Convergence of Y Chromosome STR Haplotypes from Different SNP Haplogroups Compromises Accuracy of Haplogroup Prediction

The paternally inherited Y chromosome has been widely used in forensics for personal identification, in anthropology and population genetics to understand origin and migration of human populations, and also in medical and clinical studies （Wang and Li, 2013; Wang et al., 2014）. There are two kinds of extremely useful markers in Y chromosome, single nucle- otide polymorphism （SNP） and short tandem repeats （STRs）. With a very low mutation rate on the order of 3.0 x 10-8 mutations/nucleotide/generation （Xue et al., 2009）, SNP markers have been used in constructing a robust phylogeny tree linking all the Y chromosome lineages from world pop- ulations （Karafet et al., 2008）. Those lineages determined by the pattern of SNPs are called haplogroups. That is to say, we have to genotype an appropriate number of SNPs in order to assign a given Y chromosome to a haplogroup. Compared with SNPs, the mutation rates of STR markers are about four to five orders of magnitude higher （Gusmgo et al., 2005; Ballantyne et al., 2010）. Typing STR has advantages of saving time and cost compared with typing SNPs in phylogenetic assignment of a Y chromosome （Wang et al., 2010）. A set of STR values for an individual is called a haplotype. Because of the disparity in mutation rates between SNP and STR, one SNP haplogroup could actually comprise many STR haplotypes （Wang et al., 2010）. It is most interesting that STR variability is clustered more by haplogroups than by populations （Bosch et al., 1999; Behar et al., 2004）, which indicates that STR haplotypes could be used to infer the haplogroup information of a given Y chromosome. There has been increasing interest in this cost- effective strategy for predicting the haplogroup from a given STR haplotype when SNP data are unavailable. For instance, Vadim Urasin＇s YPredictor （http：//predictor.ydna.ru/）, Whit Atheys＇ haplogroup predictor （http：//www.hprg.com/hapest5/） （Athey, 2005, 2006）, and haplogroup classifier of Arizona University （Schlecht et al., 2008） have been widely employed in previous studies for haplogroup prediction （Larmuseau et al., 2010; Bembea et al., 2011; Larmuseau et al., 2012; Tarlykov et al., 2013）.

Emerging patterns of antimicrobial resistance:Concurrent presence of mcr-1.1 and mcr-8.1 in a ST15 Klebsiella pneumoniae isolated from poultry in China

Colistin serves as a crucial treatment for multidrugresistant(MDR)Gram-negative bacterial infections.However,its excessive use has contributed to an increase in colistin-resistant strains within livestock production(Binsker et al.2022).The mobile colistin resistance gene,mcr,which reduces colistin affinity by incorporating phosphoethanolamine(pEtN)into the bacterial lipopolysaccharide,significantly compromises the effectiveness of colistin treatments(Liu et al.2016).

STEINER CEPHALOMETRIC NORMS FOR SHANGHAI ADULT

In this paper, 60 samples (30 male and 30 female) with normal occlusion in permanent dentition were selected. 60 lateral radiographic cephalograms were taken. By mean of Steiner analysis, means, standard deviations were calculated. Acceptable compromises for individual use were established. Comparison these data with Beijing and Korean were made. Thus the characteristics of craniofacial morphology and denture patterns of Shanghai adult were observed.

窗无恶

窗是建筑得以成立的基本要素之一。我们今天还在引用的“……凿户牖以为室,有室之用……”足以证明先人在文明之初给予窗的重视。在不同时代与不同文化的建筑中,如果审视墙、柱、顶、台阶、门、窗等这些建筑基本要素,不难发现窗是几乎唯一的总与正向的事物联系在一起的要素。当墙与割裂、柱与耻辱、顶与压迫、台阶与距离、门与特权可以产生各种暗淡的社会文化纠葛时,窗似乎是完全幸免的。

莎士比亚与英语词汇(18)

该词的意思是“相互承诺，达成一致”。英语的释义是to bind by mutual agreement；to come to terms。

An efficient hash-based authenticated key agreement scheme for multi-server architecture resilient to key compromise impersonation

