This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the t...This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the theta(4-9 Hz)and beta(12-35 Hz)frequency bands have been demonstrated to be associated with the tremor and rigidity/bradykinesia symptoms in Parkinson’s disease(PD).Although the clinical application of open-loop deep brain stimulation(DBS)is effective,the stimulation waveform with the fixed parameters cannot be self-adjusted as the disease progresses,and thus the stimulation effects go poor.To deal with this difficult problem,a variable universe fuzzy closed-loop strategy is proposed to modulate different PD states.We establish a cortico-basal ganglia-thalamocortical network model to simulate pathological oscillations and test the control effect.The results suggest that the proposed closed-loop control strategy can accommodate the variation of brain states and symptoms,which may become an alternative method to administrate the symptoms in PD.展开更多
Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure ...Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,展开更多
Autism spectrum disorder is classified as a spectrum of neurodevelopmental disorders with an unknown definitive etiology.Individuals with autism spectrum disorder show deficits in a variety of areas including cognitio...Autism spectrum disorder is classified as a spectrum of neurodevelopmental disorders with an unknown definitive etiology.Individuals with autism spectrum disorder show deficits in a variety of areas including cognition,memory,attention,emotion recognition,and social skills.With no definitive treatment or cure,the main interventions for individuals with autism spectrum disorder are based on behavioral modulations.Recently,noninvasive brain modulation techniques including repetitive transcranial magnetic stimulation,intermittent theta burst stimulation,continuous theta burst stimulation,and transcranial direct current stimulation have been studied for their therapeutic properties of modifying neuroplasticity,particularly in individuals with autism spectrum disorder.Preliminary evidence from small cohort studies,pilot studies,and clinical trials suggests that the various noninvasive brain stimulation techniques have therapeutic benefits for treating both behavioral and cognitive manifestations of autism spectrum disorder.However,little data is available for quantifying the clinical significance of these findings as well as the long-term outcomes of individuals with autism spectrum disorder who underwent transcranial stimulation.The objective of this review is to highlight the most recent advancements in the application of noninvasive brain modulation technology in individuals with autism spectrum disorder.展开更多
Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Adv...Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.展开更多
Brain-computer interfaces(BCIs) can provide direct bidirectional communication between the brain and a machine. Recently, the BCI technique has been used in seizure control. Usually, a closed-loop system based on BCI ...Brain-computer interfaces(BCIs) can provide direct bidirectional communication between the brain and a machine. Recently, the BCI technique has been used in seizure control. Usually, a closed-loop system based on BCI is set up which delivers a therapic electrical stimulus only in response to seizure onsets. In this way, the side effects of neurostimulation can be greatly reduced. In this paper, a new BCI-based responsive stimulation system is proposed. With an efficient morphology-based seizure detector, seizure events can be identified in the early stages which trigger electrical stimulations to be sent to the cortex of the brain. The proposed system was tested on rats with penicillin-induced epileptic seizures. Online experiments show that 83% of the seizures could be detected successfully with a short average time delay of 3.11 s. With the therapy of the BCI-based seizure control system, most seizures were suppressed within 10 s. Compared with the control group, the average seizure duration was reduced by 30.7%. Therefore, the proposed system can control epileptic seizures effectively and has potential in clinical applications.展开更多
Deep brain stimulation(DBS)is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease(PD)and other movement disorders symptoms along with some psychiatric conditions.Over the last few...Deep brain stimulation(DBS)is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease(PD)and other movement disorders symptoms along with some psychiatric conditions.Over the last few decades DBS has been shown to provide remarkable therapeutic effect on carefully selected patients.Although its precise mechanism of action is still unknown,DBS improves motor functions and therefore quality of life.To date,two main targets have emerged in PD patients:the globus pallidus pars interna and the subthalamic nucleus.Two other targets,the ventralis intermedius and zona incerta have also been selectively used,especially in tremor-dominant PD patients.The main indications for PD DBS have traditionally been motor fluctuations,debilitating medication induced dyskinesias,unpredictable“off time”state,and medication refractory tremor.Medication refractory tremor and intolerable dyskinesia are potential palliative indications.Besides aforementioned targets,the brainstem pedunculopontine nucleus(PPN)is under investigation for the treatment of ON-state freezing of gait and postural instability.In this article,we will review the most recent literature on DBS therapy for PD,including cutting-edge advances and data supporting the role of DBS in advanced neural-network modulation.展开更多
