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Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo 被引量:9
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作者 Wolfgang H.Caselmann Matthias Serwe +3 位作者 Thomas Lehmann János Ludwig Brian S.Sproat Joachim W.Engels 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第5期626-629,共4页
Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be ... Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are 展开更多
关键词 hepatitis C-like viruses/therapy gene expression in VITRO in vivo nucleic acids/therapeutic use CYTOMEGALOVIRUS
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Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review 被引量:5
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作者 Pankaj K. Sahu Deen Dayal Giri +5 位作者 Ritu Singh Priyanka Pandey Sharmistha Gupta Atul Kumar Shrivastava Ajay Kumar Kapil Dev Pandey 《Pharmacology & Pharmacy》 2013年第8期599-610,共12页
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, ... The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative. 展开更多
关键词 ALOE vera Antimicrobial therapeutic MEDICINAL useS Cosmetic Application
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Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use
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作者 Daisuke Kudo Hiroshi Toshida +1 位作者 Toshihiko Ohta Akira Murakami 《Open Journal of Ophthalmology》 2012年第4期110-113,共4页
Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one w... Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired. 展开更多
关键词 therapeutic use BANDAGE Soft Contact LENS CONTINUOUS WEAR COMPLICATION
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Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration 被引量:3
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作者 REN Ming Shan, ZHANG Zhi, WU Jun Xia, LI Fei, XUE Ben Chun and YANG Ren Min 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第6期75-77,共3页
AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. ... AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. Group A ( n =60) received Suc 750mg , po. bid. Group B ( n =60) received Pen 250mg , po. qid. The period of maintenance treatment varied from 6 months to 3 years, averaging 1 5 years. Symptoms and therapeutic effects were evaluated by modified Goldstein scale. RESULTS The total effectiveness of group A in two different periods of treatment were 80% and 85% respectively, higher than those of group B (58% and 59% respectively) ( P <0 05). Suc also had obvious curative effects for the patients who failed in the use of Pen. There were fewer side effect in group A than in group B ( P <0 05). Suc and Pen could increase urinary copper excretion effectively and continually. CONCLUSION Suc is more effective and safer than Pen. Clinically, it can replace Pen as first choice drug for long term maintenance therapy of HLD. 展开更多
