Sociodemographic and Clinical Aspects of Climacteric Syndrome of Menopause in the City of Kati in Mali Involving 113 Women

Objective: This paper aims to study the sociodemographic and clinical aspects of menopausal climacteric syndrome in the city of Kati in Mali. Patients and Methods: This was a quantitative descriptive and cross-sectional study, conducted in the city of Kati from February 1 to July 31, 2021. We included 112 menopausal women. Women were selected from a household survey using the sampling step. We were interested in conjugal, family and professional life, self-esteem and the state of health of women in general. Results: More than half of the women in our study were already postmenopausal (52.2%);the mean age was 50.5 years with the extremes ranging from 41 to 62 years. The majority of them were married (69.9%), housewives (43.4%) and Bambara (53.1%). The most common climacteric syndromes were: joint pain (65.5%), hot flashes (62.8%) and night sweats (56.6%). Genital-urinary syndromes (42.5%) were dominated by decreased libido (41.7%), urinary disorder (23%) and vaginal dryness (14.6%). Genitalia-urinary syndromes increased the frequency of disagreements;Pearson’s Chi-square = 33.63;ddl = 1;P = 0.001. There was a statistically significant relationship between night sweat, genital-urinary syndromes, joint pain, and increased disease frequency with, respectively: Pearson’s chi-square = 4.660;ddl = 1;P = 0.031;Fisher’s exact test, P = 0.001, Pearson’s Chi-square = 8.434;ddl = 1;P = 0.004. There was no statistically significant relationship between climacteric syndrome and family life, work life and self-esteem. Changes in the professional relationship between women and their co-workers included, respectively: arguments (50%);disagreements (25%) and disobedience (25%). Conclusion: Menopause deteriorates the quality of life of women who suffer in silence, hence the need to pay special attention to them.

ADVANCES OF EXPERIMENTAL RESEARCH ON ACUPUNCTURE AND MOXIBUSTION FOR TREATMENT OF WOMEN'S CLIMACTERIC SYNDROME

To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.

Prevalence and Genotype Distribution of Oncogenic-Risk Human Papilloma Virus in the Cervix of Climacteric Women with Normal Pap Smears

Objective: To find out the incidence of high-risk HPV infections on climacteric women within our area of influence;and to typify HPV genotypes on women with normal cytology that come to our hospitalary unit of menopausia. Material and Method: Cross-sectional study;with a random sample of 140 cases of climacteric women of ≥50 years of age, with normal Pap smears for the last 12 months. HPV determination was carried out by PCR for screening, and by hybrid capture for genotype typification. Results: The percentage of climacteric women who are carriers of oncogenic HPV and a normal Pap smear was of 11.43% (16/140 cases). The genotype found most frequently was HPV-16, followed by HPV-58, 51 and 18. Conclusions: We found a high prevalence of women who were carriers of oncogenic HPV in climacteric women with normal Pap smears (latent infections) in our health region. We consider that cervical cancer screening, either by PCR or conventional Pap smear, should not be minimized or ignored from 50 years of age onwards.

Acupuncture for Treatment of Climacteric Syndrome—A Report of 35 Cases

To evaluate the effects of acupuncture for treatment of climacteric syndrome.Methods:The 65 cases in this series were randomly assigned to the acupuncture group (N=35) and the control group (N=30), with the former treated by acupuncture and the latter by medication respectively.The therapeutic effects were evaluated by means of the clinical outcome,improvement in the symptom scores and the results of radioimmunoassays.Results:In the acupuncture group,12 cases were cured,16 cases markedly effective,and 6 cases improved,the total effective rate being as high as 97.14%.The decrease in the symptom scores,and especially the elevation of the decreased E_2 level and the decrease of the increased FSH and LH levels, demonstrated that acupuncture therapy was superior to medication.Conclusion:Acupuncture for regulating the mental activities and reinforcing the kidney is an effective therapy for climacteric syndrome.

Effect of the Ginseng extractive E on experimental climacteric disturbance in rats

Objective To search the effects of the extractive E of Ginseng(EG)on experimental climacteric syndrome in rats.Methods Extirpating the both sides of ovary of rats to turbulence estrogen secretion,induce climacteric syndrome.The weight,bite and sup,substance of bone,blood lipid,calcium urine biochemistry,estrodiol,behavior perfomance were also observed.Results The body weight of ovariotomied rat was controlled,bone density was increased,estradiol level increased,the weight of bone increased.Conclusions EG ameliorated climacteric syndrome.Increase bone density and bone mine content,enhanced the level of estradiol.