Temporal lobe epilepsy(TLE)is difficult to treat as it is often refractory to treatment.Apart from traditional medical treatment,surgical resection is also a choice of treatment,but it may be associated with significa...Temporal lobe epilepsy(TLE)is difficult to treat as it is often refractory to treatment.Apart from traditional medical treatment,surgical resection is also a choice of treatment,but it may be associated with significant cognitive deficits.As a result,treatment strategies using targeted and adjustable stimulation of malfunctioning brain circuits have been developed.These neuromodulatory therapies using approaches of electric and magnetic neuromodulation are already in clinical use for refractory epilepsy while others such as optogenetics,chemo-genetics and ultrasound modulation are being tested in pre-clinical TLE animal models.In this review,we conducted an in-depth literature search on the clinically available neuromodulatory approaches for TLE,focusing on the possible mechanism of action and the clinical outcomes including adverse effects.Techniques that are currently explored in preclinical animal models but may have therapeutic applications in future are also discussed.The efficacy and subsequent adverse effects vary among the different neuromodulatory approaches and some still have unclear mechanisms of action in TLE treatment.Further studies evaluating the benefits and potential limitations are needed.Continued research on the therapeutic mechanisms and the epileptic brain network is critical for improving therapies for TLE.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62173241 and 62171312)the Natural Science Foundation of Tianjin,China(Grant Nos.20JCQNJC01160 and 19JCZDJC36500)the financial support provided by Opening Foundation of Key Laboratory of Opto-technology and Intelligent Control(Lanzhou Jiaotong University),Ministry of Education,China(Grant No.KFKT2020-01)
文摘This paper provides an adaptive closed-loop strategy for suppressing the pathological oscillations of the basal ganglia based on a variable universe fuzzy algorithm.The pathological basal ganglia oscillations in the theta(4-9 Hz)and beta(12-35 Hz)frequency bands have been demonstrated to be associated with the tremor and rigidity/bradykinesia symptoms in Parkinson’s disease(PD).Although the clinical application of open-loop deep brain stimulation(DBS)is effective,the stimulation waveform with the fixed parameters cannot be self-adjusted as the disease progresses,and thus the stimulation effects go poor.To deal with this difficult problem,a variable universe fuzzy closed-loop strategy is proposed to modulate different PD states.We establish a cortico-basal ganglia-thalamocortical network model to simulate pathological oscillations and test the control effect.The results suggest that the proposed closed-loop control strategy can accommodate the variation of brain states and symptoms,which may become an alternative method to administrate the symptoms in PD.
基金supported by Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for young scientists(B)15K19984JSPS Fujita Memorial Fund for Medical Research,Takeda Science Foundation+1 种基金Uehara Memorial FoundationCentral Research Institute of Fukuoka University(No.161042)
文摘Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric disorders.Various efforts to improve the clinical outcomes of the procedure have been previously made.Several factors affect the DBS clinical outcomes such as lead position,programming technique,
基金supported by translational grant from the HERA Foundation(to AAE).
文摘Autism spectrum disorder is classified as a spectrum of neurodevelopmental disorders with an unknown definitive etiology.Individuals with autism spectrum disorder show deficits in a variety of areas including cognition,memory,attention,emotion recognition,and social skills.With no definitive treatment or cure,the main interventions for individuals with autism spectrum disorder are based on behavioral modulations.Recently,noninvasive brain modulation techniques including repetitive transcranial magnetic stimulation,intermittent theta burst stimulation,continuous theta burst stimulation,and transcranial direct current stimulation have been studied for their therapeutic properties of modifying neuroplasticity,particularly in individuals with autism spectrum disorder.Preliminary evidence from small cohort studies,pilot studies,and clinical trials suggests that the various noninvasive brain stimulation techniques have therapeutic benefits for treating both behavioral and cognitive manifestations of autism spectrum disorder.However,little data is available for quantifying the clinical significance of these findings as well as the long-term outcomes of individuals with autism spectrum disorder who underwent transcranial stimulation.The objective of this review is to highlight the most recent advancements in the application of noninvasive brain modulation technology in individuals with autism spectrum disorder.
