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VARIATION OF SERUM ACTIVIN A LEVEL IN PATIENTS WITH LIVER CIRRHOSIS
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作者 黄新 周璐 +1 位作者 李定国 陆汉明 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2004年第2期71-73,78,共4页
Objective To evaluate the variation of serum activin A level in liver cirrhotic patients.Methods 83 liver cirrhotic patients (32 Child-Pugh A, 30 Child-Pugh B and 21 Child-Push C) and 32 normal subjects entered the st... Objective To evaluate the variation of serum activin A level in liver cirrhotic patients.Methods 83 liver cirrhotic patients (32 Child-Pugh A, 30 Child-Pugh B and 21 Child-Push C) and 32 normal subjects entered the study. The serum levels of activin A, procollagen Ⅲ peptide and collagen Ⅳ were measured by ELISA. Results Compared with those of normal subjects (0. 76±0. 31ng/ml) ,the serum activin A levels were significantly increased in liver cirrhotic patients(1. 33±0. 83ng/ml, P <0. 01). The levels were higher in Child-Pugh C (1. 45±0. 39ng/ml, P <0. 01) and B( 1. 47±0. 81ng/ml, P <0. 01) than in Child-Pugh A (1.00±0. 35 ng/ml) and normal control group(0. 76±0. 31ng/ml). There was no significant difference between Child-Pugh B and C patients or between Child-Pugh A patients and normal control. In corresponding Child-Pugh grades, the serum activin A levels of those suffering from hepatic encephalopathy, digestive tract hemorrhage, infection or ascites were not different from those without such complications. The Serum activin A level was positively correlated with those of procollagen Ⅲ peptides, collagen Ⅳ and alanine aminotransferase. Conclusion Serum activin A was increased in cirrhotic patients and activin A may be involved in the pathogenesis of hepatic flbrosis. 展开更多
关键词 liver cirrhosis serum activin A child-pugh class
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高频超声肝实质纹理特征定量联合血清AFP-L3水平评估乙型肝炎肝硬化患者肝功能分级价值研究 被引量:1
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作者 李芳 王衍森 翁璐昕 《实用肝脏病杂志》 CAS 2022年第4期542-545,共4页
目的探讨应用高频超声肝实质纹理特征定量联合血清甲胎蛋白-L3(AFP-L3)水平评估乙型肝炎肝硬化患者肝功能分级的价值。方法2019年6月~2021年5月我院诊治的乙型肝炎肝硬化患者87例和在本院进行体检的健康志愿者80例,将肝硬化患者依据肝... 目的探讨应用高频超声肝实质纹理特征定量联合血清甲胎蛋白-L3(AFP-L3)水平评估乙型肝炎肝硬化患者肝功能分级的价值。方法2019年6月~2021年5月我院诊治的乙型肝炎肝硬化患者87例和在本院进行体检的健康志愿者80例,将肝硬化患者依据肝功能分级分为A级、B级和C级。使用高频超声检查,获取肝实质纹理特征定量指标,包括缺陷图单位面积局部最大值(x D)、缺陷图均值(mean D)和缺陷图的熵(εD)。采用ELISA法检测血清AFP-L3水平。应用MedCalc15.1统计学软件绘制受试者工作特征曲线(ROC),以曲线下面积(AUC)评价指标的评估价值。结果肝硬化患者高频超声肝实质纹理特征定量指标x D、mean D、εD和血清AFP-L3水平分别为(6.1±1.8)、(4.8±1.2)、(3.2±1.1)和(7.5±2.1)%,显著高于健康人【分别为(2.5±0.9)、(1.9±0.6)、(1.3±0.4)和(5.6±1.3)%,P<0.05】;24例Child C级患者x D、mean D、εD和血清AFP-L3水平分别为(6.9±2.2)、(7.0±2.2)、(4.3±1.3)和(9.0±2.4)%,显著高于29例Child B级患者【分别为(6.5±1.7)、(5.4±1.5)、(3.8±1.1)和(7.9±2.1)%,P<0.05】或34例A级患者【分别为(5.3±1.3)、(3.2±1.0)、(2.1±0.6)和(6.1±1.5)%,P<0.05】;联合应用mean D、εD和血清AFP-L3水平评估乙型肝炎肝硬化患者肝功能Child B级的AUC为0.910,其诊断的特异度为91.4%,显著高于各指标单独诊断(其特异度分别为70.7%、77.6%和75.9%,P<0.05)。结论应用高频超声肝实质纹理特征定量联合血清AFP-L3水平评估乙型肝炎肝硬化患者肝功能分级有一定的价值,可为临床早期发现肝功能Child B级患者提供参考指标。 展开更多
