In vivo label-free measurement of blood flow velocity symmetry based on dual line scanning third-harmonic generation microscopy excited at the 1700 nm window

Measurement of bloodflow velocity is key to understanding physiology and pathology in vivo.While most measurements are performed at the middle of the blood vessel,little research has been done on characterizing the instantaneous bloodflow velocity distribution.This is mainly due to the lack of measurement technology with high spatial and temporal resolution.Here,we tackle this problem with our recently developed dual-wavelength line-scan third-harmonic generation(THG)imaging technology.Simultaneous acquisition of dual-wavelength THG line-scanning signals enables measurement of bloodflow velocities at two radially symmetric positions in both venules and arterioles in mouse brain in vivo.Our results clearly show that the instantaneous bloodflow velocity is not symmetric under general conditions.

Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow

Objective To investigate the role of sea-level cerebral blood flow(CBF)in predicting acute mountain sickness(AMS)using three-dimensional pseudo-continuous arterial spin labeling(3D-pCASL).Methods Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging(MRI)including 3D-pCASL at sea level.The CBF values of the bilateral anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA),and posterior inferior cerebellar artery(PICA)territories and the laterality index(LI)of CBF were compared between the AMS and non-AMS groups.Statistical analyses were performed to determine the relationship between CBF and AMS,and the predictive performance was assessed using receiver operating characteristic(ROC)curves.Results The mean cortical CBF in women(81.65±2.69 mL/100 g/min)was higher than that in men(74.35±2.12 mL/100 g/min)(P<0.05).In men,the cortical CBF values in the bilateral ACA,PCA,PICA,and right MCA were higher in patients with AMS than in those without.Cortical CBF in the right PCA best predicted AMS(AUC=0.818).In women,the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of 0.753.Conclusion Although the mechanism and prediction of AMS are quite complicated,higher cortical CBF at sea level,especially the CBF of the posterior circulatory system,may be used for prediction in male volunteers using non-invasive 3D-pCASL.

Measurements Of Cerebral Blood Flow in Postasphyxiated Newborns by Color Doppler Imaging（CDI）

Cerebral blood flow of 10 asphyxiated term newborns was continuously measured during the first 7 days of life and compared with that of 10 normal term infants by CDI. Frequency spectrum and blood flow variables in the anterior, middle and posterior cerebral arteries were studied. The results showed evidently lower systolic amplitude in patients than that in normal subjects. End diastolic amplitude was zero in part of vessels, and values of bloed flow variables were all lower in day 1 of the life as compared with the control groups. Frequency spectrum recovered to normal patterns in 9 survived infants in day 2. but blood flow variables recovered to normal by day 7. Values of resistance index (RI) rose to 1 in some vessels of moderate hypoxic ischemic encephalopathy (HIE) infants and stayed at 1 in the severe HIE infants. It is concluded that low CBF plays a key role in brain damage of post-asphyxiated newborns and RI may be an important parameter in the evaluation prognosis.

A New Method for Evaluating Regional Cerebral Blood Flow Changes:Laser Speckle Contrast Imaging in a C57BL/6J Mouse Model of Photothrombotic Ischemia

The present study aimed to improve the processing of data acquired from laser speckle contrast imaging（LSCI） to provide a standardization method to explore changes in regional cerebral blood flow（r CBF） and to determine the correlations among r CBF, cerebral ischemic lesion volume and microvascular density over time in a focal ischemic region. C57BL/6J mice were subjected to focal photothrombotic（PT） ischemia. r CBF was measured using LSCI at different time points before and after PT ischemia through an intact skull. Standardized r CBF（Sr CBF）, defined as the ratio of r CBF measured in the ipsilateral region of interest（ROI） to that in the corresponding contralateral region, was calculated to evaluate potential changes. In addition, the volume of the ischemic lesion and the microvascular density were determined using Nissl staining and immunofluorescence, respectively. The relationships among the ischemic lesion volume, microvascular density and Sr CBF were analyzed over time. The results showed that the cortical r CBF measured using LSCI following PT ischemia in the C57BL/6J mice gradually increased. Changes in the cerebral ischemic lesion volume were negatively correlated with Sr CBF in the ischemic region. Changes in the microvascular density were similar to those observed in Sr CBF. Our findings indicate that LSCI is a practical technique for observing changes in murine cortical r CBF without skull opening and for analyzing the relationships among the ischemic lesion volume, microvascular density and Sr CBF following focal cerebral ischemia. Preliminary results also suggest that the use of LSCI to observe the formation of collateral circulation is feasible.

