Background There is little information of non-perianal fistulating Crohn＇s disease in the consensus published by the European Crohn＇s and Colitis Organization in 2006 and 2010. This study was designed to demonstrate...Background There is little information of non-perianal fistulating Crohn＇s disease in the consensus published by the European Crohn＇s and Colitis Organization in 2006 and 2010. This study was designed to demonstrate the clinical characteristics of non-perianal fistulating Crohn＇s disease among homogenous Chinese population. Methods One-hundred-and-eighty-four patients were retrospectively collected. All of these patients were diagnosed of Crohn＇s disease between February 2001 and April 2011. Results The male-to-female ratio was 2.7：1. The most common symptoms at onset were abdominal pain （88.0%）, diarrhea （34.7%）, and fever （28.3%）. The most common disease location and behavior at diagnosis were small bowel （56.0%） and penetrating （51.6%）. Among 324 non-perianal fistulae, the most common types were ileocolonic anastomotic （30.9%）, terminal ileocutaneous （19.7%）, and enteroenteric anastomotic （11.4%）. One-hundred-and-thirty- eight （75.0%） patients received antibiotics, and I^-Iactam （85.5%） and metronidazole （67.4%） are most frequently used. One-hundred-and-seventy-eight （96.7%） patients suffered 514 surgical operations, and the cumulative surgical rates after 1, 3, and 5 years were 38.0%, 52.2%, and 58.7% respectively. Nine patients died during the follow-up period, and the cumulative survival rates after 1, 3, and 5 years were 97.8%, 96.7%, and 96.2% respectively. Conclusions This study displayed the clinical characteristics of non-perianal fistulating Crohn＇s disease in our center. Large population-based studies are required for further investigation in China.展开更多
文摘Background There is little information of non-perianal fistulating Crohn＇s disease in the consensus published by the European Crohn＇s and Colitis Organization in 2006 and 2010. This study was designed to demonstrate the clinical characteristics of non-perianal fistulating Crohn＇s disease among homogenous Chinese population. Methods One-hundred-and-eighty-four patients were retrospectively collected. All of these patients were diagnosed of Crohn＇s disease between February 2001 and April 2011. Results The male-to-female ratio was 2.7：1. The most common symptoms at onset were abdominal pain （88.0%）, diarrhea （34.7%）, and fever （28.3%）. The most common disease location and behavior at diagnosis were small bowel （56.0%） and penetrating （51.6%）. Among 324 non-perianal fistulae, the most common types were ileocolonic anastomotic （30.9%）, terminal ileocutaneous （19.7%）, and enteroenteric anastomotic （11.4%）. One-hundred-and-thirty- eight （75.0%） patients received antibiotics, and I^-Iactam （85.5%） and metronidazole （67.4%） are most frequently used. One-hundred-and-seventy-eight （96.7%） patients suffered 514 surgical operations, and the cumulative surgical rates after 1, 3, and 5 years were 38.0%, 52.2%, and 58.7% respectively. Nine patients died during the follow-up period, and the cumulative survival rates after 1, 3, and 5 years were 97.8%, 96.7%, and 96.2% respectively. Conclusions This study displayed the clinical characteristics of non-perianal fistulating Crohn＇s disease in our center. Large population-based studies are required for further investigation in China.
