Treatment of 140 cerebral palsied children with a combined method based on traditional Chinese medicine(TCM)and western medicine

Objective: To observe and evaluate a method that is effective and practical for treatment of cerebral palsied (CP)children in China. Method: The patient's age and disease type and individual specific conditions were considered in choosing therapy methods accordingly: Chinese herbs, acupuncture, auricular seed pressure, point finger pressing, massage, orthopedic hand manipulation, physiotherapy, occupational therapy, language therapy, etc. Meanwhile we created a new CP treatment model that combines hospitalized treatment with family therapy. Results: The majority of CP patients improved greatly in motor and social adaptation capacities after treatment. Wilcoxon paired rank sum test analysis showed that there were significant differences between the data before and after treatment (P＜0.01). Conclusion: This combined therapy method, based on traditional Chinese medicine and western medicine plus family supplemental therapy, is an effective and practical treatment strategy for CP children in China.

meta-analysis of randomized controlled trials of combined treatment with DGSN and western medicine on diabetic peripheral neuropathy

背景:为了系统研究当归四逆汤联合西医治疗糖尿病周围神经病的临床疗效。方法:检索了包括CNKI、CBM、万方数据库、维普数据库、MEDLINE、PubMed、荷兰医学文摘在内的7个数据库。检索出2012年1月至今(近5年)当归四逆汤联合西医治疗糖尿病周围神经病随机对照试验的相关文献。采用RevMan5.3软件分析发表偏倚并对比当归四逆汤联合西医和单独西医治疗糖尿病周围神经病的临床疗效。结果:共纳入19篇随机对照研究,1690例患者。Meta分析结果显示与对照组相比当归四逆汤联合西医治疗糖尿病周围神经病有更好的总有效率,差异有统计学意义(P<0.05)。异质性检验分析显示均为同质(P=0.94>0.05)。当归四逆汤联合西医治疗的总有效率明显高于对照组(P<0.00001,OR=3.98,95%CI:3.01~5.27)。结论:与单独西医治疗相比,当归四逆汤联合西医治疗糖尿病周围神经病更有效。然而,由于受原始研究数量、质量的影响,该结论仍有待于临床大样本、高质量、多中心的随机双盲对照试验来证实。

Clinical Observation of Integrated Traditional Chinese and Western Medicine in the Treatment of Chronic Ulcerative Rectitis

Objective:To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis(UR).Methods:70 cases of chronic ulcerative rectitis were selected in all hospitals of our hospital for comparison.Observation and control were set up.The number of people was the same,but there were differences in methods.The control group retained enema,and the observation group was treated with traditional Chinese medicine.Rectal mucosa scores after different treatments were compared to evaluate the effect of intervention.Results:It was found that the observation group scored lower(P<0.05),and the effect was better.Conclusion:For the treatment of patients with chronic ulcerative rectitis,the combination of traditional Chinese and Western medicine will help to promote the prognosis of the disease,improve the problem of ulcer,promote the improvement of gastrointestinal function and bring a more positive impact.

Clinical Efficacy of Western Medicine Combined with Chinese Medicine for Pelvic Inflammatory Disease(Damp-Heat and Stasis Type)

Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.

Analysis of the Clinical Value of Baogan Lishui Decoction and Conventional Western Medicine in Treating Hepatitis B Cirrhosis Refractory Ascites

The objective of this study was to investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B(Hep B)cirrhosis-related refractory ascites.The control group was given conventional western medicine therapy while the observation group was given same conventional western medicine therapy with additional of Chinese medicine Baogan Lishui decoction.The total effective of clinical treatment on Hep B cirrhosis-related refractory ascites in observation group was higher than that of the control group which was 88.89%compared to 71.11%,respectively,and it was significant different(P<0.05).The combination treatment of Chinese medicine Baogan Lishui decoction and conventional western medicine can significantly increase the treatment effect on Hep B cirrhosis refractory ascites,and thus increases the quality and safety of life.

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Objective:Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine,and the final results were observed.Methods:70 patients with such symptoms were randomly divided into two groups.The number of people is the same,and the treatment methods are different.The control group uses western medicine,while the observation group uses traditional Chinese medicine to evaluate the treatment effect.Results:After treatment,the effective rate of the observation group was(P<0.05),indicating that the treatment effect was significantly better.Conclusion:Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair,and with Chinese medicine,the effect is more satisfactory,and the effect is positive,so as to promote the optimization of their health.

