Exploring Biocomplexity in Cancer: A Comprehensive Review

Living objects have complex internal and external interactions. The complexity is regulated and controlled by homeostasis, which is the balance of multiple opposing influences. The environmental effects finally guide the self-organized structure. The living systems are open, dynamic structures performing random, stationary, stochastic, self-organizing processes. The self-organizing procedure is defined by the spatial-temporal fractal structure, which is self-similar both in space and time. The system’s complexity appears in its energetics, which tries the most efficient use of the available energies;for that, it organizes various well-connected networks. The controller of environmental relations is the Darwinian selection on a long-time scale. The energetics optimize the healthy processes tuned to the highest efficacy and minimal loss (minimalization of the entropy production). The organism is built up by morphogenetic rules and develops various networks from the genetic level to the organism. The networks have intensive crosstalk and form a balance in the Nash equilibrium, which is the homeostatic state in healthy conditions. Homeostasis may be described as a Nash equilibrium, which ensures energy distribution in a “democratic” way regarding the functions of the parts in the complete system. Cancer radically changes the network system in the organism. Cancer is a network disease. Deviation from healthy networking appears at every level, from genetic (molecular) to cells, tissues, organs, and organisms. The strong proliferation of malignant tissue is the origin of most of the life-threatening processes. The weak side of cancer development is the change of complex information networking in the system, being vulnerable to immune attacks. Cancer cells are masters of adaptation and evade immune surveillance. This hiding process can be broken by electromagnetic nonionizing radiation, for which the malignant structure has no adaptation strategy. Our objective is to review the different sides of living complexity and use the knowledge to fight against cancer.

Scale, Complexity, and Cybersecurity Risk Management

Elementary information theory is used to model cybersecurity complexity, where the model assumes that security risk management is a binomial stochastic process. Complexity is shown to increase exponentially with the number of vulnerabilities in combination with security risk management entropy. However, vulnerabilities can be either local or non-local, where the former is confined to networked elements and the latter results from interactions between elements. Furthermore, interactions involve multiple methods of communication, where each method can contain vulnerabilities specific to that method. Importantly, the number of possible interactions scales quadratically with the number of elements in standard network topologies. Minimizing these interactions can significantly reduce the number of vulnerabilities and the accompanying complexity. Two network configurations that yield sub-quadratic and linear scaling relations are presented.

Topographic Map Analysis of Laramie Range Bedrock-Walled Canyon Complex and the Goshen Hole Escarpment-Surrounded Basin, Albany and Platte Counties, Southeast Wyoming, USA

The Laramie River after flowing in a north direction through southeast Wyoming’s Laramie Basin abruptly turns in an east direction to flow across the north-to-south oriented Laramie Range in a bedrock-walled canyon and eventually reaches the lower elevation Great Plains and southeast-oriented North Platte River. The North Laramie River, Bluegrass Creek, and North Sybille/Sybille Creek also flow from the Laramie Basin in separate bedrock-walled valleys into the Laramie Range before eventually joining the Laramie River. Bedrock-walled through valleys link the various Laramie Range stream and river crossing valleys and detailed topographic maps were used to determine how this anastomosing bedrock-walled canyon complex and the large escarpment-surrounded Goshen Hole basin (located just to the east of the anastomosing canyon complex) originated. Map evidence shows multiple streams of water must have diverged in the Laramie Basin from the north-oriented Laramie River to enter the Laramie Range before converging in or east of the Laramie Range and also shows how present day through valleys enabled diverging and converging streams of water to cross the Laramie Range. The anastomosing bedrock-walled valley complex studied here extends from north of the North Laramie River valley to south of the North Sybille/Sybille Creek valley. Large volumes of water flowing from the Laramie Basin to the Great Plains are interpreted to have eroded the anastomosing canyon complex and the “downstream” Goshen Hole escarpment-surrounded basin. Headward erosion of the north-oriented Sybille and Chugwater Creek valleys across large sheets of east-oriented water are interpreted to have left the Goshen Hole escarpment-surrounded basin as a large abandoned headcut. A water source was not determined, although a continental ice sheet that deeply eroded and warped the North American continent is considered to be a possible source.

Protection of Sensitive Messages Based on Quadratic Roots of Gaussians: Groups with Complex Modulus

This paper considers three algorithms for the extraction of square roots of complex integers {called Gaussians} using arithmetic based on complex modulus p + iq. These algorithms are almost twice as fast as the analogous algorithms extracting square roots of either real or complex integers in arithmetic based on modulus p, where is a real prime. A cryptographic system based on these algorithms is provided in this paper. A procedure reducing the computational complexity is described as well. Main results are explained in several numeric illustrations.