During the past decade,rapid advances in wireless communication technologies have made it possible for users to access desired services using hand-held devices.Service providers have hosted multiple servers to ensure seamless online services to end-users.To ensure the security of this online communication,researchers have proposed several multi-server authentication schemes incorporating various cryptographic primitives.Due to the low power and computational capacities of mobile devices,the hash-based multi-server authenticated key agreement schemes with offline Registration Server(RS)are the most efficient choice.Recently,Kumar-Om presented such a scheme and proved its security against all renowned attacks.However,we find that their scheme bears an incorrect login phase,and is unsafe to the trace attack,the Session-Specific Temporary Information Attack(SSTIA),and the Key Compromise Impersonation Attack(KCIA).In fact,all of the existing multi-server authentication schemes(hash-based with offline RS)do not withstand KCLA.To deal with this situation,we propose an improved hash-based multi-server authentication scheme(with offline RS).We analyze the security of the proposed scheme under the random oracle model and use the t4Automated Validation of Internet Security Protocols and Applications''(AVISPA)tool.The comparative analysis of communication overhead and computational complexity metrics shows the efficiency of the proposed scheme.

Resolution of epidural hematoma related to osteoporotic fracture after percutaneous vertebroplasty

We are the first to report a case that showed spontaneous resolution of epidural hematoma which was related to a steroid-induced osteoporotic compression fracture.The patient had a painful fracture with an intravertebral cleft at L1 accompanying an epidural hematoma posteriorly.Immediate pain relief was achieved after percutaneous vertebroplasty.Complete resolution of hematoma was noted three months after procedure.We theorized that intravertebral stability after treatment might have played a role in this patient.

Method for multi-attribute group decision-making based on the compromise weights

Multi-attribute group decision-making problems are considered where information on both attribute weights and value scores of consequences is incomplete.In group decision analysis,if preference information about alternatives is provided by participants,it should be verified whether there exist compromise weights that can support all the preference relations.The different compromise weight vectors may differ for the ranking of the alternatives.In the case that compromise weights exist,the method is proposed to find out all the compromise weight vectors in order to rank the alternatives.Based on the new feasible domain of attribute weights determined by all the compromise weight vectors and the incomplete information on value scores of consequences,dominance relations between alternatives are checked by a nonlinear goal programming model which can be transformed into a linear one by adopting a transformation.The checked dominance relations uniformly hold for all compromise weight vectors and the incomplete information on value scores of consequences.A final ranking of the alternatives can be obtained by aggregating these dominance relations.

Multi-criteria group decision making with fuzzy data:an extension of the VIKOR method

The VIKOR method is a multi-criteria decision making aid, which employs linear normalization to offer compromise solu- tions and has been successfully applied to various group decision making problems. However, the conventional VIKOR techniques used to integrate group judgments and the information loss arising from defuzzification are problematic and distort final outcomes. An improved integration method, which is optimization-based, is proposed. And it can handle fuzzy criteria values and weights. The precondition for accurately defuzzifying triangular fuzzy num- bers is identified. Several effective defuzzification procedures are proposed to improve the extant VIKOR, and a comprehensive evaluation framework is offered to aid multi-criteria group decision making. Finally, a numerical example is provided to illustrate the practicability of the proposed method.

Fuzzy distances based FMAGDM compromise ratio method and application

An extended compromise ratio method（CRM） based on fuzzy distances is developed to solve fuzzy multi-attribute group decision making problems in which weights of attributes and ratings of alternatives on attributes are expressed with values of linguistic variables parameterized using triangular fuzzy numbers.A compromise solution is determined by introducing the ranking index based on the concept that the chosen alternative should be as close as possible to the positive ideal solution and as far away from the negative ideal solution as possible simultaneously.This proposed method is compared with other existing methods to show its feasibility and effectiveness and illustrated with an example of the military route selection problem as one of the possible applications.

Molecular Dynamics Simulation of Effect of Salt on the Compromise of Hydrophilic and Hydrophobic Interactions in Sodium Dodecyl Sulfate Micelle Solutions

The presence of salt has a profound effect on the size,shape and structure of sodium dodecyl sulfate(SDS)micelles.There have been a great number of experiments on SDS micelles in the presence and absence of salt to study this complex problem.Unfortunately,it is not clear yet how electrolyte ions influence the structure of micelles.By describing the compromise between dominant mechanisms,a simplified atomic model of SDS in presence of salt has been developed and the molecular dynamics(MD)simulations of two series of systems with different concentrations of salt and charges of ion have been performed.Polydispersity of micelle size is founded at relatively high concentration of SDS and low charge of cation.Although the counter-ion pairs with head groups are formed,the transition of micelle shape is not observed because the charge of cation is not enough to neutralize the polar of micelle surface.