A Case Report on Treating Progressive Supranuclear Palsy with a Combination of Chinese and Western Medicine

A case of progressive supranuclear palsy in a 66-year-old woman is presented.The patient complained of“progressive stiffness of both lower limbs for five years,accompanied by choking and coughing for more than 1 year,”and was diagnosed with paralysis in traditional Chinese medicine(TCM),which was characterized by a deficiency of liver and kidney,and phlegm and blood stasis blocking the collaterals.Western medicine diagnosed it as progressive supranuclear palsy.The patient was diagnosed with“Parkinson’s disease”several times in the past and was given“polybasic hydrazide”and“amantadine hydrochloride tablets,”etc.The patient did not have significant symptomatic relief,so she sought further treatment with a combination of traditional Chinese and Western medicine.Based on the concept of deficiency and excess,this disease is categorized as a paralytic disease in Chinese medicine,and the onset of the disease is closely related to the deficiency of the body after a long period of illness,with wind,phlegm,blood stasis,and deficiency as the main pathogenetic mechanism.The treatment is based on the combination of disease and evidence,with traditional Chinese medicine and acupuncture as the main treatments,supplemented by intermediate-frequency pulsed electrical stimulation,transcranial repetitive magnetic stimulation,medicated canisters,wax therapy,traditional Chinese medicine guasha,and acupoint injections.Western medicine is based on symptomatic treatment,and the patient’s symptoms were relieved significantly after the combination of Chinese and Western medicine.

Combined Treatment of Advanced Primary Hepatocellular Carcinoma with Traditional Chinese Medicine and Western Medicine

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阿尔茨海默病不同治疗方式研究新进展

阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的、起病隐秘的、病因不明的、缺乏特异性诊断方式的神经退行性病变。面对与日俱增的患病率,却缺乏有效的治疗方式。中医药治疗方式具有多层次、多靶点、多通路的独特优势,中西医结合方式的互补,非药物疗法的辅助,干细胞疗法、新的分子药物、抗体及蛋白疫苗、γ感官刺激等新颖的实验阶段新疗法等方式治疗AD。本文综述近年来的不同治疗方式治疗AD研究新进展,旨在为临床上治疗AD提供新思路、新方法及参考价值。

外侧盘状半月板的中西医治疗新进展

盘状半月板作为半月板的一种先天变异,由Young在1889年首次提出,属中医学“伤筋”范畴。该病的形成机制尚不明确,多存在于外侧半月板,损伤多与活动相关,且在亚洲人群多发。临床上多建议以手术治疗为主,而随着中医治疗的不断研究,也为我们临床治疗提供了多种方案。本文对当前外侧盘状半月板的中西医治疗情况进行综述,以期为临床工作提供一定的指导作用。

心房颤动的中西医研究进展

西医认为,心房颤动(简称房颤)的发病机制与心房的电重构、结构重构、炎症因子、氧化应激及分子遗传机制等因素有一定的相关性,临床治疗房颤除了使用常规抗心律失常药物外,射频消融术、左心耳封堵术等非药物疗法也有较好的疗效。中医则认为,房颤的病因病机多为本虚标实,其中本虚多以气阴两虚为主,标实多以痰浊、瘀血、水饮为主。历代医家治疗房颤是在经方、时方、验方的基础上结合临证经验而自拟方剂,可获得较好疗效。目前,关于房颤的研究仍存在以下问题:(1)缺乏从不同机制的交叉关系去研究是否存在有共同的靶点或信号通路;(2)中医证型较为繁杂,尚无统一的诊疗规范及疗效判定标准;(3)缺乏大样本、多中心、随机的双盲试验。今后,应充分利用现代药理学研究,探究中药疗效背后存在的作用机制,从而开展严谨、有效的大样本的临床试验。

中西医结合治疗高脂血症性急性胰腺炎的研究进展

高脂血症性急性胰腺炎(hyperlipidemia in acute pancreatitis,HTG-AP)是由血清甘油三酯升高引起的急性胰腺炎,临床以保守治疗为主,除西医常规治疗以外,传统中医药治疗具有显著疗效,大柴胡汤、大承气汤等化裁被临床广泛应用,且联合中药外治法治疗,效果更佳。目前,中外学者从不同靶点探究HTG-AP的治疗。文章从靶向治疗、炎症机制及肠道菌群等方面介绍HTG-AP中西医治疗的研究进展。

