In hypertrophic scar tissue, no sweet gland and hair follicle exist usuallybecause of the dermal and epidermal damage in extensive thermal skin injury, thus imparingregulation of body temperature. This study was desig...In hypertrophic scar tissue, no sweet gland and hair follicle exist usuallybecause of the dermal and epidermal damage in extensive thermal skin injury, thus imparingregulation of body temperature. This study was designed to reveal the morphological anddistributional characteristics of the sweat glands in normal skin and hypertrophic scar obtainedfrom children and adults, and to study the possible interfering effects of the scar on regenerationof the sweat gland after burn injury. Biopsies of hypertrophic scar were taken from four children(4 - 10 years) and four adults (35 -51 years). Normal, uninjured full-thickness skin adjacent to thescar of each patient was used as control. Keratin 19 (K19) was used as the marker for epidermalstem cells and secretory portion of the sweat glands, and keratin 14 (K14) for the tube portion,respectively. Immunohistochemical and histological evaluations were performed. Histological andimmunohistochemical staining of skin tissue sections from both the children and adults showed K19positive cells in the basement membrane of epidermis of normal skin. These cells were seen onlysingle layer and arranged regularly. The secretory or duct portion of the eccrine sweat glands wassituated in the dermis and epidermal layer. However, in the scar tissue, K19 positive cells werescant in the basal layer, and the anatomic location of the secretory portion of sweat glandschanged. They were located between the border of the scar and reticular layer of the dermis. Thesesecretory portions of sweat glands were expanded and were organized irregularly. But a few K14positive cells were scattered in the scar tissues in cyclic form. There are some residual sweatglands in scar tissues, in which the regeneration process of active sweat glands is present.Possibly the sweat glands could regenerate from adult epidermal stem cells or residual sweat glandsin the wound bed after burn injury.展开更多
Hypertrophic scars often develop following burn-related injuries.These scars can be cosmetically unappealing,but associated symptoms of pruritus,pain and restricted range of motion can impair a person’s quality of li...Hypertrophic scars often develop following burn-related injuries.These scars can be cosmetically unappealing,but associated symptoms of pruritus,pain and restricted range of motion can impair a person’s quality of life.Laser and light therapies offer a minimally invasive,low-risk approach to treatment,with a short postoperative recovery period.As laser technology developed,studies have shown decreased scar thickness,neuropathic pain and need for surgical excision,as well as improved scar pigmentation,erythema,pliability,texture,height and pruritus.In this review,we present the evolution of laser therapy for hypertrophic burn scars,how different types of lasers work,indications,perioperative considerations and guidelines for practice management.展开更多
文摘In hypertrophic scar tissue, no sweet gland and hair follicle exist usuallybecause of the dermal and epidermal damage in extensive thermal skin injury, thus imparingregulation of body temperature. This study was designed to reveal the morphological anddistributional characteristics of the sweat glands in normal skin and hypertrophic scar obtainedfrom children and adults, and to study the possible interfering effects of the scar on regenerationof the sweat gland after burn injury. Biopsies of hypertrophic scar were taken from four children(4 - 10 years) and four adults (35 -51 years). Normal, uninjured full-thickness skin adjacent to thescar of each patient was used as control. Keratin 19 (K19) was used as the marker for epidermalstem cells and secretory portion of the sweat glands, and keratin 14 (K14) for the tube portion,respectively. Immunohistochemical and histological evaluations were performed. Histological andimmunohistochemical staining of skin tissue sections from both the children and adults showed K19positive cells in the basement membrane of epidermis of normal skin. These cells were seen onlysingle layer and arranged regularly. The secretory or duct portion of the eccrine sweat glands wassituated in the dermis and epidermal layer. However, in the scar tissue, K19 positive cells werescant in the basal layer, and the anatomic location of the secretory portion of sweat glandschanged. They were located between the border of the scar and reticular layer of the dermis. Thesesecretory portions of sweat glands were expanded and were organized irregularly. But a few K14positive cells were scattered in the scar tissues in cyclic form. There are some residual sweatglands in scar tissues, in which the regeneration process of active sweat glands is present.Possibly the sweat glands could regenerate from adult epidermal stem cells or residual sweat glandsin the wound bed after burn injury.
文摘Hypertrophic scars often develop following burn-related injuries.These scars can be cosmetically unappealing,but associated symptoms of pruritus,pain and restricted range of motion can impair a person’s quality of life.Laser and light therapies offer a minimally invasive,low-risk approach to treatment,with a short postoperative recovery period.As laser technology developed,studies have shown decreased scar thickness,neuropathic pain and need for surgical excision,as well as improved scar pigmentation,erythema,pliability,texture,height and pruritus.In this review,we present the evolution of laser therapy for hypertrophic burn scars,how different types of lasers work,indications,perioperative considerations and guidelines for practice management.
