Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvi...Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvic vein, etc. , are mentioned as the often encountered causes of pelvic pain. It has been reported in the recent ten or more years that intramuscular injection of vitamin K3 (Vit K3) could relieve pain induced by smooth muscle spasm. In order to evaluate the effect of Vit K3 administered by acupoint injection in relieving pelvic pain, 180 patients were treated and observed from April 1997 to April 1999 in our hospital, and good therapeutic effect was obtained. It was reported as follows.展开更多
目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组...目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组采用布地奈德联合维生素K_(3)注射液治疗。比较两组治疗前后白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、γ干扰素(interferon-γ,IFN-γ)炎症因子水平,用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等肺功能指标及效果。结果:两组治疗前IL-6、CRP、IFN-γ、FVC、FEV_(1)水平比较,差异无统计学意义(P>0.05);观察组治疗后IL-6、CRP水平低于对照组,IFN-γ、FVC、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果显著,不仅能有效降低机体炎症因子水平,还能改善肺功能。展开更多
目的探讨丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)―细胞外信号调节激酶1和2(extracellular signal regulated kinase1/2,ERK1/2)信号转导通路在复方丹参注射液对人足月妊娠羊膜上皮细胞水通道蛋白3(aquaporin3,AQ...目的探讨丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)―细胞外信号调节激酶1和2(extracellular signal regulated kinase1/2,ERK1/2)信号转导通路在复方丹参注射液对人足月妊娠羊膜上皮细胞水通道蛋白3(aquaporin3,AQP3)表达调节中的作用。方法原代培养足月妊娠羊水量正常与羊水过少人羊膜上皮细胞,将人羊膜上皮细胞均分为4组:分别为空白对照组、U0126组、复方丹参注射液组和U0126加复方丹参注射液组。采用免疫印迹技术检测人羊膜上皮细胞中磷酸化ERK1/2(p-ERK1/2)和AQP3的表达。结果 (1)在羊水量正常和羊水过少人羊膜上皮细胞中,均发现p-ERK1/2表达水平在U0126组较空白对照组明显下降(P<0.05),而复方丹参注射液组可以明显上调p-ERK1/2表达水平(P<0.05),U0126加复方丹参注射液组人羊膜上皮细胞中p-ERK1/2表达水平高于U0126组,但低于复方丹参注射液组(P<0.05)。(2)在羊水量正常的人羊膜上皮细胞中,U0126组AQP3的表达与空白对照组比较无明显变化(P>0.05);复方丹参注射液组和U0126加复方丹参注射液组AQP3的表达水平均高于空白对照组(P<0.05),但两组间比较差异无统计学意义(P>0.05)。(3)在羊水过少羊膜上皮细胞中,U0126组AQP3的表达较空白对照组下降(P<0.05);复方丹参注射液组可以明显上调AQP3的表达水平(P<0.05),而U0126加复方丹参注射液组AQP3的表达水平低于复方丹参注射液组(P<0.05),但高于U0126组(P<0.05)。结论羊水过少时,复方丹参注射液通过激活MAPK-ERK1/2信号转导通路来调节人羊膜上皮细胞中AQP3的表达水平。展开更多
文摘Pelvic pain is one of the most common symptoms in gynecologic outpatients. Primary dysmenorrhea, acute or chronic pelvic inflammatory disease, endometriosis, post-operational pelvic adhesion, blood stagnation of pelvic vein, etc. , are mentioned as the often encountered causes of pelvic pain. It has been reported in the recent ten or more years that intramuscular injection of vitamin K3 (Vit K3) could relieve pain induced by smooth muscle spasm. In order to evaluate the effect of Vit K3 administered by acupoint injection in relieving pelvic pain, 180 patients were treated and observed from April 1997 to April 1999 in our hospital, and good therapeutic effect was obtained. It was reported as follows.
文摘目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组采用布地奈德联合维生素K_(3)注射液治疗。比较两组治疗前后白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、γ干扰素(interferon-γ,IFN-γ)炎症因子水平,用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等肺功能指标及效果。结果:两组治疗前IL-6、CRP、IFN-γ、FVC、FEV_(1)水平比较,差异无统计学意义(P>0.05);观察组治疗后IL-6、CRP水平低于对照组,IFN-γ、FVC、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果显著,不仅能有效降低机体炎症因子水平,还能改善肺功能。
文摘目的探讨丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)―细胞外信号调节激酶1和2(extracellular signal regulated kinase1/2,ERK1/2)信号转导通路在复方丹参注射液对人足月妊娠羊膜上皮细胞水通道蛋白3(aquaporin3,AQP3)表达调节中的作用。方法原代培养足月妊娠羊水量正常与羊水过少人羊膜上皮细胞,将人羊膜上皮细胞均分为4组:分别为空白对照组、U0126组、复方丹参注射液组和U0126加复方丹参注射液组。采用免疫印迹技术检测人羊膜上皮细胞中磷酸化ERK1/2(p-ERK1/2)和AQP3的表达。结果 (1)在羊水量正常和羊水过少人羊膜上皮细胞中,均发现p-ERK1/2表达水平在U0126组较空白对照组明显下降(P<0.05),而复方丹参注射液组可以明显上调p-ERK1/2表达水平(P<0.05),U0126加复方丹参注射液组人羊膜上皮细胞中p-ERK1/2表达水平高于U0126组,但低于复方丹参注射液组(P<0.05)。(2)在羊水量正常的人羊膜上皮细胞中,U0126组AQP3的表达与空白对照组比较无明显变化(P>0.05);复方丹参注射液组和U0126加复方丹参注射液组AQP3的表达水平均高于空白对照组(P<0.05),但两组间比较差异无统计学意义(P>0.05)。(3)在羊水过少羊膜上皮细胞中,U0126组AQP3的表达较空白对照组下降(P<0.05);复方丹参注射液组可以明显上调AQP3的表达水平(P<0.05),而U0126加复方丹参注射液组AQP3的表达水平低于复方丹参注射液组(P<0.05),但高于U0126组(P<0.05)。结论羊水过少时,复方丹参注射液通过激活MAPK-ERK1/2信号转导通路来调节人羊膜上皮细胞中AQP3的表达水平。
