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Bilateral Retinal Nerve Fiber Layer Loss and Recovery with Teprotumumab in Thyroid Eye Disease
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作者 Christine Wang Abdulaziz Alsumait +1 位作者 Nikisha Q. Richards Surbhi Bansal 《Open Journal of Ophthalmology》 2024年第3期196-203,共8页
Background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on measured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This c... Background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on measured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This case evaluates the effect of teprotumumab on gRNFL in a patient with moderate TED. Observations: A 60-year-old female with controlled ocular hypertension and moderate TED received 8 standard IV teprotumumab infusions. Comprehensive ocular evaluations were performed pre-, during-, and post-treatment. Bilateral gRNFL thickness decreased (10 m OD;12 m OS) at 4 months post-treatment start, persisting at 8 months, but recovered at 20 months. Conclusions and Importance: Teprotumumab treatment in patients with TED led to a transient bilateral decrease in gRNFL thickness, which was restored to baseline levels with no adverse events reported. Monitoring gRNFL changes in teprotumumab-treated patients is crucial as gRNFL thinning indicates retinal ganglion cell damage. Teprotumumabs ability to dampen the IGF-IR inflammatory cascade may have reduced retinal inflammation, leading to recovery. 展开更多
关键词 Teprotumumab Thyroid Eye Disease RNFL clinical activity Score Ocular Hypertension
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Active Learning Improves Nursing Student Clinical Performance in an Academic Institution in Macao 被引量:1
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作者 Cindy Sin U Leong Lynn B.Clutter 《Chinese Nursing Research》 CAS 2015年第3期108-115,共8页
Objective: To assess the outcome of the application of active learning during practicum among nursing students using clinical assessment and evaluation scores as a measurement. Methods: Nursing students were instruc... Objective: To assess the outcome of the application of active learning during practicum among nursing students using clinical assessment and evaluation scores as a measurement. Methods: Nursing students were instructed on the basics of active learning prior to the initiation of their clinical experience. The participants were divided into 5groups of nursing students ( n = 56) across three levels (years 2-4) in a public academic institute of a bachelor degree program in Macao. Final clinical evaluation was averaged and compared between groups with and without intervention. Results: These nursing students were given higher appraisals in verbal and written comments than previous students without interventian. The groups with the invention achieved higher clinical assessment and evaluation scores on average than comparable groups without the active learning intervention. One group of sophomore nursing students (year 2) did not receive as high of evaluations as the other groups, receiving an average score of above 80. Conclusions" Nursing students must engage in active learning to demonstrate that they are willing to gain knowledge of theory, nursing skills and communication skills during the clinical practicum. 展开更多
关键词 Active learning clinical competence Nursing students
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Immune checkpoint inhibitor-associated arthritis in advanced pulmonary adenocarcinoma:A case report
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作者 Yan Yang Xiao-Jie Huang 《World Journal of Clinical Cases》 SCIE 2022年第29期10701-10707,共7页
BACKGROUND With the wide application of immune checkpoint inhibitors(ICIs)in cancer treatment,immune-related adverse events occur frequently,involving almost all organs and systems.The incidence of ICI-associated arth... BACKGROUND With the wide application of immune checkpoint inhibitors(ICIs)in cancer treatment,immune-related adverse events occur frequently,involving almost all organs and systems.The incidence of ICI-associated arthritis(IA)is unknown.In most cases,IA is not serious and non-lethal.Higher checkpoint inhibitor arthritis disease activity may be associated with cancer progression.Here,we report a severe case of IA with high arthritis disease activity in advanced pulmonary adenocarcinoma,causing permanent withdrawal of pembrolizumab,but the patient remained in complete remission(CR)20 mo after the development