微血管血流联合LumiFlow成像技术获取早中孕期胎儿心脏标准切面中的应用

目的探讨微血管血流(MV-Flow)联合LumiFlow成像技术在获取11~17^(+6)周胎儿心脏标准切面中的应用价值。资料与方法回顾性收集2022年7月-2023年8月在解放军总医院第一医学中心接受胎儿超声心动图检查的正常早中孕期孕妇63例,行胎儿超声心动图彩色多普勒血流显像(CDFI)及MV-Flow联合LumiFlow检查,分别获取国际妇产科超声学会推荐的8个诊断切面,对不同模式下各标准切面图的血流要素进行评分,比较CDFI及MV-Flow联合LumiFlow在各诊断切面的显示成功率及评分。结果63例孕妇共进行66次胎儿超声心动图检查,MV-Flow联合LumiFlow在上腹横切面、四腔心切面、主动脉弓切面显示成功率分别为98.48%、98.48%、96.97%,高于CDFI(χ^(2)=5.143、8.100、6.125,P<0.05),在三血管气管切面和左心室流出道切面显示成功率分别为39.40%和43.94%,显著低于CDFI(χ^(2)=13.885、7.579,P<0.05)。MV-Flow联合LumiFlow及CDFI两者在动脉导管弓切面、上下腔静脉长轴切面及所有切面总体评分差异无统计学意义(Z/t=-1.56、-1.77、-0.41,P>0.05);在上腹横切面、四腔心切面及主弓脉弓切面,MV-Flow联合LumiFlow评分显著高于传统CDFI(t=-5.14、-6.08、-6.63,P<0.001),左、右心室流出道切面及三血管气管切面CDFI评分显著高于MV-Flow联合LumiFlow(Z=-4.00、-2.93、-4.61,P<0.05)。结论MV-Flow联合LumiFlow在上腹横切面、四腔心切面与主弓脉弓切面的显示较CDFI更具优势,可以作为早期胎心筛查中血流显像技术的有效补充。

超声B-Flow联合外周血NLR、CRP对颈动脉粥样硬化斑块易损性的诊断效能研究

目的探讨超声二维灰阶血流显像技术(B-Flow)联合外周血中性粒细胞与淋巴细胞比值(NLR)、C反应蛋白(CRP)诊断颈动脉粥样硬化(CAS)斑块易损性的价值。方法纳入2019年2月至2022年8月在天津市永久医院诊查的152例CAS患者为研究对象,均利用颈动脉斑块超声B-Flow和数字减影血管造影(DSA)检查斑块性质,并检测外周血NLR、CRP水平,以DSA结果为“金标准”,将患者分为易损斑块组和稳定斑块组,统计超声B-Flow检查结果,比较两组外周血NLR、CRP水平,分析超声B-Flow、外周血NLR、CRP水平三者单独及联合诊断CAS斑块易损性的价值。结果DSA检查结果显示,152例CAS患者检出66例易损斑块,86例为稳定斑块;超声B-Flow检查出72例易损斑块,80例稳定斑块,以DSA检查结果作为“金标准”,超声B-Flow诊断易损斑块的灵敏度、特异度、准确度分别为84.85%、81.39%、82.89%;易损斑块组外周血NLR、CRP水平均高于稳定斑块组(P<0.05);超声B-Flow联合外周血NLR、CRP水平诊断CAS易损性斑块的灵敏度、特异度、曲线下面积(AUC)分别为98.48、81.39%、0.907,联合诊断的灵敏度高于单独诊断,AUC高于单独诊断(P<0.05),特异度与单独诊断相近。结论超声B-Flow、外周血NLR、CRP均对CAS斑块易损性具有一定的诊断效能,但三者联合诊断效能更好。

A Hybrid De-Noising Method on LASCA Images of Blood Vessels

A de-noising approach is proposed that based on the combination of wiener filtering, nonlinear filtering and wavelet fusion, which de-noise the LASCA (LAser Speckle Contrast Analysis) image of blood vessels in Small Animals. The approach first performs laser spectral contrast analysis on brain blood flow in rats, get their spatial and temporal contrast images. Then, a de-noising filtering method is proposed to deal with noise in LASCA. The image restoration is achieved by applying the proposed admixture filtering, and the subjective estimation and objective estimation are given to the de-noising images. As our experimental results shown, the proposed method provides clearer subjective sense and improved to over 25 db for PSNR.