Emergent reintubation following elective cervical surgery:A case series

AIM To review cases of emergent reintubation after cervical surgery.METHODS Patients who were emergently intubated in the postoperative period following cervical surgery were identified. The patients' prospectively documented demographic parameters, medical history and clinical symptoms were ascertained. Pre-operative radiographs were examined for the extent of their pathology. The details of the operative procedure were discerned.RESULTS Eight hundred and eighty patients received anterioror combined anterior-posterior cervical surgery from 2008-2013. Nine patients(1.02%) required emergent reintubation. The interval between extubation to reintubation was 6.2 h [1-12]. Patients were kept intubated after reintubation for 2.3 d [2-3]. Seven patients displayed moderate postoperative edema. One patient was diagnosed with a compressive hematoma whichwas subsequently evacuated in the OR. Another patient was diagnosed with a pulmonary effusion and treated with diuretics. One patient received a late debridement for an infected hematoma. Six patients reported residual symptoms and three patients made a complete recovery. CONCLUSION Respiratory compromise is a rare but potentially life threatening complication following cervical surgery. Patients at increased risk should be monitored closely for extended periods of time post-operatively. If the airway is restored adequately in a timely manner through emergent re-intubation, the outcome of the patients is generally favorable.

A neighbor information based false data filtering scheme in wireless sensor networks

In sensor networks,the adversaries can inject false data reports from compromised nodes.Previous approaches to filter false reports,e.g.,SEF,only verify the correctness of the message authentication code (MACs) carried in each data report on intermediate nodes,thus cannot filter out fake reports that are forged in a collaborative manner by a group of compromised nodes,even if these compromised nodes distribute in different geographical areas.Furthermore,if the adversary obtains keys from enough (e.g.,more than t in SEF) distinct key partitions,it then can successfully forge a data report without being detected en-route.A neighbor information based false report filtering scheme (NFFS) in wireless sensor networks was presented.In NFFS,each node distributes its neighbor information to some other nodes after deployment.When a report is generated for an observed event,it must carry the IDs and the MACs from t detecting nodes.Each forwarding node checks not only the correctness of the MACs carried in the report,but also the legitimacy of the relative position of these detecting nodes.Analysis and simulation results demonstrate that NFFS can resist collaborative false data injection attacks efficiently,and thus can tolerate much more compromised nodes than existing schemes.

Fermented Black Turmeric Designed by Lactobacillus Rearranged Leukocyte Subsets and Anti-Oxidative Activity

A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigate changes of immune-competent cells that commonly utilized FBT, including after administration of immno-suppressed animals, the effects by FBT on the regulated effect on the cells were evaluated. Our results showed that FBT augmented the level of lymphocytes in number, while FBT regulated the level of granulocytes in both number and function. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio suggesting their constitution as neutral in peripheral blood were increased significantly 30 days after the administration of FBT in rodents, and compromised host was prepared with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against intracellular parasite, and that FBT augmented intercellular pathogen through humoral immunity. We discussed the significance and mechanism of FBT on the level of leukocyte subsets in number and function that were considered to be potential indicators for the activation of the compromised host. We also proposed an idea that FBT exhibited tonic effects via activating complement components. The evidences were shown by immune-electrophoretic method. Moreover, we tried to access further to the anti-oxidative activities of this FBT. This modification brought to the significant lift up for antibody producing cells and anti-oxidative activity for phagocytic cells.

