Value of Chuanjin Qinggan decoction in improving the depressive state of patients with herpes zoster combined with depression

BACKGROUND Western medicine is beneficial for the recovery of neurological function in patients with depression,but some patients experience side effects such as headaches,dizziness,nausea,gastrointestinal symptoms,insomnia,and cardiac dysfunction.In recent years,integrative medicine has achieved positive results in the treatment of various diseases.AIM To study Chuanjin Qinggan decoction combined with selective serotonin reuptake inhibitors(SSRIs)in patients with herpes zoster complicated by depression.METHODS Patients with herpes zoster complicated by depression who were treated at the Yantai Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were retrospectively selected as research participants.Among them,43 patients with herpes zoster complicated by depression who received SSRI treatment between January and December 2021 were assigned to the Western medicine group,while those who received combined treatment of traditional Chinese and Western medicine between January and December 2022 were assigned to the combined group.Both groups were treated for eight weeks.The degree of pain,effect of herpes zoster treatment,degree of improvement in depressive symptoms,serum neurotransmitter levels,sleep quality,and occurrence of adverse reactions were compared between the two groups.RESULTS We found that after eight weeks of drug treatment,the two treatment schemes achieved differing efficacy.In further comparison,we found that,compared with patients treated with SSRIs alone,patients treated with Chuanjin Qinggan decoction combined with SSRIs showed more significant improvement in depression and a greater increase in dopamine and 5-hydroxytryptamine levels after treatment(P<0.05).Patients treated with Chuanjin Qinggan decoction combined with SSRIs also experienced lower pain,better treatment efficacy for herpes zoster,better sleep quality,and a lower incidence of adverse reactions compared to those treated with SSRIs alone(P<0.05).All minor adverse reactions occurring during treatment were resolved after symptomatic treatment.CONCLUSION The treatment scheme of Chuanjin Qinggan decoction combined with SSRIs can improve the psychological state of patients with herpes zoster complicated by depression and alleviate adverse reactions.

川金解郁汤干预轻中度抑郁患者的疗效分析及代谢组学研究

目的分析川金解郁汤(Chuanjin Jieyu Decoction,CJJYD)对轻中度抑郁(mild to moderate depression,MTMD)患者干预前后的代谢物差异性及相关代谢物变化规律,为CJJYD治疗MTMD提供科学依据。方法纳入湖南省脑科医院2020年1月至12月期间23名MTMD患者作为病例组(Dep组)、健康人21名作为对照组(CT组),Dep组予以CJJYD干预6周,早晚各服1剂,每次100 mL。采用汉密尔顿抑郁量表(Hamilton depression scale,HAMD)和抑郁自评量表(self-rating depression scale,SDS)评定疗效;超高效液相色谱-高分辨质谱联用技术分析干预前后血浆代谢物变化;采用多维度统计分析,筛选差异代谢物并进行分析。结果MTMD患者经CJJYD干预后,HAMD和SDS评分明显降低(P<0.01)。与CT组相比,Dep组患者血浆中检测145个差异代谢物,涉及亚油酸代谢等38条代谢通路;Dep组经CJJYD干预后,患者血浆中检测46个差异代谢物,涉及烟酸和烟酰胺代谢等11条代谢通路。结论MTMD患者经CJJYD干预后,抑郁症状得到改善,代谢组学有差异性代谢物,涉及亚油酸代谢、烟酸和烟酰胺代谢、精氨酸和脯氨酸代谢等代谢通路,可能为其抗抑郁的机制之一。

早熟白色金针菇优良品种川金5号选育

以黄色金针菇与白色金针菇为亲本,利用双单杂交方法构建杂交种,从F2代中筛选出白色金针菇优良品种川金5号,该品种保持了黄色金针菇早熟、菌柄基部无绒毛、不粘连、子实体弯曲度低、高产等特性;平均产量为1.012 kg.袋-1,较江山白菇和F21分别增产56.41%、104.32%,与黄色金针菇相比菌株产量差异不大;子实体菌柄基部无绒毛、不粘连,可食率达到84.1%,较江山白菇和F21分别高8.94%和11.24%,与黄色金针菇菌株"金丝"在可食率上差异不显著。