关键词 肝硬化 高频超声 肝实质纹理特征 甲胎蛋白-L3 CHILD分级 诊断
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肝硬化伴或不伴胆结石胆囊排空的比较 被引量:6
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作者 赵波 郝晓云 《中国医学创新》 CAS 2010年第8期61-63,共3页
目的观察肝硬化患者伴或不伴有胆囊结石时胆囊的排空功能,以探讨胆囊的排空是否与胆囊结石的形成有关。方法24位肝硬化并胆囊结石患者纳入研究,作为试验组,ChildA、B、C级各8例;另24例不伴胆囊结石的肝硬化患者为对照组,每级均有8... 目的观察肝硬化患者伴或不伴有胆囊结石时胆囊的排空功能,以探讨胆囊的排空是否与胆囊结石的形成有关。方法24位肝硬化并胆囊结石患者纳入研究,作为试验组,ChildA、B、C级各8例;另24例不伴胆囊结石的肝硬化患者为对照组,每级均有8位患者。利用超声波检查测量空腹胆囊体积,后嘱受试者摄入脂餐计箅胆囊体积,估测胆囊最小体积、胆囊排空分数。统计分析使用Students’t检验和Pearson’S相关性分析。结果对照组中空腹胆囊体积和胆囊最小体积均增大,但胆囊排空分数并无明显变化。试验组中,与Child A级比较,Child C级胆囊排空分数显著降低,并且也比对照组中Child C级的胆囊排空分数显著下降。结论肝硬化患者的胆囊收缩功能明显下降,胆囊的运动减弱则与肝脏病变的严重程度呈平等趋势,胆囊的运动减弱是肝硬化晚期患者胆囊结石形成的主要原因,胆囊结石的数量和大小及胆囊壁的厚度与胆囊排空并无明显的相关性。 展开更多
关键词 胆囊排空分数 超声波检查 胆囊 肝硬化 肝功能分级
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多层螺旋CT门静脉成像评价肝硬化患者肝功能分级价值研究 被引量:13
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作者 巴正武 栗海龙 《实用肝脏病杂志》 CAS 2019年第3期397-400,共4页
目的探讨采用多层螺旋CT门静脉成像(MSCTP)检查对肝硬化患者肝功能分级的评价价值。方法2015年8月~2017年9月我院收治的肝硬化患者62例,选择同期健康人62例作为对照组,均行MSCTP检查,观察脾静脉(SPV)、肝内门静脉左支(IHLPV)、门静脉主... 目的探讨采用多层螺旋CT门静脉成像(MSCTP)检查对肝硬化患者肝功能分级的评价价值。方法2015年8月~2017年9月我院收治的肝硬化患者62例,选择同期健康人62例作为对照组,均行MSCTP检查,观察脾静脉(SPV)、肝内门静脉左支(IHLPV)、门静脉主干(MPV)和肝内门静脉右支(IHRPV)直径,并比较不同Child-Pugh分级患者的上述指标及胃左静脉(LGV)直径和食管下段静脉曲张断面数。结果肝硬化患者SPV、IHLPV、MPV和IHRPV直径分别为(14.4±3.6) mm、(13.5±3.1) mm、(17.9±4.2) mm和(13.8±3.9) mm,均显著大于健康人[分别为(8.9±1.7) mm、(9.7±2.3) mm、(11.2±2.9) mm和(9.5±2.5) mm,P<0.05];随着肝功能Child-Pugh分级变差,SPV、IHLPV、MPV和IHRPV直径也逐渐增大[A级为(13.2±2.7) mm、(12.1±3.2) mm、(16.4±4.6) mm和(12.3±3.3) mm,B级为(15.1±3.5) mm、(14.3±3.7) mm、(18.5±4.8) mm和(14.7±3.6)mm,C级为(16.3±4.1) mm、(15.8±4.3) mm、(20.8±5.1) mm和(16.1±4.7) mm,P<0.05],差异显著,LGV直径和食管下段静脉曲张断面数亦逐渐增大或增多[Child-Pugh A级分别为(6.4±1.5) mm和(3.8±1.1)个,B级为(9.1±2.2) mm和(7.4±1.6)个,C级为(9.7±2.6) mm和(7.7±1.8)个],其中Child-Pugh B级或C级与A级比,差异有统计学意义(P<0.05),而Child-Pugh B级与C级比较,差异无统计学意义(P>0.05)。结论采用MSCTP检查门静脉系统并检测有关指标,能很好地评估肝硬化患者肝功能状态,具有重要的临床意义。 展开更多
关键词 肝硬化 多层螺旋CT 门静脉 肝功能分级 评价
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Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study 被引量:7
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作者 Rodolfo Sacco Marco Bertini +14 位作者 Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第15期1843-1848,共6页
AIM: To prospectively long term clinical impact evaluate the short and of selective transarterial chemoembolization (TACE) on fiver function in patients with hepatocellular carcinoma (HCC). To assess side effects... AIM: To prospectively long term clinical impact evaluate the short and of selective transarterial chemoembolization (TACE) on fiver function in patients with hepatocellular carcinoma (HCC). To assess side effects in relation to treatments. To analyze the overall survival and HCC progression free survival probability. METHODS: One hundred and seventeen cirrhotic patients with HCC were enrolled. Baseline liver function included Child-Pugh score and serum levels of