Based on network pharmacology and molecular docking technology to explore the mechanism of Panax notoginseng in the treatment of membranous nephropathy

Objective:Based on network pharmacology and molecular docking technology to explore the mechanism of Professor Cao Enze's application of Panax notoginseng in the treatment of membranous nephropathy.Methods:TCMSP database was used to obtain the effective components and corresponding target information of Panax notoginseng,and Gene Cards database was used to obtain the disease target genes of membranous nephropathy.The intersection targets of the two were taken and the Venn diagram was drawn.The STRING database was used to obtain the protein interaction relationship,and the PPI network diagram was constructed by Cytoscape 3.9.1 software to screen out the core targets of Panax notoginseng in the treatment of membranous nephropathy.GO function and KEGG pathway enrichment analysis were performed using the David database to obtain the potential pathway of Panax notoginseng in the treatment of membranous nephropathy.Finally,Autodock software was used to verify the molecular docking of the main active components of the drug with the core targets.Results:A total of 7 effective components such as quercetin,ginsenoside rh2,Mandenol and Stigmasterol were retrieved,and 127 potential targets of Panax notoginseng in the treatment of membranous nephropathy were screened out.By PPI network topology analysis,23 core targets such as JUN,TP53,RELA,AKT1 and MAPK1 were screened out.GO functional enrichment analysis contained 703 biological processes,55 cell components and 121 molecular functions,and KEGG signal pathway enrichment analysis enriched 171 signal pathways.The results of molecular docking showed that there was a strong binding ability between the main core targets and the main components of Panax notoginseng.Conclusion:Through network pharmacology,it is concluded that Panax notoginseng treats membranous nephropathy through multiple targets and multiple pathways,which provides a theoretical basis for subsequent basic research.

The Principal Component Analysis on Yielding and Agronomic Traits of Hybrid Rice of Liangyou 2111

In order to define the relationship between yield and important agronomic traits of two lines hybrid Uangyou 2111, the principal component analysis method was used to analyze the expadmental data of six test points in Yunnan Province. The results showed that the main factors influencing the production of Liangyou 2111 were grain number, grains seed number, panicle length, growth padod and panicle rate; then were 1 O00-grain weight, seed setting rate, effective panicle and highest stem tillers number; again was plant height. Therefore, when hybrid rice of Uangyou 2111 will be planted widely in yunnan province, we should focus on en- sudng the panicle traits, especially increase grain number and grain seed number, and coordinately develop other traits to achieve high yield.

New pattern recognition system in the e-nose for Chinese spirit identification

This paper presents a new pattern recognition system for Chinese spirit identification by using the polymer quartz piezoelectric crystal sensor based e-nose. The sensors are designed based on quartz crystal microbalance（QCM） principle,and they could capture different vibration frequency signal values for Chinese spirit identification. For each sensor in an8-channel sensor array, seven characteristic values of the original vibration frequency signal values, i.e., average value（A）,root-mean-square value（RMS）, shape factor value（S_f）, crest factor value（C_f）, impulse factor value（I_f）, clearance factor value（CL_f）, kurtosis factor value（K_v） are first extracted. Then the dimension of the characteristic values is reduced by the principle components analysis（PCA） method. Finally the back propagation（BP） neutral network algorithm is used to recognize Chinese spirits. The experimental results show that the recognition rate of six kinds of Chinese spirits is 93.33% and our proposed new pattern recognition system can identify Chinese spirits effectively.

Constrained regularization for noninvasive glucose sensing using Raman spectroscopy

Multivariate calibration is an important tool for spectroscopic measurermnent of analyte con-centrations.We present a detailed study of a hybrid multivariate calibration technique,con-strained regularization(CR),and demonstrate its utility in noninvasive glucose sensing uasing Raman spectroscopy.Similar to partial least squares(PIS)and principal component regression(PCR),CR builds an implicit model and requires knowledge only of the concentrations of the analyte of interest.Calibration is treated as an inverse problem in which an optimal balance between model complexity and noise rejection is achieved.Prior information is included in the form of a spectroscopic constraint that can be obtained conveniently.When used with an appropriate constraint,CR provides a better calibration model compared to PLS in both numerical and experimental studies.

Effect of blank quenching on shear spinning forming precision of 2219 aluminum alloy complex thin-walled components

The quenching-spinning(Q-S)process,i.e.,shear spinning after blank quenching,has been increasingly utilized to form 2219 aluminum alloy complex thin-walled components.However,the changes in material property,shape and stress of the blanks after quenching will affect the spin-ning forming precision.In this study,the rules and mechanisms of these effects are investigated based on a combined finite element(FE)model including blank quenching and component spinning process.The results indicate that the increase of material strength and the existence of distortion of the quenched blank lead to a notable increase in the non-uniformity of the circumferential compres-sive stress in the spinning area and the increase of the flange swing height during spinning.These changes result in an increase in the wall thickness and component-mandrel gap of the components.The quenching residual stress has little effect on wall thickness and roundness but can noticeably reduce the component-mandrel gap.This is because that the existence of quenching residual stress of the blank can lead to the decrease of the maximum circumferential compressive stress of the workpiece in spinning and an obvious drop in the maximum compressive stress after reaching the stress peak.Quenching distortion is the main factor affecting the roundness.Moreover,the opti-mized installation way of the blank for spinning is obtained.

Three-Dimensional Conjugate Gradient Inversion of Magnetotelluric Impedance Tensor Data

We developed a three-dimensional（3D） conjugate gradient inversion algorithm for in-verting magnetotelluric impedance tensor measurements.In order to show the importance of including diagonal components of magnetotelluric impedance tensor in 3D inversion,synthetic data were inverted using the 3D conjugate gradient inversion,and the inversion results were compared and analyzed.The results from the 3D inversion of synthetic data indicate that both the off-diagonal and the diagonal components are required in inversions to obtain better inversion results when there are no enough data sites to recover the target resistivity structure.These examples show that lots of information about 3D structure is also contained in the diagonal components;as a result,diagonal components should be in-cluded in 3D inversions.The inversion algorithm was also used to invert the impedance tensor data ac-quired in the Kayabe area in Japan.Inversions with the synthetic and real data demonstrated the va-lidity and practicability of the inversion algorithm.