Coupled maps serving the exchange processes on the environmental interfaces regarded as complex systems

We have defined the environmental interface through the exchange processes between media forming this interface. Considering the environmental interface as a complex system we elaborated the advanced mathematical tools for its modelling. We have suggested two coupled maps serving the exchange processes on the environmental interfaces spatially ranged from cellular to planetary level, i.e. 1) the map with diffusive coupling for energy exchange simulation and 2) the map with affinity, which is suitable for matter exchange processes at the cellular level. We have performed the dynamical analysis of the coupled maps using the Lyapunov exponent, cross sample as well as the permutation entropy in dependence on different map parameters. Finally, we discussed the map with affinity, which shows some features making it a promising toll in simulation of exchange processes on the environmental interface at the cellular level.

Discovery of nano organo-clay complex pore-fractures in shale and its scientific significance:A case study of Cretaceous Qingshankou Formation shale,Songliao Basin,NE China

A new pore type,nano-scale organo-clay complex pore-fracture was first discovered based on argon ion polishing-field emission scanning electron microscopy,energy dispersive spectroscopy and three-dimensional reconstruction by focused ion-scanning electron in combination with analysis of TOC,R_(o)values,X-ray diffraction etc.in the Cretaceous Qingshankou Formation shale in the Songliao Basin,NE China.Such pore characteristics and evolution study show that:(1)Organo-clay complex pore-fractures are developed in the shale matrix and in the form of spongy and reticular aggregates.Different from circular or oval organic pores discovered in other shales,a single organo-clay complex pore is square,rectangular,rhombic or slaty,with the pore diameter generally less than 200 nm.(2)With thermal maturity increasing,the elements(C,Si,Al,O,Mg,Fe,etc.)in organo-clay complex change accordingly,showing that organic matter shrinkage due to hydrocarbon generation and clay mineral transformation both affect organo-clay complex pore-fracture formation.(3)At high thermal maturity,the Qingshankou Formation shale is dominated by nano-scale organo-clay complex pore-fractures with the percentage reaching more than 70%of total pore space.The spatial connectivity of organo-clay complex pore-fractures is significantly better than that of organic pores.It is suggested that organo-complex pore-fractures are the main pore space of laminar shale at high thermal maturity and are the main oil and gas accumulation space in the core area of continental shale oil.The discovery of nano-scale organo-clay complex pore-fractures changes the conventional view that inorganic pores are the main reservoir space and has scientific significance for the study of shale oil formation and accumulation laws.

Complexity estimation of image sequence for automatic target track

In the field of automatic target recognition and tracking,traditional image complexity metrics,such as statistical variance and signal-to-noise ratio,all focus on single-frame images.However,there are few researches about the complexity of image sequence.To solve this problem,a criterion of evaluating image sequence complexity is proposed.Firstly,to characterize this criterion quantitatively,two metrics for measuring the complexity of image sequence,namely feature space similarity degree of global background(FSSDGB)and feature space occultation degree of local background(FSODLB)are developed.Here,FSSDGB reflects the ability of global background to introduce false alarms based on feature space,and FSODLB represents the difference between target and local background based on feature space.Secondly,the feature space is optimized by the grey relational method and relevant features are removed so that FSSDGB and FSODLB are more reasonable to establish complexity of single-frame images.Finally,the image sequence complexity is not a linear sum of the single-frame image complexity.Target tracking errors often occur in high-complexity images and the tracking effect of low-complexity images is very well.The nonlinear transformation based on median(NTM)is proposed to construct complexity of image sequence.The experimental results show that the proposed metric is more valid than other metrics,such as sequence correlation(SC)and interframe change degree(IFCD),and it is highly relevant to the actual performance of automatic target tracking algorithms.

Saturation Estimation with Complex Electrical Conductivity for Hydrate-Bearing Clayey Sediments:An Experimental Study