基金supported by the National Natural Science Foundation of China(Nos.T2293730,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400)the National Key Research and Development Program of China(Nos.2022YFC2402501 and 2022YFB3205602)+1 种基金the Major Program of Scientific and Technical Innovation 2030(No.2021ZD02016030)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(No.GJJSTD20210004).
文摘Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders.Advances in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in situ.This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously.Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently resolved.In this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field.This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.
基金Project supported by the National Basic Research Program(973)of China(No.2013CB329500)the National High-Tech R&D Program(863)of China(No.2012AA020408)+1 种基金the National Natural Science Foundation of China(No.61103107)the Research Fund for the Doctoral Program of Higher Education of China(No.20110101120154)
文摘Brain-computer interfaces(BCIs) can provide direct bidirectional communication between the brain and a machine. Recently, the BCI technique has been used in seizure control. Usually, a closed-loop system based on BCI is set up which delivers a therapic electrical stimulus only in response to seizure onsets. In this way, the side effects of neurostimulation can be greatly reduced. In this paper, a new BCI-based responsive stimulation system is proposed. With an efficient morphology-based seizure detector, seizure events can be identified in the early stages which trigger electrical stimulations to be sent to the cortex of the brain. The proposed system was tested on rats with penicillin-induced epileptic seizures. Online experiments show that 83% of the seizures could be detected successfully with a short average time delay of 3.11 s. With the therapy of the BCI-based seizure control system, most seizures were suppressed within 10 s. Compared with the control group, the average seizure duration was reduced by 30.7%. Therefore, the proposed system can control epileptic seizures effectively and has potential in clinical applications.
文摘Deep brain stimulation(DBS)is considered a safe and well tolerated surgical procedure to alleviate Parkinson’s disease(PD)and other movement disorders symptoms along with some psychiatric conditions.Over the last few decades DBS has been shown to provide remarkable therapeutic effect on carefully selected patients.Although its precise mechanism of action is still unknown,DBS improves motor functions and therefore quality of life.To date,two main targets have emerged in PD patients:the globus pallidus pars interna and the subthalamic nucleus.Two other targets,the ventralis intermedius and zona incerta have also been selectively used,especially in tremor-dominant PD patients.The main indications for PD DBS have traditionally been motor fluctuations,debilitating medication induced dyskinesias,unpredictable“off time”state,and medication refractory tremor.Medication refractory tremor and intolerable dyskinesia are potential palliative indications.Besides aforementioned targets,the brainstem pedunculopontine nucleus(PPN)is under investigation for the treatment of ON-state freezing of gait and postural instability.In this article,we will review the most recent literature on DBS therapy for PD,including cutting-edge advances and data supporting the role of DBS in advanced neural-network modulation.
文摘Temporal lobe epilepsy(TLE)is difficult to treat as it is often refractory to treatment.Apart from traditional medical treatment,surgical resection is also a choice of treatment,but it may be associated with significant cognitive deficits.As a result,treatment strategies using targeted and adjustable stimulation of malfunctioning brain circuits have been developed.These neuromodulatory therapies using approaches of electric and magnetic neuromodulation are already in clinical use for refractory epilepsy while others such as optogenetics,chemo-genetics and ultrasound modulation are being tested in pre-clinical TLE animal models.In this review,we conducted an in-depth literature search on the clinically available neuromodulatory approaches for TLE,focusing on the possible mechanism of action and the clinical outcomes including adverse effects.Techniques that are currently explored in preclinical animal models but may have therapeutic applications in future are also discussed.The efficacy and subsequent adverse effects vary among the different neuromodulatory approaches and some still have unclear mechanisms of action in TLE treatment.Further studies evaluating the benefits and potential limitations are needed.Continued research on the therapeutic mechanisms and the epileptic brain network is critical for improving therapies for TLE.
