Hypoglycemic Effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi Green Tea and Their Compatibility on Mice

[Objectives]To explore the hypoglycemic effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi green tea and their compatibility on mice,so as to provide more options for the adjuvant treatment of diabetes and improve the comprehensive utilization value of Guixi green tea.[Methods]After being fed adaptively for 7 d,60 SPF-grade male mice were intraperitoneally injected with alloxouracil(180 mg/kg)to induce hyperglycemia model,from which 35 mice with a successful model were selected.They were randomly divided into 5 groups(Danshen group,green tea group,compatible group,positive control group and blank control group),with 7 animals in each group.The mice in all groups were administered according to the dose of 200 mg/kg once a day for 15 d.After the last administration,their body weight was measured on the 15 th day after fasting for 12 h,and their fasting blood glucose was measured by tail clipping.[Results]After modeling,the mice in each group showed typical hyperglycemia symptoms,namely obvious polydipsia,polyphagia,polyuria and weight loss.Compared with the blank control group,Danshen group and green tea group had obvious hypoglycemic effect(P<0.05),and compatible group had significant hypoglycemic effect(P<0.01).Compared with the blank control group,the weight loss of diabetic mice could also be inhibited in green tea group and compatible group(P<0.05).[Conclusions]Danshen,Guixi green tea and their compatibility had the effect of lowering blood sugar,among which the compatible group had the most obvious effect.

Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice

[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.

Interest of Transcranial Doppler (TCD) in Emergency in Traumatic Brain Injury Patients at Gabriel Touré University Hospital, Bamako, Mali

Introduction: Transcranial Doppler is a simple, non-invasive and inexpensive examination which allows the assessment of cerebral perfusion. In countries with limited resources, which do not have a means of monitoring intracranial pressure, this examination offers hope of survival for patients with traumatic brain injury. This study was designed to investigate the incidence of early cerebral circulation abnormalities after traumatic brain injury using transcranial Doppler (TCD). Methodology: A descriptive and analytical study was conducted over one year, including patients with traumatic brain injury and an initial Glasgow Coma Scale (GCS) score of less than 15. Non-inclusion criteria: Stroke, brain tumor, cerebral abscess. Exclusion criteria: Inadequate insonation window. Results: Out of 854 traumatic brain injury patients admitted to the emergency department, 112 were included in the study. The average age was 30.14 years, with a sex ratio of 4.1. Initially, 83.5% had moderate traumatic brain injury, and 12.1% had severe traumatic brain injury. Brain CT scans were performed in 95.7% of the patients. Edematous-hemorrhagic contusion was observed in 95% of the patients. On initial TCD, the pulsatility index in the middle cerebral artery was greater than 1.3 in 49.4% of the patients. Diastolic velocity was less than 20 cm/s in 46.4% of cases, and mean velocity was greater than 150 cm/s in 8.7% of cases. In this group, low diastolic velocity indicated cerebral hypoperfusion suggestive of intracranial hypertension. When the pulsatility index was greater than 1.9, no patient had a normal diastolic velocity. Among patients with severe traumatic brain injury, 61.5% had an abnormal pulsatility index compared to 42.3% of patients with moderate traumatic brain injury. Conclusion: TCD is a simple tool for analyzing intracerebral hemodynamics.

超声联合TCD技术诊断颈部动脉粥样硬化性脑梗死的临床价值

目的:探讨超声联合TCD技术诊断颈部动脉粥样硬化性脑梗死(CAEI)的临床价值。方法:以62例CAEI患者为对象,以同期62例健康人为对照组。均接受血管超声及TCD检查,分析二者诊断CAEI的价值。结果:观察组颈总动脉收缩期内径(Ds)、内中膜厚度(IMT)值高于对照组(P<0.05)。观察组Vd、Vs低于对照组,RI、PI高于对照组(P<0.05)。观察组斑块检出率为85.48%,高于对照组(19.35%,P<0.05)。模型1(Ds+IMT)诊断CAEI的AUC、灵敏度、特异度分别为0.754(95%CI:0.669-0.827)、79.03%、74.19%;模型2(Vs+Vd+RI+PI)诊断CAEI的AUC、灵敏度、特异度分别为0.814(95%CI:0.735-0.878)、82.26%、70.97%;模型3(Ds+IMT+Vs+Vd+RI+PI)诊断CAEI的AUC、灵敏度、特异度分别为0.871(95%CI:0.799-0.924)、90.32%、74.19%。模型3诊断CAEI的AUC高于模型1、模型2(P<0.05)。结论:超声联合TCD检测可了解CAEI患者的颈动脉斑块及血流信息,有助于提高诊断的准确度。

