google Scholar,and Scopus was performed.An a priori set of inclusion criteria was predefined for the studies to be included:(1)clear distinction between urticaria and other allergies;(2)precise distinction between acute and CU;(3)participants younger than 18 years old,exclusively;(4)use of appropriate standardized questionnaires,psychometric tools,and standard diagnostic nomenclature for the mental health and behavioral disorders diagnosis;and(5)manuscripts written or published in the English language.Results Our search identified 582 potentially relevant papers.Only eight of them satisfied the inclusion criteria.Quantita-tive meta-analysis was not deemed appropriate,given the lack of relevant randomized control trials,the small number of relevant shortlisted,the small sample size of the patients included in each study,and the remarkable heterogeneity of the studies'protocols.Conclusions The included studies suggest an increased incidence of psychopathology among children and adolescents with CU as opposed to healthy age-matched individuals,but the data are scarce.Further research is required to clarify whether psychopathology is just a comorbid entity,the cause,or the consequence of CU.Meanwhile an interdisciplinary collaboration between allergists/dermatologists and psychiatrists is expected to substantially minimize CU burden and improve patients'quality of life.

Chronic Refractory Idiopathic Urticaria

Background: Chronic spontaneous urticaria (CSU) is a complex medical condition characterized by substantial morbidity and a negative impact on one’s quality of life. There are several treatment approaches available, tailored to the severity of the condition, which can enhance overall quality of life. Aim: In this article, we outline a systematic approach to managing chronic urticaria, while also elucidating the available treatment strategies for cases that prove resistant to conventional therapies. To illustrate our points, we present a clinical case as a practical example. Case Presentation: Here, we present a patient with CSU since childhood who presented in the context of refractory hives and generalized arthralgia that responded well to omalizumab therapy with no further relapse. Conclusion: Omalizumab is a biological agent that offers a potential treatment option for CSU. It is available for individuals twelve years and older who have not responded well to conventional treatments. It has demonstrated good efficacy with a relatively low rate of clinically significant adverse effects. Nonetheless, there is a dearth of research regarding the optimal method for tapering the dosage and determining the duration of treatment.

Chronic Spontaneous Urticaria on Omalizumab Therapy and Latent Tuberculosis Infection: A New Case Report

Background: Chronic Spontaneous urticarial (CSU) is a common dermatological problem characterized by recurrent pruritic or burning wheals last less than 24 hours and treated by many modalities of therapy including systemic antihistamines and in refractory cases with Omalizumab anti-IgE antibody biological injection. Latent tuberculosis infection (LTBI) is diagnosed based on a positive tuberculin skin test or QuantiFERON-TB test without evidence of active tuberculosis. Aim: To document a new case report of a patient with a history of CSU and latent tuberculosis on Omalizumab therapy during Isoniazid (INH) prophylaxis. Case Report: A-53-year-old woman with a history of CSU and newly identified LTBI who have been treated with INH monotherapy before starting Omalizumab injection followed up over 24 weeks course of therapy for any sign of tuberculosis reinfection. Conclusion: Omalizumab injection was used effectively for the treatment of CSU in a patient with latent tuberculosis infection with minimal risk of tuberculosis reactivation.

Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis

Background:Chronic urticaria(CU)is a common skin disease,which has a negative effect on quality of life.Current treatments do not fully control the symptoms of urticaria for many CU patients,thus effective and safe treatments for CU are still needed.Objective:This review aims to evaluate the effectiveness and safety of cupping therapy in patients with CU.Search strategy:The search strategy looked for the presence of related keywords,such as‘‘chronic urticaria"and‘‘cupping therapy,"in the title and abstract of research articles indexed in major databases.Randomized controlled trials(RCTs)were selected after querying nine electronic databases from their inception to May 2019 with the above search terms.Inclusion criteria:RCTs were included if they recruited patients with CU who were intervened with dry or wet cupping.Publications could be written in Chinese or English.Data extraction and analysis:Data were extracted,and the studies were assessed for the quality of their methodological design and risk of bias.Meta-analyses of the RCT data were conducted to assess the total effective rate of the treatment as the primary outcome.Skin disease quality of life index score,recurrence rate,and adverse events were assessed as secondary outcomes.Subgroup analyses were conducted based on different interventions.Results:Thirteen comparisons from 12 RCTs involving 842 participants were included.There were no significant differences between wet cupping and medications in total effective rate(n=372;risk ratio[RR]=1.10,95%confidence interval[CI]0.97 to 1.25;P=0.14)or recurrence rate(n=240;RR=0.56,95%CI 0.23 to 1.36;P=0.20).Cupping therapy,in combination with antihistamine treatment was more efficacious than antihistamines alone,with a greater total effective rate(n=342;RR=1.18,95%CI 1.01 to1.39;P=0.03)and lower recurrence rate(n=342;RR=0.52,95%CI 0.32 to 0.84;P=0.007).Cupping therapy combined with acupuncture was more effective than acupuncture alone(n=156;RR=1.25,95%CI 1.07 to 1.46;P=0.006).No serious adverse events were reported.Conclusion:Wet cupping may be as effective as treatment with antihistamines.When cupping therapy is used as an adjuvant therapy to antihistamines or acupuncture,it may enhance the efficacy.Results drawn from these studies should be interpreted with caution and applied with care to clinical practice,because of the poor quality among the studies that were reviewed.Systematic review registration:PROSPERO,CRD42019137451.