经阴道超声结合MV-Flow成像技术在育龄期女性排卵期子宫内膜超声特点分析中的作用

目的探讨经阴道超声结合微血管血流(MV-Flow)成像技术在育龄期女性排卵期子宫内膜超声特点分析中的应用价值。方法选取2022年5-7月在解放军总医院第一医学中心超声诊断科行经阴道妇科超声检查的74例育龄期女性,年龄22~48(34.4±5.0)岁,其中≥35岁的高龄组女性35例,<35岁的低龄组女性39例。根据是否临床诊断为不孕分为不孕组(n=27)与健康对照组(n=47)。于患者排卵日利用经阴道超声测量子宫内膜的厚度、蠕动性评分及容积,子宫螺旋动脉的搏动指数(PI)和阻力指数(RI),双侧子宫动脉的PI和RI,三维能量多普勒血流参数[血流指数(FI)、血管化指数(VI)、血管化血流指数(VFI)]及内膜微血流血管化指数(VIMV)并进行组间比较。结果低龄组与高龄组的不孕病史差异无统计学意义(P=0.281)。低龄组子宫螺旋动脉RI低于高龄组(P<0.05),而内膜三维能量多普勒血流参数(VI、FI、VFI)及内膜VIMV均明显高于高龄组(P<0.05)。不孕组与健康对照组年龄分层差异无统计学意义(P=0.281)。不孕组子宫内膜的厚度、蠕动性评分、容积、三维能量多普勒血流参数(VI、FI、VFI)及VIMV均明显低于健康对照组(P<0.05)。结论经阴道超声检查可在一定程度上评估育龄期女性排卵期子宫内膜的特点,尤其VIMV可定量分析子宫内膜的微血流灌注情况。

Arterial pulse impact on blood flow

Numerous pathophysiologic observations in humans and animals led to the formulation of the response-to-injury hypothesis of atherosclerosis, which proposed that endothelial denu- dation by the blood flow was the first step in atherosclerosis. At present it is impossible to describe hemodynamics only by the Navier-Stokes or Oldroyd-B equations because in the large arteries blood flow is unsteady, with the flow separation and waveform propagation of the thyxotropic mass. The purpose of this paper is to study the impact of the arterial pulse wave on the blood flow and initial factors of atherosclerosis. In 12 healthy men (25-39 years of age) peak velocity, mean velocity, mean flow and net flow in the aorta have been investigated by МR angiography. Initial velocity was registered after 43msec of the ECG-R wave, and it differed from zero at all sites of the aorta, although net flow was equal to zero. Womersley’s number from the ascending to the thoracic aorta decreased from 12.5 &#177;1.5 to 7.3 &#177;1.2;flow modified from inertio-elastic to viscous. In the aortic arch in protodiastole blood flow separated into the opposite directed streams resulting in wave superposition with the high net flow. At the isthmus area separated waves interferences and reflects to anterograde direction. Here flow acceleration in protodiastole is 6 times higher than in systole. Pulse waves move on artery walls fifteen or more times more rapidly than the blood flow. Pulse oscillation increases strain rate to the contiguous vessel wall flow layers. At the sites with the flow wave negative interference vessel pulse oscillation attenuates and at the boundary reflection flow wave can shift the vessel wall.

APPLICATION OF DOPPLER OPTICAL COHERENCE TOMOGRAPHY IN RHEOLOGICAL STUDIES:BLOOD FLOW AND VESSELS MECHANICAL PROPERTIES EVALUATION

Doppler Optical Coherence Tomography(DOCT)is a noninvasive optical diagnostic technique,which is well suited for the quantitative mapping of microflow velocity profiles and the analysis of flow-vessel interactions.The noninvasive imaging and quantitative analysis of blood flow in the complex-structured vascular bed is required in many biomedical applications,including those where the determination of mechanical properties of vessels or the knowledge of the mechanic interactions between the flow and the housing medium plays a key role.The change of microvessel wall elasticity could be a potential indicator of cardiovascular disease at the very early stage,whilst monitoring the blood flow dynamics and associated temporal and spatial variations in vessel’s wall shear stress could help predicting the possible rupture of atherosclerotic plaques.The results of feasibility studies of application of DOCT for the evaluation of mechanical properties of elastic vessel model are presented.The technique has also been applied for imaging of sub-cranial rat blood flow in vivo.

