This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the t...This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the theta(4-9 Hz)and beta(12-35 Hz)frequency bands have been demonstrated to be associated with the tremor and rigidity/bradykinesia symptoms in Parkinson’s disease(PD).Although the clinical application of open-loop deep brain stimulation(DBS)is effective,the stimulation waveform with the fixed parameters cannot be self-adjusted as the disease progresses,and thus the stimulation effects go poor.To deal with this difficult problem,a variable universe fuzzy closed-loop strategy is proposed to modulate different PD states.We establish a cortico-basal ganglia-thalamocortical network model to simulate pathological oscillations and test the control effect.The results suggest that the proposed closed-loop control strategy can accommodate the variation of brain states and symptoms,which may become an alternative method to administrate the symptoms in PD.展开更多
In neurodegenerative disorders such as Parkinson＇s disease （PD）, deep brain stimulation （DBS） is a desirable approach when the medication is less effective for treating the symptoms. DBS incorporates transferring...In neurodegenerative disorders such as Parkinson＇s disease （PD）, deep brain stimulation （DBS） is a desirable approach when the medication is less effective for treating the symptoms. DBS incorporates transferring electrical pulses to a specific tissue of the central nervous system, obtaining therapeutic results by modulating the neuronal activity of that region. DBS has certain advantages such as reversibility and adjustability features over medication, since the neuronal firing patterns can be recorded and used to alter the parameters of the DBS signal （Benabid et al., 2009）. One of the DBS indications is its ability to suppress the abnormal neuronal activity to treat symptoms like tremor, akinesia and dystonia.展开更多
Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure ...Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,展开更多
Biophysical computational models are complementary to experiments and theories,providing powerful tools for the study of neurological diseases.The focus of this review is the dynamic modeling and control strategies of...Biophysical computational models are complementary to experiments and theories,providing powerful tools for the study of neurological diseases.The focus of this review is the dynamic modeling and control strategies of Parkinson’s disease(PD).In previous studies,the development of parkinsonian network dynamics modeling has made great progress.Modeling mainly focuses on the cortex-thalamus-basal ganglia(CTBG)circuit and its sub-circuits,which helps to explore the dynamic behavior of the parkinsonian network,such as synchronization.Deep brain stimulation(DBS)is an effective strategy for the treatment of PD.At present,many studies are based on the side effects of the DBS.However,the translation from modeling results to clinical disease mitigation therapy still faces huge challenges.Here,we introduce the progress of DBS improvement.Its specific purpose is to develop novel DBS treatment methods,optimize the treatment effect of DBS for each patient,and focus on the study in closed-loop DBS.Our goal is to review the inspiration and insights gained by combining the system theory with these computational models to analyze neurodynamics and optimize DBS treatment.展开更多
Deep brain stimulation (DBS) has become an effective therapeutic option for neurological and psychiatric disorders such as Parkinson’s disease (PD), dystonia, and obsessive-compulsive disorder. The subthalamic nucleu...Deep brain stimulation (DBS) has become an effective therapeutic option for neurological and psychiatric disorders such as Parkinson’s disease (PD), dystonia, and obsessive-compulsive disorder. The subthalamic nucleus (STN) and internal globus pallidus (GPi) are by far the most commonly used targets for DBS in the treatment of PD. However, STN/GPi stimulation sometimes causes side effects, including motor fluctuations, cognitive declines, and worse emotional experience, which affect patients’ postoperative quality of life. Recent invasive electrophysiological studies are driven by the desire to better understand the mechanisms of therapeutic actions and side effects of STN/GPi stimulation. These studies investigated the function of the STN and GPi in motor, cognitive and affective processes by recording single- neuron firing patterns during the surgery or local field potentials after the surgery. Here we review the relevant studies to provide an integrative picture of the functional roles of the STN and GPi within the basal ganglia loops for motor, cognition, and emotion. Previous studies suggested that STN and GPi gamma oscillations encode the strength and speed of voluntary movements (execution), whereas beta oscillations reflect the effort and demand of potential movements (preparation). In the cognitive domain, oscillatory beta activity in the STN is involved when people have to stop an inappropriate action or to suppress salient but task-irrelevant information, whereas theta/delta activity is associated with the adjustment of decision thresholds and cost-benefit trade-off. In the affective domain, STN activity in the alpha band may represent the valence and arousal of emotional information.展开更多