TCD监测颅内血流动力学参数评估脑血管病患者颈动脉狭窄程度及神经功能恶化的风险

目的探讨经颅射绝超声多普勒系统(TCD)监测颅内血流动力学对脑血管病患者颈动脉狭窄严重程度和神经功能恶化风险的评估价值。方法前瞻性纳入122例脑血管病患者为病例组,根据患者颈动脉狭窄程度分为轻度狭窄组(n=43)、中度狭窄组(n=47)、重度狭窄组(n=32),并纳入同期健康体检者60例为对照组,比较4组颅内血流动力学指标,并采用Pearson分析其与患者颈动脉狭窄严重程度的相关性;根据患者神经功能恶化程度分为神经功能恶化组(n=55)和神经功能未恶化组(n=67),采用单因素和多因素Logistic回归分析明确影响患者发生神经功能恶化的高危因素,并采用受试者工作特征(ROC)曲线进一步分析独立危险因素对神经功能恶化的诊断效能。结果轻、中、重度狭窄组舒张期峰值血流速度(EDV)、收缩期峰值血流速度(PSV)及平均血流速度(MV)水平均较对照组偏低,搏动指数(PI)和阻力指数(RI)较对照组偏高,有统计学差异(P<0.05);重度狭窄组PSV、MV、EDV水平较轻、中度狭窄组显著偏低,PI及RI水平显著偏高(P<0.05)。Pearson相关性分析结果显示,PSV、EDV及MV与颈动脉狭窄程度呈显著正相关(r=0.541,0.763,0.822,均P<0.05),PI及RI与颈动脉狭窄程度呈显著负相关(r=-0.133,-0.375,均P<0.05)。神经功能恶化组平均年龄、入院GCS评分、ICU停留时间及住院时长等临床指标均明显高于神经功能未恶化组(P<0.05);两组大脑中动脉血流动力学参数对比,神经功能恶化组收缩期血流速度(FVs)、PI显著高于神经功能未恶化组,FVd、平均流速(FVm)明显低于神经功能未恶化组(P<0.05)。Logistic回归分析结果显示,ICU停留时间、住院时间、FVs、舒张期血流速度(FVd)、PI均是影响脑血管病患者神经功能恶化的独立危险因素(P<0.05)。ROC曲线分析结果显示,FVs、FVd、FVm及PI对预测脑血管病患者发生神经功能的ROC曲线下面积(AUC)分别为0.643、0.834、0.336、0.866(均P<0.05)。诊断效能:PI>FVd>FVs>FVm。结论应用TCD对脑血管病患者颅内血流动力学参数进行监测可辅助临床评估患者的颈动脉狭窄程度,对此类患者发生神经功能病变具有较高的预测价值。

Rapid evolution of T2/S-RNase genes in Fragaria linked to multiple transitions from self-incompatibility to self-compatibility