Four-dimensional flow magnetic resonance imaging incirrhosis

Since its introduction in the 1970’s,magnetic resonance imaging(MRI)has become a standard imaging modality.With its broad and standardized application,it is firmly established in the clinical routine and an essential element in cardiovascular and abdominal imaging.In addition to sonography and computer tomography,MRI is a valuable tool for diagnosing cardiovascular and abdominal diseases,for determining disease severity,and for assessing therapeutic success.MRI techniques have improved over the last few decades,revealing not just morphologic information,but functional information about perfusion,diffusion and hemodynamics as well.Four-dimensional(4D)flow MRI,a time-resolved phase contrast-MRI with three-dimensional(3D)anatomic coverage and velocity encoding along all three flow directions has been used to comprehensively assess complex cardiovascular hemodynamics in multiple regions of the body.The technique enables visualization of 3D blood flow patterns and retrospective quantification of blood flow parameters in a region of interest.Over the last few years,4D flow MRI has been increasingly performed in the abdominal region.By applying different acceleration techniques,taking 4D flow MRI measurements has dropped to a reasonable scanning time of 8 to 12 min.These new developments have encouraged a growing number of patient studies in the literature validating the technique’s potential for enhanced evaluation of blood flow parameters within the liver’s complex vascular system.The purpose of this review article is to broaden our understanding of 4D flow MRI for the assessment of liver hemodynamics by providing insights into acquisition,data analysis,visualization and quantification.Furthermore,in this article we highlight its development,focussing on the clinical application of the technique.

Optimal velocity encoding during measurement of cerebral blood flow volume using phase-contrast magnetic resonance angiography

This study investigated the effect of velocity encoding on measurement of brain blood flow and blood volume of inflow and outflow using phase-contrast magnetic resonance angiography. A single two-dimensional phase-contrast magnetic resonance angiography slice was applied perpendicular to the internal carotid artery and the vertebral artery at C2 level. For each subject, the velocity encoding was set from 30 to 90 cm/s with an interval of 10 cm/s for a total of seven settings. Various velocity encodings greatly affected blood flow volume, maximal blood flow velocity and mean blood flow velocity in the internal carotid artery, but did not significantly affect vertebral arteries and jugular veins. When velocity encoding was 60-80 cm/s, the inflow blood volume was 655 _＋ 118 mL/min, and the outflow volume was 506 _＋ 186 mL/min. The ratio of outflow/inflow was steady at 0.78-0.83, and there was no aliasing in any of the images. These findings suggest that velocity encodings of 60 80 cm/s should be selected during measurement of cerebral blood flow volume using phase-contrast magnetic resonance angiography.

One-Hour Contact with the Earth’s Surface (Grounding) Improves Inflammation and Blood Flow—A Randomized, Double-Blind, Pilot Study

Earthing (grounding) refers to the human body being in contact with the surface of the Earth by barefoot exposure outdoors or using special indoor systems connected to the Earth. Previous studies have showed multiple beneficial effects as a result of such contact, including better sleep, normalization of cortisol, reduced inflammation, pain and stress, and better blood flow. To determine if Earthing for one hour improves facial blood circulation, forty middle-aged volunteers were divided into a grounded group and a sham-grounded group according to a double-blind procedure. They were asked to sit in a comfortable recliner chair equipped with a grounding mat, pillow and patches. The grounding systems were either grounded or sham-grounded via a wire to the ground port of a power outlet. An infrared imaging camera was used to measure changes in blood flow and temperature. Thermal imaging showed clearly improved circulation of fluids (including blood) throughout the torso, which in turn, translates into enhanced delivery of blood to the head and improved blood circulation in the face as well. The results of this innovative study demonstrate that even one-hour contact with the Earth appears to promote significantly autonomic nervous system control of body fluids and peripheral blood flow that may improve blood circulation in the torso and face, facial tissue repair, skin health and vitality and optimize facial appearance (face anterior view p = 0.002;face lateral views p = 0.017;full anterior torso view p = 0.002). Further study using larger comparison groups and following subjects for a longer period of time (longitudinal study) is warranted.