alanine- aminotransferase (ALT), prothrombin time (PT) and bilirubin. According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems, 71 patients were eligible for TACE; 32 had previously received treatment for HCC. No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions. While hospitalized, patients underwent clinical, hematologic and ultrasonographic assessments. One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed "on demand" Liver function tests were checked in all patients every four months. RESULTS: After first TACE, the mean Child-Pugh score increased from a mean baseline 5.62 ±1.12 to 6.11 ±1.57 at discharge time (P 〈 0.0001), decreasing after four months to 5.81 ± 0.73 (not significant). ALT, PT and bilirubin significantly (P 〈 0.0001) increased 24 h after TACE and progressively decreased until discharge. After the second TACE, variations in Child-Pugh score, ALT, PT and bilirubin were comparable to that described after the first TACE. No major complications were observed. The mean follow-up was 14.7 + 6.3 mo (median: 16 mo). Only one patient died. No other patient experienced important long term worsening of clinical status. The overall survival probability at twenty-four months was 98.18% with a correspondent HCC progression free survival probability of 69%. CONCLUSION: Selective TACE may produce significant, but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score. Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles. Liver function can remain stable in the long-term, with optimal medium term survival. This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. 展开更多
关键词 Hepatocellular carcinoma Transarterialchemoembolization liver function liver cirrhosis child-pugh score
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Evaluating the risk of adverse events with interventional endoscopic retrograde cholangiopancreatography and endoscopic ultrasound procedures in cirrhotic patients 被引量:1
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作者 Timothy Yoo Raisa Epistola +5 位作者 Jordan Epistola Lawrence Ku Michael W Fleischman Sofiya Reicher Viktor E Eysselein Linda A Hou 《World Journal of Gastrointestinal Endoscopy》 CAS 2019年第11期523-530,共8页
BACKGROUND Hepatic cirrhosis is associated with greater adverse event rates following surgical procedures and is thought to have a higher risk of complications with interventional procedures in general.However,these s... BACKGROUND Hepatic cirrhosis is associated with greater adverse event rates following surgical procedures and is thought to have a higher risk of complications with interventional procedures in general.However,these same patients often require interventional gastrointestinal procedures such as endoscopic retrograde cholangiopancreatography(ERCP)and endoscopic ultrasound(EUS).While studies examining this scenario exist,the overall body of evidence for adverse event rates associated with ERCP/EUS procedures is more limited.We sought add to the literature