关键词 hepatolenticular degeneration/drug THERAPY succimer/therapeutic use penicillamine/therapeutic use
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Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy 被引量:3
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作者 WANG XiaoZhong and LIN GuZhen 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第4期95-96,共2页
Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhe... Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhenSubjectheaadings... 展开更多
关键词 dyspepsia/drug therapy famotidine/therapeutic use cisapride/therapeutic use peptic ULCER gastrointestinal motility
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Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract 被引量:5
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作者 Tsunenori Kondo Toshio Takagi Kazunari Tanabe 《World Journal of Clinical Oncology》 CAS 2015年第6期237-251,共15页
Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional n... Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy. 展开更多
关键词 LYMPHADENECTOMY LYMPH node EXCISION UROTHELIAL carcinoma Treatment outcome therapeutic uses Diagnosis GUIDELINE
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Blastocystis hominis as a cause of chronic diarrhea in low-resource settings:A systematic review
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作者 Stephen Amoak Jonathan Soldera 《World Journal of Meta-Analysis》 2024年第3期30-41,共12页
BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is... BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is particularly prevalent in developing nations.Examining the symptoms and treatment outcomes of B.hominis infection in low-resource settings holds immense significance,providing healthcare practi-tioners with valuable insights to enhance patient care.AIM To synthesize existing evidence on the symptomatology and treatment outcomes of B.hominis infection in low-resource settings.METHODS Following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines,a systematic review was conducted.The search spanned electronic databases including PubMed,Scopus,and Google Scholar.After a comprehensive screening process,a thorough examination of the papers,adhering to inclusion and exclusion criteria,and data extraction from eligible studies was conducted.The findings underwent summarization through simple descriptive analysis.RESULTS The search yielded 1200 papers,with 17 meeting inclusion criteria.Chronic diarrhea due to B.hominis infection was reported in only two studies,while abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting emerged as the most commonly documented symptoms.Recovery rates after one week of treatment ranged from 71.8%to 100%,and after two weeks,from 60%to 100%.CONCLUSION In low-resource settings,chronic diarrhea resulting from B.hominis infection is infrequent.Common symptoms include abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting.Post-treatment,clinical outcomes are notably favorable,supporting the recommendation for treatment.Metronidazole is advocated as the first-line agent,with consideration for switching to a second-line option in cases of treatment failure or poor response. 展开更多
