To understand the role of genetic factors in the occurrence of esophageal cancer (EC) Methods A genetic epidemiological survey of 132?039 subjects, one tenth of the whole population of Yangquan city, Shanxi Provi...To understand the role of genetic factors in the occurrence of esophageal cancer (EC) Methods A genetic epidemiological survey of 132?039 subjects, one tenth of the whole population of Yangquan city, Shanxi Province in Northern China, was conducted in 1994 A total of 228 families with at least one newly occurring EC patient in each family were matched with equal number of control families for a 1∶1 case control study Results The heritability of esophageal cancer among first degree relatives was 52 6%, that among second degree relatives was 31 2%, and the weighted average heritability was 49 2% The segregation ratio was 0 176±0 033, significantly less than 0 25, suggesting a multifactorial inheritance or decreased penetrance of a major locus EC patients in families did not fit the binominal distribution, suggesting evidently familial aggregation The relative risks among the first degree relatives were 10 49 for males, 7 69 for females, and 9 17 for combined data The attributive risks among first degree relatives were 62 13/100?000 for males, 99 94/100?000 for females and 75 15/100?000 for combined data All of these figures were higher than 40 17/100?000, the average of general population of the city Conclusion Genetic factors play an important role in the pathogenesis of esophageal cancer in this area展开更多
On the basis of the analysis of the standards for the city/town populationstatistics in the past censuses,the author makes a proportional analysis of the city/townpopulation according to the data obtained from the fou...On the basis of the analysis of the standards for the city/town populationstatistics in the past censuses,the author makes a proportional analysis of the city/townpopulation according to the data obtained from the fourth census,and points out the dis-crepancies in the standard for the the city/town population statistics used in the fourthcensus and proposes ways for their correction.展开更多
Viewed from a macro scope,the cultureof a community is closely related to its econ-omy.Economy being the basis,the level ofeconomic growth determines the level ofcultural development.Conversely,culturecan act as the p...Viewed from a macro scope,the cultureof a community is closely related to its econ-omy.Economy being the basis,the level ofeconomic growth determines the level ofcultural development.Conversely,culturecan act as the precursor and cultural devel-opment enhances economic growth.Likewise,the education attainment of an in-dividual reflects the same sort展开更多
文摘To understand the role of genetic factors in the occurrence of esophageal cancer (EC) Methods A genetic epidemiological survey of 132?039 subjects, one tenth of the whole population of Yangquan city, Shanxi Province in Northern China, was conducted in 1994 A total of 228 families with at least one newly occurring EC patient in each family were matched with equal number of control families for a 1∶1 case control study Results The heritability of esophageal cancer among first degree relatives was 52 6%, that among second degree relatives was 31 2%, and the weighted average heritability was 49 2% The segregation ratio was 0 176±0 033, significantly less than 0 25, suggesting a multifactorial inheritance or decreased penetrance of a major locus EC patients in families did not fit the binominal distribution, suggesting evidently familial aggregation The relative risks among the first degree relatives were 10 49 for males, 7 69 for females, and 9 17 for combined data The attributive risks among first degree relatives were 62 13/100?000 for males, 99 94/100?000 for females and 75 15/100?000 for combined data All of these figures were higher than 40 17/100?000, the average of general population of the city Conclusion Genetic factors play an important role in the pathogenesis of esophageal cancer in this area
文摘On the basis of the analysis of the standards for the city/town populationstatistics in the past censuses,the author makes a proportional analysis of the city/townpopulation according to the data obtained from the fourth census,and points out the dis-crepancies in the standard for the the city/town population statistics used in the fourthcensus and proposes ways for their correction.
文摘Viewed from a macro scope,the cultureof a community is closely related to its econ-omy.Economy being the basis,the level ofeconomic growth determines the level ofcultural development.Conversely,culturecan act as the precursor and cultural devel-opment enhances economic growth.Likewise,the education attainment of an in-dividual reflects the same sort
