A Case Report on Treating Progressive Supranuclear Palsy with a Combination of Chinese and Western Medicine

A case of progressive supranuclear palsy in a 66-year-old woman is presented.The patient complained of“progressive stiffness of both lower limbs for five years,accompanied by choking and coughing for more than 1 year,”and was diagnosed with paralysis in traditional Chinese medicine(TCM),which was characterized by a deficiency of liver and kidney,and phlegm and blood stasis blocking the collaterals.Western medicine diagnosed it as progressive supranuclear palsy.The patient was diagnosed with“Parkinson’s disease”several times in the past and was given“polybasic hydrazide”and“amantadine hydrochloride tablets,”etc.The patient did not have significant symptomatic relief,so she sought further treatment with a combination of traditional Chinese and Western medicine.Based on the concept of deficiency and excess,this disease is categorized as a paralytic disease in Chinese medicine,and the onset of the disease is closely related to the deficiency of the body after a long period of illness,with wind,phlegm,blood stasis,and deficiency as the main pathogenetic mechanism.The treatment is based on the combination of disease and evidence,with traditional Chinese medicine and acupuncture as the main treatments,supplemented by intermediate-frequency pulsed electrical stimulation,transcranial repetitive magnetic stimulation,medicated canisters,wax therapy,traditional Chinese medicine guasha,and acupoint injections.Western medicine is based on symptomatic treatment,and the patient’s symptoms were relieved significantly after the combination of Chinese and Western medicine.

meta-analysis of randomized controlled trials of combined treatment with DGSN and western medicine on diabetic peripheral neuropathy

Objective:To systematically study the clinical effects of combined treatment with Dang gui si ni tang(DGSN)and western medicine(WM)on diabetic peripheral neuropathy.Methods:Seven databases,including Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical Database(CBM),Wanfang full-text database,VIP Database for Chinese Technical Periodicals,MEDLINE,PubMed,Embase,were retrieved.Related references about randomized controlled trials on the combination of DGSN and WM on diabetic peripheral neuropathy published during January 2012 up to now(recent 5 years)were reviewed.Related grey literatures were also reviewed according to the selected articles.RevMan5.3 software was used to analyze the publish bias,and to compare the total clinical effects of the combination of DGSN and WM with WM alone.Results:Ultimately,19 randomized controlled trials with 1690 patients were incorporated.The results of meta-analysis showed that combined treatment of diabetic peripheral neuropathy with DGSN and WM showed better general efficacy compared with control group,with a statistically significant difference(P<0.05).The results of study showed homogeneity(P=0.94>0.05).The general efficacy of combined treatment with DGSN and WM was significantly higher than that of control group(P<0.00001,OR=3.98,95%CI:3.01~5.27).Conclusion:Compared with treatment with WM alone,combined treatment of diabetic peripheral neuropathy with DGSN and WM is more effective.Meanwhile,due to the limited literature samples and low quality of literatures,large samples and high quality of multi-center randomized controlled double-blind trials are needed to verify these results.

Clinical Observation of Integrated Traditional Chinese and Western Medicine in the Treatment of Chronic Ulcerative Rectitis

Objective:To observe and compare whether the combination of traditional Chinese and Western medicine can achieve more satisfactory results in the treatment of patients with chronic ulcerative rectitis(UR).Methods:70 cases of chronic ulcerative rectitis were selected in all hospitals of our hospital for comparison.Observation and control were set up.The number of people was the same,but there were differences in methods.The control group retained enema,and the observation group was treated with traditional Chinese medicine.Rectal mucosa scores after different treatments were compared to evaluate the effect of intervention.Results:It was found that the observation group scored lower(P<0.05),and the effect was better.Conclusion:For the treatment of patients with chronic ulcerative rectitis,the combination of traditional Chinese and Western medicine will help to promote the prognosis of the disease,improve the problem of ulcer,promote the improvement of gastrointestinal function and bring a more positive impact.

