Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches i...Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.展开更多
[Objective]In order to summarize the research progress of animal-specific antibiotics. [Methods]Mechanism of action and clinical application of animal-specific antibiotics which were commonly used in clinical were sim...[Objective]In order to summarize the research progress of animal-specific antibiotics. [Methods]Mechanism of action and clinical application of animal-specific antibiotics which were commonly used in clinical were simply summarized. [Results] The most common animal-specific antibiotics are cephalosporins,aminoglycoside,pleuromutilin,macrolides,quinolones and chloramphenicols. [Conclusions] The study provides a reference for clinical veterinary staff.展开更多
文摘Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.
基金Study on Correlation of Escherichia coli Virulence Variation and Biofilm Formation and Its Drug Resistance Under Antibiotic Pressure
文摘[Objective]In order to summarize the research progress of animal-specific antibiotics. [Methods]Mechanism of action and clinical application of animal-specific antibiotics which were commonly used in clinical were simply summarized. [Results] The most common animal-specific antibiotics are cephalosporins,aminoglycoside,pleuromutilin,macrolides,quinolones and chloramphenicols. [Conclusions] The study provides a reference for clinical veterinary staff.
