Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeut...Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very limited. This study aimed to investigate the CT features of this tumor. Methods Institutional review board approval was obtained for this study. Seven patients with pathologically proven colloid carcinoma of the pancreas were included. Unenhanced and dynamic enhanced CT was performed in all the patients. CT features were analyzed retrospectively and correlations with pathological findings were evaluated. Results Mean age of the patients was 59.8 years （41-76 years）. Five tumors were located in the pancreatic head, and the other two in body and tail respectively. The maximum mean diameter of the tumors on axial scanning was 3.9 cm （3.0-6.7 cm）. Tumors were round （n=-5） and Iobular （n=2）. Tumors appeared slight hyp-attenuation on unenhanced CT, and peripheral and internal meshlike progressive delayed enhancement with great percent of cystic areas on enhanced CT. Calcification and gas in the tumor was seen in one patient whose duodenum was invaded by the tumor. Conclusions Colloid carcinomas of the pancreas appear as round or labular masses with great percent of cystic areas and slight hyp-attenuation on unenhanced CT and peripheral and internal meshlike progressive delayed enhancement on enhanced CT.展开更多
目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510...目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510例患者,将其分为训练集和验证集,并根据训练集的临床变量构建预后模型,以预测CC患者在1、3、5年的癌症特异性生存率的概率值,而后用验证集验证训练集筛选出的变量及校准预测模型。结果:利用SEER数据库筛选CC患者预后的影响因素,包括肿瘤分级、检出淋巴结数量、是否手术、T分期、是否转移,并根据以上影响因素构建了临床预后模型。受试者特征曲线及曲线下面积值表明本预测模型具有较高的准确性。校正曲线显示模型预测的生存率与实际生存率相近。结论:本研究构建出CC患者的临床预后模型,并利用此模型对患者的生存预后进行了有效评估,填补了这种罕见肿瘤预后研究的空白,为临床医生评估CC患者预后提供了一项有力依据。展开更多
目的建立快速用于筛查膀胱移行细胞癌(transitional cell carcinoma of bladder,TCC)的尿液细胞角蛋白20(CK20)单克隆抗体胶体金检测试条的方法。方法自行研制CK20单克隆抗体,建立CK20单克隆抗体胶体金试条,对膀胱移行细胞癌、泌尿系统...目的建立快速用于筛查膀胱移行细胞癌(transitional cell carcinoma of bladder,TCC)的尿液细胞角蛋白20(CK20)单克隆抗体胶体金检测试条的方法。方法自行研制CK20单克隆抗体,建立CK20单克隆抗体胶体金试条,对膀胱移行细胞癌、泌尿系统良性疾病和健康人尿液进行检测。结果成功获得一株稳定分泌抗CK20单克隆抗体的杂交瘤细胞,其腹水抗体和纯化的抗体效价均为1∶106,Western-blotting显示得到纯化CK20单克隆抗体。CK20试条检测结果:50例膀胱移行细胞癌患者尿样检出阳性率为78%(39/50),特异性为87%。20例泌尿系统良性疾病患者血尿检测的阳性率是25%(5/20),20例健康人尿液检测均阴性。肿瘤组与对照组敏感性之间差异具有统计学意义(P<0.005)。结论CK20试条法具有特异性好、敏感性高、操作简单、快速和一般实验室可开展的特点,可作为膀胱移行细胞癌快速筛查和疗效观察的一种新方法。展开更多
Background The value of artificial colloids in treating patients with liver disease is controversial. The effects of intravascular volume replacement regimens on liver function secondary to alteration of the postopera...Background The value of artificial colloids in treating patients with liver disease is controversial. The effects of intravascular volume replacement regimens on liver function secondary to alteration of the postoperative inflammatory response are not known. In this study, we evaluated the effects of different volume replacement regimens in hepatocellular carcinoma patients undergoing hepatectomy to clarify whether albumin administration can be replaced by other volume replacement products.Methods Ninety consecutive hepatocellular carcinoma patients scheduled for hepatectomy were prospectively randomized to receive 20% human albumin （HA）, 6% hydroxyethyl starch （HES） or lactated Ringer＇s solution （LR） for postoperative volume replacement. Hemodynamic, liver function and inflammatory response parameters were recorded on postoperative days one, three, and five throughout the investigation period.Results Significantly less volume was required in the HA and the HES groups. Although patients in all groups had similar baseline values, the plasma osmolality was significantly higher in the HA and HES groups. Total bilirubin （TB）, alanine aminotransferase （ALT）, and aspartate aminotransferase （AST） increased from baseline in all groups, and did not differ significantly between groups. C-reactive protein （CRP） was significantly lower in the HES group compared with the other groups.Conclusions In hepatocellular carcinoma patients undergoing hepatectomy, HA can be replaced by HES or LR in well selected patients. Hemodynamic stability, liver function, and postoperative clinical outcomes could be equivalently achieved in the HES group; also, HES may exert more favorable effects on the acute phase response. （Registered in the Chinese Clinical Trial Registry, ChiCTR-TRC-10000790）展开更多
胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白...胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白表达及与生物学行为的关系，并将结果报告如下。展开更多
文摘Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very limited. This study aimed to investigate the CT features of this tumor. Methods Institutional review board approval was obtained for this study. Seven patients with pathologically proven colloid carcinoma of the pancreas were included. Unenhanced and dynamic enhanced CT was performed in all the patients. CT features were analyzed retrospectively and correlations with pathological findings were evaluated. Results Mean age of the patients was 59.8 years （41-76 years）. Five tumors were located in the pancreatic head, and the other two in body and tail respectively. The maximum mean diameter of the tumors on axial scanning was 3.9 cm （3.0-6.7 cm）. Tumors were round （n=-5） and Iobular （n=2）. Tumors appeared slight hyp-attenuation on unenhanced CT, and peripheral and internal meshlike progressive delayed enhancement with great percent of cystic areas on enhanced CT. Calcification and gas in the tumor was seen in one patient whose duodenum was invaded by the tumor. Conclusions Colloid carcinomas of the pancreas appear as round or labular masses with great percent of cystic areas and slight hyp-attenuation on unenhanced CT and peripheral and internal meshlike progressive delayed enhancement on enhanced CT.
