Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have an antispasmodic and antisecretory effect on the gastrointestinal tract.Inhibits the muscarinic effects ...Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have an antispasmodic and antisecretory effect on the gastrointestinal tract.Inhibits the muscarinic effects of acetylcholine at neurotransmitter sites after parasympathetic ganglia.It is used to treat peptic ulcer disease and to help relieve stomach or stomach cramps or cramps due to abdominal cramps,diverticulitis,and irritable bowel syndrome.Mononuclear complexes of the manganese(Ⅱ),nickel(Ⅱ)and mercury(Ⅱ)with clidinium bromide drug(C_(22)H_(26)NO_(3))types[M(C_(22)H_(25)NO 3)_(2)(H_(2)O)_(4)]and[Hg(C_(22)H_(25)NO_(3))_(2)(H_(2)O)_(2)]where M=Mn(Ⅱ)and Ni(Ⅱ),have been synthesized and characterized on the basis of elemental analysis,conductivity measurements,magnetic,electronic,1H-NMR and infrared spectral studies.The complexes confirm to 1∶2 stoichiometry and are non-electrolytes.The clidinium drug ligand(C_(22)H_(26)NO_(3))act as a deprotonated monovalent monodentate chelate coordinating through hydroxyl oxygen where IR spectral bands of clidinium bromide shows a band at 3226 cm^(-1)assigned to the OH group stretching frequency,this bandν(O—H)stretching vibration motion is disappeared in case of the infrared spectra of the Mn(Ⅱ),Ni(Ⅱ),and Hg(Ⅱ)complexes suggesting the involvement of the oxygen atom of the deprotonated OH group of clidinium ligand in complexation.The band for theν(C—O)of alcoholic group of clidinium that appears at 1240 cm^(-1)has blue shifted after complexity,indicating the participation of the alcoholic group in the coordination.1H NMR spectrum for clidinium bromide show a singlet peak at 3.65 ppm due to proton of OH group which isn’t observed in the spectrum of mercury(Ⅱ)complex referring to the deprotonation of OH group and participated in the complexation.Based on electronic spectra,IR spectra and magnetic moment measurements;six coordinated octahedral structures have been proposed for the manganese and nickel(Ⅱ)complexes,while mercury(Ⅱ)complex has a four coordinated geometry.Thermogravimetric analyses studies revealed the presence of coordinated water molecules.For instance the X-ray powder diffraction pattern and scanning electronic microscopy for the Hg(Ⅱ)complex deduced that it was isolated in nanostructured with crystallinity form.展开更多
A simple,rapid and sensitive method has been described for the determination of the trace amounts of bromide.The method is based on the catalytic effect of bromide ion on the oxidation of methylene blue by bromate in ...A simple,rapid and sensitive method has been described for the determination of the trace amounts of bromide.The method is based on the catalytic effect of bromide ion on the oxidation of methylene blue by bromate in sulfuric acid media.The reaction is monitored spectrophotometrically by measuring the decrease in the absorbance of methylene blue at 665 nm. Bromide was determined in the range of 0.05-1.90μg/mL with the detection limit of 0.03μg/mL.The relative standard deviations of five replicate determinations of 0.20 and 10.0μg/mL of bromide were 2.4%and 1.8%,respectively.The influence of potential interfering ions and substances was studied.The method is applied to the analysis of bromide in clidinium-c tablet as a real sample.展开更多
基金Taif University Researches Supporting Project number(TURSP-2020/15),Taif University,Taif,Saudi Arabia。
文摘Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have an antispasmodic and antisecretory effect on the gastrointestinal tract.Inhibits the muscarinic effects of acetylcholine at neurotransmitter sites after parasympathetic ganglia.It is used to treat peptic ulcer disease and to help relieve stomach or stomach cramps or cramps due to abdominal cramps,diverticulitis,and irritable bowel syndrome.Mononuclear complexes of the manganese(Ⅱ),nickel(Ⅱ)and mercury(Ⅱ)with clidinium bromide drug(C_(22)H_(26)NO_(3))types[M(C_(22)H_(25)NO 3)_(2)(H_(2)O)_(4)]and[Hg(C_(22)H_(25)NO_(3))_(2)(H_(2)O)_(2)]where M=Mn(Ⅱ)and Ni(Ⅱ),have been synthesized and characterized on the basis of elemental analysis,conductivity measurements,magnetic,electronic,1H-NMR and infrared spectral studies.The complexes confirm to 1∶2 stoichiometry and are non-electrolytes.The clidinium drug ligand(C_(22)H_(26)NO_(3))act as a deprotonated monovalent monodentate chelate coordinating through hydroxyl oxygen where IR spectral bands of clidinium bromide shows a band at 3226 cm^(-1)assigned to the OH group stretching frequency,this bandν(O—H)stretching vibration motion is disappeared in case of the infrared spectra of the Mn(Ⅱ),Ni(Ⅱ),and Hg(Ⅱ)complexes suggesting the involvement of the oxygen atom of the deprotonated OH group of clidinium ligand in complexation.The band for theν(C—O)of alcoholic group of clidinium that appears at 1240 cm^(-1)has blue shifted after complexity,indicating the participation of the alcoholic group in the coordination.1H NMR spectrum for clidinium bromide show a singlet peak at 3.65 ppm due to proton of OH group which isn’t observed in the spectrum of mercury(Ⅱ)complex referring to the deprotonation of OH group and participated in the complexation.Based on electronic spectra,IR spectra and magnetic moment measurements;six coordinated octahedral structures have been proposed for the manganese and nickel(Ⅱ)complexes,while mercury(Ⅱ)complex has a four coordinated geometry.Thermogravimetric analyses studies revealed the presence of coordinated water molecules.For instance the X-ray powder diffraction pattern and scanning electronic microscopy for the Hg(Ⅱ)complex deduced that it was isolated in nanostructured with crystallinity form.
文摘A simple,rapid and sensitive method has been described for the determination of the trace amounts of bromide.The method is based on the catalytic effect of bromide ion on the oxidation of methylene blue by bromate in sulfuric acid media.The reaction is monitored spectrophotometrically by measuring the decrease in the absorbance of methylene blue at 665 nm. Bromide was determined in the range of 0.05-1.90μg/mL with the detection limit of 0.03μg/mL.The relative standard deviations of five replicate determinations of 0.20 and 10.0μg/mL of bromide were 2.4%and 1.8%,respectively.The influence of potential interfering ions and substances was studied.The method is applied to the analysis of bromide in clidinium-c tablet as a real sample.