Clinical Efficacy of Western Medicine Combined with Chinese Medicine for Pelvic Inflammatory Disease(Damp-Heat and Stasis Type)

Objective:This study was undertaken to evaluate the clinical efficacy of Western medicine combined with Chinese medicine for pelvic inflammatory disease(damp-heat and stasis type).Methods:Seventy-four patients who were diagnosed with pelvic inflammatory disease(damp-heat and stasis type)by our hospital during July 2021 to July 2022 were randomized into two groups:the participants in the control group received conventional Western medicine treatment,and the participants in the study group received Western medicine combined with Chinese medicine.Results:After treatment,the total effectiveness of the control group(72.98%)was significantly lower than that of the study group(94.59%),(P<0.05);the whole blood viscosity high cut,whole blood viscosity low cut,fibrinogen and plasma viscosity of the control group were all lower than those of the study group(P<0.05);the levels of CRP,IL-6,and TNF-αin the control group were higher and IL-2 levels in the control group were lower than those in the study group(P<0.05).Conclusion:Western medicine combined with Chinese medicine is more effective in curing damp-heat and stasis-type pelvic inflammatory disease by improving the blood rheological indexes and lowering the level of inflammatory factors.

CLINICAL OBSERVATION ON 40 CASES OF ANKYLOSING SPONDYLITIS TREATED WITH ACUPUNCTURE AND CHINESE DRUGS

Objective： To observe the clinical therapeutic effect of acupuncture plus Chinese herbal medicines for ankylceing Methods： A total of 80 cases of AS patients were evenly and randomly divided into treatment group and control group. In treatment group, patients were treated with acupuncture of Jiaji （夹脊 EX-B 2） and oral administration of Yishen Tongdu Won （益肾通督丸,Bolus for Reinforcing the Kidney and Dredging Governor Vessesl） and those of control group treated with oral administration of Sulfasalazin （0.5 g, twice daily）. Before and after treatment, the thoracic-dilaion scale, Schober test, Bath ankylceing spondylitis disease activity index （BASDAI）, Bath ankylosing spondylitis functional index （BASFI）, erythrocyte sedimentation rate （ESR） and C-reaction protein （CRP） were detected separately. Results： After 6 months of treatment, of the both 40cases in treatment and control groups, 27 （67.5%） and 13 （32.5%） were improved remarkably, 11 （27.5%） and 16 （40.0%） effective, and 2 （5.0%） and 11 （27.5%） failed, with the effective rates being 95.0% and 72.5% separately. The therapeutic effect of treatment group was significantly superior to that of control group （P〈 0.05）. After treatment, the thoracicdilaion scale and Schober test values increased significantly （ P〈 0.05）, while BASDAI, BASFI, ESR and CRP lowered considerably （P〈0.01, P〈0.05）. Comparison between two groups indicated that after treatment, the decreased values of BASDAI, BASFI, ESR and CRP of treatment group were significantly lower than those of control group （ P〈 0.01 ）, while those of the thoracio-dilaion scale and Schober test of treatment group were significantly higher than those of control group （ P 〈 0.05, P 〈 0.01 ）. Results displayed that both acupuncture combined with Chinese drugs and Sulfasalazin could lower BASDAI, BASFI, ESR and CRP, raise the thoracic-dilaion scale and Schober test values considerably in AS patients, and the therapeutic effect of combined acupunclure and Chinese drugs was apparently superior to that of Westem medicine. Conclusion： Joint application of acupuncture and Chinese drugs is superior to Western medicine in the therapeutic effect for AS and has fewer side effects.

Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

Objective:Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine,and the final results were observed.Methods:70 patients with such symptoms were randomly divided into two groups.The number of people is the same,and the treatment methods are different.The control group uses western medicine,while the observation group uses traditional Chinese medicine to evaluate the treatment effect.Results:After treatment,the effective rate of the observation group was(P<0.05),indicating that the treatment effect was significantly better.Conclusion:Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair,and with Chinese medicine,the effect is more satisfactory,and the effect is positive,so as to promote the optimization of their health.

