To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible publishe...To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk （0R=0.85, 95% CI： 0.74-0.97）; this was also the case for the homozygous comparison （0R--0.72, 95% Ch 0.55-0.95） and the dominant genetic model （0R=0.79, 95% Ch 0.65-0.96）. The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy （0R=0.85, 95% Ch 0.75-0.96） in the overall analysis, as well as in the heterozygous comparison （0R=0.79, 95% Ch 0.65-0.96）, homozygous comparison （0R=0.76, 95% Ch 0.58-0.98） and dominant genetic model （0R=0.81, 95% CI： 0.68-0.96）. Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk （0R=0.77, 95% Ch 0.61-0.96）; this was also the case in the homozygous comparison （0R=0.51, 95% Ch 0.31-0.86）. The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.展开更多
The concepts of ability, practice ability, and professional practice ability were analyzed using a theoretical research method. Based on the results of the analysis, the concept of clinical practice ability for Master...The concepts of ability, practice ability, and professional practice ability were analyzed using a theoretical research method. Based on the results of the analysis, the concept of clinical practice ability for Master Degree of Nursing（specialty） students was de？ned, and the characteristics were interpreted to provide references for future in-depth studies.展开更多
目的探讨呼吸困难指数气流受限程度指数(dyspnea index air flow restriction degree,ADO)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者近期预后评估中的价值。方法选取新疆医科大学第二附属医院呼吸内科自2021...目的探讨呼吸困难指数气流受限程度指数(dyspnea index air flow restriction degree,ADO)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者近期预后评估中的价值。方法选取新疆医科大学第二附属医院呼吸内科自2021年3月—2023年3月的COPD患者120例,并依照患者最终转归情况将其分为存活组(n=95)与死亡组(n=25)。观察2组患者的基础病情况及患者性别、年龄、第1秒用力呼气容积(first second forced expiratory volume,FEV1)占预计值的百分比和ADO指数等相关指标。比较ADO指数不同分数患者病死率。比较ADO指数预测180 d死亡的受试者工作特征(receiver operating characteristic,ROC)曲线面积。结果2组患者的高血压、冠心病、心律失常、糖尿病、慢性肝病、慢性肾病、亚临床甲减发生情况对比,差异无统计学意义(P>0.05)。死亡组患者的FEV1占预计值的百分比、FEV1占预计值的百分比评分、呼吸困难分[英国医学研究委员会(the Medical Research Council,MRC)]评分以及ADO指数均高于存活组患者(P<0.05)。ADO指数<5分者的死亡率高于ADO指数≥5分者(P<0.05)。ADO指数预测180 d死亡的ROC曲线面积为0.851(95%CI:0.767~0.928,P<0.001),ADO指数为5.5时,约登指数最大,为0.565。结论ADO可有效反映COPD病情严重程度,对于患者而言可准确反映其病情进展情况,帮助其获得良好的疾病治疗效果,对于患者近期预后而言也具有积极意义,临床应用效果良好。展开更多
文摘To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk （0R=0.85, 95% CI： 0.74-0.97）; this was also the case for the homozygous comparison （0R--0.72, 95% Ch 0.55-0.95） and the dominant genetic model （0R=0.79, 95% Ch 0.65-0.96）. The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy （0R=0.85, 95% Ch 0.75-0.96） in the overall analysis, as well as in the heterozygous comparison （0R=0.79, 95% Ch 0.65-0.96）, homozygous comparison （0R=0.76, 95% Ch 0.58-0.98） and dominant genetic model （0R=0.81, 95% CI： 0.68-0.96）. Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk （0R=0.77, 95% Ch 0.61-0.96）; this was also the case in the homozygous comparison （0R=0.51, 95% Ch 0.31-0.86）. The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.
基金supported by planning project of “12th Five-Year” in philosophy and social sciences of Sichuan province(No.SC13B081)
文摘The concepts of ability, practice ability, and professional practice ability were analyzed using a theoretical research method. Based on the results of the analysis, the concept of clinical practice ability for Master Degree of Nursing（specialty） students was de？ned, and the characteristics were interpreted to provide references for future in-depth studies.
文摘目的探讨呼吸困难指数气流受限程度指数(dyspnea index air flow restriction degree,ADO)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者近期预后评估中的价值。方法选取新疆医科大学第二附属医院呼吸内科自2021年3月—2023年3月的COPD患者120例,并依照患者最终转归情况将其分为存活组(n=95)与死亡组(n=25)。观察2组患者的基础病情况及患者性别、年龄、第1秒用力呼气容积(first second forced expiratory volume,FEV1)占预计值的百分比和ADO指数等相关指标。比较ADO指数不同分数患者病死率。比较ADO指数预测180 d死亡的受试者工作特征(receiver operating characteristic,ROC)曲线面积。结果2组患者的高血压、冠心病、心律失常、糖尿病、慢性肝病、慢性肾病、亚临床甲减发生情况对比,差异无统计学意义(P>0.05)。死亡组患者的FEV1占预计值的百分比、FEV1占预计值的百分比评分、呼吸困难分[英国医学研究委员会(the Medical Research Council,MRC)]评分以及ADO指数均高于存活组患者(P<0.05)。ADO指数<5分者的死亡率高于ADO指数≥5分者(P<0.05)。ADO指数预测180 d死亡的ROC曲线面积为0.851(95%CI:0.767~0.928,P<0.001),ADO指数为5.5时,约登指数最大,为0.565。结论ADO可有效反映COPD病情严重程度,对于患者而言可准确反映其病情进展情况,帮助其获得良好的疾病治疗效果,对于患者近期预后而言也具有积极意义,临床应用效果良好。