中西医治疗腹膜透析患者微炎症状态概况

腹膜透析(peritoneal dialysis, PD)是慢性肾脏病终末期的肾脏替代治疗方法之一,长期PD会导致患者微炎症状态等并发症发生。西医主要采用血管紧张素受体阻滞药(angiotensin receptor blockers, ARB)类、他汀类、左卡尼汀(肉碱)等药物治疗;中医药治疗主要包括中成药、中药复方、中西医结合以及其他治疗等。目前,研究存在的问题是:⑴主要为临床试验研究,缺乏高质量的基础研究;(2)临床研究样本量较小,缺乏多中心、大样本、随机的对照研究,治疗周期相对较短,缺乏对其远期疗效资料的统计分析;(3)缺乏公认的证型标准和诊疗规范,缺乏统一的结果指标。今后,应加强该领域的基础研究,充分利用现代科学技术来阐明疾病的发病机制,为中医药治疗PD微炎症状态提供更多的科学依据,完善临床研究相关设计,提供更加合理的研究成果,制定更加规范的诊疗标准,在临床治疗中,根据实际情况去选择合适的治疗手段,发挥出中西医结合治疗的优势,完善中西医结合诊疗体系,提高腹膜透析患者生存率及生活质量。

功能性消化不良与内脏高敏感性相关性的研究进展

功能性消化不良是一种常见的消化系统疾病,具有反复发作、迁延难愈的特点,临床表现为慢性或反复的上腹部疼痛、腹胀、恶心、呕吐和腹泻等症状。其发病机制与内脏高敏感性、胃肠动力障碍、幽门螺杆菌感染、胃酸分泌增加、微生物失调、精神障碍等多种因素相关。近年来,由于生活节奏加快和饮食结构改变,该病发病率不断上升,引起了临床工作者的广泛关注。内脏高敏感性作为功能性消化不良的一个重要病理机制,发病原因极为复杂,主要由中枢敏感性增高、受体激活、递质释放等引起。西医治疗该病侧重于对神经递质及受体进行干预,同时也注重患者心理对疾病进展程度的影响,采用多种药物联合,可有效降低患者内脏高敏感性引起的一系列不良反应,并改善生活质量。中医药治疗功能性消化不良有独特的优势,能够多维度、多层面、多靶点的整体性调节。目前,对于功能性消化不良与内脏高敏感性之间的关系,以及中医药干预措施的研究,仍处于探索初期。探讨功能性消化不良与内脏高敏感性之间的关系,对于指导临床治疗以及新药研发有一定意义。文章从内脏高敏感性角度出发,全面搜集和整理了相关文献,系统梳理了当前关于内脏高敏感性与功能性消化不良之间关系的研究进展,为今后深入探索二者之间的关系提供理论依据,也为功能性消化不良的针对性治疗提供新思路。

非小细胞肺癌免疫检查点抑制剂相关性肺炎研究进展及中西医结合治疗

免疫检查点抑制剂(ICIs)主要包括细胞毒性T淋巴细胞抗原4(CTLA-4)抑制剂和程序性细胞死亡蛋白1/配体1(PD-1/PD-L1)抑制剂,为非小细胞肺癌(NSCLC)患者带来显著的治疗效益。但是,在增强机体抗肿瘤免疫反应的同时,ICIs产生免疫相关不良事件(irAEs),包括免疫检查点抑制剂相关性肺炎(CIP)。虽然CIP临床发病率较低,但在一些严重病例中可能导致免疫治疗的延迟或终止,甚至危害生命。本文拟从CIP的临床表现、病理特征、生物学机制、易感人群、诊断与鉴别诊断以及中西医结合治疗等角度进行总结,以期更加清晰地认识CIP。

中医理论体系下西药的运用——西药中药化的方法探究

随着中西医结合的不断深入,医学工作者在临床工作中发现,西药因囿于西医体系,很难在中医药理论体系指导下的临床诊疗上发挥作用,极有必要走西药中药化之路,以弥补这一方面的不足。本文以阿司匹林为主要范例,从推测西药的中药性质入手,总结归纳几种研究方法及注意事项,并大致总结目前研究西药中药化上的诸多不足,同时收集汇总目前相关文献中提到的西药的中药性质,以抛砖引玉,供后续研究者参考。

