AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patient...AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patients with non-metastatic rectal cancer from March 2004 to November 2008 were analyzed retrospectively at our institute.The mRNA expressions of VEGFR1 and TUBB3 were detected by multiplex branched DNA liquid-chip technology.The Cutoff Finder application was applied to determine cutoff point of mRNA expression.SPSS software version 22.0was used for analysis.RESULTS The median follow-up was 102.7 mo(range,6-153.6).Theχ~2 and Fisher’s exact tests showed that VEGFR1expression was related to lymph node metastasis(P=0.013),while no relationships between TUBB3 and clinicopathological features were observed.Univariate analysis showed that T stage,lymph node metastasis,tumor differentiation,VEGFR1 and TUBB3 mRNA expression were correlated to overall survival(OS)(P=0.048,P=0.003,P=0.052,P=0.003 and P=0.015,respectively).Also,lymph node metastasis and VEGFR1expression independently influenced OS by multivariate analysis(P=0.027 and P=0.033).VEGFR1 expression was positively correlated with TUBB3(P=0.024).The patients with low expression of both TUBB3 and VEGFR1 presented a better OS(P=0.003).In addition,the receiver operating characteristic analysis suggested that the combination of lymph node metastasis and VEGFR1 had a more favorable prognostic value(P<0.001).CONCLUSION VEGFR1 expression and lymph node metastasis independently and jointly affect survival.Moreover,low expression of VEGFR1 and TUBB3 presented a better OS in patients with non-metastatic rectal cancer,which might serve as a potential prognostic factor.展开更多
随着口腔种植技术的普及,如何能够安全的为全身复杂系统疾病患者实施种植手术是当下种植医生不得不面临的挑战。根据患者身体状况,美国麻醉医师协会(American Society of Anesthesiologists,ASA)将围手术期风险进行分级,ASAⅠ~Ⅱ级的患...随着口腔种植技术的普及,如何能够安全的为全身复杂系统疾病患者实施种植手术是当下种植医生不得不面临的挑战。根据患者身体状况,美国麻醉医师协会(American Society of Anesthesiologists,ASA)将围手术期风险进行分级,ASAⅠ~Ⅱ级的患者手术风险极低,ASAⅣ级以上的患者风险极高,不适合手术。对于ASAⅢ级患者,如何评估围手术期风险、实施种植外科手术、降低围手术期严重并发症是越来越多种植医生关注的问题。本文拟从临床最常见合并心血管疾病的ASAⅢ级患者入手,探讨此类患者口腔种植手术的风险评估、防范及并发症防治,为该类患者安全进行种植修复提供参考。展开更多
基金Supported by Fujian Province Natural Science Foundation,Nos.2016J01437,2017J01260 and 2018J01266the Fujian Medical Innovation Project,No.2015-CX-8+1 种基金the Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research,Ministry of Education/Beijing(2017 Open Project-9)Joint Funds for the innovation of science and Technology,Fujian Province,No.2017Y9074
文摘AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patients with non-metastatic rectal cancer from March 2004 to November 2008 were analyzed retrospectively at our institute.The mRNA expressions of VEGFR1 and TUBB3 were detected by multiplex branched DNA liquid-chip technology.The Cutoff Finder application was applied to determine cutoff point of mRNA expression.SPSS software version 22.0was used for analysis.RESULTS The median follow-up was 102.7 mo(range,6-153.6).Theχ~2 and Fisher’s exact tests showed that VEGFR1expression was related to lymph node metastasis(P=0.013),while no relationships between TUBB3 and clinicopathological features were observed.Univariate analysis showed that T stage,lymph node metastasis,tumor differentiation,VEGFR1 and TUBB3 mRNA expression were correlated to overall survival(OS)(P=0.048,P=0.003,P=0.052,P=0.003 and P=0.015,respectively).Also,lymph node metastasis and VEGFR1expression independently influenced OS by multivariate analysis(P=0.027 and P=0.033).VEGFR1 expression was positively correlated with TUBB3(P=0.024).The patients with low expression of both TUBB3 and VEGFR1 presented a better OS(P=0.003).In addition,the receiver operating characteristic analysis suggested that the combination of lymph node metastasis and VEGFR1 had a more favorable prognostic value(P<0.001).CONCLUSION VEGFR1 expression and lymph node metastasis independently and jointly affect survival.Moreover,low expression of VEGFR1 and TUBB3 presented a better OS in patients with non-metastatic rectal cancer,which might serve as a potential prognostic factor.
文摘随着口腔种植技术的普及,如何能够安全的为全身复杂系统疾病患者实施种植手术是当下种植医生不得不面临的挑战。根据患者身体状况,美国麻醉医师协会(American Society of Anesthesiologists,ASA)将围手术期风险进行分级,ASAⅠ~Ⅱ级的患者手术风险极低,ASAⅣ级以上的患者风险极高,不适合手术。对于ASAⅢ级患者,如何评估围手术期风险、实施种植外科手术、降低围手术期严重并发症是越来越多种植医生关注的问题。本文拟从临床最常见合并心血管疾病的ASAⅢ级患者入手,探讨此类患者口腔种植手术的风险评估、防范及并发症防治,为该类患者安全进行种植修复提供参考。