The T2/RNase gene family is widespread in eukaryotes,and particular members of this family play critical roles in the gametophytic self-incompatibility(GSI) system in plants.Wild diploid strawberry(Fragaria)species have diversified their sexual systems via self-incompatible and self-compatible traits,yet how these traits evolved in Fragaria remains elusive.By integrating the published and de novo assembled genomes and the newly generated RNA-seq data,members of the RNase T2 gene family were systematically identified in six Fragaria species,including three self-incompatible species(Fragaria nipponica,Fragaria nubicola,and Fragaria viridis) and three self-compatible species(Fragaria nilgerrensis,Fragaria vesca,and Fragaria iinumae).In total,115 RNase T2 genes were identified in the six Fragaria genomes and can be classified into three classes(Ⅰ-Ⅲ) according to phylogenetic analysis.The identified RNase T2 genes could be divided into 22 homologous gene sets according to amino acid sequence similarity and phylogenetic and syntenic relationships.We found that extensive gene loss and pseudogenization coupled with small-scale duplications mainly accounted for variations in the RNase T2 gene numbers in Fragaria.Multiple copies of homologous genes were mainly generated from tandem and segmental duplication events.Furthermore,we newly identified five S-RNase genes in three self-incompatible Fragaria genomes,including two in F.nipponica,two in F.viridis,and one in F.nubicola,which fit for typical features of a pistil determinant,including highly pistil-specific expression,highly polymorphic proteins and alkaline isoelectric point(pI),while no S-RNase genes were found in all three selfcompatible Fragaria species.Surprisingly,these T2/S-RNase genes contain at least one large intron(>10 kb).This study revealed that the rapid evolution of T2/S-RNase genes within the Fragaria genus could be associated with its sexual mode,and repeated evolution of the self-compatible traits in Fragaria was convergent via losses of S-RNase.

TCD发泡试验在诊断隐源性脑卒中相关危险因素PFO中的应用研究

研究TCD发泡试验在隐源性脑卒中中相关危险因素PFO应用效果开展诊断评估。方法 选择我院2019-2023年所接受到的80名隐源性脑卒中患者为分析对象,比较患者经颅多普勒超声(TCD)发泡试验和经胸心脏超声心动图(TTE)检查结果阳性率和影像学特征。结果 TCD发泡试验在隐源性脑卒中相关危险因素卵圆孔未闭(PFO)阳性率检出率和TTE阳性检出率检查方面,检查具备统计学意义。在TCD发泡试验对隐源性脑卒中脑卒中相关危险因素中PFO阳性和阴性患者检查内,阳性患者梗死病大部分出现在皮层、皮层下区域,阴性患者主要出现深部灰质区域。结论 TCD发泡试验可以有效检测出由于PFO该危险因素造成隐源性脑卒中,PFO阳性病灶大部分位于皮层、皮层下区域,就隐源性脑卒中相关危险因素PFO筛查、诊断、病因研究等角度具备关键意义,适宜临床推广与应用。

Epidemiological Investigation of Brucellosis Spondylitis and Optimal Selection of Clinical Drug Compatibility, Treatment Course and Treatment Plan

Background: Brucellosis is a zoonotic endemic disease, the main source of infection is infected cattle, sheep, pigs and their products. In recent years, the global incidence of brucellosis spondylitis has increased year by year, and it has spread from pastoral areas to semi-agricultural and semi-pastoral areas, agricultural areas and cities. It has changed from a mainly occupational disease to a mainly food-borne disease, and it is also a zoonotic specific spinal infectious disease that WHO and governments around the world pay great attention to. Due to the low cure rate and high recurrence rate of traditional drug therapy regimen. Therefore, to carry out epidemiological investigation and Related research on clinical drug therapy of brucellosis spondylitis has practical significance for improving diagnosis rate, cure rate and reducing recurrence rate. Objective: To analyze the epidemiological characteristics of Brucellosis spondylitis and explore the choice of drugs and the best drug treatment plan, so as to provide scientific basis for improving the prevention and control of the disease and treatment effect. Methods: Clinical epidemiodogical materials were collected from 113 patients with brucellar spondylitis. All these patients were divided into 5 different groups according to 5 kinds of drugs adopted respectively, and then the patients were given different course of treatment. Results: In the 113 patients, brucellar spondylitis morbility of female patients were higher than that of male ones, and the morbility of Bashang were higher than that of Baxia. These patients were infected mainly through browsing and breeding beasts. Lumbars were the major focus of infection. It was very comnlon that two adjacent lumbars were involved in concurrently. L4 was the most common infection location and its demolishment was most serious. The curative effect of group treated with doxycycline was better than that of group treated without doxycycline. If the course of treatment Was increased, the curative effect Was not increased obviously. Conclusions: There are characteristic features in clinical epidemiology of brucell spondylitis. Doxycycline + Rifampicin + Sulfamethoxazole was used as the preferred antibiotic. Using antibiotics adequately and jointly by two courses of treatment for a long time is the most reasonable way to treat the disease and prevent the disease from recurrence.

