Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart

The major constituent from the hexane extract of the seeds ofP. insignis is GFC （garcinielliptone FC）. Doses of 25, 50 and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline （vehicle） and orally administered for 30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes, demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weight gain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore, no differences in weight and macroscopic structure of the brain, liver, kidney, lung, heart and spleen between groups of male and female adult mice were observed after treatment. During the periods of treatment, GFC produced no significant changes on haematological and biochemical parameters in male and female mice treated with all doses used. The aim of this study was to investigate the toxicological potential of GFC through behavioral, hematological, biochemical and morphological parameters in animals in order to ensure the safe use ofPlatonia insignis in folk medicine.

Flavonol Glycoside from Psorospermum androsaemifofium

A new flavonol glycoside, 3＇-（4＇＂-（3＇＂＇,4＇＂＇-dihydroxyphenoxy）-2＇＂-hydroxyphenoxy）acanthophorin B （la） to- gether with 3＇-（2＇＂,4＂＇-dihydroxyphenoxy）acanthophorin B （1）, acanthophorin B （2）, vismiaquinone （3）, rheochrysidin （3a）, lupeol acetate and fatty acid were isolated from the chloroform extract of the stem bark of Psorospermum androsaemifolium Baker （Clusiaceae）. The structure of la was determined on the basis of detailed spectroscopic analysis and comparison with the literature. Compounds la and 3a showed moderate antimicrobial activity.

Garcinia spp:Products and by-products with potential pharmacological application in cancer

The Garcinia genus belongs to the Clusiaceae family and is composed of approximately 240 species,distributed throughout the tropical regions,with a significant representation in Brazil.Their edible fruits have a high dietary value and have been recognized for their economic value as food and health.By-products of Garcinia fruits,such as the peel and seed of Garcinia brasiliensis,are a rich source of fibers,proteins,and bioactive metabolites,producing flour with an energetic value near wheat flour and antioxidant properties.Peel waste of G.mangostana(mangosteen)has been used as a green absorbent to recover valuable metals such as gold and silver from electronic waste.Many Garcinia species have obtained great prominence for extracts and isolated compounds,such as polyphenols,bioflavonoids,anthocyanins,benzophenones,and xanthones in the treatment of various illnesses.Thus,natural products isolated from Garcinia species have been described as having a chemical diversity and potential for medicinal uses with emphasizing adipogenesis,diabetes,cardiovascular illness,and cancer.This review comprises works published from January 2017 to March 2022 and highlights the promising anticancer activity and potential use of natural compounds from Garcinia species and fruit wastes.