Neurological disorders with symptoms such as chronic pain,depression,and insomnia are widespread.Very weak electric fields applied through the skull can enhance or diminish neural activity and modulate brain waves in ...Neurological disorders with symptoms such as chronic pain,depression,and insomnia are widespread.Very weak electric fields applied through the skull can enhance or diminish neural activity and modulate brain waves in order to treat many of these common medical problems.This approach is to be contrasted with well-established pharmacological methods or more recent invasive electrical Deep Brain Stimulation(DBS)techniques that require surgery to insert electrodes deep into the brain.We claim that Non-Invasive Brain Stimulation(NIBS)will provide new treatment methods with much greater simplicity,lower cost,improved safety and in some cases,possibly greater effectiveness.This emerging use of NIBS is a branch of a new multidisciplinary field that we coined Neuro-systems Engineering[1].This field involves neuroscientists,psychologists,and electrical engineers.This emerging field relies on existing standards for the safe implementation of these novel treatment modalities[2].Methods of stimulating the brain are based on emerging electro-technologies such as transcranial Direct Current/Alternating Current(DC/AC)electric fields and pulsed magnetic fields.Application of functional and time-dependent brain imaging methods can be used to locate relevant brain regions and determine the most appropriate stimulation method.Application of tailored and individualized control can be combined with other therapy methods to effectively treat neurological disorders while minimizing or even eliminating the use of pharmaceuticals.In this paper,we are presenting our embodiment for a closed loop,feedback controlled,non-invasive application of electrical stimulation of the brain to enhance individual/group performance or to treat neurological disorders.展开更多
Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Adv...Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.展开更多
BACKGROUND AND OBJECTIVE Internal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particul...BACKGROUND AND OBJECTIVE Internal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particular, how a single-pulse GPi DBS changes cortical circuits has never been investigated. We studied the modulation of motor cortical excitability and plasticity with single-pulse GPi DBS in dystonia patients with bilateral implantation of GPi DBS. METHODS The cortical evoked potentials from DBS were recorded with electroencephalography.展开更多
Deep brain stimulation(DBS)has been used as a safe and effective neuromodulation technique for treatment of various diseases.A large number of patients suffering from movement disorders such as dyskinesia may benefit ...Deep brain stimulation(DBS)has been used as a safe and effective neuromodulation technique for treatment of various diseases.A large number of patients suffering from movement disorders such as dyskinesia may benefit from DBS.Cerebral palsy(CP)is a group of permanent disorders mainly involving motor impairment,and medical interventions are usually unsatisfactory or temporarily active,especially for dyskinetic CP.DBS may be another approach to the treatment of CP.In this review we discuss the targets for DBS and the mechanisms of action for the treatment of CP,and focus on presurgical assessment,efficacy for dystonia and other symptoms,safety,and risks.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62173241 and 62171312)the Natural Science Foundation of Tianjin,China(Grant Nos.20JCQNJC01160 and 19JCZDJC36500)the financial support provided by Opening Foundation of Key Laboratory of Opto-technology and Intelligent Control(Lanzhou Jiaotong University),Ministry of Education,China(Grant No.KFKT2020-01)
文摘This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the theta(4-9 Hz)and beta(12-35 Hz)frequency bands have been demonstrated to be associated with the tremor and rigidity/bradykinesia symptoms in Parkinson’s disease(PD).Although the clinical application of open-loop deep brain stimulation(DBS)is effective,the stimulation waveform with the fixed parameters cannot be self-adjusted as the disease progresses,and thus the stimulation effects go poor.To deal with this difficult problem,a variable universe fuzzy closed-loop strategy is proposed to modulate different PD states.We establish a cortico-basal ganglia-thalamocortical network model to simulate pathological oscillations and test the control effect.The results suggest that the proposed closed-loop control strategy can accommodate the variation of brain states and symptoms,which may become an alternative method to administrate the symptoms in PD.
文摘In neurodegenerative disorders such as Parkinson＇s disease （PD）, deep brain stimulation （DBS） is a desirable approach when the medication is less effective for treating the symptoms. DBS incorporates transferring electrical pulses to a specific tissue of the central nervous system, obtaining therapeutic results by modulating the neuronal activity of that region. DBS has certain advantages such as reversibility and adjustability features over medication, since the neuronal firing patterns can be recorded and used to alter the parameters of the DBS signal （Benabid et al., 2009）. One of the DBS indications is its ability to suppress the abnormal neuronal activity to treat symptoms like tremor, akinesia and dystonia.
基金supported by Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for young scientists(B)15K19984JSPS Fujita Memorial Fund for Medical Research,Takeda Science Foundation+1 种基金Uehara Memorial FoundationCentral Research Institute of Fukuoka University(No.161042)
文摘Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,
基金Project supported by the National Natural Science Foundation of China(Nos.11932003 and 11772019)。
文摘Biophysical computational models are complementary to experiments and theories,providing powerful tools for the study of neurological diseases.The focus of this review is the dynamic modeling and control strategies of Parkinson’s disease(PD).In previous studies,the development of parkinsonian network dynamics modeling has made great progress.Modeling mainly focuses on the cortex-thalamus-basal ganglia(CTBG)circuit and its sub-circuits,which helps to explore the dynamic behavior of the parkinsonian network,such as synchronization.Deep brain stimulation(DBS)is an effective strategy for the treatment of PD.At present,many studies are based on the side effects of the DBS.However,the translation from modeling results to clinical disease mitigation therapy still faces huge challenges.Here,we introduce the progress of DBS improvement.Its specific purpose is to develop novel DBS treatment methods,optimize the treatment effect of DBS for each patient,and focus on the study in closed-loop DBS.Our goal is to review the inspiration and insights gained by combining the system theory with these computational models to analyze neurodynamics and optimize DBS treatment.