Enhancing the compatibility of the amyloid-dye hybrid nanostructure for improved photo-biocatalysis

Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental protection.Dye-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocatalysis),but their performances are far lower than the plant photosystems,partially because of the incompatibility between dye and the protein matrix that limits excited state electron transfer of the included dyes.Here,using ThT-insulin amyloid assembly as a model system,we proposed that increasing the dye-protein compatibility could lead to the improved photo-biocatalytic performance.A ThT derivative,ThTPD,was designed with the same electron acceptor but extended π-conjugated donor structure.When integrated into the insulin amyloid,the extended π-conjugated donor structure allowed increased binding affinity and energy with the amyloid matrix,thus better electron transport to the mediator to drive the photocatalytic reaction.Meanwhile,compared with ThT, ThTPD exhibited improved light absorption and longer excited state lifetime.The photo-biocatalytic performance of ThTPD-insulin amyloid was greatly improved as compared with that of ThT in reduced nicotinamide adenine dinucleotide(NADH) regeneration.When integrating with NADH-dependent L-glutamate reductase,the efficiency of the ThTPD-insulin amyloid hybrid was 2.8-fold higher than that of ThT in glutamate generation,showing promising feature in biocatalytic solar-to-chemical conversion.

TCD发泡试验在卵圆孔未闭中的应用

对卵圆孔未闭采用TCD发泡实验,做好效果分析。方法 通过选取本院收治的隐源性卒中患者42例,患者在入院后进行MRI以及CT检查,采用TCD发泡实验,做好阳性率情况的比较。结果 通过对42例患者进行检查,其中阳性率为88.4%。卵圆孔直径在1-3mm之间。结论 对卵圆孔未闭采用TCD发泡实验,能够更好的探查卒中,明确隐源性脑梗的发生概率,整体效果良好,为患者预后提供一定基础。

TCD5 Enhances the Photosynthesis Capacity,Increases the Panicle Number and the Yield in Rice

Improvement of photosynthetic efficiency is a major approach to increase crop yield potential.Previously,we cloned a gene encoding the chloroplast-located putative monooxygenase TCD5,which is essential in plastid development under low temperature in rice(Oryza sativa L.).In this study,the effects of TCD5 on the photosynthesis and the yields were investigated in rice.Two sets of genetic materials with three levels of TCD5 expression,including tcd5 mutant or TCD5 RNAi transgenic lines and TCD5 over-expression transgenic lines in Jiahua1 and Nipponbare backgrounds,were used in the field trails of multi-locations and multi-years.TCD5 positively affected the panicle number and the yield at dosage.Compared with the wild-types,the panicle numbers were 12.4%-14.6%less in tcd5 mutant and 8.3%-38.6%less in TCD5 RNAi lines,but 26.2%-61.8%more in TCD5 over-expression lines.The grain yields per plant were 9.1%-18.4%less in tcd5 mutant and 14.3%-56.7%less in TCD5 RNAi lines,but 6.9%-56.5%more in TCD5 over-expression lines.The measurements of net photosynthetic rate indicated that mutation or knock down of TCD5 decreased the net photosynthetic rate by 10.4%and 15.6%,respectively,while increasing it by 8.9%and 8.7%in the TCD5 over-expression lines in Jiahua1 and Nipponbare backgrounds,respectively.Accordingly,the measurements of chlorophyll fluorescence parameters showed that the electron transport rate and quantum yield decreased in tcd5 mutant or TCD5 RNAi lines but increased in TCD5 overexpression lines,both in Jiahua1 and Nipponbare backgrounds.IP-MS screening revealed that TCD5 interacts with 29 chloroplast proteins involved in chlorophyll synthesis,photo-reactions of the photosynthesis,carbon assimilation and metabolism,energy metabolism,redox balance,protein synthesis and transportation.Two TCD5 interacted proteins,D1 and FBA were effective targets for improving photosynthesis.These results suggest a potentially new strategy for increasing rice yield by enhancing photosynthesis.