文摘目的:明确影响胰腺胶样癌(colloid carcinoma,CC)患者预后的危险因素,构建临床预后模型,对患者生存预后进行评估。方法:选取美国国家癌症研究所监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库中510例患者,将其分为训练集和验证集,并根据训练集的临床变量构建预后模型,以预测CC患者在1、3、5年的癌症特异性生存率的概率值,而后用验证集验证训练集筛选出的变量及校准预测模型。结果:利用SEER数据库筛选CC患者预后的影响因素,包括肿瘤分级、检出淋巴结数量、是否手术、T分期、是否转移,并根据以上影响因素构建了临床预后模型。受试者特征曲线及曲线下面积值表明本预测模型具有较高的准确性。校正曲线显示模型预测的生存率与实际生存率相近。结论:本研究构建出CC患者的临床预后模型,并利用此模型对患者的生存预后进行了有效评估,填补了这种罕见肿瘤预后研究的空白,为临床医生评估CC患者预后提供了一项有力依据。
文摘目的建立快速用于筛查膀胱移行细胞癌(transitional cell carcinoma of bladder,TCC)的尿液细胞角蛋白20(CK20)单克隆抗体胶体金检测试条的方法。方法自行研制CK20单克隆抗体,建立CK20单克隆抗体胶体金试条,对膀胱移行细胞癌、泌尿系统良性疾病和健康人尿液进行检测。结果成功获得一株稳定分泌抗CK20单克隆抗体的杂交瘤细胞,其腹水抗体和纯化的抗体效价均为1∶106,Western-blotting显示得到纯化CK20单克隆抗体。CK20试条检测结果:50例膀胱移行细胞癌患者尿样检出阳性率为78%(39/50),特异性为87%。20例泌尿系统良性疾病患者血尿检测的阳性率是25%(5/20),20例健康人尿液检测均阴性。肿瘤组与对照组敏感性之间差异具有统计学意义(P<0.005)。结论CK20试条法具有特异性好、敏感性高、操作简单、快速和一般实验室可开展的特点,可作为膀胱移行细胞癌快速筛查和疗效观察的一种新方法。
文摘Background The value of artificial colloids in treating patients with liver disease is controversial. The effects of intravascular volume replacement regimens on liver function secondary to alteration of the postoperative inflammatory response are not known. In this study, we evaluated the effects of different volume replacement regimens in hepatocellular carcinoma patients undergoing hepatectomy to clarify whether albumin administration can be replaced by other volume replacement products.Methods Ninety consecutive hepatocellular carcinoma patients scheduled for hepatectomy were prospectively randomized to receive 20% human albumin （HA）, 6% hydroxyethyl starch （HES） or lactated Ringer＇s solution （LR） for postoperative volume replacement. Hemodynamic, liver function and inflammatory response parameters were recorded on postoperative days one, three, and five throughout the investigation period.Results Significantly less volume was required in the HA and the HES groups. Although patients in all groups had similar baseline values, the plasma osmolality was significantly higher in the HA and HES groups. Total bilirubin （TB）, alanine aminotransferase （ALT）, and aspartate aminotransferase （AST） increased from baseline in all groups, and did not differ significantly between groups. C-reactive protein （CRP） was significantly lower in the HES group compared with the other groups.Conclusions In hepatocellular carcinoma patients undergoing hepatectomy, HA can be replaced by HES or LR in well selected patients. Hemodynamic stability, liver function, and postoperative clinical outcomes could be equivalently achieved in the HES group; also, HES may exert more favorable effects on the acute phase response. （Registered in the Chinese Clinical Trial Registry, ChiCTR-TRC-10000790）
文摘胰腺胶样癌（colloid carcinoma of the pancreas，CC）又称为胰腺黏液性非囊性癌，是指基质内黏液池中漂浮着散在成束、成条或单个肿瘤细胞，其中黏液区域占50％以上。CC是一种独特的浸润性肿瘤，我们初步探讨其病理学形态、相关蛋白表达及与生物学行为的关系，并将结果报告如下。