Clinical Observation on the Treatment of Chronic Urticaria with Total Glucosides of Paeony Capsule Combined with Citirizine

目的将在为长期的荨麻疹的治疗与 citirizine 结合估计效果和 paeony 囊(TGPC ) 的全部的配糖物的不利反应。120 个病人全部的方法 A 被彩票分到二个组， 65 在对待的组并且 55 在控制组。他们都口头上地与 citirizine 被对待药片 10 mg 每天，但是到对待的组，另外 0.2 g TGPC 每天被给三次，为两个组的治疗学的功课是 4 个星期。治疗的有效性被观察，并且全部的症状分数， interleukin-4 (IL-4 ) 的浆液层次，和免疫球蛋白 E (IgE ) 的变化在治疗前后被测量。而且，后续被执行在结束治疗以后的一个月。结果掉的盒子在对待的组是二并且七在控制组；那么，学习在控制组在对待的组和 48 个病人在 63 个病人上被完成。全部的有效的率在 73.02% 点被估计(46/63 ) 在里面比(23/48 )47.92% 在控制组织的对待组，它显著地高(P < 0.01 ) 。在治疗以后，全部的症状分数在两个组减少了，但是在对待的组的减少是更重要的(P < 0.05 ) 。在当在控制的变化组织时，显著地降低的对待的组的 IL-4 和 IgE 的浆液层次是不足道的，因此统计重要差别在组之间被显示出(P < 0.01 ) 。后续研究证明在对待的组的恶化率是 30.00%(6/20 ) 当那在控制组是 90.00% 时(9/10 ) ，并且前者比后者低(P < 0.01 ) 。不利反应，作为睡意，头昏，和软弱揭示了，分别地在二个组在八种情况和七个盒子中被看见。而且，温和腹泻发生在对待的组的二种情况中。联合 citirizine 的 TGPC 的治疗看明确的药品的结论在对待长期的荨麻疹完成，与低恶化率并且没有明显的不利反应。它的治疗学的效果可能借助于调整病人鈥 ? 免疫者功能被认识到。而且，药应该被继续让一个相当长的时期完成完整的效果。paeony 囊的关键词全部的配糖物 - citirizine - 联合治疗 -

Evidence-Based Therapies of Chinese Medicine for Chronic Urticaria:Where Do We Stand and Where Are We Going?

Chronic urticaria(CU)is characterized by repeated occurrence of wheals or itching for more than 6 weeks.When urticaria symptoms repeatedly occur despite taking Western medicines such as antihistamines,Chinese medicine(CM)has been shown to relieve symptoms and prevent recurrence.However,the lack of robust evidence from the evidence-based medicine perspective is hindering acceptance of CM by the Western medicine community.In recent years,more and more evidence-based studies of CU treatment by CM were report in English literatures,including acupuncture,herbs,and food,although some of evidence is still with low quality.These progress in CM treatment of CU will inspire high quality evidences via randomized,controlled trials assessing efficacy and safety of CM treatment of CU.

Cost of Treatment of Chronic Spontaneous Urticaria in Turkey

Chronic Spontaneous Urticaria (CSU) is a chronic disease with significant negative impact on quality of life of patients. The direct and indirect costs of the disease can be substantial both for the health care system and society. The aim of this research is to estimate the cost of mild, moderate and severe CSU in Turkey and to forecast the cost of the disease from the payer (Social Security Institution—SSI) perspective. Expert opinions with Delphi technique were used in order to determine the cost items and their frequency. A questionnaire was designed to outline resources used in the out-patient, inpatient and emergency care episodes and was answered by dermatologists followed by a consensus meeting. Unit costs were calculated from the price list of the SSI. The annual total cost of treating the disease to the SSI was estimated as 262,111,978TL (94,417,870€) comprising 0.06% of the total healthcare budget in 2013. Since there is limited information about the cost of CSU in Turkey, the methodology and results of this study are unique and very important.