Exploring the compatibility theory of traditional Chinese medicine formulae:the disassembled prescriptions study

Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.

Compatibility Rules of Prescriptions of Tibetan Medicine Polygonatum cirrhifolium Based on Data Mining

[Objectives]To study the prescription compatibility rules of the Tibetan medicine Polygonatum cirrhifolium(Polygonati Rhizoma,Huangjing)based on data mining,so as to provide data support for clinical application and new drug development.[Methods]Prescriptions containing Tibetan medicine Huangjing were collected from Tibetan Medicine Prescriptions Encyclopedia and Tibetan Medicine Classic Literature Collection.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)and R version 4.1.3 were used to mine and analyze the compatibility rules of prescriptions containing Tibetan medicinal material Huangjing,the rules of medication for high-frequency diseases,and the association rules of various medicinal materials.[Results]A total of 124 prescriptions were collected from the classic literature of Tibetan medicine,and the frequency statistical analysis showed that drugs compatible with Huangjing(≥15)included Tianmendong(Root of Cochinchinese Asparagus)(80),Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)(72),Jili(Tribuli Fructus)(70),Tibetan Aoruqin(Vicatia coniifolia)(58),Baidoukou(Round Cardamom Fruit)(47),Hezi(Chebulae Fructus)(45),Shouzhangshen(Rhizome of Conic Gymnadenia)(28),Yuganzi(Phyllanthi Fructus)(26),Pomegranate(25),Maohezi(Terminaliae Belliricae Fructus)(24),Zicaorong(Lacca)(23),Rougui(Cinnamomi Cortex)(15).The main diseases were yellow water disease(20),gynecological diseases(19),kidney cold disease(17),and other Tibetan medicine diseases.Association rule analysis showed that the drug combinations with the highest frequency were Huangjing—Tianmendong,Huangjing—Himalayan purple jasmine,and Huangjing—Jili.[Conclusions]The frequency of combined use of Tibetan medicine Huangjing with dry yellow water,tonifying kidney and diuresis,nourishing health,and treating gynecological diseases is relatively high.

Compatibility Rules of Prescriptions of Tibetan Medicinal Material Mirabilis himalaica(Edgew.)Heimerl Based on Data Mining

[Objectives]To study the prescription compatibility rules of the Tibetan medicinal material Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)based on data mining,and to provide reference for clinical application and new drug development.[Methods]The literature data were collected and the prescriptions containing Himalayan purple jasmine were sorted and classified by Microsoft Excel 2019 software.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)was used to statistically analyze the high-frequency drugs and core drug combinations,the frequency of disease treatment,and the rules of"tastes transforming flavors"of drugs.The FP-tree algorithm was used to analyze the association rules among various Tibetan medicinal materials in the prescriptions,and different supports were set to analyze the compatibility rules of the prescriptions.[Results]There were a total of 129 prescriptions containing Himalayan purple jasmine,297 medicinal materials used in combination with it,and 34 Tibetan medicinal materials with a frequency of≥15.The medicinal flavors were mostly sweet,bitter,and pungent.Among the three flavors,bitterness and sweetness were the majority.At the same time,the medicinal properties were blunt,soft,cool,and warm.A total of 130 kinds of diseases were involved,among which 8 kinds of diseases such as gynecology,kidney cold and yellow water disease had a high frequency.Through association rule analysis,33 commonly used core drug combinations were obtained.The support,confidence,and frequency of the five drug combinations[Jili(Tribuli Fructus),Huangjing(Polygonati Rhizoma),Tianmendong(Root of Cochinchinese Asparagus),and Tibetan Aoruqin(Vicatia coniifolia)]→Himalayan purple jasmine were the basic prescription of Tibetan medicine Wudagen Powder.The drug combinations with higher confidence included Bibo(Piperis Longi Fructus)→Himalayan purple jasmine,Pomegranate(Punica granatum→Himalayan purple jasmine,Baidoukou(Round Cardamom Fruit)→Himalayan purple jasmine,Hezi(Chebulae Fructus)→Himalayan purple jasmine.Jili(Tribuli Fructus)→Himalayan purple jasmine,Huangjing(Polygonati Rhizoma)→Himalayan purple jasmine and Tianmendong(Root of Cochinchinese Asparagus)→Himalayan purple jasmine had highest frequency.[Conclusions]Through the TCMICS,this paper analyzed the compatibility rules of commonly used drugs containing Himalayan purple jasmine and the characteristics of the main diseases.It can be seen that Himalayan purple jasmine is sweet in taste and warm in nature.It assists sovereign drugs in the form of ministerial drugs,which enhances the effect of regulating"long"and nourishing,and plays the role of regulating"long",dispelling cold,and reconciling various drugs,which embodies the compatibility rules of sovereign and ministerial drugs of Tibetan medicines.The main diseases of Himalayan purple jasmine are related to"long"regulation,and it is mostly used in the treatment of gynecological diseases after being combined with other drugs to form a prescription.Most drugs in the prescriptions are sweet,which is the therapeutic principle of regulating"long"and nourishing,and verifies the scientific and rational principle of clinical use of Tibetan medicine.In the prescription,the medicinal properties include both warm and cool,and the medicinal taste is sweet and bitter,which is in line with the compatibility theory of"tastes transforming flavors"in traditional Tibetan medicine prescriptions.

