Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousa...Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousands of alarmed tech leaders recently signed an open letter to pause AI research to prepare for the catastrophic threats to humanity from uncontrolled AGI (Artificial General Intelligence). Perceived as an “epistemological nightmare”, AGI is believed to be on the anvil with GPT-5. Two computing rules appear responsible for these risks. 1) Mandatory third-party permissions that allow computers to run applications at the expense of introducing vulnerabilities. 2) The Halting Problem of Turing-complete AI programming languages potentially renders AGI unstoppable. The double whammy of these inherent weaknesses remains invincible under the legacy systems. A recent cybersecurity breakthrough shows that banning all permissions reduces the computer attack surface to zero, delivering a new zero vulnerability computing (ZVC) paradigm. Deploying ZVC and blockchain, this paper formulates and supports a hypothesis: “Safe, secure, ethical, controllable AGI/QC is possible by conquering the two unassailable rules of computability.” Pursued by a European consortium, testing/proving the proposed hypothesis will have a groundbreaking impact on the future digital infrastructure when AGI/QC starts powering the 75 billion internet devices by 2025.展开更多
In this paper, the sticker based DNA computing was used for solving the independent set problem. At first, solution space was constructed by using appropriate DNA memory complexes. We defined a new operation called “...In this paper, the sticker based DNA computing was used for solving the independent set problem. At first, solution space was constructed by using appropriate DNA memory complexes. We defined a new operation called “divide” and applied it in construction of solution space. Then, by application of a sticker based parallel algorithm using biological operations, independent set problem was resolved in polynomial time.展开更多
Deep vein thrombosis (DVT) is a common and potentially fatal vascular event when it leads to pulmonary embolism. Occurring as part of the broader phenomenon of Venous Thromboembolism (VTE), DVT classically arises when...Deep vein thrombosis (DVT) is a common and potentially fatal vascular event when it leads to pulmonary embolism. Occurring as part of the broader phenomenon of Venous Thromboembolism (VTE), DVT classically arises when Virchow’s triad of hypercoagulability, changes in blood flow (e.g. stasis) and endothelial dysfunction, is fulfilled. Although such immobilisation is most often seen in bedbound patients and travellers on long distance flights, there is increasing evidence that prolonged periods of work or leisure related to using computers while seated at work desks, is an independent risk factor. In this report, we present two cases of “e-thrombosis” from prolonged sitting while using a computer.展开更多
We are already familiar with computers——computers work for us at home, in offices and in factories. But it is also true that many children today are using computers at schools before they can write. What does this m...We are already familiar with computers——computers work for us at home, in offices and in factories. But it is also true that many children today are using computers at schools before they can write. What does this mean for the future? Are these children lucky or not?展开更多
In this letter,we propose a duality computing mode,which resembles particle-wave duality property whena quantum system such as a quantum computer passes through a double-slit.In this mode,computing operations arenot n...In this letter,we propose a duality computing mode,which resembles particle-wave duality property whena quantum system such as a quantum computer passes through a double-slit.In this mode,computing operations arenot necessarily unitary.The duality mode provides a natural link between classical computing and quantum computing.In addition,the duality mode provides a new tool for quantum algorithm design.展开更多
A new approach for the implementation of variogram models and ordinary kriging using the R statistical language, in conjunction with Fortran, the MPI (Message Passing Interface), and the "pbdDMAT" package within R...A new approach for the implementation of variogram models and ordinary kriging using the R statistical language, in conjunction with Fortran, the MPI (Message Passing Interface), and the "pbdDMAT" package within R on the Bridges and Stampede Supercomputers will be described. This new technique has led to great improvements in timing as compared to those in R alone, or R with C and MPI. These improvements include processing and forecasting vectors of size 25,000 in an average time of 6 minutes on the Stampede Supercomputer and 2.5 minutes on the Bridges Supercomputer as compared to previous processing times of 3.5 hours.展开更多
BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases reported.CASE SUMMARY This study reports a 51-year-old man with primary SCC of the renal parenchyma.The pat...BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases reported.CASE SUMMARY This study reports a 51-year-old man with primary SCC of the renal parenchyma.The patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross hematuria.SCC antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated calculi.The patient underwent laparoscopic unilateral nephrectomy and lymph node dissection.Postoperative pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and ureter.The pathological stage was Pt3aN1M0.Four months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena cava.The patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease progression.CONCLUSION We report a case of primary SCC of the renal parenchyma,a rare renal malignancy.The clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis challenging.According to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.展开更多