Elevated Serum Total IgE Levels in Patients with Chronic Urticaria Indicate Insensitivity to Antihistamine Treatment

Objective:Serum total IgE (tlgE) levels are elevated in patients with chronic urticaria (CU);however,the nature of the elevated serum tlgE level in CU patients remains unclear.The aim of this study was to investigate the relationship between elevated serum levels of tlgE in patients with CU and the sensitivity of these patients to antihistamine treatments.Methods:Blood samples of 302 patients with CU were collected,and their levels of serum tlgE were measured.The patients were divided into two groups according to their serum tlgE level:High serum tlgE level group (>150 U/mL)and Low serum tlgE level group (< 150 U/mL).The correlations between the serum tlgE end disease severity as well as the sensitivity of patients to antihistamine treatments were assessed.Data were statistically analyzed using t-tasts and Chi-square tests.Results:Higher rates of positive autologous serum skin test results (X2=5.707,P=0.017) and skin scratch test results (x2 =5.878,P=0.015),higher CU scores (average:2.88±0.73 vs.2.18±0.59,t =6.377,P< 0.001),and longer disease course durations (median:8.5 vs.14.6,z=5.525,P<0.001) were observed in patients with high levels of serum tlgE compared with those with low levels of serum tlgE;moreover,patients with higher levels of serum tlgE were less sensitive to antihistamine therapies compared with those with lower levels of serum tlgE (x2=16.783,P < 0.001).Conclusion:Our study indicates that the high serum tlgE level is associated with the disease severity as well as with low sensitivity to antihistamine treatment of patients.

Efficacy of the H2-receptor antagonist famotidine on chronic spontaneous urticaria in children

Urticaria is a common pediatric skin disorder. Histamine H1-receptor antagonists are effective in chronic as well as acute urticaria. When H1-anti-histamines are ineffective, add-on use of H2-receptor antagonists is thought to give better symptom relief. However, there are few reports on the therapeutic efficacy in pediatric patients. We retrospectively reviewed the medical records of pediatric patients with chronic spontaneous urticaria (csU) who met the following criteria. They were consulted our outpatient clinic between April 2010 and March 2012;were unsuccessfully treated with H1 antihistamines;and were treated with add-on H2-receptor antagonist (famotidine). In six patients who met the inclusion criteria (mean age 6.1 ± 5.1 years), urticaria activity score was significantly decreased from 4.3 ± 0.8 just before administration of famotidine to 1.3 ± 1.0 on the first outpatient visit within 4 weeks after the first administration of famotidine

Quality of Life of Patients with Urticaria in Ouagadougou (Burkina Faso)

Introduction: The prevalence of urticaria is increasing. Approximately 20% of individuals have suffered from an acute episode of urticaria at least at some point in their lives. The objective of this study was to evaluate the clinical and therapeutic socio-demographic profile and quality of live of patients followed for urticaria in the dermatology-venereology department of the Yalgado Ouédraogo University Hospital in Ouagadougou. Methodology: We conducted a descriptive cross-sectional study over a 5-year period from 1 January 2015 to 31 December 2019. The data were collected retrospectively by analysing the files and prospectively by evaluating the quality of life with DLQI. All the records of patients treated for urticaria at the Dermatology-Venerology Department of the Yalgado Ouédraogo University Hospital during the period were included. Results: Urticarial frequency is 1.91%. There were 36 men (25.71%) and 104 women (74.28%), i.e. a sex ratio of 0.34. The median age was 31 years with extremes of 4 to 70 years. The 30 - 45 age group accounted for 51.42%, followed by the 16 - 29 age group (31.42%), then the 46 - 65 age group (9.28%), the 4 - 15 age group (5.71%) and the over 66 age group (2.14%). In terms of occupation, pupils/students accounted for 37.1%, housewives for 18.6% and workers for 44.3%. As for the residence of the patients, 88.57% lived in Ouagadougou Personal history of atopy, it concerned 19.26% of patients, with precisely 9.28% having asthma history, 7.14% having rhino-sinusitis history, 1.42% of atopic dermatitis and allergic conjunctivitis respectively. For clinical aspects, 97.14% of the patients had superficial urticaria, and 2.86% had facial angioedema. There were 35% (49) patients with acute urticaria and 65% (91) with chronic urticaria. Chronic urticaria was spontaneous in 55% (50) and physically inducible in 10% (9) (sweating, pressure or friction). 97.14% of patients received antihistamines associated with systemic corticoids in 2.86%. For Quality of life, the mean DLQI score was 7.51, indicating a moderate effect of urticaria on patients’ quality of life. The quality of life of women was more affected than that of men, especially in the professional and social spheres. Conclusion: In hospital frequency of urticaria is low in Ouagadougou, a predominance of chronic spontaneous urticaria whose management involves the use of second generation antihistamines at a dosage and duration that do not meet international recommendations. The patients’ quality of life was moderately impaired.