Compatibility mechanism of Chinese medicine formula:state of the art and perspectives

Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility.

托莫西汀联合感觉统合训练治疗注意缺陷多动障碍患儿效果及对TCD参数、动态肌电图的影响

目的:探讨托莫西汀联合感觉统合训练治疗注意缺陷多动障碍(ADHD)患儿效果及对经颅多普勒超声检查(TCD)参数、动态肌电图的影响。方法:按随机数字表法将2021年9月至2022年9月我院收治的60例ADHD患儿分为两组,各30例。对照组采用托莫西汀治疗,研究组在对照组基础上加用感觉统合训练治疗,对比两组临床疗效、TCD参数[大脑基底动脉(BA)、左侧中动脉(MCA-L)、左侧前动脉(ACA-L)、左侧后动脉(PCA-L)]、儿童感觉统合能力发展评定量表评分、中文版注意缺陷多动障碍评定量表-父母版(SNAP-IV)评分和不良反应。结果:研究组治疗后总有效率高于对照组(P<0.05);两组治疗后BA对比,无统计学差异(P>0.05);研究组治疗后MCA-L、ACA-L、PCA-L高于对照组(P<0.05);研究组治疗后儿童感觉统合能力发展评定量表评分高于对照组(P<0.05);研究组治疗后SNAP-IV评分低于对照组(P<0.05);两组治疗期间均无严重不良反应发生。结论:托莫西汀联合感觉统合训练可有效提升ADHD患儿的注意力和感觉统合能力,促进大脑动脉局部灌注的恢复,利于纠正患儿行为抑制缺陷,值得在临床上推广和应用。

蒲公英、忍冬藤抗菌活性组分及配伍研究

为了探寻蒲公英和忍冬藤高效抗菌活性组分及其配伍活性,试验以蒲公英和忍冬藤为研究对象,通过70%乙醇提取、大孔树脂D101柱层析和抗菌活性跟踪相结合的方式优选各自的高效抗菌活性组分,并对这些组分进行总黄酮、有机酸和多酚含量分析和活性配伍研究。结果表明蒲公英和忍冬藤的高效抗菌活性组分分离工艺为:先用70%乙醇回流提取,浓缩后用大孔树脂D101柱层析,70%或50%乙醇洗脱部位即为它们的高效抗菌活性组分。这些组分对9种供试病原菌都具有较强的广谱抗菌性,蒲公英的最小抑菌浓度(MIC)和最小杀菌浓度(MBC)分别约为1.95 mg/mL和15.63 mg/mL,忍冬藤的MIC和MBC分别约为1.95 mg/mL和31.25 mg/mL。且含量分析显示,蒲公英高效抗菌活性组分黄酮和多酚含量相对较高,忍冬藤高效抗菌活性组分多酚含量相对较高。配伍研究发现,当蒲公英高效抗菌活性部位与少量忍冬藤水洗脱部位(16∶1~4∶1)或其高效抗菌部位(16∶1~1∶1)配伍使用时,对部分供试菌的抗菌活性存在一定的相加作用。说明所得的蒲公英和忍冬藤高效抗菌活性组分提取分离工艺简单、易得,广谱抗菌作用强,合适的配伍使用可以实现更好的抗菌作用。