Characterization of cerebral blood flow dynamics with multiscale entropy

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral vessels.We discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group distinctions.We also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound exposure.We show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

Grounding the Human Body Improves Facial Blood Flow Regulation: Results of a Randomized, Placebo Controlled Pilot Study

Earthing (grounding) refers to bringing the human body in direct contact with the negative electric charge of the earth’s surface by barefoot exposure outdoors or using special conductive indoor systems that are connected to the Earth. To determine if earthing improves facial blood circulation/flow, a double-blind study was designed with forty subjects either grounded or sham-grounded (27 grounded subjects and 13 sham-grounded subjects acting as controls) for at least one hour in a comfortable recliner chair equipped with conductive mat, pillow, and patches. The grounding systems were either grounded or sham-grounded via a wire to the ground port (third hole) of a power outlet. A Laser Speckle Contrast Imaging camera was used to continuously record changes in facial blood flow non-invasively. Facial blood flow regulation clearly improved among grounded— but not sham-grounded—subjects. The results demonstrate, for the first time, that even one-hour contact with the earth restores blood flow regulation to the face suggesting enhanced skin tissue repair and improved facial appearance with possible implications for overall health. Further studies, using larger comparison groups, longer monitoring times, and more measuring methods, are warranted in order to confirm the novel influence of the Earth as a protector of skin health and appearance.

OCULAR BLOOD FLOW EVALUATION (POBF AND GDI) IN INJURED AND HEALTHY FELLOW EYES

Purpose: To assess if injured eyes develop ocular blood flow disturbances that may contribute to development of traumatic glaucoma. Materials and Methods: 25 patients hospitalized for eye injury and elevated IOP were evaluated 24 months after the trauma. All injured and fellow eyes underwent IOP measure, visual field (HFAII, Central 30/2SITA), pulsatile ocular blood flow analysis (POBF, OBF Labs UK), CDI examination (PSV, EDV, and RI) of Ophthalmic Artery, Central Retinal Artery, Short Posterior Ciliary Arteries. Results: IOP was significantly higher in injured eyes (15.1 vs 13.0±2.7mmHg) (P= 0,01), but only 2 eyes (8.8%) were under medical treatment POBF values were significantly lower in injured eyes: 11,25 μl/s in traumatised eyes and 15,40 μl/s in fellow eyes (P = 0.002). Resistivity Index (RI) of all investigated retrobulbar vessels was very significantly higher in injured eyes than in fellow eyes (P= 0.0001). There is no significant correlation between IOP and ocular blood flow disturbances.

二维超声联合微血管血流成像对睾丸结核的诊断价值

目的:探讨二维超声联合微血管血流成像(MV-flow)对睾丸结核的诊断价值。方法:选择2023年1月至12月在郑州大学第一附属医院因阴囊疼痛、坠胀,或伴有阴囊肿块就诊,疑似睾丸结核的91例患者为研究对象。均行二维超声检查、彩色多普勒血流显像(CDFI)和MV-flow。以病理结果为金标准,比较二维超声联合MV-flow及二维超声联合CDFI诊断睾丸结核的效能,同时计算血流像素占比。另外选取20例疑似睾丸结核患者,通过MV-flow获取血管指数(VI),采用同类相关系数(ICC)评估MV-flow检测结果的一致性。结果:91例患者中共有80例病理确诊为睾丸结核。二维超声联合MV-flow诊断睾丸结核的敏感度、特异度、准确度分别为96.3%、54.6%和91.2%,高于二维超声联合CDFI(87.5%、18.2%、79.1%)。MV-flow睾丸内血流像素占比高于CDFI[(2.13±0.81)%vs(1.86±0.70)%,P=0.360]。VI在观察者内和观察者间的一致性良好[ICC(95%CI)分别为0.874(0.683~0.950)、0.945(0.860~0.978)]。结论:相比二维超声联合CDFI,二维超声联合MV-flow对睾丸结核的诊断效能更高。