CLINICAL STUDY ON CLIMACTERIC SYNDROME TREATED WITH AURICULAR PLUS BODY ACUPUNCTURE

Aim: To search for the best therapeutic method for climacteric syndrome. Methods: A total of 190 cases of climacteric syndrome participants were randomly divided into auricular plus body acupuncture group (treatment group, n=96) and simple body acupuncture group (control group, n=94). Serum sexual hormone (FSH, LH and E2) and blood lipid (TC, LDL C, HDL C and TG) levels were detected before and after treatment. Results: After 30 sessions of treatment, the total effective rates of treatment and control groups were 82.29% and 76.02% respectively, with the former being significantly higher than the later (P<0.01). In comparison with pre treatment of each group, serum follicle stimulating hormone (FSH) and luterotropic hormone (LH) levels lowered significantly; serum estradiol (E 2) increased remarkably (P<0.05-0.01); serum high density lipoprotein cholesterol (HDL C) of two groups raised significantly (P<0.05-0.01), and low density lipoprotein (LDL) C of treatment group decreased evidently (P<0.05). In addition, the improvement of complaints of hot flushes, sweating, paresthesia, insomnia and emotional irritability in treatment group is significantly better than that of control group. Conclusion: Auricular acupuncture combined with body acupuncture has a better therapeutic effect than that of simple body acupuncture in the treatment of climacteric syndrome.

Identification of Differentially Expressed Genes During Ethylene Climacteric of Melon Fruit by Suppression Subtractive Hybridization

Melon （Cucumis melo L.） is an important horticultural crop worldwide. Ethylene regulates the ripening process and affects the ripening rate. To screen genes that are differentially expressed at the burst of ethylene climacteric in melon fruit, we performed suppression subtractive hybridization （SSH） to generate forward and reverse libraries, for which we sequenced 439 and 445 clones, respectively. Our BLAST analysis showed that the genes from the 2 libraries were involved in metabolism, signal transduction, cell structure, transcription, translation, and defense. Six genes were analyzed by qRT-PCR during the differential developmental stage of melon fruit. Our results provide new insight into the understanding of climacteric ripening of melon fruit.

The age at natural menopause and the frequency of climacteric symptoms in Chinese women

Objectives: To estimate the age at natural menopause and the frequency of climacteric symptoms in Chinese women.Design: A cross-sectional study of randomly recruited 788 women, aged 45 to 55 years in Beijing.Results: The mean age at natural menopause was 48. 2 years. there was a trend that women with more parities, more babies breast fed or longer duration of breastfeeding had a delayed age at natural menopause. Higher socio-economic status was related to a later cessetion of menstruation. Vasomotor and psychological symptoms increased during menopause transition. However, psychological disorders tended to decrease after the menopause. Bone-joint problems were inversely associated with daily activi-ty or physical exercise. Perimenopausal women experienced the most frequent climacteric symptoms.Conclusion: The menopausal age was influenced by reproductive factors and socio-economic status-Vasomotor and psychological symptoms were associated with the menopausal status. However, bone-joint problems was not.

Differences in Male Climacteric Symptoms and Lifestyle Depending on the Duration of Working among Rotating Night Shift Workers

Background: There are various health problems in rotating shift workers. There have been few studies on the associations of male climacteric symptoms with duration of working and lifestyle. Objective: The aim of this study was to determine the differences in male climacteric symptoms depending on the number of working years and to determine whether lifestyle habits differ depending on the number of working years in rotating shift workers. Methods: We collected participant’s data from the manufacturing companies in Japan during the period from March to May in 2017. We conducted a self-administered questionnaire survey in 1561 male rotating night shift workers. Male climacteric symptoms were evaluated by using the Aging Males’ Symptoms (AMS) rating scale. We analyzed 636 rotating shift workers aged over 40 years old whose all AMS data was collected. Results: A significant difference in psychological AMS score was found between men who had worked for 10 - 19 years (9.4 ± 3.9) and men who had worked for more than 40 years (7.6 ± 3.0) (p = 0.011). Sexual functional AMS score significantly differed depending on the number of working years (less than 10 years: 8.1 ± 3.9, 10 - 19 years: 9.8 ± 4.1, 20 - 29 years: 7.9 ± 3.3, 30 - 39 years: 9.3 ± 3.5, more than 40 years: 9.3 ± 3.5) (p < 0.001). The proportion of workers with a balanced meal intake was significantly lower in men who had worked for less than 10 years and the proportions of such workers were significantly higher in men who had worked for 10 - 19 years and for more than 40 years. The proportions of men who did not drink alcohol were high in men who had worked for less than 10 years and 20 - 29 years and low in men who had worked more than 30 years. Conclusion: Psychological AMS score and sexual functional AMS score are significantly different among the 5 groups according to the number of working years on rotating shift. In addition, well-balanced diet on day shift and reduction of alcohol drinking is a related-factor for long-term rotating night shift workers.