of IA.CASE SUMMARY An 81-year-old smoking man was admitted to our hospital because of left chest pain for 9 mo.He was finally diagnosed with advanced pulmonary adenocarcinoma,with programmed cell death 1 ligand 1 expression of 70%.The patient responded to pembrolizumab treatment and achieved CR,but IA occurred after the 5th cycle of pembrolizumab administration.Although non-steroidal antiinflammatory drugs and disease-modifying anti-rheumatic drugs were prescribed,arthralgia and joint swelling occurred.The symptoms of arthritis were further aggravated when immunotherapy was given again after short-term withdrawal.Clinical Disease Activity Index(CDAI)score,a traditional measure of arthritis activity,was 43.Intravenous methylprednisolone was prescribed at 20 mg/d and then tapered over the subsequent 4 wk.The symptoms of arthritis steadily improved and completely resolved 4 mo after withdrawal of pembrolizumab.A recent follow-up in June 2022 revealed satisfactory clinical recovery of arthritis and the patient remained in CR.CONCLUSION This case report highlights that early recognition of IA and appropriate treatment are critical to improving the outcome of both ICI-arthritis and lung cancer. 展开更多
关键词 Immune checkpoint inhibitors Immune checkpoint inhibitor-associated arthritis Pembrolizumab clinical Disease activity Index Case report
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CLINICAL SIGNIFICANCE OF MEASURING SERUM IL-6 ACTIVITIES IN MULTIPLE MYELOMA AN ANALYSIS OF 81 CASES 被引量:1
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作者 候健 孔宪涛 《Chinese Medical Journal》 SCIE CAS CSCD 1994年第11期70-71,共2页
Interleukin 6(IL-6) is known as hybridoma cell growth factor,B-cell differentiating factor and so on One of its important biological functions in to induce
关键词 IL In clinical SIGNIFICANCE OF MEASURING SERUM IL-6 ACTIVITIES IN MULTIPLE MYELOMA AN ANALYSIS OF 81 CASES
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A NEW EXPERIMENTAL AND CLINICAL APPROACH OF COMBINING USAGE OF HIGHLY ACTIVE TUMOR-INFILTRATING LYMPHOCYTES AND HIGHLY SENSITIVE ANTITUMOR DRUGS FOR THE ADVANCED MALIGNANT TUMOR
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作者 李彪如 童善庆 +3 位作者 张希衡 陆静 顾琴龙 陆德源 《Chinese Medical Journal》 SCIE CAS CSCD 1994年第11期5-9,共5页
In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosen... In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients. 展开更多
关键词 TIL A NEW EXPERIMENTAL AND clinical APPROACH OF COMBINING USAGE OF HIGHLY ACTIVE TUMOR-INFILTRATING LYMPHOCYTES AND HIGHLY SENSITIVE ANTITUMOR DRUGS FOR THE ADVANCED MALIGNANT TUMOR In HLA test
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Clinical characteristics of macrophage activation syndrome secondary to systemic lupus erythematosus
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作者 姜楠 《China Medical Abstracts(Internal Medicine)》 2017年第1期14-,共1页
Objective To investigate the clinical features of macrophage activation syndrome(MAS)associated with systemic lupus erythematosus(SLE).Methods The clinical data of 15 patients with SLE-induced MAS diagnosed in Peking ... Objective To investigate the clinical features of macrophage activation syndrome(MAS)associated with systemic lupus erythematosus(SLE).Methods The clinical data of 15 patients with SLE-induced MAS diagnosed in Peking Union Medical College Hospital from July 展开更多
关键词 SLE clinical characteristics of macrophage activation syndrome secondary to systemic lupus erythematosus
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Association of secretory IgA with clinical pathological characteristics and complement activation in IgA nephropathy
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作者 张军军 《China Medical Abstracts(Internal Medicine)》 2016年第3期175-,共1页
Objective To further investigate the association among clinical pathology,complement activation and renal secretory IgA(SIgA)deposition in patients with IgA nephropathy(IgAN).Methods The activation of serum complement... Objective To further investigate the association among clinical pathology,complement activation and renal secretory IgA(SIgA)deposition in patients with IgA nephropathy(IgAN).Methods The activation of serum complements was detected by immunoturbidimetry and ELISA.Renal deposition of SIgA and activation of complements were detected by immunofluorescence. 展开更多
关键词 IGA Association of secretory IgA with clinical pathological characteristics and complement activation in IgA nephropathy
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