Objective: To study the effect of adjuvant reduced glutathione therapy on vasoactive molecules and oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage. Methods: Patients diagnosed wit...Objective: To study the effect of adjuvant reduced glutathione therapy on vasoactive molecules and oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage. Methods: Patients diagnosed with cirrhosis-induced upper gastrointestinal hemorrhage in No. 215 Hospital of Shaanxi Nuclear Industry between June 2015 and March 2017 were selected as the research subjects, and random number table was used to divide them into the GSH group who accepted reduced glutathione combined with conventional therapy and the control group who accepted conventional therapy. Serum levels of liver function indexes, vasoactive molecules and oxidative stress reaction molecules in two groups of patients were detected before treatment and 3 d after treatment. Results: 3 d after treatment, serum ALT, AST, γ-GT, TBIL, PRA, AT-Ⅱ, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of both groups of patients were significantly lower than those before treatment while SOD, GSH-Px and CAT levels were significantly high than those before treatment, and serum ALT, AST, γ-GT, TBIL, PRA, AT-II, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of GSH group were significantly lower than those of control group while SOD, GSH-Px and CAT levels were significantly higher than those of control group. Conclusion: The adjuvant reduced glutathione therapy for cirrhosis-induced upper gastrointestinal hemorrhage can improve the liver function, regulate the secretion of vasoactive molecules and reduce the oxidative stress response.展开更多
目的系统评价特利加压素联合生长抑素治疗肝硬化上消化道出血的疗效及安全性。方法检索自建库至2023年7月在PubMed、Cochrane Library、Embase、Web of Science、中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(...目的系统评价特利加压素联合生长抑素治疗肝硬化上消化道出血的疗效及安全性。方法检索自建库至2023年7月在PubMed、Cochrane Library、Embase、Web of Science、中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(SinoMed)等发表的关于特利加压素联合生长抑素治疗肝硬化上消化道出血的随机对照试验(RCTs),试验组采用特利加压素联合生长抑素,对照组单用生长抑素。采用Revman5.3和Stata17软件对全因死亡率、总体有效率、不良事件发生率、止血时间、输血量和住院时间进行Meta分析。结果纳入20项RCTs,共计1502例患者。Meta分析结果显示:与对照组相比,试验组治疗肝硬化上消化道出血可降低全因死亡率(OR=0.34,95%CI:0.19~0.59,P<0.01)和输血量(SMD=-2.29,95%CI:-3.13~-1.46,P<0.01),缩短止血时间(SMD=-1.64,95%CI:-2.03~-1.25,P<0.01)和住院时间(MD=-7.12,95%CI:-7.47~-6.77,P<0.01),提高总体有效率(OR=3.50,95%CI:2.46~4.97,P<0.01);而不良事件的发生率比较差异无统计学意义(OR=1.20,95%CI:0.82~1.75,P=0.34)。结论现有证据表明,与单用生长抑素相比,特利加压素联合生长抑素治疗肝硬化上消化道出血可显著提高总体有效率,降低死亡风险和输血量,缩短止血时间及住院时间,且不增加不良反应。展开更多
目的:探讨肝硬化上消化道大出血患者体内脂质过氧化状态的变化及丹参注射液对其的影响.方法:肝硬化上消化道大出血患者91例,随机分为丹参注射液治组(n=36)和传统治疗组(n=55).分别测定患者血中超氧化物岐化酶(SOD)活性和过氧化脂质(LPO...目的:探讨肝硬化上消化道大出血患者体内脂质过氧化状态的变化及丹参注射液对其的影响.方法:肝硬化上消化道大出血患者91例,随机分为丹参注射液治组(n=36)和传统治疗组(n=55).分别测定患者血中超氧化物岐化酶(SOD)活性和过氧化脂质(LPO)含量.结果:传统治疗组患者血中LPO含量在出血后明显增加,72h左右达最高峰(11.0±4.1 nmol/L),较出血前或12h内(7.8±3.3 nmol/L)明显升高(P<0.01),1wk后开始下降,4wk后可不同程度恢复.而经丹参注射液治疗的患者血中LPO含量亦于72h左右达最高峰,但变化幅度较小(9.9±4.6nmol/L vs 7.8±3.1nmol/L,P<0.05),恢复较快.两组SOD活性变化与LPO含量变化相反,72h降至最小值(传统治疗组:0.87±0.2 nkat/L vs 1.3±0.2 nkat/L,P<0.01;丹参注射液治组:0.9±0.3 nkat/L vs 1.4±0.2 nkat/L,P<0.01),4 wk后可不同程度恢复.丹参注射液治疗组患者的预后明显优于传统治疗组(P<0.01),且Child-Pugh B级者优于C级(P<0.05).结论:丹参注射液可提高机体的抗氧化能力,改善肝硬化上消化道大出血患者的预后.展开更多
基金Project of Shaanxi Provincial Natural Science Foundation No:2017JM8163.