TCD发泡试验在肝硬化门静脉高压患者中的临床价值探讨

探讨经颅多普勒(transcranialDoppler,TCD)发泡试验在肝硬化门静脉高压患者中的临床价值。方法 收集2021年5月~2023年4月玉林市红十字会医院消化内科收治肝硬化门静脉高压患者141例作为观察组,选择同期门诊就诊健康体检者58例作为对照组,两组均进行发泡试验,记录观察组和对照组发泡试验阳性率并对比分析,同时将肝硬化门静脉高压伴和不伴食管胃静脉曲张出血的发泡试验阳性率、不同肝功能分级发泡试验阳性率进行比较,分析其差异性。结果 门静脉高压患者发泡试验阳性率高于健康者,差异有统计学意义(P<0.05)。食管胃底静脉曲张破裂出血发泡试验阳性率低于非食管胃底静脉曲张破裂出血,P<0.05。结论 在肝硬化门静脉高压患者中,进行TCD发泡试验具有临床应用的价值。该试验可以作为一种新的指导方法,用于在内镜下治疗食管胃底静脉曲张破裂出血时提供指导。

偏头痛患者采用TCD发泡试验筛查卵圆孔未闭的价值分析与探讨

探讨分析偏头痛患者的TCD发泡试验筛查卵圆孔未闭的临床表现,针对偏头痛患者的卵圆孔功能进行判断,为患者的诊断提供进一步的参考方案。方法 本次研究在进行实验设置时,选择实验时间段为2019年6月,至2022年3月,研究人员在该时段内将我院资料登记有效的偏头痛患者共计80名作为研究对象,选择同期内院中接受健康体检的成人共计80名作为对照对象。研究人员在针对所有患者的一般资料进行记录后,针对患者进行TCD发泡试验筛查卵圆孔未闭检查,诊断完成后,研究人员针对患者的TCD发泡试验筛查卵圆孔未闭指标进行评价,分析组间差异。结果 在本次研究结果中显示,相较于对照组来说,实验组内患者的TCD发泡试验筛查卵圆孔未闭结果中发生率明显更高,数据进行对比分析后,差异显著,具有统计学意义(P<0.05)。结论 偏头痛患者的TCD发泡试验可以用于筛查卵圆孔未闭。在本次结果中表明卵圆孔未闭与偏头痛之间存在相关性。这项检查可以为偏头痛患者的诊断提供重要的参考信息,特别是在考虑手术干预或其他治疗方案时。TCD发泡试验可用于评估偏头痛患者的卵圆孔功能和筛查卵圆孔未闭。这一方法对于指导偏头痛患者的诊断和治疗决策具有重要的临床意义。

基于Comsol软件的电磁兼容课程案例式教学设计

该文介绍基于Comsol软件的电磁兼容课程案例式教学方法。通过案例教学和仿真,学生将理论知识应用于实际问题,深入理解电磁兼容的概念和原理。通过仿真案例的可视化结果,学生直观地理解电磁辐射和传导,观察不同参数对电磁兼容性的影响。结果表明,仿真案例具有直观性和可视化等优势,同时又有简化模型、缺乏实际操作经验和对计算机的依赖等局限性。在设计仿真案例时,要充分发挥其优势,规避不足,为学生的学习提供实践性、直观性和灵活性,培养学生的工程设计与研发能力。