关键词 Blastocystis infections Gastrointestinal diseases Treatment outcome Developing countries Metronidazole/therapeutic use
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Clinacanthus nutans:a review of the medicinal uses,pharmacology and phytochemistry 被引量:10
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作者 Md.Ariful Alam Sahena Ferdosh +4 位作者 Kashif Ghafoor Md.Abdul Hakim Abdul Shukor Juraimi Alfi Khatib Md.Zaidul I.Sarker 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第4期393-399,共7页
Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bite... Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work. 展开更多
关键词 Clinacanthus nutans MEDICINAL useS PHYTOCHEMICALS PHARMACOLOGY therapeutic potential
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High-intensity focused ultrasound extracorporeal ablation of liver tissuesin rabbits
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《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期16-16,共1页
HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZ... HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZhaoYou1,YUYao1,B... 展开更多
关键词 LIVER neoplasms experimental/therapy ultrasonic THERAPY iodized oil/therapeutic use liver/radiation effects randomized controlled trials
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替格瑞洛与氯吡格雷在老年冠心病经皮冠状动脉介入术患者中的治疗效果比较
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作者 吴鹏翠 叶国红 《临床合理用药杂志》 2024年第22期1-4,共4页
目的 比较替格瑞洛与氯吡格雷在老年冠心病经皮冠状动脉介入术患者中的治疗效果。方法 选取2021年12月—2022年12月长沙市中心医院收治的拟行经皮冠状动脉介入术的老年冠心病患者100例作为研究对象,采用随机数字表法分为研究组和对照组... 目的 比较替格瑞洛与氯吡格雷在老年冠心病经皮冠状动脉介入术患者中的治疗效果。方法 选取2021年12月—2022年12月长沙市中心医院收治的拟行经皮冠状动脉介入术的老年冠心病患者100例作为研究对象,采用随机数字表法分为研究组和对照组,每组50例。研究组采用替格瑞洛联合阿司匹林双抗血小板治疗,对照组采用氯吡格雷联合阿司匹林双抗血小板治疗,2组均用药12个月。比较2组临床疗效,治疗前后凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(Fib)、D-二聚体(D-D)、血小板聚集率(ADP)]、血清炎性指标[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]、微循环功能指标[冠状动脉血流储备分数(CFR)、微循环阻力指数(IMR)]及心血管不良事件。结果 研究组总有效率为98.00%,高于对照组的84.00%(χ^(2)=5.982,P=0.014)。治疗12个月后,2组APTT、PT及TT长于治疗前,Fib、D-D水平、ADP低于治疗前,且研究组长/低于对照组(P<0.05或P<0.01);2组TNF-α、IL-6及CRP水平低于治疗前,且研究组低于对照组(P<0.01);2组CFR及IMR高于治疗前,研究组CFR高于对照组,而IMR低于对照组(P<0.05或P<0.01)。研究组心血管不良事件总发生率为2.00%,低于对照组的14.00%(χ^(2)=4.891,P=0.026)。结论 替格瑞洛用于老年冠心病经皮冠状动脉介入术的疗效较氯吡格雷更好,可改善患者凝血功能,降低心血管不良事件发生率,改善机体炎性指标及微循环功能。 展开更多
关键词 冠状动脉粥样硬化性心脏病 老年 经皮冠状动脉介入术 替格瑞洛 氯吡格雷 治疗效果
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阿司匹林联合氯吡格雷治疗CIS的疗效及对患者ACA、MCA、PCA的影响
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作者 郭会月 王欣格 +1 位作者 靳玫 李凤鹏 《海南医学》 CAS 2024年第13期1840-1843,共4页