文摘Objective: To study the effect of adjuvant reduced glutathione therapy on vasoactive molecules and oxidative stress in patients with cirrhosis-induced upper gastrointestinal hemorrhage. Methods: Patients diagnosed with cirrhosis-induced upper gastrointestinal hemorrhage in No. 215 Hospital of Shaanxi Nuclear Industry between June 2015 and March 2017 were selected as the research subjects, and random number table was used to divide them into the GSH group who accepted reduced glutathione combined with conventional therapy and the control group who accepted conventional therapy. Serum levels of liver function indexes, vasoactive molecules and oxidative stress reaction molecules in two groups of patients were detected before treatment and 3 d after treatment. Results: 3 d after treatment, serum ALT, AST, γ-GT, TBIL, PRA, AT-Ⅱ, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of both groups of patients were significantly lower than those before treatment while SOD, GSH-Px and CAT levels were significantly high than those before treatment, and serum ALT, AST, γ-GT, TBIL, PRA, AT-II, ALD, MDA, ox-LDL, AOPP and 8-OHdG levels of GSH group were significantly lower than those of control group while SOD, GSH-Px and CAT levels were significantly higher than those of control group. Conclusion: The adjuvant reduced glutathione therapy for cirrhosis-induced upper gastrointestinal hemorrhage can improve the liver function, regulate the secretion of vasoactive molecules and reduce the oxidative stress response.
文摘目的系统评价特利加压素联合生长抑素治疗肝硬化上消化道出血的疗效及安全性。方法检索自建库至2023年7月在PubMed、Cochrane Library、Embase、Web of Science、中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(SinoMed)等发表的关于特利加压素联合生长抑素治疗肝硬化上消化道出血的随机对照试验(RCTs),试验组采用特利加压素联合生长抑素,对照组单用生长抑素。采用Revman5.3和Stata17软件对全因死亡率、总体有效率、不良事件发生率、止血时间、输血量和住院时间进行Meta分析。结果纳入20项RCTs,共计1502例患者。Meta分析结果显示:与对照组相比,试验组治疗肝硬化上消化道出血可降低全因死亡率(OR=0.34,95%CI:0.19~0.59,P<0.01)和输血量(SMD=-2.29,95%CI:-3.13~-1.46,P<0.01),缩短止血时间(SMD=-1.64,95%CI:-2.03~-1.25,P<0.01)和住院时间(MD=-7.12,95%CI:-7.47~-6.77,P<0.01),提高总体有效率(OR=3.50,95%CI:2.46~4.97,P<0.01);而不良事件的发生率比较差异无统计学意义(OR=1.20,95%CI:0.82~1.75,P=0.34)。结论现有证据表明,与单用生长抑素相比,特利加压素联合生长抑素治疗肝硬化上消化道出血可显著提高总体有效率,降低死亡风险和输血量,缩短止血时间及住院时间,且不增加不良反应。
文摘目的:探讨肝硬化上消化道大出血患者体内脂质过氧化状态的变化及丹参注射液对其的影响.方法:肝硬化上消化道大出血患者91例,随机分为丹参注射液治组(n=36)和传统治疗组(n=55).分别测定患者血中超氧化物岐化酶(SOD)活性和过氧化脂质(LPO)含量.结果:传统治疗组患者血中LPO含量在出血后明显增加,72h左右达最高峰(11.0±4.1 nmol/L),较出血前或12h内(7.8±3.3 nmol/L)明显升高(P<0.01),1wk后开始下降,4wk后可不同程度恢复.而经丹参注射液治疗的患者血中LPO含量亦于72h左右达最高峰,但变化幅度较小(9.9±4.6nmol/L vs 7.8±3.1nmol/L,P<0.05),恢复较快.两组SOD活性变化与LPO含量变化相反,72h降至最小值(传统治疗组:0.87±0.2 nkat/L vs 1.3±0.2 nkat/L,P<0.01;丹参注射液治组:0.9±0.3 nkat/L vs 1.4±0.2 nkat/L,P<0.01),4 wk后可不同程度恢复.丹参注射液治疗组患者的预后明显优于传统治疗组(P<0.01),且Child-Pugh B级者优于C级(P<0.05).结论:丹参注射液可提高机体的抗氧化能力,改善肝硬化上消化道大出血患者的预后.