Clays have considerable influence on the electrical properties of hydrate-bearing sediments.It is desirable to understand the electrical properties of hydrate-bearing clayey sediments and to build hydrate saturation(S_(h))models for reservoir evaluation and monitoring.The electrical properties of tetrahydrofuran-hydrate-bearing sediments with montmorillonite are characterized by complex conductivity at frequencies from 0.01 Hz to 1 kHz.The effects of clay and Sh on the complex conductivity were analyzed.A decrease and increase in electrical conductance result from the clay-swelling-induced blockage and ion migration in the electrical double layer(EDL),respectively.The quadrature conductivity increases with the clay content up to 10%because of the increased surface site density of counterions in EDL.Both the in-phase conductivity and quadrature conductivity decrease consistently with increasing Sh from 0.50 to 0.90.Three sets of models for Sh evaluation were developed.The model based on the Simandoux equation outperforms Archie’s formula,with a root-mean-square error(E_(RMS))of 1.8%and 3.9%,respectively,highlighting the clay effects on the in-phase conductivity.The fre-quency effect correlations based on in-phase and quadrature conductivities exhibit inferior performance(E_(RMS)=11.6%and 13.2%,re-spectively)due to the challenge of choosing an appropriate pair of frequencies and intrinsic uncertainties from two measurements.The second-order Cole-Cole formula can be used to fit the complex-conductivity spectra.One pair of inverted Cole-Cole parameters,i.e.,characteristic time and chargeability,is employed to predict S_(h) with an E_(RMS) of 5.05%and 9.05%,respectively.

Vertical dominant migration channel and hydrocarbon migration in complex fault zone, Bohai Bay sag, China

The quantitatively/semi-quantitatively formation conditions of vertical dominant hydrocarbon migration pathways were analyzed based on the big data analysis of petroleum geological parameters of complex fault Zone zone in the central-south Bohai Bay. According to this condition, the vertical dominant migration pathway and its charge points/segments are searched through structural modeling assistant analysis in the East Sag of Huanghekou. Under the constraints of charge points/segments, numerical simulation of hydrocarbon charge and migration is carried out to successfully predict hydrocarbon migration pathways and hydrocarbon enrichment blocks in shallow layers of complex fault zone. The main results are as follows:(1) The hydrocarbon charge in shallow layers of the active fault zone is differential, the charge points/sections of vertical dominant migration pathways are the starting points of shallow hydrocarbon migration and are very important for the hydrocarbon migration and accumulation in the shallow layers.(2) Among the shallow faults, those cutting the deep transfer bins or deep major migration pathways, with fault throw of more than 80 m in the accumulation period and the juxtaposition thickness between fault and caprock of the deep layers of less than 400 m are likely to be vertical dominant migration pathways in the sag area.(3) By controlling the vertical dominant migration pathways and charging points/segments in carrier layer, Neo-tectonic movement caused the differential hydrocarbon accumulation in the complex fault zone. The research results are of great significance for the fine exploration of the complex fault zone.

Earthquake disaster chain model based on complex networks for urban engineering systems

According to news reports on severe earthquakes since 2008,a total of 51 cases with magnitudes of 6.0 or above were analyzed,and 14 frequently occurring secondary disasters were identified.A disaster chain model was developed using principles from complex network theory.The vulnerability and risk level of each edge in this model were calculated,and high-risk edges and disaster chains were identified.The analysis reveals that the edge“floods→building collapses”has the highest vulnerability.Implementing measures to mitigate this edge is crucial for delaying the spread of secondary disasters.The highest risk is associated with the edge“building collapses→casualties,”and increased risks are also identified for chains such as“earthquake→building collapses→casualties,”“earthquake→landslides and debris flows→dammed lakes,”and“dammed lakes→floods→building collapses.”Following an earthquake,the prompt implementation of measures is crucial to effectively disrupt these chains and minimize the damage from secondary disasters.

Lymphovenous anastomosis and complex decongestive therapy for severe deformed lymphedema with recurrent infection:A case report

BACKGROUND Lower extremity lymphedema is a common complication following treatment for gynecological malignancies.Its incidence rate can reach up to 70%,affecting~20 million people worldwide.However,specialized treatment centers are scarce,and there is a lack of consensus on treatment approaches.Furthermore,there are even fewer reports on the systematic and effective treatment of severe lymphedema with malformations.Effective management of this condition remains a significant challenge for clinicians.CASE SUMMARY A 40-year-old woman developed bilateral leg swelling 6 years after receiving treatment for endometrial cancer.Since August 2018,she experienced>30 episodes of lymphangitis.Upon presentation,she exhibited bilateral leg swelling and deformation,with four large swellings in the posterior thigh that impeded movement,and pain in the limbs.Skin manifestations included lichenoid lesions and features of deep sclerosis.Radionuclide lymphoscintigraphy confirmed the diagnosis of lower limb lymphedema.After 6 mo of complex decongestive therapy(CDT)and three lymphaticovenous anastomosis(LVA)treatments,the patient lost 49 kg in weight.She also experienced a maximum circumference reduction of 35.2 cm in the left lower limb and 37.5 cm in the right lower limb.The leg pain disappeared,her swelling significantly decreased,and she regained the ability to walk,cycle,and run normally.CONCLUSION The combined application of CDT and LVA therapy demonstrates significant positive effects in the treatment of severe,deformed stage III lymphedema.