by examining the incidence of adverse events after ERCP/EUS procedures in our safety-net hospital population with the hypothesis that severity of cirrhosis correlates with higher adverse event rates.AIM To examine whether increasing severity of cirrhosis is associated with greater incidence of adverse events after interventional ERCP/EUS procedures.METHODS We performed a retrospective study of patients diagnosed with hepatic cirrhosis who underwent ERCP and/or EUS-guided fine needle aspirations/fine needle biopsies from January 1,2016 to March 14,2019 at our safety net hospital.We recorded Child-Pugh and Model for End-stage Liver Disease(MELD-Na)scores at time of procedure,interventions completed,and 30-day post-procedural adverse events.Statistical analyses were done to assess whether Child-Pugh class and MELD-Na score were associated with greater adverse event rates and whether advanced techniques(single-operator cholangioscopy,electrohydraulic lithotripsy/laser lithotripsy,or needle-knife techniques)were associated with higher complication rates.RESULTS 77 procedures performed on 36 patients were included.The study population consisted primarily of middle-aged Hispanic males.30-d procedure-related adverse events included gastrointestinal bleeding(7.8%),infection(6.5%),and bile leak(2%).The effect of Child-Pugh class C vs class A and B significantly predicted adverse events(β=0.55,P<0.01).MELD-Na scores also significantly predicted adverse events(β=0.037,P<0.01).Presence of advanced techniques was not associated with higher adverse events(P>0.05).When MELD-Na scores were added as predictors with the effect of Child-Pugh class C,logistic regression showed MELD-Na scores were a significant predictor of adverse events(P<0.01).The findings held after controlling for age,gender,ethnicity and repeat cases.CONCLUSION Increasing cirrhosis severity predicted adverse events while the presence of advanced techniques did not.MELD-Na score may be more useful in predicting adverse events than Child-Pugh class. 展开更多
关键词 ENDOSCOPIC retrograde CHOLANGIOPANCREATOGRAPHY ENDOSCOPIC ultrasound FINE-NEEDLE ASPIRATION FINE-NEEDLE biopsy Hepatic cirrhosis Model for END-STAGE liver Disease child-pugh class Adverse events
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肝特异性对比剂Gd-EOB-DTPA在肝功能评价中的应用 被引量:5
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作者 张静 许乙凯 +1 位作者 崔丹婷 唐力昊 《临床放射学杂志》 CSCD 北大核心 2015年第4期558-562,共5页
目的探讨肝特异性对比剂钆塞酸二钠(Gd-EOB-DTPA)增强后肝脏信号强度在肝功能评价中的应用。方法 80例患者(肝硬化49例,非肝硬化31例)使用Gd-EOB-DTPA作为对比剂行肝脏MR检查,肝硬化组按照Child-Pugh分级法进行肝功能分级。统计分析肝... 目的探讨肝特异性对比剂钆塞酸二钠(Gd-EOB-DTPA)增强后肝脏信号强度在肝功能评价中的应用。方法 80例患者(肝硬化49例,非肝硬化31例)使用Gd-EOB-DTPA作为对比剂行肝脏MR检查,肝硬化组按照Child-Pugh分级法进行肝功能分级。统计分析肝硬化组及非肝硬化组、肝硬化组不同功能级别间肝脏信号强度的差异是否有统计学意义。结果肝硬化组与非肝硬化组间、肝硬化组中三种不同级别肝功能间肝脏与脾脏、竖脊肌信号强度比值的差异均有统计学意义。肝脏信号强度与Child-Pugh分级间呈负相关关系。结论 Gd-EOB-DTPA MR增强后肝脏信号强度可反映肝脏细胞的功能,有望成为肝脏功能评估的一种可靠方法。 展开更多
关键词 肝硬化 child-pugh分级 肝功能 gd-eob-dtpa
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