Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression w...Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression was evaluated immunohistochemically using the modified H-score method.Results:The present study included 20%of patients with stage I disease,22%of patients with stage II disease,18%of patients with stage III disease,and 40%of patients with stage IV disease.Nibrin showed a significant positive correlation with moderately/poorly differentiated tumor tissues(P=0.028),while significant inverse correlation of Nibrin expression was observed with tumor size(P=0.018)and tumor stage(P=0.039).Further,using univariate survival analysis it was observed that strong Nibrin expression was significantly associated with disease relapse in early stage OSCC patients(P=0.049).Conclusion:Thus,the present study revealed that Nibrin could be used as a prognostic marker in patients with early stage OSCC.展开更多
Array comparative genomic hybridization （CGH） has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patien...Array comparative genomic hybridization （CGH） has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artificial chromosome （2GH arrays. A number of highly frequent genomic aberrations were discovered, which may act as ＂drivers＂ of tumor progression. Meanwhile, the genomic profiles of four ＂normal＂ breast tissue samples taken at least 2 cm away from the primary tumor sites were also found to have some genomic aberrations that recurred with high frequency in the primary tumors, which may have important implications for clinical therapy. Additionally, we performed class comparison and class prediction for various clinicopathological parameters, and a list of characteristic genomic aberrations associated with different clinicopathological phenotypes was compiled. Our study provides clues for further investigations of the underlying mechanisms of breast carcinogenesis.展开更多
基金supported by the Gujarat Cancer Society and the Gujarat Cancer and Research Institute.
文摘Aim:The present study sought to discover the role of Nibrin protein in 100 patients with oral squamous cell carcinoma(OSCC)and its potential relationship with clinicopathological parameters.Methods:Nibrin expression was evaluated immunohistochemically using the modified H-score method.Results:The present study included 20%of patients with stage I disease,22%of patients with stage II disease,18%of patients with stage III disease,and 40%of patients with stage IV disease.Nibrin showed a significant positive correlation with moderately/poorly differentiated tumor tissues(P=0.028),while significant inverse correlation of Nibrin expression was observed with tumor size(P=0.018)and tumor stage(P=0.039).Further,using univariate survival analysis it was observed that strong Nibrin expression was significantly associated with disease relapse in early stage OSCC patients(P=0.049).Conclusion:Thus,the present study revealed that Nibrin could be used as a prognostic marker in patients with early stage OSCC.
基金supported by the Danish Cancer Soci-ety through the budget of the Institute of Cancer Biol-ogy and by grants from the Danish Medical Research Council, the Natural and Medical Sciences Committee of the Danish Cancer Society, Novo Nordisk, the John and Birthe Meyer Foundation, the Solar Fonden, the Stensbygaard Fonden, the Kai Langeog Gundhild Kai Lange Fond, the will of Edith Stern, and the "Race Against Breast Cancer" ProjectThe support of the Marketing Department at the Danish Cancer Society is greatly appreciatedsupported by a project grant from the Hi-Tech Research and Development Program of China (2006AA02A301)
文摘Array comparative genomic hybridization （CGH） has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artificial chromosome （2GH arrays. A number of highly frequent genomic aberrations were discovered, which may act as ＂drivers＂ of tumor progression. Meanwhile, the genomic profiles of four ＂normal＂ breast tissue samples taken at least 2 cm away from the primary tumor sites were also found to have some genomic aberrations that recurred with high frequency in the primary tumors, which may have important implications for clinical therapy. Additionally, we performed class comparison and class prediction for various clinicopathological parameters, and a list of characteristic genomic aberrations associated with different clinicopathological phenotypes was compiled. Our study provides clues for further investigations of the underlying mechanisms of breast carcinogenesis.