生物制剂在慢性自发性荨麻疹治疗中的应用进展

慢性自发性荨麻疹(CSU)是一种临床常见的免疫反应性皮肤病,其发病的关键效应细胞是肥大细胞。随着近年来对CSU发病机制的不断认识,不少新型生物制剂被应用于CSU患者的治疗。生物制剂可通过靶向作用于肥大细胞的活化过程的不同阶段,阻断肥大细胞的活化、脱颗粒,从而有效治疗CSU;根据作用靶点和作用机制,可分为抑制肥大细胞激活、抑制胞内信号转导、激活抑制性受体的药物。本文对生物制剂在CSU治疗中的应用展开综述。

咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性分析

目的分析咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性。方法回顾性选取2020年2月—2021年2月山东省临朐县人民医院耳鼻喉科收治的100例急慢性荨麻疹并发过敏性鼻炎患者的临床资料,依据用药方法分为咪唑斯汀组、西替利嗪组,各50例。咪唑斯汀组口服咪唑斯汀、西替利嗪组口服西替利嗪。比较两组的风团数、风团直径评分、症状评分、生活质量、临床疗效、不良反应发生情况、复发情况。结果用药前,两组风团数、风团直径评分、瘙痒、鼻痒、鼻塞、打喷嚏、流涕评分、生活质量评分比较,差异无统计学意义(P均>0.05),用药后,两组的风团数、风团直径评分、瘙痒、鼻痒、鼻塞、打喷嚏、流涕评分均低于用药前,且咪唑斯汀组低于西替利嗪组,差异有统计学意义(P均<0.05);用药后,生活质量评分均高于用药前,且咪唑斯汀组高于西替利嗪组,差异有统计学意义(P均<0.05);咪唑斯汀组的总有效率为96.00%,高于西替利嗪组的80.00%,差异有统计学意义(χ^(2)=6.061,P<0.05)。咪唑斯汀组患者的不良反应发生率和复发率均低于西替利嗪组,差异有统计学意义(P均<0.05)。结论咪唑斯汀治疗急慢性荨麻疹并发过敏性鼻炎的可行性较高。

玉屏风颗粒联合卡介菌多糖核酸治疗慢性荨麻疹的效果分析

目的:探讨玉屏风颗粒联合卡介菌多糖核酸治疗慢性荨麻疹的效果。方法:选取2021年7月—2023年7月滨州市中心医院收治的慢性荨麻疹患者96例作为研究对象,随机分为试验组和对照组,各48例。对照组采用卡介菌多糖核酸治疗,试验组在对照组基础上采用玉屏风颗粒治疗。比较两组治疗效果。结果:治疗后,试验组瘙痒程度、风团数目、每日风团发作次数、风团最大直径、匹兹堡睡眠质量指数、皮肤病生活质量指数评分,白细胞介素-4、白细胞介素-10、CD8^(+)水平,复发率均低于对照组,白细胞介素-2、CD3^(+)、CD4^(+)水平均高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:玉屏风颗粒联合卡介菌多糖核酸治疗慢性荨麻疹的效果良好,能够改善患者临床症状、睡眠质量与生活质量,减轻炎性反应,提高免疫功能,减少复发,且安全性较高。

地氯雷他定与氯雷他定治疗慢性特发性荨麻疹的临床效果分析

目的:探讨地氯雷他定与氯雷他定治疗慢性特发性荨麻疹的临床效果。方法:选取2021年1月—2023年12月临沂市中医医院收治的慢性特发性荨麻疹患者104例作为研究对象,采用随机数字表法分为观察组与对照组,各52例。对照组接受氯雷他定治疗,观察组接受地氯雷他定治疗。比较两组治疗效果、不良反应发生情况、满意度、起效时间。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.028);两组不良反应总发生率比较,差异无统计学意义(P>0.05);观察组总满意度高于对照组,差异有统计学意义(P=0.008);两组治疗起效时间比较,差异无统计学意义(P>0.05)。结论:地氯雷他定治疗慢性特发性荨麻疹效果优于氯雷他定,患者满意度更高,且未增加不良反应发生风险,未延长治疗起效时间。

从内风论治慢性自发性荨麻疹

慢性自发性荨麻疹(CSU)是慢性荨麻疹(CU)最常见的表型。西医治疗以二代抗组胺药为主,但约有50%的患者对抗组胺治疗产生抵抗,且容易复发。中医方面,多数医家从表风如风寒束表、风热犯表等角度进行论治,但仍有部分患者治疗效果欠佳。导师张丰川教授提出内风致病的观点,临床从内风论治CSU,效果较好,复发率低,本文从CSU的中医病因病机;内风与CSU的关系;从调整机体气血阴阳平衡、祛风填络、健脾祛湿、调畅情志四方面入手治疗CSU,深入探讨从内风论治CSU,为临床论治CSU提供理论参考。