Prediction of Damping Capacity Demand in Seismic Base Isolators via Machine Learning

Base isolators used in buildings provide both a good acceleration reduction and structural vibration control structures.The base isolators may lose their damping capacity over time due to environmental or dynamic effects.This deterioration of them requires the determination of the maintenance and repair needs and is important for the long-termisolator life.In this study,an artificial intelligence prediction model has been developed to determine the damage and maintenance-repair requirements of isolators as a result of environmental effects and dynamic factors over time.With the developed model,the required damping capacity of the isolator structure was estimated and compared with the previously placed isolator capacity,and the decrease in the damping property was tried to be determined.For this purpose,a data set was created by collecting the behavior of structures with single degrees of freedom(SDOF),different stiffness,damping ratio and natural period isolated from the foundation under far fault earthquakes.The data is divided into 5 different damping classes varying between 10%and 50%.Machine learning model was trained in damping classes with the data on the structure’s response to random seismic vibrations.As a result of the isolator behavior under randomly selected earthquakes,the recorded motion and structural acceleration of the structure against any seismic vibration were examined,and the decrease in the damping capacity was estimated on a class basis.The performance loss of the isolators,which are separated according to their damping properties,has been tried to be determined,and the reductions in the amounts to be taken into account have been determined by class.In the developed prediction model,using various supervised machine learning classification algorithms,the classification algorithm providing the highest precision for the model has been decided.When the results are examined,it has been determined that the damping of the isolator structure with the machine learning method is predicted successfully at a level exceeding 96%,and it is an effective method in deciding whether there is a decrease in the damping capacity.

A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures

A metamaterial vibration isolator,termed as wave-insulating isolator,is proposed,which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave insulation.It consists of plate-shaped metacells,whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and narrow.The bandgap mechanisms,vibration isolation properties,effects of key parameters,and robustness to complex conditions are clarified.As experimentally demonstrated,the wave-insulating isolator can improve the vibration insulation in the ranges of[50 Hz,180 Hz]and[260 Hz,400 Hz]by 15 dB and 25 dB,respectively,in contrast to the conventional isolator with the same first resonant frequency.

A vibration isolator with a controllable quasi-zero stiffness region based on nonlinear force design

To achieve stability optimization in low-frequency vibration control for precision instruments,this paper presents a quasi-zero stiffness(QZS)vibration isolator with adjustable nonlinear stiffness.Additionally,the stress-magnetism coupling model is established through meticulous theoretical derivation.The controllable QZS interval is constructed via parameter design and magnetic control,effectively segregating the high static stiffness bearing section from the QZS vibration isolation section.Furthermore,a displacement control scheme utilizing a magnetic force is proposed to regulate entry into the QZS working range for the vibration isolation platform.Experimental results demonstrate that the operation within this QZS region reduces the peak-to-peak acceleration signal by approximately 66.7%compared with the operation outside this region,thereby significantly improving the low frequency performance of the QZS vibration isolator.

Theoretical and experimental investigations on an X-shaped vibration isolator with active controlled variable stiffness

A novel X-shaped variable stiffness vibration isolator(X-VSVI)is proposed.The Runge-Kutta method,harmonic balance method,and wavelet transform spectra are introduced to evaluate the performance of the X-VSVI under various excitations.The layer number,the installation angle of the X-shaped structure,the stiffness,and the active control parameters are systematically analyzed.In addition,a prototype of the X-VSVI is manufactured,and vibration tests are carried out.The results show that the proposed X-VSVI has a superior adaptability to that of a traditional X-shaped mechanism,and shows excellent vibration isolation performance in response to different amplitudes and forms of excitations.Moreover,the vibration isolation efficiency of the device can be improved by appropriate adjustment of parameters.

Impact of surface-reflected seismic waves on the seismic isolation performance of circular tunnel isolation layers

Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored.In this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic space.By comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic waves.Our findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic space.Specifically,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain stable.Overall,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic waves.Our results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers.

