[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),mode...[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),model group(M group),"the Complementary Acupoints"Yanglingquan and Yinlingquan group(AB group),Shenshu and Zusanli group(CD group),with 8 rats in each group.Moxibustion was performed using refined moxa floss(2 mg/pc)on acupoints in both sides every other day,5 pieces for each acupoint,and implemented for 10 times.Before and after the modeling and after the intervention,the left foot sole thermal pain threshold of each group was measured.After the intervention,the rats'left paws were examined by X-ray to detect the number of mast cells(MCs)and degranulation in the affected area of the foot.[Results]The thermal pain threshold of the model group was lower than that of the K group(P<0.05).The number of MC in the affected area and the degranulation were increased.After the moxibustion intervention,the thermal pain threshold of the AB and CD groups was higher than that of the M group(P<0.05);the number of MCs and degranulation were decreased compared with M group,and the degree of reduction was better than that of CD group.The data of foot and claw showed that the foot and paw soft tissue swelling,bone and joint deformity and bone destruction were better in AB and CD groups were more relieved than that in M group.[Conclusions]The moxibustion of Complementary Acupoints can effectively intervene with RA of rats,and its mechanism may be closely related to the MC degranulation.展开更多
基金Natural Science Foundation of Hebei Province of China(H2014406047)Scientific and Technological Research Project for Institutions of Higher Education in Hebei Province of China(ZD2019085)Key Scientific Research Project of Chengde Medical University(201812).
文摘[Objectives]To explore the moxibustion effect and mechanism of"Complementary Acupoints"on rheumatoid arthritis(RA).[Methods]A total of 32 Wistar rats were randomly divided into 4 group:normal control(K),model group(M group),"the Complementary Acupoints"Yanglingquan and Yinlingquan group(AB group),Shenshu and Zusanli group(CD group),with 8 rats in each group.Moxibustion was performed using refined moxa floss(2 mg/pc)on acupoints in both sides every other day,5 pieces for each acupoint,and implemented for 10 times.Before and after the modeling and after the intervention,the left foot sole thermal pain threshold of each group was measured.After the intervention,the rats'left paws were examined by X-ray to detect the number of mast cells(MCs)and degranulation in the affected area of the foot.[Results]The thermal pain threshold of the model group was lower than that of the K group(P<0.05).The number of MC in the affected area and the degranulation were increased.After the moxibustion intervention,the thermal pain threshold of the AB and CD groups was higher than that of the M group(P<0.05);the number of MCs and degranulation were decreased compared with M group,and the degree of reduction was better than that of CD group.The data of foot and claw showed that the foot and paw soft tissue swelling,bone and joint deformity and bone destruction were better in AB and CD groups were more relieved than that in M group.[Conclusions]The moxibustion of Complementary Acupoints can effectively intervene with RA of rats,and its mechanism may be closely related to the MC degranulation.