Source complexity of the 2016 M_W7.8 Kaikoura (New Zealand) earthquake revealed from teleseismic and InSAR data

On November 13, 2016, an MW7.8 earthquake struck Kaikoura in South Island of New Zealand. By means of back-projection of array recordings, ASTFs-analysis of global seismic recordings, and joint inversion of global seismic data and co-seismic In SAR data, we investigated complexity of the earthquake source. The result shows that the 2016 MW7.8 Kaikoura earthquake ruptured about 100 s unilaterally from south to northeast(~N28°–33°E), producing a rupture area about 160 km long and about 50 km wide and releasing scalar moment 1.01×1021 Nm. In particular, the rupture area consisted of two slip asperities, with one close to the initial rupture point having a maximal slip value ~6.9 m while the other far away in the northeast having a maximal slip value ~9.3 m. The first asperity slipped for about 65 s and the second one started 40 s after the first one had initiated. The two slipped simultaneously for about 25 s.Furthermore, the first had a nearly thrust slip while the second had both thrust and strike slip. It is interesting that the rupture velocity was not constant, and the whole process may be divided into 5 stages in which the velocities were estimated to be 1.4 km/s, 0 km/s, 2.1 km/s, 0 km/s and 1.1 km/s, respectively. The high-frequency sources distributed nearly along the lower edge of the rupture area, the highfrequency radiating mainly occurred at launching of the asperities, and it seemed that no high-frequency energy was radiated when the rupturing was going to stop.

The reaction of the iron thiosulfate-nitrosyl complex with adenosine triphosphoric acid

Iron tetranitrosyl complex bearing the thiosulfate ligand (TNIC) is an efficient nitrogen monoxide donor (NO). He shows antitumor properties and may be used as an original drug for the therapy of acute coronary syndrome. In this work, the reaction of the TNIC with adenosine triphosphoric acid (ATP) was studied. Formation of the products for the reaction of ATP with TNIC was shown by electronic microscopy. The kinetics of the reaction was controlled by spectrofluorometric method, and the complexation constant was measured. The mechanism of interaction of ATP with TNIC was proposed, and the relevant kinetic model satisfactorily described the experimental data, which permitted to calculate the rate constants for these process stages. NMR, IR, and M?ssbauer studies were used for determination of the reaction product structure. NMR study showed TNIC interaction only with adenine part of ATP. The method of IR spectroscopy identified both the absence NO in the reaction products and the occurrence of new Fe-S and Fe-N bonds. M?ssbauer study showed that iron in the reaction products was presented by two forms: Fe(II) and Fe(III). Thus, the structures for the [ATP-Fe2+S] and [ATP-Fe3+S] complexes were proposed.

High complex anal fistula managed by the modified transanal opening of the intersphincteric space via the inter-sphincteric approach:A case report

BACKGROUND High complex anal fistulas are epithelialized tunnels,with the main fistula piercing above the deep external sphincter and the internal opening approaching the dentate line.Conventional surgical procedures for high complex anal fistulas remove most of the external sphincter and damage the anorectal ring.Postoperative loss of anal function can cause physical and mental damage.Transanal opening of the intersphincteric space(TROPIS)is an effective procedure that completely preserves the external anal sphincter.However,its clinical application is limited by challenges in the localization of the internal opening of a fistula and the high risk of complications.On the basis of our clinical experience,we modified the TROPIS procedure for the treatment of treating high complex anal fistulas.CASE SUMMARY A patient with a high complex anal fistula located above the anorectal ring underwent modified TROPIS,which involved sepsis drainage and identification of the internal opening in the intersphincteric space.The patient with the high complex anal fistula recovered well postoperatively,without any postoperative complications or anal dysfunction.Anal function returned to normal after 17 months of follow-up.CONCLUSION The modified TROPIS procedure is the most minimally invasive surgery for anal fistulas that minimally impairs anal function.It allows the complete removal of infected anal glands and reduces the risk of postoperative complications.Modified TROPIS via the intersphincteric approach is an alternative sphincter-preserving treatment for high complex anal fistulas.