A human-sensitive frequency band vibration isolator for heavy-duty truck seats

In this study,a human-sensitive frequency band vibration isolator(HFBVI)with quasi-zero stiffness(QZS)characteristics for heavy-duty truck seats is designed to improve the comfort of heavy-duty truck drivers on uneven roads.First,the analytical expressions for the force and displacement of the HFBVI are derived with the Lagrange equation and d'Alembert's principle,and are validated through the prototype restoring force testing.Second,the harmonic balance method(HBM)is used to obtain the dynamic responses under harmonic excitation,and further the influence of pre-stretching on the dynamic characteristics and transmissibility is discussed.Finally,the experimental prototype of the HFBVI is fabricated,and vibration experiments are conducted under harmonic excitation to verify the vibration isolation performance(VIP)of the proposed vibration isolator.The experimental results indicate that the HFBVI can effectively suppress the frequency band(4-8 Hz)to which the human body is sensitive to vertical vibration.In addition,under real random road spectrum excitation,the HFBVI can achieve low-frequency vibration isolation close to 2 Hz,providing new prospects for ensuring the health of heavy-duty truck drivers.

Application and optimization design of non-obstructive particle damping-phononic crystal vibration isolator in viaduct structure-borne noise reduction

The problems associated with vibrations of viaducts and low-frequency structural noise radiation caused by train excitation continue to increase in importance.A new floating-slab track vibration isolator-non-obstructive particle damping-phononic crystal vibration isolator is proposed herein,which uses the particle damping vibration absorption technology and bandgap vibration control theory.The vibration reduction performance of the NOPD-PCVI was analyzed from the perspective of vibration control.The paper explores the structure-borne noise reduction performance of the NOPD-PCVIs installed on different bridge structures under varying service conditions encountered in practical engineering applications.The load transferred to the bridge is obtained from a coupled train-FST-bridge analytical model considering the different structural parameters of bridges.The vibration responses are obtained using the finite element method,while the structural noise radiation is simulated using the frequency-domain boundary element method.Using the particle swarm optimization algorithm,the parameters of the NOPD-PCVI are optimized so that its frequency bandgap matches the dominant bridge structural noise frequency range.The noise reduction performance of the NOPD-PCVIs is compared to the steel-spring isolation under different service conditions.

Regional dynamic cerebral autoregulation across anterior and posterior circulatory territories:A detailed exploration and its clinical implications

Cerebral autoregulation(CA)is the mechanism that maintains stable cerebral blood flow(CBF)despite fluctuations in systemic blood pressure,crucial for brain homeostasis.Recent evidence highlights distinct regional variations in CA between the anterior(carotid)and posterior(vertebrobasilar)circulations.Noninvasive neuromonitoring techniques,such as transcranial Doppler,transfer function analysis,and near-infrared spectroscopy,facilitate the dynamic assessment of CBF and autoregulation.Studies indicate a robust autoregulatory capacity in the anterior circulation,characterized by rapid adjustments in vascular resistance.On the contrary,the posterior circulation,mainly supplied by the vertebral arteries,may have a lower autoregulatory capacity.in acute brain injuries such as intracerebral and subarachnoid hemorrhage,and traumatic brain injuries,dynamic CA can be significantly altered in the posterior circulation.Proposed physiological mechanisms of impaired CA in the posterior circulation include:(1)Decreased sympathetic innervation of the vasculature impairing compensatory vasoreactivity;(2)Endothelial dysfunction;(3)Increased cerebral metabolic rate of oxygen consumption within the visual cortex causing CBFmetabolism(i.e.,neurovascular)uncoupling;and(4)Impaired blood-brain barrier integrity leading to impaired astrocytic mediated release of vasoactive substances(e.g.nitric oxide,potassium,and calcium ions).Furthermore,more research is needed on the effects of collateral circulation,as well as the circle of Willis variants,such as the fetal-type posterior cerebral artery,on dynamic CA.Improving our understanding of these mechanisms is crucial to improving the diagnosis,prognosis,and management of various cerebrovascular disorders.

Experimental research on static characteristics of special wire-rope isolator

Based on analysis of the work conditions and structural characteristics of the exterior pipeline of the aero-engine, a kind of cantilever-structure wire-rope isolator fitted to the exterior pipeline of the aero-engine is designed for supporting and damping purposes. By static experiments, the static hysteresis loop, the relationship of stiffness and amplitude, and the relationship between the energy dissipation coefficient and the amplitude are obtained. Analyses show that the wire-rope isolator presents obvious hysteresis characteristics, and the characteristics of the isolator, such as stiffness and damping, behave obviously nonlinearly when the amplitude value of deformation changes. At the same time, by changing the structure parameters of the wire-rope, the wirerope isolators can be made with different functions to satisfy different work conditions. The research results have important reference values for the application of the wire-rope isolator on the exterior pipeline of an aeroengine.