Combined Treatment of Advanced Primary Hepatocellular Carcinoma with Traditional Chinese Medicine and Western Medicine

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Progress of Integrative Chinese and Western Medicine in Treating Polycystic Ovarian Syndrome Caused Infertilit

Polycystic ovarian syndrome （PCOS） is one of the most popular diseases that cause menstrual dysfunction and infertility in women. The present paper is a brief retrospection on the progress in treatment of PCOS caused infertility with integrative Chinese and Western medicine （ICWM）. It can be seen from these materials that using traditional Chinese medicine （TCM） recipes formulated by Shen-replenishing herbs or acupuncture to reinforce Gan-Shen, regulate Chong-Ren Channels in treating PCOS, stable clinical efficacy could be obtained, with less adverse reaction, though the effect initiated somewhat late. Whereas, when Shen-replenishing recipe and acupuncture are combined with hormone or ovulation promoting drugs of Western medicine, the above-mentioned shortcomings would be overcome. So, this combined therapy is frequently used in clinical practice.

中西医结合治疗膀胱癌的研究进展

膀胱癌(bladder cancer,BC)是一种在全球影响广泛的常见且危险的疾病。西医和中医各自对膀胱癌有其独特的理解、诊断方法和治疗方法。概述西医和中医对膀胱癌的流行病学、统计学、诊断和治疗方面的认识。此外,还探讨了中西医结合治疗膀胱癌的方法,包括中医在手术治疗、化疗、放疗、靶向治疗、免疫治疗以及其他西医治疗中的应用。最后,讨论了中医对膀胱癌的循证和临床研究,包括单一化合物、提取物、方剂和专利药物的应用。

红皮病型银屑病中西医治疗研究进展

红皮病型银屑病是一种严重的特殊类型银屑病,病程较长,治疗难度大且极易复发,严重者可危及生命。在治疗上,中医依据传统理论辨证论治,给予红皮病型银屑病患者中药内服及外用,往往取得良好的临床疗效;西医通过抗炎、调节免疫等治法,改善患者临床症状,从而达到治愈疾病的目的。目前,中西医治疗红皮病型银屑病的诊疗指南尚未更新,有待未来进一步研究探索。通过挖掘国内外相关文献,总结近年来红皮病型银屑病中西医治疗方案,以期为红皮病型银屑病临床治疗提供参考。

阿尔茨海默病不同治疗方式研究新进展

阿尔茨海默病(Alzheimer’s disease,AD)是一种复杂的、起病隐秘的、病因不明的、缺乏特异性诊断方式的神经退行性病变。面对与日俱增的患病率,却缺乏有效的治疗方式。中医药治疗方式具有多层次、多靶点、多通路的独特优势,中西医结合方式的互补,非药物疗法的辅助,干细胞疗法、新的分子药物、抗体及蛋白疫苗、γ感官刺激等新颖的实验阶段新疗法等方式治疗AD。本文综述近年来的不同治疗方式治疗AD研究新进展,旨在为临床上治疗AD提供新思路、新方法及参考价值。

跨医学体系下医疗知识图谱的构建与药物预测研究——以动脉粥样硬化为例

[目的/意义]探讨跨医学体系下的医疗知识图谱构建框架,促进医疗健康数据的有机融合和深层次互通。[方法/过程]以5个国内公开的大型医学数据库为数据来源,通过知识重组、实体对齐、关系融合构建医疗知识图谱,在此基础上,以动脉粥样硬化这一疾病为例,进行药物预测实证研究。[结果/结论]最终形成包含153849个实体、6569280个三元、73种语义关系的医疗知识图谱,为改善因医学体系差异性而导致的中西医“松散”联系现状做出了积极探索,提升了现有医疗知识图谱的知识服务范围,同时也为解析药物预测结果带来了新的研究思路。

中西医结合治疗高脂血症性急性胰腺炎的研究进展

高脂血症性急性胰腺炎(hyperlipidemia in acute pancreatitis,HTG-AP)是由血清甘油三酯升高引起的急性胰腺炎,临床以保守治疗为主,除西医常规治疗以外,传统中医药治疗具有显著疗效,大柴胡汤、大承气汤等化裁被临床广泛应用,且联合中药外治法治疗,效果更佳。目前,中外学者从不同靶点探究HTG-AP的治疗。文章从靶向治疗、炎症机制及肠道菌群等方面介绍HTG-AP中西医治疗的研究进展。

