期刊文献+

二次检索

题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

年份

学科

共找到1篇文章
< 1 >
每页显示 20 50 100
Compound Tufuling Granules (复方土茯苓颗粒) Regulate Glucose Transporter 9 Expression in Kidney to Influence Serum Uric Acid Level in Hyperuricemia Mice 被引量:10
1
作者 刘颖琬 孙维峰 +2 位作者 张娴娴 李静 张欢欢 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第11期823-829,共7页
Objective: To explore the effect of Compound Tufuling Granules (复方土茯苓颗粒, CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and ser... Objective: To explore the effect of Compound Tufuling Granules (复方土茯苓颗粒, CTG) on regulating glucose transporter 9 (GLUT9) expression in the kidney to influence the uric acid excretion by the kidney and serum uric acid (SUA) level in hyperuricemia mice. Methods: Sixty Kunming male mice were randomly divided into the control group, model group, benzbromarone group, and CTG high-, middle- and low- dose groups. The yeast extract and uricase inhibition method were used to build hyperuricemia model, and the corresponding drugs were administrated on the 7th day. On the 21st day the 24-h urine was collected, on the 22rid day the blood was collected, the SUA level was detected by uricase colorimetry, and the mRNA and protein expressions of GLUT9 were detected by quantitative real-time polymerase chain reaction and Western blot, respectively. Results: Compared with the model group, the levels of SUA and the mRNA and protein expressions of GLUT9 were significantly decreased, and the fraction excretion of uric acid (FEUA) was significantly increased in the CTG groups and benzbromarone group (all P〈0.05). There was no significant difference in the above indicators between the CTG high-dose group and benzbromarone group (P〉0.05). SUA is positively related to the GLUT9 mRNA and protein expressions in the kidney (P〈0.05 or P〈0.01). Conclusions: CTG can significantly reduce the SUA and increase the FEUA. In addition, CTG can effectively inhibit the mRNA and protein expressions of GLUT9 in the kidney of hyperuricemia mice to inhibit the uric acid re-absorption, promote uric acid excretion and reduce SUA. 展开更多
关键词 compound tufuling Granules HYPERURICEMIA glucose transporter 9 uric acid Chinese medicine
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部