目的探讨阿司匹林联合氯吡格雷治疗急性缺血性脑卒中(CIS)的疗效及对患者双侧大脑前动脉(ACA)、双侧大脑中动脉(MCA)、双侧大脑后动脉(PCA)的影响。方法选择2020年1月至2023年1月新乡医学院第三附属医院神经内科收治的120例CIS患者进行... 目的探讨阿司匹林联合氯吡格雷治疗急性缺血性脑卒中(CIS)的疗效及对患者双侧大脑前动脉(ACA)、双侧大脑中动脉(MCA)、双侧大脑后动脉(PCA)的影响。方法选择2020年1月至2023年1月新乡医学院第三附属医院神经内科收治的120例CIS患者进行研究,按随机数表法分为观察组和对照组,每组60例。两组患者均接受常规治疗,对照组患者在常规治疗基础上加用阿司匹林治疗,观察组患者在对照组治疗的基础上加用氯吡格雷治疗,所有患者均治疗1个月。比较两组患者的疗效,以及治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、神经生长相关蛋白43(GAP43)、血管内皮生长因子(VEGF)及ACA、MCA、PCA的变化,同时比较两组患者治疗期间的不良反应发生情况。结果观察组患者的治疗总有效率为93.33%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);治疗后,两组患者的NIHSS评分、GAP43、VEGF均降低,且观察组患者的NIHSS评分、GAP43、VEGF分别为(3.98±0.91)分、(20.13±2.17)ng/L、(23.09±2.74)ng/L,明显低于对照组的(5.21±1.09)分、(27.28±2.42)ng/L、(30.71±3.01)ng/L,差异均有统计学意义(P<0.05);治疗后,两组患者的ACA、MCA、PCA均降低,且观察组患者的ACA、MCA、PCA分别为(51.28±3.27)cm/s、(70.93±5.20)cm/s、(40.21±3.01)cm/s,明显低于对照组的(56.27±3.09)cm/s、(76.21±4.82)cm/s、(45.21±3.74)cm/s,差异均有统计学意义(P<0.05);观察组患者的不良反应总发生率为8.33%,略低于对照组的11.67%,但差异无统计学意义(P>0.05)。结论阿司匹林联合氯吡格雷治疗CIS患者的疗效显著,且能明显改善ACA、MCA、PCA水平,具有临床应用价值。 展开更多
关键词 急性缺血性脑卒中 阿司匹林 氯吡格雷 疗效 颅内血流动力学 不良反应
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阿司匹林联合氯吡格雷治疗老年冠心病的临床效果
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作者 韩金国 刘睦松 《中国卫生标准管理》 2024年第16期119-122,共4页
目的分析老年冠心病(coronary artery heart disease,CHD)患者采用阿司匹林与氯吡格雷联合用药对其治疗效果与不良反应的影响。方法选取2022年3月—2023年3月滕州市中医医院心血管内科收治的94例老年CHD患者为对象。采用随机数字表法分... 目的分析老年冠心病(coronary artery heart disease,CHD)患者采用阿司匹林与氯吡格雷联合用药对其治疗效果与不良反应的影响。方法选取2022年3月—2023年3月滕州市中医医院心血管内科收治的94例老年CHD患者为对象。采用随机数字表法分为对照组与研究组,各47例。对照组单独给予阿司匹林用药,研究组于对照组基础上联合氯吡格雷给药。治疗后,针对2组治疗效果、血小板聚集率(platelet aggregation rate,PAR)、纤维蛋白原(fibrinogen,FIB)、部分凝血酶原时间(prothrombin time,PT)、心绞痛症状以及不良反应发生率进行对比分析。结果治疗后,研究组总有效率为97.87%,高于对照组的82.98%(P<0.05);研究组PAR为(51.15±4.21)%、FIB为(2.47±0.56)g/L,低于对照组的(58.43±4.67)%、(3.48±0.70)g/L,而PT为(13.34±1.27)s,长于对照组的(10.07±0.92)s(P<0.05);研究组心绞痛发作次数为(2.01±0.82)次/周、持续时间为(2.12±0.95)min/次,优于对照组的(3.08±0.97)次/周、(4.67±1.28)min/次(P<0.05);研究组不良反应总发生率为4.26%,低于对照组的23.40%(P<0.05)。结论老年CHD同时以阿司匹林与氯吡格雷联用治疗可有效提升疾病治疗效果,改善患者的心绞痛症状,不仅能够降低血栓形成风险,还能减少药物不良反应,疗效优异,安全性佳,临床应用价值较高。 展开更多
关键词 老年 CHD 阿司匹林 氯吡格雷 治疗效果 不良反应
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Controversies regarding transplantation of mesenchymal stem cells
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作者 Tsvetelina Velikova Tereza Dekova Dimitrina Georgieva Miteva 《World Journal of Transplantation》 2024年第2期48-61,共14页
Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intric... Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation. 展开更多
关键词 Mesenchymal stem cells Transplantation controversies Regenerative medicine Autoimmune diseases Chronic inflammatory illnesses Tumor growth METASTASIS therapeutic potential Clinical use of mesenchymal stem cell
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依达拉奉与氯吡格雷联合应用于急性脑梗死治疗中的效果分析
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作者 李光丽 连雨晴 李久达 《系统医学》 2024年第21期95-98,共4页
