[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury ...[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.展开更多
目的:观察自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂在肛周脓肿患者术后的应用效果。方法:选取2022年2月至2024年2月我院收治的100例肛周脓肿患者为研究对象,将其随机分为单药组和联合组,每组50例。单药组患者术后给予复方黄柏液涂剂治...目的:观察自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂在肛周脓肿患者术后的应用效果。方法:选取2022年2月至2024年2月我院收治的100例肛周脓肿患者为研究对象,将其随机分为单药组和联合组,每组50例。单药组患者术后给予复方黄柏液涂剂治疗,联合组患者术后给予自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂治疗,比较2组患者的疗效,记录患者症状改善时间、创面愈合时间及住院时间,比较不同时点患者疼痛评分、血管内皮生长因子(VEGF)、转化生长因子β(TGF-β)以及炎症因子水平。结果:术后14 d时,联合组患者总有效率显著高于单药组(P<0.05);联合组患者症状改善时间、创面愈合时间以及住院时间均显著短于单药组(P<0.05);术后1 d 2组患者疼痛评分比较差异无统计学意义(P>0.05),术后7 d、14 d时2组患者疼痛评分均显著降低,且联合组低于单药组(P<0.05);术后1 d 2组患者VEGF、TGF-β水平比较差异无统计学意义(P>0.05),术后14 d 2组患者VEGF、TGF-β水平均显著升高,且联合组高于单药组(P<0.05);术后1 d 2组患者炎症因子水平比较差异无统计学意义(P>0.05),术后14 d 2组患者炎症因子水平均显著降低,且联合组低于单药组(P<0.05)。结论:自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂用于肛周脓肿患者术后能够提高患者的临床疗效,减轻患者疼痛,促进术后创面愈合。展开更多
文摘[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.
文摘目的:观察自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂在肛周脓肿患者术后的应用效果。方法:选取2022年2月至2024年2月我院收治的100例肛周脓肿患者为研究对象,将其随机分为单药组和联合组,每组50例。单药组患者术后给予复方黄柏液涂剂治疗,联合组患者术后给予自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂治疗,比较2组患者的疗效,记录患者症状改善时间、创面愈合时间及住院时间,比较不同时点患者疼痛评分、血管内皮生长因子(VEGF)、转化生长因子β(TGF-β)以及炎症因子水平。结果:术后14 d时,联合组患者总有效率显著高于单药组(P<0.05);联合组患者症状改善时间、创面愈合时间以及住院时间均显著短于单药组(P<0.05);术后1 d 2组患者疼痛评分比较差异无统计学意义(P>0.05),术后7 d、14 d时2组患者疼痛评分均显著降低,且联合组低于单药组(P<0.05);术后1 d 2组患者VEGF、TGF-β水平比较差异无统计学意义(P>0.05),术后14 d 2组患者VEGF、TGF-β水平均显著升高,且联合组高于单药组(P<0.05);术后1 d 2组患者炎症因子水平比较差异无统计学意义(P>0.05),术后14 d 2组患者炎症因子水平均显著降低,且联合组低于单药组(P<0.05)。结论:自拟清热止痛生肌汤熏洗联合复方黄柏液涂剂用于肛周脓肿患者术后能够提高患者的临床疗效,减轻患者疼痛,促进术后创面愈合。
