Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related...Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.展开更多
1.Arms and scopeChinese-German Journal of Clinical Oncology is an international professional academic periodical on oncology, being co-edited by China and Germany. The Journal, with the authors from around world, espe...1.Arms and scopeChinese-German Journal of Clinical Oncology is an international professional academic periodical on oncology, being co-edited by China and Germany. The Journal, with the authors from around world, especially from China, is dominated in introducing the clinical experience of diagnosis and treatment as well as leading scientific research achievement in the tumor domain, in addition to report basic theory researches that help instruct the clinical practice of oncology and closely connect with the discipline.展开更多
Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only a...Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only accomplished through the collective efforts and support of our Editorial Board members,peer reviewers,authors,readers and editorial office staff.In 2020,the WJCO published 12 issues encompassing 84 papers,a 115.4%increase over 2019(39 papers).In December of 2020,we strategized a plan to solicit even more high-quality contributions for WJCO in 2021.So far,we have registered and accepted 188 manuscript titles,including 132 reviews and 56 original articles.In the New Year,we will work with our internal and external colleagues who care about and support the development of WJCO with the express aim of improving the academic rank of WJCO in the field of oncology.Ultimately,our goal is to merit and gain inclusion in the Science Citation Index Expanded,with the first impact factor being awarded as soon as possible.展开更多
Responding to an increasing number of requests, the UICC is pleased to announce that thewell known International Cancer Research Technology Transfer Project (ICRETT) has widenedits scope to include the study of approp...Responding to an increasing number of requests, the UICC is pleased to announce that thewell known International Cancer Research Technology Transfer Project (ICRETT) has widenedits scope to include the study of appropriate, up-to-ate clinical management skills.What is the purpose of the extended Project?展开更多
Specific research foci:(1) Mouse models of gamma-herpes virus-68(γHV-68) and polyomavirus(Py V) infections during neonatal versus adult life.(2) For human papilloma virus(HPV)-positive oropharyngeal carcinoma(OPC)—(...Specific research foci:(1) Mouse models of gamma-herpes virus-68(γHV-68) and polyomavirus(Py V) infections during neonatal versus adult life.(2) For human papilloma virus(HPV)-positive oropharyngeal carcinoma(OPC)—(a) Asking the question: Is oral sex a powerful carcinogen?(b) Examining the evidence for the vertical transmission of HPV infection.(c) Examining the relationship between HPV and Epstein–Barr virus(EBV) infections and nasopharyngeal cancer(NPC) in West European, East European, and East Asian countries.(d) Examining the association between HPVpositive OPC and human leukocyte antigen(HLA).(3) For non-smoking East Asian female lung adenocarcinoma—(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts.(b) Examining the association between female lung adenocarcinoma and HPV.(c) Examining the associations of lung adenocarcinoma with immune modulating factors.(4) For triple-negative breast carcinoma(TNBC) in East Asians—(a) Examining the association between TNBC and HPV.(b) Examining the unique epidemiological characteristics of patients with TNBC. A summary "epidemiological" model tying some of these findings together.展开更多
1. Arms and scope Chinese-German Journal of Clinical Oncologyis an international professional academic periodicalon oncology, being co-edited by China and Germany.The Journal, with the authors from around world,
This review summarizes the major advances inclinical oncology presented at the 2009 ASCO annual meeting,with emphasis on studies that are potentially practice-changing.Emerging new drugs are also discussed.
文摘Obesity is recognized as the second highest risk factor for cancer. The pathogenic mechanisms underlying tobaccorelated cancers are well characterized and efective programs have led to a decline in smoking and related cancers, but there is a global epidemic of obesity without a clear understanding of how obesity causes cancer. Obesity is heterogeneous, and approximately 25% of obese individuals remain healthy(metabolically healthy obese, MHO), so which fat deposition(subcutaneous versus visceral, adipose versus ectopic) is "malignant"? What is the mechanism of carcinogenesis? Is it by metabolic dysregulation or chronic inflammation? Through which chemokines/genes/signaling pathways does adipose tissue influence carcinogenesis? Can selective inhibition of these pathways uncouple obesity from cancers? Do all obesity related cancers(ORCs) share a molecular signature? Are there common(overlapping) genetic loci that make individuals susceptible to obesity, metabolic syndrome, and cancers? Can we identify precursor lesions of ORCs and will early intervention of high risk individuals alter the natural history? It appears unlikely that the obesity epidemic will be controlled anytime soon; answers to these questions will help to reduce the adverse efect of obesity on human condition.
文摘1.Arms and scopeChinese-German Journal of Clinical Oncology is an international professional academic periodical on oncology, being co-edited by China and Germany. The Journal, with the authors from around world, especially from China, is dominated in introducing the clinical experience of diagnosis and treatment as well as leading scientific research achievement in the tumor domain, in addition to report basic theory researches that help instruct the clinical practice of oncology and closely connect with the discipline.
文摘Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only accomplished through the collective efforts and support of our Editorial Board members,peer reviewers,authors,readers and editorial office staff.In 2020,the WJCO published 12 issues encompassing 84 papers,a 115.4%increase over 2019(39 papers).In December of 2020,we strategized a plan to solicit even more high-quality contributions for WJCO in 2021.So far,we have registered and accepted 188 manuscript titles,including 132 reviews and 56 original articles.In the New Year,we will work with our internal and external colleagues who care about and support the development of WJCO with the express aim of improving the academic rank of WJCO in the field of oncology.Ultimately,our goal is to merit and gain inclusion in the Science Citation Index Expanded,with the first impact factor being awarded as soon as possible.
文摘Responding to an increasing number of requests, the UICC is pleased to announce that thewell known International Cancer Research Technology Transfer Project (ICRETT) has widenedits scope to include the study of appropriate, up-to-ate clinical management skills.What is the purpose of the extended Project?
文摘Specific research foci:(1) Mouse models of gamma-herpes virus-68(γHV-68) and polyomavirus(Py V) infections during neonatal versus adult life.(2) For human papilloma virus(HPV)-positive oropharyngeal carcinoma(OPC)—(a) Asking the question: Is oral sex a powerful carcinogen?(b) Examining the evidence for the vertical transmission of HPV infection.(c) Examining the relationship between HPV and Epstein–Barr virus(EBV) infections and nasopharyngeal cancer(NPC) in West European, East European, and East Asian countries.(d) Examining the association between HPVpositive OPC and human leukocyte antigen(HLA).(3) For non-smoking East Asian female lung adenocarcinoma—(a) Examining the incidence trends of HPV-positive OPC and female lung adenocarcinoma according to birth cohorts.(b) Examining the association between female lung adenocarcinoma and HPV.(c) Examining the associations of lung adenocarcinoma with immune modulating factors.(4) For triple-negative breast carcinoma(TNBC) in East Asians—(a) Examining the association between TNBC and HPV.(b) Examining the unique epidemiological characteristics of patients with TNBC. A summary "epidemiological" model tying some of these findings together.
文摘1. Arms and scope Chinese-German Journal of Clinical Oncologyis an international professional academic periodicalon oncology, being co-edited by China and Germany.The Journal, with the authors from around world,
文摘This review summarizes the major advances inclinical oncology presented at the 2009 ASCO annual meeting,with emphasis on studies that are potentially practice-changing.Emerging new drugs are also discussed.