地塞米松联合加味桑白皮汤治疗急性呼吸窘迫综合征30例临床分析

目的 探讨中西医结合治疗急性呼吸窘迫综合征的应用价值。方法 选择2019年1月至2023年12月兴化市人民医院接诊的30例急性呼吸窘迫综合征患者为研究对象,采用随机数字表法分为对照组和观察组。对照组采用西药地塞米松治疗,观察组采用地塞米松联合加味桑白皮汤的治疗方式。对比两组患者的治疗有效率,接受治疗之后两组患者的呼吸频率、氧合指数、肿瘤坏死因子-α、白细胞介素-6、ICU停留时间、住院时间、机械通气时间等。结果 观察组患者治疗有效率高于对照组(P <0.05)。观察组患者的呼吸频率以及氧合指数比对照组高,肿瘤坏死因子-α以及白细胞介素-6指标比对照组低(P <0.05)。观察组患者ICU停留时间、机械通气时间以及总体住院时间均比对照组少(P <0.05)。结论 治疗急性呼吸窘迫综合征患者过程中应用中西结合治疗方式能使得患者的治疗有效率有较大幅度的提升,呼吸频率、氧合指数均有所提高,肿瘤坏死因子-α、白细胞介素-6均有较大幅度的下降,而从患者恢复指标的情况来看,观察组患者的ICU停留时间、机械通气时间、住院时间均有所减少。

羚角钩藤汤辅助西医治疗对中风后偏瘫患者中医症候、肢体功能的影响研究

目的:观察羚角钩藤汤辅助西医治疗对改善中风后偏瘫患者中医症候、肢体功能的影响。方法:选取2020年7月—2022年2月平顶山市第二人民医院收治的129例中风后偏瘫患者作为研究对象,经随机数表法分为观察组(65例,予以中药羚角钩藤汤+西医治疗)和对照组(64例,仅予以西医治疗),比较两组患者治疗后的中医症候、肢体功能及脑组织血液流变学改善情况,对所有患者开展为期6个月的短期随访,观察患者脑神经功能恢复情况以及药物相关副反应发生情况。结果:治疗后,观察组的头痛眩晕、心烦易怒等主证以及面赤身热,气粗口臭等次证均低于对照组,差异有统计学意义(t=3.252、2.760、2.895、3.255,P<0.05);治疗后,观察者的Fugl-Meyer运动功能评分量表(FMA)高于对照组,差异有统计学意义(t=3.016、3.220,P<0.05);治疗后,观察组血浆黏度(PSV)、全血高切黏度(HSV)、全血低切黏度(LSV)均低于对照组,差异有统计学意义(t=3.021、3.000、3.498,P<0.05);随访期间,观察组的卒中量表(NIHSS)评分低于对照组,改良Barthel指数(MBI)评分高于对照组,差异有统计学意义(t=2.950、3.081,P<0.05);随访期间,观察组的不良反应发生率略高于对照组,差异无统计学意义(χ^(2)=0.160,P>0.05)。结论:在予以中风后偏瘫患者常规西医治疗的同时采用羚角钩藤汤配合治疗可促进患者症候恢复,还可以有效改善患者肢体功能、促进脑组织血液流变学及神经功能恢复,且此疗法安全性较高。

中西医结合治疗口腔颌面部牙源性感染研究进展

该文分析了近年来中西医结合治疗方法在治疗口腔颌面部牙源性感染(OIOFR)方面的研究概况。通过回顾学习与中西医结合诊治OIOFR疾病的相关文献,对其研究的成果进行系统总结分析。中西医结合诊疗技术在OIOFR方面不仅可以提高临床治愈率、缩短愈合周期,还可降低复发率。中西医结合治疗手段为OIOFR患者的治疗提供了广阔的参考依据。

马脑震荡的诊断与治疗

脑震荡及脑挫伤,是由于钝性暴力物作用于颅骨或头部受大力撞击引起的脑神经全面损伤的一种急性疾病,军马多发。随着社会生产力水平的不断进步,马的功能属性由役用转变为休闲骑乘,现阶段马脑震荡的病例并不多见。本文介绍了一例调教训练操作不慎,撞击引起的马脑震荡的诊断和中西医结合治疗,为该病的预防和治疗提供一定参考。