Female Climacteric Syndrome Treated by Ear Embedding

Female climacteric syndrome is a common disease occurring before and after menopause. The author has treated the disease with ear embedding therapy, and achieved satisfactory therapeutic results. The following is a report of the clinical observation.

Clinical efficacy of anti-Mullerian hormone inspection in supporting diagnosis for climacteric disorders

The diagnosis of climacteric disorders in gynecology is performed on the basis of symptoms rather than hormonal levels. Generally, the follicle-stimulating hormone (FSH) level increases when the 17β-estradiol (E2) level decreases in menopause. However, the problem of these hormones should be determined by strict timing of sampling, and there are individual specificities of decreases of hormone levels. We considered that anti-Mullerian hormone (AMH) can be measured at any time of the menstrual cycle and that it shows ovary functional decline earlier than FSH/E2, and we examined whether AMH would possibly become a good index for climacteric disorders. The subjects were 163 healthy females and 21 patients with climacteric disorders between 20 and 59 years old. We examined AMH, FSH and E2 at the same time. It is understood that in healthy females, AMH decreases with age and a decline in ovary function occurs at a relatively early age. Patients visiting clinics for climacteric disorders often have normal-range serum FSH/E2 levels, and it is clear that these values could not serve as indices of menopause at these inspections. Upon measurement of AMH in patients with climacteric disorders, most showed less than normal range (< 14 pmol/L), suggesting a decline in ovarian function. In addition, AMH was low in females with climacteric disorders compared with those without them. In conclusion, AMH was suggested as an objective index for climacteric disorders and possibly as a new diagnostic marker.

Menopausal Status and Metabolic Syndrome in Women in Climacteric Period Treated at a Clinic in Southern Brazil

Background: This study aims to understand the relationship between menopausal status and the presence of Metabolic Syndrome in women from 40 to 65 years, as well as to describe the distribution of each component of Metabolic Syn- drome according to sample characteristics. Methods: A cross-sectional study was conducted with 551 women treated at a clinic in southern Brazil. MetS and its components were defined according to NCEP-ATP III and menopausal status as pre, peri, and post-menopause. Prevalences of menopausal status and of MetS and its components were calculated. Estimates of prevalence ratios crude and adjusted with confidence intervals of 95% were calculated by Poisson Regression with robust variance. Demographic, socioeconomic, behavioral, and reproductive characteristics were considered as potential confounding factors in multivariable models based on a conceptual framework of MetS determination. Results: The prevalence of Metabolic Syndrome in the sample was 56.1% (CI95%: 51.9 to 60.2), being more common among older women (56 to 65 years), with low education, menarche 11 years old, with three or more pregnancies and in the post-menopausal period. In multivariate analysis, there was an increase of prevalence ratios when comparing perimenopause and post-menopause with pre-menopause;however, the confidence intervals include the unit. Regarding the analysis of isolated components in the sample, the most prevalent altered components were: hypertension (84.8%;CI95%: 81.7 to 87.8), waist circumference (66.4%;CI95%: 62.5 to 70.4) and HDL cholesterol (51.7%;CI95%: 47.5 to 55.9). There was a linear increase on mean blood glucose through menopausal status. Conclusions: Our study indicates variation on the distribution of MetS and each component according to menopausal status and other women characteristics. Future studies on MetS should also have foresight to use this type of approach to improve understanding and targeting of actions and programs focusing on women in this period of life.

Depression in Climacteric Women:Most Meaningful Symptoms

Background: With population aging occurring worldwide, promoting climacteric women’s health has become the object of important studies. Purpose: Observing the prevalence of depression in climacteric women and their self-evaluation of the depression factors is the main goal of this study. Design: This cross-sectional research is enquiry descriptive. Methods: The sample was composed of 48 climacteric women (between 45 and 65 years old) non-selected volunteers, served by the Centers for Psycho and Social Attention (CAPS) of Specialized Mental Medicine, in Sorocaba, via the Beck Depression Inventory (BDI) questionnaire. Results: Checking the mean and frequency distribution, the climacteric women presented a prevalence of 37.5% of moderate depression (BDIindex = 24.39 ± 3.13), and 47.92% of severe depression (BDIindex = 38.13 ± 6.78). Concerning the symptoms, Spearman rank order correlation was found as the highest concerns, hierarchically: indecision (r = 0.72, p Conclusions: The prevalence of depression in these CAPS climacteric women was considered very high (86% ranking from moderate to severe) caused mostly by indecision, anhedonia, guilt, crying and self-esteem, followed by inutility, self-criticism and loss of concentration.