EXPERIMENTAL STUDY OF FORCED SHOCK TRAIN OSCILLATION IN ISOLATOR UNDER ASYMMETRIC INCOMING FLOW

To analyze the response of the wall pressure fluctuation in an isolator when the shock train is subjected to a periodic motion at a low frequency,the isolator experiment is conducted in a blow-down supersonic wind tunnel at free stream Mach number of 1.98 under asymmetric incoming flow.Experimental results show that：The isolator effectively isolates the periodic back pressure fluctuation from affecting upstream undisturbed flow;The wall pressure fluctuations are due to the propagation of wave fronts with the second acoustic mode,but they are subjected to an oscillating shock train in the most part of the shock oscillation region;The attenuation of wall pressure fluctuations on the lower wall with thick boundary layer accords with the exponential law,but it fluctuates on the upper wall with thin boundary layer in the shock oscillation region.

EFFECTS OF INCOMING FLOW ASYMMETRY ON SHOCK TRAIN STRUCTURES IN CONSTANT-AREA ISOLATORS

To simulate the actual flowfield at the exit of the supersonic/hypersonic inlet, a wind tunnel is designed to study the flow in the scramjet isolator under the asymmetric incoming flow. And compression fields in the isolator are investigated using wall static and pitot pressure measurements. Three incoming Mach numbers are considered as 1.5, 1.8 and 2. Results show that the increase of the asymmetry of the flow at the isolator entrance leads to the increase of the shock train length in the isolator for a given pressure ratio. Based on the analysis of the flow asymmetry effect at the isolator entrance on the shock train length, a modified correlation is proposed to calculate the length of the shock train. Predicted results of the proposed correlation are in good agreement with the experimental data.

Mechanical properties of disc-spring vibration isolators based on boundary friction

To ascertain the influence of the boundary friction on mechanical properties of disc-spring vibration isolators a load-displacement hysteresis curve formula of disc-spring vibration isolators is derived on the basis of the energy conservation law as well as considering the effect of the boundary friction.The formula is validated through the finite element analysis and static load tests.On this basis the effect of the boundary friction on the bearing capacity is researched. Then the dynamic performance of disc-spring vibration isolators is studied by dynamic tests.The experimental results indicate that the boundary friction can promise a larger damping with a ratio of 0.23 for disc-spring vibration isolators.Compared with the loading frequency the loading amplitude has a greater impact on the energy consumption dynamic stiffness and damping of vibration isolators.This research can provide valuable information for the design of disc-spring vibration isolators.

Theoretical Research on Electrorheological Isolator

A new type of isolator, the electrorheology (ER) isolator, is mainly described. Through theoretical analysis, a simplified physical model is established under some hypotheses and a series of motion equations are deduced. According to the transmissibility curve simulation under different electric field strengths, the main factors influencing ER isolator’s working properties have been ascertained. Finally, it proves that ER isolator works well in both low and high frequency zones, it can decrease the force transmitted and enlarge the isolation frequency domain efficiently.

基于TypeMock Isolator隔离框架的单元测试

首先分析了单元测试的重要性,然后讨论了单元测试面临的难题,重点介绍了解决这些难题的隔离框架TypeMock Isolator的众多优点,最后研究了该框架在一个平台开发中的应用,包括测试环境搭建、测试组织、典型案例、代码运行,实践证明,应用该框架可以大大提高单元测试效率,是.Net项目的单元测试隔离框架的首选。

Advances in isolation and detection of circulating tumor cells based on microfluidics

Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements. In this study, we review the main advances in isolation and detection methods of CTC based on microfluidics research over several years, propose five technical indicators for evaluating these methods, and explore the application prospects. We also discuss the concepts, issues, approaches, advantages, limitations, and challenges with an aim of stimulating a broader interest in developing microfluidics-based CTC detection technology.