Optimized Complex Power Quality Classifier Using One vs. Rest Support Vector Machines

Nowadays, power quality issues are becoming a significant research topic because of the increasing inclusion of very sensitive devices and considerable renewable energy sources. In general, most of the previous power quality classification techniques focused on single power quality events and did not include an optimal feature selection process. This paper presents a classification system that employs Wavelet Transform and the RMS profile to extract the main features of the measured waveforms containing either single or complex disturbances. A data mining process is designed to select the optimal set of features that better describes each disturbance present in the waveform. Support Vector Machine binary classifiers organized in a “One Vs Rest” architecture are individually optimized to classify single and complex disturbances. The parameters that rule the performance of each binary classifier are also individually adjusted using a grid search algorithm that helps them achieve optimal performance. This specialized process significantly improves the total classification accuracy. Several single and complex disturbances were simulated in order to train and test the algorithm. The results show that the classifier is capable of identifying >99% of single disturbances and >97% of complex disturbances.

Exploration Technology for Complex Sandstone Reservoirs in the Developed Area of Shengli Oilfield

Jiyang depression, which is the main oil productive area of Shengli oil field, is located at the southeast part of the Bohai Bay Basin and is a terrestrial lacustrine rift subsidence basin formed in the late Mesozoic with fully developed fault system. The main hydrocarbon productive formations of this depression are the terrestrial clastic rocks of the Tertiary, which are of strong lateral variation. The complex fault reservoirs and subtle lithological reservoirs distributed extensively and are becoming the main exploration targets in recent years. The exploration and development practice in these years has formed the exploration technologies, mainly including detailed study and description of low grade faults, delineation of microstructures, facies constrained formation description and prediction and low resistivity oil bearing formation’s identification. These exploration technologies have resulted in remarkable effectiveness on the reserve and oil production increments.

Mapping epistasis and environment × QTX interaction based on four-omics genotypes for the detected QTX loci controlling complex traits in tobacco

Using newly developed methods and software, association mapping was conducted for chromium content and total sugar in tobacco leaf, based on four-omics datasets. Our objective was to collect data on genotype and phenotype for 60 leaf samples at four developmental stages, from three plant architectural positions and for three cultivars that were grown in two locations. Association mapping was conducted to detect genetic variants at quantitative trait SNP(QTS) loci, quantitative trait transcript(QTT) differences,quantitative trait protein(QTP) variability, and quantitative trait metabolite(QTM) changes,which can be summarized as QTX locus variation. The total heritabilities of the four-omics loci for both traits tested were 23.60% for epistasis and 15.26% for treatment interaction.Epistasis and environment × treatment interaction had important impacts on complex traits at all-omics levels. For decreasing chromium content and increasing total sugar in tobacco leaf, six methylated loci can be directly used for marker-assisted selection, and expression of ten QTTs, seven QTPs and six QTMs can be modified by selection or cultivation.

Space Complexity of Algorithm for Modular Multiplicative Inverse

In certain computational systems the amount of space required to execute an algorithm is even more restrictive than the corresponding time necessary for solution of a problem. In this paper an algorithm for modular multiplicative inverse is introduced and its computational space complexity is analyzed. A tight upper bound for bit storage required for execution of the algorithm is provided. It is demonstrated that for range of numbers used in public-key encryption systems, the size of bit storage does not exceed a 2K-bit threshold in the worst-case. This feature of the Enhanced-Euclid algorithm allows designing special-purpose hardware for its implementation as a subroutine in communication-secure wireless devices.

RFID Complex Event Processing: Applications in Real-Time Locating System

Complex event processing (CEP) can extract meaningful events for real-time locating system (RTLS) applications. To identify complex event accurately in RTLS, we propose a new RFID complex event processing method GEEP, which is based on the timed automata (TA) theory. By devising RFID locating application into complex events, we model the timing diagram of RFID data streams based on the TA. We optimize the constraint of the event streams and propose a novel method to derive the constraint between objects, as well as the constraint between object and location. Experiments prove the proposed method reduces the cost of RFID complex event processing, and improves the efficiency of the RTLS.

Approximate Solutions to the Discontinuous Riemann-Hilbert Problem of Elliptic Systems of First Order Complex Equations

Several approximate methods have been used to find approximate solutions of elliptic systems of first order equations. One common method is the Newton imbedding approach, i.e. the parameter extension method. In this article, we discuss approximate solutions to discontinuous Riemann-Hilbert boundary value problems, which have various applications in mechanics and physics. We first formulate the discontinuous Riemann-Hilbert problem for elliptic systems of first order complex equations in multiply connected domains and its modified well-posedness, then use the parameter extensional method to find approximate solutions to the modified boundary value problem for elliptic complex systems of first order equations, and then provide the error estimate of approximate solutions for the discontinuous boundary value problem.