基金the Thousand Young Talents Program (to Z.Y.)National Natural Science Foundation of China (31771216, to Z.Y.).
文摘Deep brain stimulation (DBS) has become an effective therapeutic option for neurological and psychiatric disorders such as Parkinson’s disease (PD), dystonia, and obsessive-compulsive disorder. The subthalamic nucleus (STN) and internal globus pallidus (GPi) are by far the most commonly used targets for DBS in the treatment of PD. However, STN/GPi stimulation sometimes causes side effects, including motor fluctuations, cognitive declines, and worse emotional experience, which affect patients’ postoperative quality of life. Recent invasive electrophysiological studies are driven by the desire to better understand the mechanisms of therapeutic actions and side effects of STN/GPi stimulation. These studies investigated the function of the STN and GPi in motor, cognitive and affective processes by recording single- neuron firing patterns during the surgery or local field potentials after the surgery. Here we review the relevant studies to provide an integrative picture of the functional roles of the STN and GPi within the basal ganglia loops for motor, cognition, and emotion. Previous studies suggested that STN and GPi gamma oscillations encode the strength and speed of voluntary movements (execution), whereas beta oscillations reflect the effort and demand of potential movements (preparation). In the cognitive domain, oscillatory beta activity in the STN is involved when people have to stop an inappropriate action or to suppress salient but task-irrelevant information, whereas theta/delta activity is associated with the adjustment of decision thresholds and cost-benefit trade-off. In the affective domain, STN activity in the alpha band may represent the valence and arousal of emotional information.
文摘Neurological disorders with symptoms such as chronic pain,depression,and insomnia are widespread.Very weak electric fields applied through the skull can enhance or diminish neural activity and modulate brain waves in order to treat many of these common medical problems.This approach is to be contrasted with well-established pharmacological methods or more recent invasive electrical Deep Brain Stimulation(DBS)techniques that require surgery to insert electrodes deep into the brain.We claim that Non-Invasive Brain Stimulation(NIBS)will provide new treatment methods with much greater simplicity,lower cost,improved safety and in some cases,possibly greater effectiveness.This emerging use of NIBS is a branch of a new multidisciplinary field that we coined Neuro-systems Engineering[1].This field involves neuroscientists,psychologists,and electrical engineers.This emerging field relies on existing standards for the safe implementation of these novel treatment modalities[2].Methods of stimulating the brain are based on emerging electro-technologies such as transcranial Direct Current/Alternating Current(DC/AC)electric fields and pulsed magnetic fields.Application of functional and time-dependent brain imaging methods can be used to locate relevant brain regions and determine the most appropriate stimulation method.Application of tailored and individualized control can be combined with other therapy methods to effectively treat neurological disorders while minimizing or even eliminating the use of pharmaceuticals.In this paper,we are presenting our embodiment for a closed loop,feedback controlled,non-invasive application of electrical stimulation of the brain to enhance individual/group performance or to treat neurological disorders.
基金supported by the National Natural Science Foundation of China(Nos.T2293730,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400)the National Key Research and Development Program of China(Nos.2022YFC2402501 and 2022YFB3205602)+1 种基金the Major Program of Scientific and Technical Innovation 2030(No.2021ZD02016030)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.GJJSTD20210004).
文摘Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.
文摘BACKGROUND AND OBJECTIVE Internal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particular, how a single-pulse GPi DBS changes cortical circuits has never been investigated. We studied the modulation of motor cortical excitability and plasticity with single-pulse GPi DBS in dystonia patients with bilateral implantation of GPi DBS. METHODS The cortical evoked potentials from DBS were recorded with electroencephalography.
文摘Deep brain stimulation(DBS)has been used as a safe and effective neuromodulation technique for treatment of various diseases.A large number of patients suffering from movement disorders such as dyskinesia may benefit from DBS.Cerebral palsy(CP)is a group of permanent disorders mainly involving motor impairment,and medical interventions are usually unsatisfactory or temporarily active,especially for dyskinetic CP.DBS may be another approach to the treatment of CP.In this review we discuss the targets for DBS and the mechanisms of action for the treatment of CP,and focus on presurgical assessment,efficacy for dystonia and other symptoms,safety,and risks.
