The last day of 2020 marked a milestone in the research and development of inactivated vaccines to fight COVID-19 in China.At a December 31 press conference organized by the State Council Joint Prevention and Control ...The last day of 2020 marked a milestone in the research and development of inactivated vaccines to fight COVID-19 in China.At a December 31 press conference organized by the State Council Joint Prevention and Control Mechanism Against COVID-19,the National Medical Products Administration announced that it granted conditional emergency usage authorization for an inactivated vaccine for COVID-19 developed by Beijing Institute of Biological Products Co.,Ltd.(BJIBP),a subsidiary of China National Biotec Group(CNBG)under China National Pharmaceutical Group(Sinopharm).It was the first COVID-19 vaccine authorized for emergency use in China.展开更多
Background: As the population age structure gradually ages, more and more elderly people were found to have pulmonary nodules during physical examinations. Most elderly people had underlying diseases such as heart, lu...Background: As the population age structure gradually ages, more and more elderly people were found to have pulmonary nodules during physical examinations. Most elderly people had underlying diseases such as heart, lung, brain and blood vessels and cannot tolerate surgery. Computed tomography (CT)-guided percutaneous core needle biopsy (CNB) was the first choice for pathological diagnosis and subsequent targeted drugs, immune drugs or ablation treatment. CT-guided percutaneous CNB requires clinicians with rich CNB experience to ensure high CNB accuracy, but it was easy to cause complications such as pneumothorax and hemorrhage. Three-dimensional (3D) printing coplanar template (PCT) combined with CT-guided percutaneous pulmonary CNB biopsy has been used in clinical practice, but there was no prospective, randomized controlled study. Methods: Elderly patients with lung nodules admitted to the Department of Oncology of our hospital from January 2019 to January 2023 were selected. A total of 225 elderly patients were screened, and 30 patients were included after screening. They were randomly divided into experimental group (Group A: 30 cases) and control group (Group B: 30 cases). Group A was given 3D-PCT combined with CT-guided percutaneous pulmonary CNB biopsy, Group B underwent CT-guided percutaneous pulmonary CNB. The primary outcome measure of this study was the accuracy of diagnostic CNB, and the secondary outcome measures were CNB time, number of CNB needles, number of pathological tissues and complications. Results: The diagnostic accuracy of group A and group B was 96.67% and 76.67%, respectively (P = 0.026). There were statistical differences between group A and group B in average CNB time (P = 0.001), number of CNB (1 vs more than 1, P = 0.029), and pathological tissue obtained by CNB (3 vs 1, P = 0.040). There was no statistical difference in the incidence of pneumothorax and hemorrhage between the two groups (P > 0.05). Conclusions: 3D-PCT combined with CT-guided percutaneous CNB can improve the puncture accuracy of elderly patients, shorten the puncture time, reduce the number of punctures, and increase the amount of puncture pathological tissue, without increasing pneumothorax and hemorrhage complications. We look forward to verifying this in a phase III randomized controlled clinical study. .展开更多
A novel method, named critical-network-based (CNB), for timing optimization in global routing is presented in this paper. The essence of this method is different from that of the typical existing ones, named nets-base...A novel method, named critical-network-based (CNB), for timing optimization in global routing is presented in this paper. The essence of this method is different from that of the typical existing ones, named nets-based (NB) and critical-path-based (CPB). The main contribution of this paper is that the CNB delay reduction method is more efficient than the typical existing ones. This new method makes it possible to reduce the delay in an overall survey.Based on CNB, a timing optimization algorithm for global routing is implemented and tested on Microelectronics Center of North Carolina (MCNC) benchmarks in this paper. The experimental results are compared between this algorithm and the existing ones. The experimental results show that this algorithm is able to control the delay efficiently.展开更多
文摘The last day of 2020 marked a milestone in the research and development of inactivated vaccines to fight COVID-19 in China.At a December 31 press conference organized by the State Council Joint Prevention and Control Mechanism Against COVID-19,the National Medical Products Administration announced that it granted conditional emergency usage authorization for an inactivated vaccine for COVID-19 developed by Beijing Institute of Biological Products Co.,Ltd.(BJIBP),a subsidiary of China National Biotec Group(CNBG)under China National Pharmaceutical Group(Sinopharm).It was the first COVID-19 vaccine authorized for emergency use in China.
文摘Background: As the population age structure gradually ages, more and more elderly people were found to have pulmonary nodules during physical examinations. Most elderly people had underlying diseases such as heart, lung, brain and blood vessels and cannot tolerate surgery. Computed tomography (CT)-guided percutaneous core needle biopsy (CNB) was the first choice for pathological diagnosis and subsequent targeted drugs, immune drugs or ablation treatment. CT-guided percutaneous CNB requires clinicians with rich CNB experience to ensure high CNB accuracy, but it was easy to cause complications such as pneumothorax and hemorrhage. Three-dimensional (3D) printing coplanar template (PCT) combined with CT-guided percutaneous pulmonary CNB biopsy has been used in clinical practice, but there was no prospective, randomized controlled study. Methods: Elderly patients with lung nodules admitted to the Department of Oncology of our hospital from January 2019 to January 2023 were selected. A total of 225 elderly patients were screened, and 30 patients were included after screening. They were randomly divided into experimental group (Group A: 30 cases) and control group (Group B: 30 cases). Group A was given 3D-PCT combined with CT-guided percutaneous pulmonary CNB biopsy, Group B underwent CT-guided percutaneous pulmonary CNB. The primary outcome measure of this study was the accuracy of diagnostic CNB, and the secondary outcome measures were CNB time, number of CNB needles, number of pathological tissues and complications. Results: The diagnostic accuracy of group A and group B was 96.67% and 76.67%, respectively (P = 0.026). There were statistical differences between group A and group B in average CNB time (P = 0.001), number of CNB (1 vs more than 1, P = 0.029), and pathological tissue obtained by CNB (3 vs 1, P = 0.040). There was no statistical difference in the incidence of pneumothorax and hemorrhage between the two groups (P > 0.05). Conclusions: 3D-PCT combined with CT-guided percutaneous CNB can improve the puncture accuracy of elderly patients, shorten the puncture time, reduce the number of punctures, and increase the amount of puncture pathological tissue, without increasing pneumothorax and hemorrhage complications. We look forward to verifying this in a phase III randomized controlled clinical study. .
文摘A novel method, named critical-network-based (CNB), for timing optimization in global routing is presented in this paper. The essence of this method is different from that of the typical existing ones, named nets-based (NB) and critical-path-based (CPB). The main contribution of this paper is that the CNB delay reduction method is more efficient than the typical existing ones. This new method makes it possible to reduce the delay in an overall survey.Based on CNB, a timing optimization algorithm for global routing is implemented and tested on Microelectronics Center of North Carolina (MCNC) benchmarks in this paper. The experimental results are compared between this algorithm and the existing ones. The experimental results show that this algorithm is able to control the delay efficiently.