This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the surviva...This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT scans.The findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient prognosis.This noninvasive approach provides valuable insights into the therapeutic management of HCC.展开更多
BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and te...BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.展开更多
We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the s...We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.展开更多
.The geometric multigrid method(GMG)is one of the most efficient solving techniques for discrete algebraic systems arising from elliptic partial differential equations.GMG utilizes a hierarchy of grids or discretizati....The geometric multigrid method(GMG)is one of the most efficient solving techniques for discrete algebraic systems arising from elliptic partial differential equations.GMG utilizes a hierarchy of grids or discretizations and reduces the error at a number of frequencies simultaneously.Graphics processing units(GPUs)have recently burst onto the scientific computing scene as a technology that has yielded substantial performance and energy-efficiency improvements.A central challenge in implementing GMG on GPUs,though,is that computational work on coarse levels cannot fully utilize the capacity of a GPU.In this work,we perform numerical studies of GMG on CPU–GPU heterogeneous computers.Furthermore,we compare our implementation with an efficient CPU implementation of GMG and with the most popular fast Poisson solver,Fast Fourier Transform,in the cuFFT library developed by NVIDIA.展开更多
In my recent visit to Britain, I was greatly impressed by the currententhusiasm for computer-assisted language learning displayed by the languageteachers and practioners there. The production and implementation of CAL...In my recent visit to Britain, I was greatly impressed by the currententhusiasm for computer-assisted language learning displayed by the languageteachers and practioners there. The production and implementation of CALLcourseware has almost become the order of the day in many British展开更多
【题目要求】学校英语俱乐部将于2019年3月举办“科技创造美好未来”主题演讲会。请结合学到的有关话题内容,以“Computers”为题写一篇英语作文。[参考词汇]engineering工程automatically自动地accomplish完成【学生习作】With the dev...【题目要求】学校英语俱乐部将于2019年3月举办“科技创造美好未来”主题演讲会。请结合学到的有关话题内容,以“Computers”为题写一篇英语作文。[参考词汇]engineering工程automatically自动地accomplish完成【学生习作】With the development of science and technology, computers have been widely used in every field of men’s activities, bringing about many changes in our world.展开更多
Computers are becoming more and more useful in our daily life.It’s very important for us to learn how to use computers.Now,I’ll give you some①advices about using computers.
文摘Although AI and quantum computing (QC) are fast emerging as key enablers of the future Internet, experts believe they pose an existential threat to humanity. Responding to the frenzied release of ChatGPT/GPT-4, thousands of alarmed tech leaders recently signed an open letter to pause AI research to prepare for the catastrophic threats to humanity from uncontrolled AGI (Artificial General Intelligence). Perceived as an “epistemological nightmare”, AGI is believed to be on the anvil with GPT-5. Two computing rules appear responsible for these risks. 1) Mandatory third-party permissions that allow computers to run applications at the expense of introducing vulnerabilities. 2) The Halting Problem of Turing-complete AI programming languages potentially renders AGI unstoppable. The double whammy of these inherent weaknesses remains invincible under the legacy systems. A recent cybersecurity breakthrough shows that banning all permissions reduces the computer attack surface to zero, delivering a new zero vulnerability computing (ZVC) paradigm. Deploying ZVC and blockchain, this paper formulates and supports a hypothesis: “Safe, secure, ethical, controllable AGI/QC is possible by conquering the two unassailable rules of computability.” Pursued by a European consortium, testing/proving the proposed hypothesis will have a groundbreaking impact on the future digital infrastructure when AGI/QC starts powering the 75 billion internet devices by 2025.
文摘In this paper, the sticker based DNA computing was used for solving the independent set problem. At first, solution space was constructed by using appropriate DNA memory complexes. We defined a new operation called “divide” and applied it in construction of solution space. Then, by application of a sticker based parallel algorithm using biological operations, independent set problem was resolved in polynomial time.
文摘Deep vein thrombosis (DVT) is a common and potentially fatal vascular event when it leads to pulmonary embolism. Occurring as part of the broader phenomenon of Venous Thromboembolism (VTE), DVT classically arises when Virchow’s triad of hypercoagulability, changes in blood flow (e.g. stasis) and endothelial dysfunction, is fulfilled. Although such immobilisation is most often seen in bedbound patients and travellers on long distance flights, there is increasing evidence that prolonged periods of work or leisure related to using computers while seated at work desks, is an independent risk factor. In this report, we present two cases of “e-thrombosis” from prolonged sitting while using a computer.