Ranking Method for Complementary Judgment Matrixes with Fuzzy Numbers Based on Hausdorff Metric Distance

A method for ranking complementary judgment matrixes with traspezoidal fuzzy numbers based on Hausdorff metric distance and fuzzy compromise decision approach is proposed. With regard to fuzzy number complementary judgment matrixes given by a decider group whose members have various weights, the expert＇s information was aggregated first by means of simple weight average（SWA） method and Bonissone calculational method. Hence a matrix including all the experts＇ preference information was got. Then the matrix＇ column members were added up and the fuzzy evaluation values of the alternatives were got. Lastly, the Hausdorff metric distance and fuzzy compromise decision approach were used to rank the fuzzy evaluation values and then the ranking values of all the alternatives were got. Because exact numbers and triangular fuzzy numbers could all be transformed into trapezoidal fuzzy numbers, the method developed can rank complementary judgment matrixes with trapezoidal fuzzy numbers, triangular fuzzy numbers and exact numbers as well. An illustrative example is also given to verify the developed method and to demonstrate its feasibility and practicality.

Coordination, Compromise, and Change： A Case of US-Japan Conflict Over Commercial Whaling

This paper, for the goal of revealing the mechanism of compromise and change in coordination, will focus on US-Japan conflict over commercial whaling. The regime like the international whaling regulation, where countries agree in general but disagree on coordination methods, is known as the Battle of the Sexes in game theory. It has been believed that in regimes presented as the Battle of the Sexes （BoS） situation, once the countries could somehow coordinate their interests and reach an agreement on the specific method of coordination, neither country would have the incentive to withdraw from that agreement. This case study, however, shows that this belief is not always true. From the analysis of this study, it will be concluded that coordination methods change over time even in regimes where the countries agree in general and disagree on coordination methods. In this case, ＂power,＂ ＂institution＂ and ＂consensus＂ are pointed out as incentives to make the two countries accept a specific coordination method.

DNS analysis of incipient drop impact dynamics using an accurate level set method

A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts.A square-root correction for neck bases was modified in accuracy as well as scope of applications.In addition,process of jet formation and evolution was studied to reveal internal dynamics in drop impacts.It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks.With the help of PDF distribution and correction calculation,a compromise in the competition is observed.This work lays a solid foundation for further studies of dynamics in gas-liquid flows.

Single Cellular Algae Digestive Supplement Designed by Yeast &Lactobacillus Rearranged Leukocyte Subsets through Activation of Complement Components

A plant fermentation was carried out by Yeast and Lactobacilli against single cellular algae (f-Chlorella). These materials were proved by as safe in animal safety experiment. We sought to look into changes of immune-competent cells that commonly utilized f-Chlorella including after administration of immno-suppressed animals. The effects by f-Chlorella on the regurational effect to the host were measured. Our results showed that f-Chlorella regulated the level of lymphocytes, while conventional-Chlorella worked to adjust the level of granulocytes. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in the peripheral blood. In rodents, immune-compromised host as well as normal animal were prepared with cancer chemotherapeutic agent (Mytomycin-C), and then tried to rescue the immune-competent rebel. Our observations showed that both Chlorella derivatives regulated in number and functions. The effect was more prominent in f-Chlorella than that of conventional one. We discussed the significance and mechanism of f-Chlorella on the level of leukocyte subsets in number and function. These effects were considered to bring the potential elevation of antibody secreting cell by the localized heamolysis in gel method. We also proposed an idea that exhibited tonic effects were brought via activating the complement components in the serum. Moreover, we tried to access further to the anti-oxidative activities of this f-Chlorella. This modification brought to the significant lifted up for immune competent cells and anti-oxidative activity for phagocytic cells.

Subcute Combined Degenaration亚急性联合变性

Key facts Synonyms：dysfunction of renal transplant due to renal artery stenosis.Classic imaging appearance：narrowing of the transplant renal artery Renal artery stenosis most common vascular complication,.venous stenosis may also be responsible for renal dysfunction.

Twist deformation and buckling behavior of veins

Introduction Twisted arteries and veins disrupt normal blood flow and elevate the risk for clinical complications such as thrombosis,heart attack,stroke,and organ dysfunction.Veins should remain mechanically stable for normal function.However,compared to arteries,veins are more vulnerable to collapse because they are thin-walled and under lower lumen pressure.Twisted veins have been shown to occur with head turning or after inadvertent twist during various vascular surgeries.In vivo and cadaver studies have demonstrated that turning the head to one side can result in torsion and compression of the internal jugular vein and can compromise cranial drain-