“肺咳宁”联合氨苄西林钠对牛呼吸道综合征的疗效观察

牛呼吸道综合征(Bovine respiratory diseases complex,BRDC)是严重影响牛养殖业的一种重要疾病。为研究“肺咳宁”结合氨苄西林钠治疗BRDC的效果,本研究分别采用微量倍比稀释法和琼脂倍比稀释法,测定“肺咳宁”对多杀性巴氏杆菌临床分离株的最小抑菌浓度(Minimal inhibitory concentration,MIC)和最低杀菌浓度(Minimum bactericidal concentration,MBC);从14头新发BRDC的犊牛中随机选取10头作为试验组,使用“肺咳宁”结合氨苄西林钠治疗,剩余4头作为对照组使用氨苄西林钠治疗,治疗周期均为5 d。记录用药开始后7 d病牛的体温变化以及用药前后的临床症状评分和肺部听诊音,采用荧光定量PCR法鉴定治疗前后鼻黏液中的病原微生物种类,进行治疗效果评价。结果表明,“肺咳宁”对牛源多杀性巴氏杆菌有抑制作用,对XN222菌株的MIC和MBC均为0.977 mg/mL;“肺咳宁”联合氨苄西林钠治疗多杀性巴氏杆菌所致BRDC的效果显著优于单独使用氨苄西林钠治疗。

蒽环类药物心脏毒性的中西药防治策略

蒽环类药物的心脏毒性对其临床使用造成极大限制,为探究蒽环类心脏毒性的规律及中西药防治策略,本文通过文献检索对蒽环类药物心脏毒性的发生机制和防治药物进行了归纳总结,其机制可分氧化应激、炎性反应、心肌细胞自噬以及DNA损伤4大类。防治药物西药以右丙亚胺、ACEI、ARB等为主,中药可分为单药、经方及中成药。在此基础上,对联合用药防治心脏毒性进行了讨论,介绍了西药、中药及中西药联合应用的理论依据及研究现状,结果表明其具有良好的可行性和安全性,可为临床上蒽环类化疗药物心脏毒性的防治策略研究提供参考。

中西医结合内外合治输卵管阻塞性不孕的随机对照多中心临床研究

目的 观察中西医结合内外合治综合方案治疗输卵管阻塞性不孕(TOI)患者的临床疗效。方法 收集2022年3月至2023年3月期间,就诊于成都中医药大学附属医院、重庆市中医院、四川省第二中医医院妇科门诊并确诊为输卵管通而不畅导致的TOI患者为研究对象,共189例。通过中心分层随机方法将患者随机分为研究组(n=90)与对照组(n=99),研究组采用中西医结合三联疗法(中药口服+中药保留灌肠+永磁旋振治疗仪)治疗,对照组采用中医二联疗法(中药口服+中药保留灌肠)治疗,连续治疗12周,观察两组患者治疗各时间节点的中医证候评分变化情况及疗效,比较治疗结束后的输卵管疏通率,并随访其治疗结束后1年内的妊娠情况。结果 两组患者的年龄、病程、不孕症类型、输卵管通畅情况等基本资料比较均无显著性差异(P>0.05)。两组患者治疗第4周、第8周、第12周的中医证候评分均较治疗前显著下降(P<0.05),且治疗第12周研究组的中医证候评分显著低于对照组(P<0.05)。治疗结束后,研究组患者的中医证候疗效总有效率(91.11%vs.80.81%)、输卵管疏通率(68.16%vs.50.25%)、妊娠率(38.89%vs.23.23%)、宫内妊娠率(36.67%vs.17.17%)均显著高于对照组(P<0.05),两组患者的异位妊娠率比较无显著性差异(P>0.05)。结论 中西医结合内外合治综合方案能有效改善输卵管通而不畅导致的TOI患者的中医证候,提高输卵管疏通率、妊娠率、宫内妊娠率,同时缩短妊娠时间,临床上值得推广应用。