超微血流成像在新生儿室管膜下疾病的应用

目的探讨超微血流成像技术对新生儿颅脑室管膜下疾病(出血及囊肿)的诊断价值。方法应用超声检查新生儿颅脑,将尾状核头部和丘脑交界处室管膜下出现强回声团或囊性回声标记为阳性指标,将患儿分为三组:正常组、强回声组和囊肿组,分别应用超微血流成像技术观测新生儿尾状核头部和丘脑交界处室管膜区的血流情况,并对病变组(强回声组和囊肿组)进行动态观察以明确诊断并随访。结果观察正常组30例患儿,室管膜下围绕脑室可见星点状及带状血流信号,血流信号丰富程度随侧脑室及脉络丛强回声增多而增丰;强回声组18例,其强回声与脉络丛回声相似,16例(16/18)超微血流成像显示此区域可以见丰富血流信号,其血流信号与脉络丛显示相似,并且其血流在室管膜下与远端脉络丛相连,其中2例(2/18)强回声内部未探及血流信号,后期随访转为囊状回声;囊肿组11例,室管膜下囊肿周边可见丰富血流信号,囊肿周边随强回声团增加其血流显示更丰富,8例(8/17)囊肿内可见血流信号。结论超微血流成像可明确室管膜下区早期病变性质,可以动态观测疾病进展及推测预后,为临床提供更全面的诊断信息,或许此技术的应用将成为室管膜下出血诊断的金标准。

超声微血流成像技术对C-TIRADS 4类甲状腺实性结节的诊断价值

目的:分析超声微血流成像技术(SMI)对C-TIRADS 4类甲状腺实性结节的诊断价值。方法:选取99例C-TIRADS 4类甲状腺实性结节患者为研究对象,患者行常规超声、彩色多普勒血流成像(CDFI)及SMI检查,分析结节的血流Alder分级情况及血流分布特征;以病理结果为对照,评价SMI对甲状腺C-TIRADS 4类甲状腺实性结节良恶性的鉴别诊断价值。结果:恶性组年龄低于良性组(P<0.05);C-TIRADS分类为4A、AB、4C类结节的恶性率分别为22.73%、55.17%、81.25%;良性结节的Adler血流等级以0~1级为主,恶性结节以3级为主;与CDFI相比,SMI对恶性结节的Adler分级0级~1级、2级血流的显示率更低,3级血流的显示率更高(P<0.05)。CDFI显示良性结节血流分型以Ⅰ型~Ⅱ型为主,恶性结节则以Ⅲ型为主;SMI显示良性结节血流分型以Ⅲ型为主,恶性结节以Ⅳ型为主。与CDFI相比,SMI对恶性结节Ⅲ型血流分布显示率更低,对Ⅳ型血流分型的显示率更高(P<0.05)。CDFI、SMI对恶性甲状腺C-TIRADS 4类实性结节均有较好的诊断效能,其ROC曲线下面积(AUC)分别为0.664、0.688,但二者之间诊断效能无统计学差异(Z=0.346,P=0.729)。结论:与CDFI相比,SMI对甲状腺C-TIRADS 4类实性结节血流分布及血流特征的显示更敏感,可用于临床辅助鉴别诊断甲状腺结节的性质。

经阴道彩色多普勒超声在子宫内膜病变患者中的应用价值

目的分析经阴道彩色多普勒超声在子宫内膜病变患者中的应用价值。方法选取2021年2月至2022年4月南昌大学第四附属医院收治的88例子宫内膜病变患者作为研究对象,所有患者均接受经阴道彩色多普勒超声及病理学检查,按照病理学检查结果将患者分为息肉组与癌变组,每组44例。比较两组二维超声子宫内膜情况、病灶血流动力学情况、经阴道彩色多普勒超声血流相关参数;以病理学检查结果为金标准,分析经阴道彩色多普勒超声对子宫内膜癌变的诊断效能。结果癌变组子宫内膜厚度厚于息肉组,内膜-肌层分界清晰、病灶回声均匀占比均低于息肉组,差异有统计学意义(P<0.05);癌变组血流丰富占比高于息肉组,差异有统计学意义(P<0.05);癌变组血流阻力指数(RI)、搏动指数(PI)均低于息肉组,时间平均峰值流速(TAP)慢于息肉组,差异有统计学意义(P<0.05);经阴道彩色多普勒超声对子宫内膜癌变的诊断灵敏度为86.36%,特异度为84.09%,准确度为85.23%;诊断息肉的灵敏度为84.09%,特异度为86.36%,准确度为85.23%。结论经阴道彩色多普勒超声对子宫内膜病变的诊断准确率较高,能通过血流动力学、RI、PI、TAP及影像学表现鉴别息肉或癌变。