Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cycl...Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cyclization of intramolecule at room temperature in aqueous solution. The advantages of the novel protocol are the mild reaction condition, free organic solvent, simple final treatment, easy isolation of products and excellent yields.展开更多
The Darzens condensation reaction of aromatic aldehydes with phenacyl chloride proceeded very efficiently in a water suspension medium in the presence of triethylbenzylammonium chloride and only trans 2,3 epoxy ...The Darzens condensation reaction of aromatic aldehydes with phenacyl chloride proceeded very efficiently in a water suspension medium in the presence of triethylbenzylammonium chloride and only trans 2,3 epoxy 1,3 diaryl 1 propanones were formed which can be isolated simply by filtration. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra. Their configurations are in agreement with that of the same compounds reported in the literature. Compared to the classical Darzens condensation, this new method has the advantages of good yields, high stereoselectivity, low running cost inexpensive and environmentally benign procedure.展开更多
基金Financial support from the National Natural Science Foundation of China(No.20802049) and Program for New Century Excellent Talents in University of Tianjin City
文摘Calix[4]-crown-5-sulfonyl cyclothiourea derivatives 6 and 7 were synthesized from calix[4]-crown-5-monosulfonylethylenediamine derivatives 4 and 5 and carbon disulfide through nucleophilic addition and subsequent cyclization of intramolecule at room temperature in aqueous solution. The advantages of the novel protocol are the mild reaction condition, free organic solvent, simple final treatment, easy isolation of products and excellent yields.
基金Projectsupportedbythe"QinglanGongcheng"FoundationofJiangsuProvince (No .QL980 0 1)
文摘The Darzens condensation reaction of aromatic aldehydes with phenacyl chloride proceeded very efficiently in a water suspension medium in the presence of triethylbenzylammonium chloride and only trans 2,3 epoxy 1,3 diaryl 1 propanones were formed which can be isolated simply by filtration. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra. Their configurations are in agreement with that of the same compounds reported in the literature. Compared to the classical Darzens condensation, this new method has the advantages of good yields, high stereoselectivity, low running cost inexpensive and environmentally benign procedure.