文摘We are already familiar with computers——computers work for us at home, in offices and in factories. But it is also true that many children today are using computers at schools before they can write. What does this mean for the future? Are these children lucky or not?
基金the National Fundamental Research Program under Grant No.2006CB921106National Natural Science Foundation of China under Grant Nos.10325521 and 60433050
文摘In this letter,we propose a duality computing mode,which resembles particle-wave duality property whena quantum system such as a quantum computer passes through a double-slit.In this mode,computing operations arenot necessarily unitary.The duality mode provides a natural link between classical computing and quantum computing.In addition,the duality mode provides a new tool for quantum algorithm design.
文摘A new approach for the implementation of variogram models and ordinary kriging using the R statistical language, in conjunction with Fortran, the MPI (Message Passing Interface), and the "pbdDMAT" package within R on the Bridges and Stampede Supercomputers will be described. This new technique has led to great improvements in timing as compared to those in R alone, or R with C and MPI. These improvements include processing and forecasting vectors of size 25,000 in an average time of 6 minutes on the Stampede Supercomputer and 2.5 minutes on the Bridges Supercomputer as compared to previous processing times of 3.5 hours.
文摘BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases reported.CASE SUMMARY This study reports a 51-year-old man with primary SCC of the renal parenchyma.The patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross hematuria.SCC antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated calculi.The patient underwent laparoscopic unilateral nephrectomy and lymph node dissection.Postoperative pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and ureter.The pathological stage was Pt3aN1M0.Four months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena cava.The patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease progression.CONCLUSION We report a case of primary SCC of the renal parenchyma,a rare renal malignancy.The clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis challenging.According to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.
文摘This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT scans.The findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient prognosis.This noninvasive approach provides valuable insights into the therapeutic management of HCC.
基金Supported by 2021 Disciplinary Construction Project in School of Dentistry,Anhui Medical University,No.2021kqxkFY05.
文摘BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in theliterature.CASE SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical level.After the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival overgrowth.Cone-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival overgrowth.CONCLUSION This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.
文摘We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.
基金the assistance provided by Mr.Xiaoqiang Yue and Mr.Zheng Li from Xiangtan University in regard in our numerical experiments.Feng is partially supported by the NSFC Grant 11201398Program for Changjiang Scholars and Innovative Research Team in University of China Grant IRT1179+4 种基金Specialized research Fund for the Doctoral Program of Higher Education of China Grant 20124301110003Shu is partially supported by NSFC Grant 91130002 and 11171281the Scientific Research Fund of the Hunan Provincial Education Department of China Grant 12A138Xu is partially supported by NSFC Grant 91130011 and NSF DMS-1217142.Zhang is partially supported by the Dean Startup Fund,Academy of Mathematics and System Sciences,and by NSFC Grant 91130011.
文摘.The geometric multigrid method(GMG)is one of the most efficient solving techniques for discrete algebraic systems arising from elliptic partial differential equations.GMG utilizes a hierarchy of grids or discretizations and reduces the error at a number of frequencies simultaneously.Graphics processing units(GPUs)have recently burst onto the scientific computing scene as a technology that has yielded substantial performance and energy-efficiency improvements.A central challenge in implementing GMG on GPUs,though,is that computational work on coarse levels cannot fully utilize the capacity of a GPU.In this work,we perform numerical studies of GMG on CPU–GPU heterogeneous computers.Furthermore,we compare our implementation with an efficient CPU implementation of GMG and with the most popular fast Poisson solver,Fast Fourier Transform,in the cuFFT library developed by NVIDIA.
文摘In my recent visit to Britain, I was greatly impressed by the currententhusiasm for computer-assisted language learning displayed by the languageteachers and practioners there. The production and implementation of CALLcourseware has almost become the order of the day in many British
文摘【题目要求】学校英语俱乐部将于2019年3月举办“科技创造美好未来”主题演讲会。请结合学到的有关话题内容,以“Computers”为题写一篇英语作文。[参考词汇]engineering工程automatically自动地accomplish完成【学生习作】With the development of science and technology, computers have been widely used in every field of men’s activities, bringing about many changes in our world.
文摘Computers are becoming more and more useful in our daily life.It’s very important for us to learn how to use computers.Now,I’ll give you some①advices about using computers.