阴阳调理灸联合自我管理在更年期肥胖患者中的应用效果

目的探究更年期肥胖患者应用阴阳调理灸联合自我管理的干预效果,评估该方法对患者体重产生的影响。方法选取2021年1月至2022年12月在湖北省中医院接受诊治的60例更年期肥胖患者为研究对象,以随机数字表法为分组方式,分为对照组和观察组,各30例。对照组接受自我管理,观察组实施阴阳调理灸联合自我管理。比较2组的体格检查指标、生活质量和体质症状评分。结果干预12周后,观察组的体格检查指标(体重、腰围、体脂和臀围)测定数值均较对照组更小(P均<0.05),且2组的体格检查指标均优于干预前(P均<0.05)。干预12周后,2组的体重对生活冲击量表(IWQOL)各维度评分均低于干预前(P均<0.05);对比组间IWQOL评分,均为观察组更低(P均<0.05)。干预12周后,2组患者的额头分泌油脂多等体质症状评分均较干预前降低(P均<0.05),且观察组均低于对照组(P均<0.05)。结论阴阳调理灸联合自我管理可调理更年期肥胖患者的体质,改善其体格检查指标,减轻肥胖对于患者日常生活产生的影响。

温经汤在肾虚型更年期综合征患者中的应用效果观察

目的 探究温经汤在肾虚型更年期综合征患者中的应用效果。方法 59例肾虚型更年期综合征患者为研究对象,以随机数字表法分为对照组(29例)和观察组(30例)。对照组接受常规西药治疗,观察组在此基础上给予温经汤治疗。比较两组临床疗效、中医证候积分、生殖内分泌激素指标水平、植物神经功能紊乱情况。结果 观察组临床治疗总有效率为93.33%,高于对照组的72.41%(P<0.05)。两组治疗前月经紊乱、烘热汗出、五心烦热、腰膝酸冷积分及总分比较,差异无统计学意义(P>0.05);观察组治疗后月经紊乱、烘热汗出、五心烦热、腰膝酸冷积分及总分分别为(1.92±0.68)、(1.89±0.73)、(1.84±0.64)、(1.83±0.65)、(7.48±2.61)分,均低于对照组的(2.36±0.69)、(2.43±0.74)、(2.24±0.63)、(2.19±0.67)、(9.22±2.52)分(P<0.05)。两组治疗前雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)水平比较,差异无统计学意义(P>0.05);观察组治疗后E2水平(49.37±3.48)pmol/L高于对照组的(46.89±3.13)pmol/L, FSH水平(33.93±8.67)U/L、LH水平(18.67±3.34)U/L均低于对照组的(41.89±8.94)、(21.76±3.09)U/L(P<0.05)。两组治疗前总植物神经功能紊乱发生率比较,差异无统计学意义(P>0.05);观察组治疗后总植物神经功能紊乱发生率6.67%低于对照组的31.03%(P<0.05)。结论 采用温经汤治疗肾虚型更年期综合征可以调节患者生殖内分泌激素水平及植物神经功能,缓解临床症状,提高治疗效果。

肠内免疫营养支持在更年期子宫内膜癌患者中的应用效果

目的探讨肠内免疫营养支持在更年期子宫内膜癌患者中的应用效果。方法根据干预方法的不同将78例更年期子宫内膜癌患者分为对照组(n=30)和观察组(n=48),对照组患者给予常规营养支持,观察组患者在对照组的基础上给予肠内免疫营养支持。比较两组患者的免疫功能指标、营养指标及肠内营养不耐受发生情况。结果干预后,两组患者CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于本组干预前,CD8^(+)水平均低于本组干预前,观察组患者CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。干预后,两组患者血红蛋白、免疫球蛋白G、血清总蛋白水平均高于本组干预前,观察组患者血红蛋白、免疫球蛋白G、血清总蛋白水平均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者肠内营养不耐受总发生率低于对照组(P﹤0.05)。结论肠内免疫营养支持能够改善更年期子宫内膜癌患者的免疫功能和营养状况,减少肠内营养不耐受的发生。