目的探讨依达拉奉与氯吡格雷联合应用于急性脑梗死治疗中的效果。方法非随机选取2022年1月—2023年10月山东省聊城市妇幼保健院收治的100例急性脑梗死患者作为研究对象。根据治疗方法不同分为对照组和观察组,各50例。对照组给予依达拉... 目的探讨依达拉奉与氯吡格雷联合应用于急性脑梗死治疗中的效果。方法非随机选取2022年1月—2023年10月山东省聊城市妇幼保健院收治的100例急性脑梗死患者作为研究对象。根据治疗方法不同分为对照组和观察组,各50例。对照组给予依达拉奉右莰醇注射用浓溶液治疗,观察组给予依达拉奉右莰醇注射用浓溶液与氯吡格雷联合治疗,比较两组凝血功能指标、炎症因子、神经功能缺损与日常生活活动能力以及不良反应发生率。结果治疗后,观察组凝血功能指标均优于对照组,炎症因子水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组美国国立卫生研究院卒中量表评分为(9.28±1.21)分,低于对照组的(12.57±1.40)分,差异有统计学意义(t=12.572,P<0.05)。研究组的Barthel指数评分为(83.50±3.89)分,高于对照组的(78.92±4.56)分,差异有统计学意义(t=5.403,P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论依达拉奉与氯吡格雷联合治疗能够有效改善急性脑梗死患者的凝血功能、降低炎症因子水平,有助于提高神经功能恢复和日常生活活动能力,且不会增加不良反应。 展开更多
关键词 依达拉奉 氯吡格雷 急性脑梗死 治疗效果
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USE OF CELL-BASED BIOASSAY FOR THE QUALITY CONTROL OF BOTANICAL THERAPEUTICS
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作者 Doo Suk Lee Min-Jung Bae Sunyoung Kim 《World Journal of Traditional Chinese Medicine》 2015年第4期91-91,共1页
The single most important factor in modernization efforts of traditional oriental medicines is the limited understanding of active compounds responsible for claimed therapeutic effects.Indeed,the unknown identity of b... The single most important factor in modernization efforts of traditional oriental medicines is the limited understanding of active compounds responsible for claimed therapeutic effects.Indeed,the unknown identity of biologically active molecules generates major difficulties associated with botanical therapeutics in general.This includes management of raw materials,poor understanding of 展开更多
关键词 use OF CELL-BASED BIOASSAY FOR THE QUALITY CONTROL OF BOTANICAL therapeuticS PG
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血栓弹力图对支架辅助颅内栓塞动脉瘤不同剂量抗血小板聚集药物疗效的初步评价 被引量:13
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作者 张翔圣 张鑫 +2 位作者 张庆荣 吴琪 陈姝娟 《中国脑血管病杂志》 CAS CSCD 北大核心 2015年第3期130-133,159,共5页
目的采用血栓弹力图检查(TEG)评估支架辅助栓塞动脉瘤患者术前不同剂量阿司匹林及氯吡格雷联合治疗方案对血小板抑制率的影响。方法回顾性连续纳入南京军区南京总医院接受支架辅助栓塞动脉瘤的57例未破裂动脉瘤患者,并按阿司匹林口服剂... 目的采用血栓弹力图检查(TEG)评估支架辅助栓塞动脉瘤患者术前不同剂量阿司匹林及氯吡格雷联合治疗方案对血小板抑制率的影响。方法回顾性连续纳入南京军区南京总医院接受支架辅助栓塞动脉瘤的57例未破裂动脉瘤患者,并按阿司匹林口服剂量的不同分为低剂量组(阿司匹林100 mg+氯吡格雷75 mg)26例和高剂量组(阿司匹林300 mg+氯吡格雷75 mg)31例。两组患者均于术前开始服用阿司匹林及氯吡格雷,于服药第3天,采用TEG检测患者花生四烯酸(AA)途径血小板抑制率和二磷酸腺苷(ADP)途径血小板抑制率。比较两组患者血小板抑制情况以及药物抵抗的发生情况。结果 (1)服药3 d血小板抑制率:低剂量组AA抑制率及ADP抑制率分别为(76±21)%、(72±26)%;高剂量组AA抑制率及ADP抑制率分别为(80±21)%、(73±29)%,两组抑制率差异均无统计学意义(均P>0.05)。(2)药物抵抗:低剂量组发生阿司匹林抵抗2例(7.7%),氯吡格雷抵抗1例(3.8%);高剂量组中发生阿司匹林抵抗3例(9.7%),氯吡格雷抵抗4例(12.9%);两组患者阿司匹林抵抗及氯吡格雷抵抗的发生率差异均无统计学意义(均P>0.05)。(3)围手术期缺血并发症:低剂量组中1例(3.8%)发生围手术期缺血事件,高剂量组中2例(6.5%)发生围手术期缺血事件,两组围手术期缺血并发症发生率差异无统计学意义(P>0.05)。结论对支架辅助栓塞动脉瘤患者,TEG评价的低剂量与高剂量抗血小板聚集治疗对血小板抑制效果无明显差异。 展开更多
关键词 支架 栓塞 治疗性 颅内动脉瘤 阿司匹林 氯吡格雷 血栓弹力图
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阿司匹林联合氯吡格雷治疗短暂性脑缺血发作临床疗效观察 被引量:11
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作者 白维 李尧 +2 位作者 刘阳 薛军 吴迪 《中国心血管病研究》 CAS 2011年第1期42-43,共2页