中西医结合肿瘤“病-期-机-证-靶”诊疗新模式的构建

中医和西医是两种独立的医学体系和诊疗模式,在强调肿瘤综合治疗的现今,探索并构建一种中西医结合肿瘤诊疗新模式意义重大。传统中医治疗肿瘤重视整体观、治未病,具有整体调节机体、实现带瘤生存、预防复发转移等优势,但在现代医学背景下,其面临诊断不明确、治疗不精准、疗效不确切、机制不清楚等难题。为了切实提高肿瘤治疗的临床疗效,该文基于传统中医的特色和优势,结合现代医学研究成果,提出“病-期-机-证-靶”的诊疗思路,初步构建中西医结合肿瘤诊疗新模式,以期实现中西医优势互补、协同增效。

中医治疗带状疱疹后神经痛的研究进展

带状疱疹后神经痛是一种常见的皮肤疾病,以疱疹皮损愈合1个月后其受累神经皮肤分布区仍感持续的针刺样、烧灼样疼痛为特点,对患者的身心健康及生活质量造成了严重的影响。中医在该病的治疗上发挥着重要作用,文章通过回顾近年来中医治疗带状疱疹后神经痛的相关文献,从内治、外治、中西医结合治疗及络病理论等方面对该病中医治疗方法进行总结后发现,中医对该病治疗方法多样,临床疗效确切,可为该病的治疗提供一定参考。

前置处方审核中西药联用药物相互作用规则的建立及优化

目的 以建立医院前置处方审核中西药联用相互作用规则和管理制度为手段,提高中西药联合应用水平。方法 通过访谈法查找前置处方审核中西药联用存在的问题,通过文献及其他资料查阅建立中西药不合理联用数据库,以数据库为依据设置前置处方审核中西药联用规则。调取北京市西城区广外医院2022年1月至12月门急诊处方,采用PDCA循环法进行药物相互作用规则及管理制度优化,比较优化前后中西药联用的合理性水平。结果 建立了57类147种中药、61类148种西药不合理联用数据库。经过四轮PDCA循环管理建立前置审核中西药联用相互作用规则和管理制度后,中西药联用不合理处方占比由9.11%降至2.44%,干预处方医师修改率由82.93%升至95.45%、医师考核平均分数由79.30分升至94.25分。结论 通过前置处方审核中西药不合理联用处方规则的建立,能提高中西药不合理联用水平,降低因不合理联用带来的风险。

一例犬免疫介导性血小板减少症的诊断与中西医治疗

3岁红色博美犬,食欲减退,精神萎靡,不愿走动;腹部、后肢内侧等部位出现出血点、瘀斑,指压不褪色;大便颜色稍黑;尿液量少、呈红色。体格检查可见背部、腹部、四肢等部位皮肤有轻重不等的紫色瘀斑,牙龈有出血点,眼结膜苍白。血常规检查结果显示,该犬血小板数目为0,白细胞、单核细胞、中性粒细胞均高于参考值;血涂片镜检可见少量多染红细胞,形态未见明显异常,也未见血液寄生虫体;尿常规检查结果显示有潜血,提示有炎症;血液生化指标结果显示,碱性磷酸酶活性、丙氨酸氨基转移酶高于参考值,肌酐质量浓度低于参考值;凝血功能检查未见异常;犬片状边虫抗体/嗜吞噬细胞无形体、心丝虫抗原、莱姆病抗体、埃里希体/伊文氏埃里希体抗体筛查结果均为阴性。综合病史及上述各项检查结果,诊断患犬为原发性免疫介导性血小板减少症(immune-mediated thrombocytopenia,ITP)。经过为期47 d的对症治疗(补液、消炎、止血、护肝、输血)、免疫抑制治疗(口服泼尼松龙)和中兽医辩证治疗,患犬各项指标得到了恢复,停药30 d后回访,未见复发。说明采用中西医结合疗法治疗犬ITP可取得良好的效果。