中医药辨治妇人更年期综合征的研究进展

更年期综合征是妇人在绝经前后常见的一种疾病,主要症状包括月经紊乱、烦躁易怒、热潮红、出汗、失眠、焦虑、抑郁等,这些症状会对患者的身心健康造成影响,给患者的生活和工作带来不便和痛苦。随着医疗技术和保健意识的提高,女性对于自身健康的重视程度也在逐渐提高,越来越多的女性开始关注自身的身体和心理健康,积极采取措施预防和治疗更年期综合征。中医药治疗更年期综合征的经验丰富,传统中医认为本病之本在肾,常累及心、肝、脾等多个脏腑,致使本病证候复杂。因此,治疗该病需要根据个体情况辨证论治,中医药治疗更年期综合征的优点在于不仅能调节人体阴阳平衡,激活身体自身调节机制,缓解症状,而且还具有较好的长期疗效和预防复发的效果。中医药也因此受到越来越多的关注和认可。文章现从更年期综合征的病因病机和治疗进展入手,结合现代实验研究,对中医药治疗本病的现状和经验作一综述。文章阐述了中医药治疗更年期综合征的理论基础和临床实践,包括中药、药膳、针灸等中医药治疗手段,总结了中医辨证论治妇人更年期综合征的经验,为临床治疗本病提供了理论依据,同时也为中医药在妇科疾病治疗方面的应用提供一定的参考。

Artificial Intelligence and Network Pharmacology Reveal the Medication Rules of Professor Wang Yu-Ying in the Treatment of Climacteric Syndrome

Objective: The objective of this study was to explore the medication rules and academic ideas of Professor Wang Yu-Ying in the treatment of climacteric syndrome(CLS) and to predict new prescriptions. Materials and Methods: The characteristics of frequency, clustering, four properties, and five flavors were analyzed, and new prescriptions were predicted through an artificial intelligence(AI)-based method. The potential pathways of new prescriptions were explored through network pharmacology-based analysis. Results: The top 16 medicinals used by Professor Wang Yu-Ying in the treatment of CLS included Danggui, Longgu, Muli, Fuling, Chuanxiong, Gancao, Xiangfu, and Tusizi. The AI method was applied to predict the basic prescription for treating CLS: Danggui 15 g, Duanlonggu 30 g, Duanmuli 30 g, Fuling 28 g, Chuanxiong 10 g, Gancao 6 g, Xiangfu 12 g, Tusizi 14 g, etc., Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses showed that the pathogenesis of CLS might be related to the estrogen pathway, involving typical steroid responses. Conclusions: This study summarized Professor Wang's medication experience in the treatment of CLS based on the data mining of clinical diagnoses and treatment cases. The AI method was used to predict the new prescription of CLS treatment, which was found to be reasonable by network pharmacology studies on its multi-target and multi-pathway mechanisms.

比索洛尔氨氯地平片联合松龄血脉康胶囊治疗女性更年期高血压患者的临床效果及对生活质量的影响

目的探究比索洛尔氨氯地平片联合松龄血脉康胶囊治疗女性更年期高血压患者的临床效果及对生活质量的影响。方法选取新疆生产建设兵团医院2021年1月至2023年1月收治的100例女性更年期高血压患者作为研究对象,采用随机数字表法分为对照组和观察组,每组各50例。对照组实施比索洛尔氨氯地平片(康忻安)治疗,观察组实施康忻安联合松龄血脉康胶囊治疗。比较两组血压水平、生活质量和临床疗效。结果治疗后,两组舒张压、收缩压均降低,且观察组低于对照组(P<0.05);观察组健康状态、生理功能、精神状态、社会功能评分均高于对照组(P<0.05);观察组治疗总有效率高于对照组(P<0.05)。结论康忻安联合松龄血脉康胶囊治疗女性更年期高血压效果显著,可有效改善患者生活质量,降低血压水平,值得推广。

常规西药联合益肾养心舒肝汤与针灸治疗更年期综合征的效果分析

目的:分析常规西药联合益肾养心舒肝汤与针灸治疗更年期综合征的效果。方法:选取2022年4月—2023年3月上海中医药大学附属龙华医院收治的110例女性更年期综合征患者作为研究对象,依据随机数字表法分为观察组与对照组,各55例。对照组采用常规西药治疗,观察组在对照组基础上加用益肾养心舒肝汤与针灸治疗。比较两组治疗效果、焦虑及抑郁情况、睡眠质量。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.001)。治疗后,两组汉密尔顿焦虑量表、汉密尔顿抑郁量表评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组匹兹堡睡眠质量指数各项评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:常规西药联合益肾养心舒肝汤与针灸治疗更年期综合征的效果较好,改善患者焦虑、抑郁症状,提升睡眠质量。