目的探讨阿司匹林联合氯吡格雷在治疗短暂性脑缺血发作(TIA)中的疗效。方法选取2008年10月至2009年10月北京市第六医院神经内科收治的36例前循环TIA患者为研究对象,所有患者均应用无创性经颅多普勒超声(TCD)诊断技术观察到微栓子... 目的探讨阿司匹林联合氯吡格雷在治疗短暂性脑缺血发作(TIA)中的疗效。方法选取2008年10月至2009年10月北京市第六医院神经内科收治的36例前循环TIA患者为研究对象,所有患者均应用无创性经颅多普勒超声(TCD)诊断技术观察到微栓子信号(MES)。将其随机分为观察组(18例)和对照组(18例),其中观察组患者采用阿司匹林联合氯吡格雷的方法进行治疗,而对照组则单纯采用阿司匹林进行治疗,其他治疗两组相同。以30d为1个疗程,疗程结束后对效果进行比较分析。结果观察组患者TIA发作频率明显低于对照组(P〈0.05),应用TCD诊断技术观察MES显著减少(P〈0.05)。结论阿司匹林联合氯吡格雷治疗TIA效果肯定,优于单用阿司匹林。 展开更多
关键词 阿司匹林 氯吡格雷 短暂性脑缺血发作 疗效
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替罗非班联合氯吡格雷对老年急性ST段抬高型心肌梗死的治疗效果分析 被引量:20
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作者 彭民建 庞孟春 +2 位作者 魏坤 黄祖荣 严辉 《临床和实验医学杂志》 2020年第9期947-951,共5页
目的探讨替罗非班联合氯吡格雷治疗老年急性ST段抬高型心肌梗死的治疗效果。方法采用前瞻性临床对比研究,选取2017年10月至2018年10月简阳市人民医院收治的138例老年急性ST段抬高型心肌梗死患者作为研究对象,按照随机数字表法分为两组:... 目的探讨替罗非班联合氯吡格雷治疗老年急性ST段抬高型心肌梗死的治疗效果。方法采用前瞻性临床对比研究,选取2017年10月至2018年10月简阳市人民医院收治的138例老年急性ST段抬高型心肌梗死患者作为研究对象,按照随机数字表法分为两组:对照组和观察组,每组各69例。两组患者入院后均给予常规溶栓治疗,对照组患者在此基础上给予口服硫酸氢氯吡格雷片,观察组患者在对照组的基础上给予替罗非班注射液,两组均治疗14 d。治疗后,比较两组患者的临床疗效,以及心肌酶指标[肌钙蛋白(c Tn I)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)]、血小板活化功能指标[单核细胞血小板聚集体(MPA)、血小板α颗粒表面膜糖蛋白(CD62P)、溶酶体膜糖蛋白(CD63)]、炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平的变化及心血管事件的发生情况。结果治疗后,观察组患者的总有效率(92. 75%)明显高于对照组(76. 91%),差异具有统计学意义(P <0. 05)。治疗后,观察组患者的c Tn I由(8. 37±1. 72)μg/L降至(4. 55±0. 93)μg/L、CK-MB由(80. 51±16. 29) U/L降至(39. 76±7. 72) U/L、LDH由(122. 64±26. 86) U/L降至(73. 52±15. 67) U/L,且观察组明显低于对照组,差异均有统计学意义(P <0. 05)。治疗后,两组患者的MPA、CD62P及CD63水平均明显降低,且观察组明显低于对照组,差异均有统计学意义(P <0. 05)。治疗后,两组患者的hs-CRP、TNF-α及IL-6水平均显著降低,且观察组明显低于对照组,差异均有统计学意义(P <0. 05)。治疗期间观察组和对照组患者的心血管事件总发生率分别为13. 04%、27. 54%,观察组明显低于对照组,差异具有统计学意义(P <0. 05)。结论替罗非班联合氯吡格雷治疗老年急性ST段抬高型心肌梗死临床效果显著,可明显抑制患者血小板活性,降低炎症反应,改善患者心功能,降低心血管事件发生率,值得在临床推广应用。 展开更多
关键词 急性ST段抬高型心肌梗死 替罗非班 氯吡格雷 治疗效果
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氯吡格雷治疗进展型缺血性脑卒中的临床研究 被引量:3
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作者 杨卉 马巧玲 林香玉 《食品与药品》 CAS 2006年第09A期46-48,共3页
目的研究氯吡格雷治疗进展型缺血性脑卒中的疗效。方法选取50例发病时间超过24 h,已不适合超早期溶栓治疗的进展型缺血性脑卒中患者,随机分为氯吡格雷组及阿司匹林组,各25例,分别在治疗前和治疗后15 d为患者进行神经功能缺损评分,评定疗... 目的研究氯吡格雷治疗进展型缺血性脑卒中的疗效。方法选取50例发病时间超过24 h,已不适合超早期溶栓治疗的进展型缺血性脑卒中患者,随机分为氯吡格雷组及阿司匹林组,各25例,分别在治疗前和治疗后15 d为患者进行神经功能缺损评分,评定疗效,观察不良反应并进行血流变量监测。结果治疗前,两组患者神经功能缺损评分和实验室各项参数差异均无统计学意义(P>0.05),治疗后两组均较治疗前明显改善,治疗组患者神经功能缺损评分比对照组明显降低(P<0.05),症状改善亦明显优于对照组(P<0.05)。血液流变学改善显著,氯吡格雷组全血黏度和血浆黏度下降程度大于阿司匹林组,无严重不良反应出现。结论进展型缺血性脑卒中患者使用氯吡格雷有效且安全。 展开更多
关键词 氯吡格雷 进展型缺血性脑卒中 疗效评定
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氯吡格雷联合阿司匹林治疗不稳定型心绞痛的疗效观察 被引量:10
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作者 李素姣 姚金坊 《河南医学研究》 CAS 2014年第4期22-23,共2页
目的:观察氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床效果。方法:选择2006年1月至2012年3月郏县人民医院心内科诊治的400例不稳定型心绞痛患者为研究对象。对照组(200例)给予阿司匹林,实验组(200例)给予氯吡格雷和阿司匹林,观察两... 目的:观察氯吡格雷联合阿司匹林治疗不稳定型心绞痛的临床效果。方法:选择2006年1月至2012年3月郏县人民医院心内科诊治的400例不稳定型心绞痛患者为研究对象。对照组(200例)给予阿司匹林,实验组(200例)给予氯吡格雷和阿司匹林,观察两组治疗6个月的效果及心血管事件的发生率。结果:治疗6个月后,实验组心绞痛较对照组明显缓解,心血管事件发生率显著降低,两组差异有统计学(P<0.05)。结论:氯吡格雷联合阿司匹林治疗不稳定型心绞痛可显著提高临床疗效,降低心血管事件的发生率。 展开更多
关键词 氯吡格雷 不稳定型心绞痛 阿司匹林 疗效
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