柴油机排气微粒净化装置的开发

在分析柴油机排气微粒产生原因的基础上 ,提出了降低微粒排放的技术路线 ,开发了一种柴油机排气微粒净化装置。试验结果表明 。

二连盆地川井坳陷构造演化对砂岩型铀矿成矿作用的约束

川井坳陷位于二连盆地西部,坳陷内目的层赛汉组上段发育辫状河、辫状河三角洲-湖沼沉积,砂体发育。受构造、构造演化影响,在坳陷东部发育晚白垩世苏海布龙剥蚀窗口,在坳陷西部白音查干地区发育古近纪剥蚀窗口,剥蚀窗口控制了后生含铀含氧流体向盆地内入渗参与成矿,找矿类型为赛汉期斜坡带型及古河谷型。东西二个剥蚀窗口的发现,为合理解释已发现的矿化异常、找矿预测模型的构建提供了基础。通过构建坳陷三位一体找矿预测模型,本文预测了苏海布龙、白音查干西及包龙凹陷东三个铀成矿远景区。

二连盆地川井坳陷铀成矿环境及成矿有利地段研究

本文在简述二连盆地川井坳陷区域地质、区域水文地质特征的基础上 ,重点阐述了白垩系岩性岩相特点、岩石后生蚀变和铀矿化特征 ,并得出坳陷在纵横两方向上存在着较大的分割性和不均匀性 ,白音查干凹陷砂体属三角洲相叠加了河流相的新认识 ,进而提出了下白垩统为湖相→三角洲相→河流相的连续演化系列。从宏观、微观两方面论述了白音查干凹陷潜水和层间氧化带砂岩型铀矿成矿前景 ,同时 ,分片对整个川井坳陷成矿有利及不利因素作了评价。在对古河道发育情况、基底、构造、水文地质和后生蚀变、有机质等成矿条件分析的基础上 。

川金解郁汤对慢性应激诱导抑郁大鼠模型的神经保护作用

目的研究川金解郁汤对慢性不可预知性应激(CUMS)诱导的抑郁大鼠模型的神经保护作用。方法48只成年雄性健康SD大鼠,随机选取12只为对照组,其余大鼠建立CUMS抑郁模型。将建模成功后的大鼠随机分成3组:CUMS组、氟西汀组和川金解郁汤组;分别给予0.9%氯化钠溶液氟西汀、川金解郁汤干预4周。造模后、干预后通过旷场实验、糖水偏爱实验,测定大鼠抑郁水平;干预后采用实时荧光定量PCR(qRT-PCR)检测脑源性神经营养因子(BDNF)、酪氨酸蛋白激酶受体B(TrkB)、环磷酸腺苷反应元件结合蛋白(CREB)mRNA在海马齿状回的表达量,免疫荧光检测BDNF与神经元核心抗原(NeuN)的表达量,蛋白免疫印迹法(Western blot)检测胶质纤维酸性蛋白(GFAP)水平。结果造模后,CUMS组、氟西汀组、川金解郁汤组的糖水消耗、糖水偏爱、垂直运动及水平运动结果明显低于对照组(均P<0.01);干预后,CUMS组以上指标低于对照组(均P<0.01),氟西汀组与川金解郁汤组以上指标均高于CUMS组(P<0.01或P<0.05),但低于对照组(P<0.01或P<0.05)。qRT-PCR结果显示,CUMS组、氟西汀组、川金解郁汤组的BDNF、TrkB、CREB mRNA表达量均明显低于对照组(均P<0.01);氟西汀组与川金解郁汤组的上述指标均显著高于CUMS组(均P<0.01)。免疫荧光结果显示,CUMS组的BDNF、NeuN表达量均显著低于对照组(均P<0.01);氟西汀组、川金解郁汤组以上指标均高于CUMS组(P<0.01或P<0.05),且川金解郁汤组所有指标及氟西汀组NeuN表达量低于对照组(P<0.01或P<0.05)。Western blot结果显示,CUMS组的GFAP蛋白表达低于对照组(P<0.01);氟西汀组GFAP蛋白表达高于CUMS组(P<0.05)。结论川金解郁汤可改善大鼠抑郁行为学指标,提高海马齿状回BDNF、TrkB、CREB及NeuN表达,提示川金解郁汤可能通过BDNF/TrkB/CREB通路发挥神经保护作用。