Splanchnic vasodilation and hyperdynamic circulatory syndrome in cirrhosis

Portal hypertension is a clinical syndrome which leads to several clinical complications, such as the formation and rupture of esophageal and/or gastric varices, ascites, hepatic encephalopathy and hepato-renal syndrome. In cirrhosis, the primary cause of the increase in portal pressure is the enhanced resistance to portal outflow. However, also an increase in splanchnic blood flow worsens and maintains portal hypertension. The vasodilatation of arterial splanchnic vessels and the opening of collateral circulation are the determinants of the increased splanchnic blood flow. Several vasoactive systems/substances, such as nitric oxide, cyclooxygenase-derivatives, carbon monoxide and endogenous cannabinoids are activated in portal hypertension and are responsible for the marked splanchnic vasodilatation. Moreover, an impaired reactivity to vasoconstrictor systems, such as the sympathetic nervous system, vasopressin, angiotensin II and endothelin-1, plays a role in this process. The opening of collateral circulation occurs through the reperfusion and dilatation of preexisting vessels, but also through the generation of new vessels. Splanchnic vasodilatation leads to the onset of the hyperdynamic circulatory syndrome, a syndrome which occurs in patients with portal hypertension and is characterized by increased cardiac output and heart rate, and decreased systemic vascular resistance with low arterial blood pressure. Understanding the pathophysiology of splanchnic vasodilatation and hyperdynamic circulatory syndrome is mandatory for the prevention and treatment of portal hypertension and its severe complications.

Performance of sand and shredded rubber tire mixture as a natural base isolator for earthquake protection

The performance of a well-designed layer of sand, and composites like layer of sand mixed with shredded rubber tire (RSM) as low cost base isolators, is studied in shake table tests in the laboratory. The building foundation is modeled by a 200 mm by 200 mm and 40 mm thick rigid plexi-glass block. The block is placed in the middle of a 1m by 1m tank filled with sand. The selected base isolator is placed between the block and the sand foundation. Accelerometers are placed on top of the footing and foundation sand layer. The displacement of the footing is also measured by LVDT. The whole setup is mounted on a shake table and subjected to sinusoidal motions with varying amplitude and frequency. Sand is found to be effective only at very high amplitude (> 0.65 g) of motions. The performance of a composite consisting of sand and 50% shredded rubber tire placed under the footing is found to be most promising as a low-cost effective base isolator.

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer

AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

Circulating tumor cell isolation:the assets of filtration methods with polycarbonate track-etched filters

Circulating tumor cells （CTCs） arise from primary or secondary tumors and enter the bloodstream by active or passive intravasation. Given the low number of CTCs, enrichment is necessary for detection. Filtration methods are based on selection of CTCs by size using a filter with 6.5 to 8 pm pores. After coloration, collected CTCs are evaluated according to morphological criteria. Immunophenotyping and fluorescence in situ hybridization techniques may be used. Selected CTCs can also be cultivated in vitro to provide more material. Analysis of genomic mutations is difficult because it requires adapted techniques due to limited DNA materials. Filtration-selected CTCs have shown prognostic value in many studies but multicentric validating trials are mandatory to strengthen this assessment. Other clinical applications are promising such as follow-up, therapy response prediction and diagnosis. Microfluidic emerging systems could optimize filtration-selected CTCs by increasing selection accuracy.

Seismic behavior of variable frequency pendulum isolator

Earthquake performance of a flexible one-story building isolated with a variable frequency pendulum isolator （VFPI） under near-fault and far-field ground motions is investigated. The frictional forces mobilized at the interface of the VFPI are assumed to be velocity dependent. The interaction between frictional forces of the VFPI in two horizontal directions is duly considered and coupled differential equations of motion of the isolated system in the incremental form are solved iteratively. The response of the system with bi-directional interaction is compared with those without interaction. In addition, the effects of velocity dependence on the response of the isolated system are also investigated. Moreover, a parametric study is carried out to critically examine the influence of important parameters on bi-directional interaction effects of the frictional forces of the VFPI. These parameters are： the superstructure time period, frequency variation factor （FVF） and friction coefficient of the VFPI. From the above investigations, it is observed that the dependence of the friction coefficient on relative velocity of the system does not have a noticeable effect on the peak response of the system isolated with VFPI, and that the bi-directional interaction of frictional forces of the VFPI is important and if neglected, isolator displacements will be underestimated and the superstructure acceleration and base shear will be overestimated.