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Study on concentration distribution and detonation characteristics for non-axisymmetric fuel dispersal
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作者 Linghui Zeng Zhongqi Wang +1 位作者 Xing Chen Jianping Li 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期484-495,共12页
The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation f... The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is built.The concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation field.The phase and component changes of fuel cloud at different locations are compared.The fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 20.94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 K.The highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is22.90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,respectively.The stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 28.37% longer than cylindrical charge. 展开更多
关键词 Fuel dispersal concentration distribution Detonation characteristic Fuel loss Numerical simulation
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Research on Distribution Regularities of Dust Concentration and Granularity in Large Mining Height Working Face
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作者 Daqing Li Qingyi Tu Yang Yang 《World Journal of Engineering and Technology》 2023年第2期208-216,共8页
The key for dust control of coal mine is to clarify the dust concentration distribution and sedimentation in different areas. Both similarity experiment and numerical simulation method have certain restrictions and ar... The key for dust control of coal mine is to clarify the dust concentration distribution and sedimentation in different areas. Both similarity experiment and numerical simulation method have certain restrictions and are quite different from the actual situation on site. In order to study the dust sedimentation regularity of coal mine in large mining height, “filter membrane method” is adopted in this paper, i.e., to dry and weigh the filter membrane before and after sampling, collect the dust of respirable zone on mining face and calculate the dust concentration based on a main airway of 100 m. The result shows that: A large amount of dust will be produced during coal mining, wherein the maximum dust concentration from 6 m upstream to 100 m downstream of coal cutter is 121 mg/m3</sup>, while the minimum dust concentration is 61 mg/m3</sup>;The dust concentration in return airway is reduced with the distance increases, while the dust concentration at the entrance is 91 mg/m3</sup>;A large amount of dust may fall from roof during section advancing and improves the dust concentration of hydraulic support in walking area obviously;The dust granularity of mining face and return airway is 0 - 100 μm, but the amount of respirable dust is higher than 80%, the larger the dust particle size, the higher the dust concentration. Besides, dust in small particle size can be suspended in air flow for longer, but that in large particle size may subside under the action of gravity;To reduce dust exposure, the mining position shall be located in the windward direction of advancing or coal cutter. This research can provide guidance for taking dust prevention measures of working face in large mining height. 展开更多
关键词 Safety Science and Engineering Dust concentration Filter Membrane Method Particle Size distribution Respirable Dust
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Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution 被引量:1
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作者 Tao Yin Changgen Peng +2 位作者 Weijie Tan Dequan Xu Hanlin Tang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第1期827-843,共17页
In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining ... In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party. 展开更多
关键词 Rate setting Tweedie distribution generalized linear models federated learning homomorphic encryption
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Extraction method of nanoparticles concentration distribution from magnetic particle image and its application in thermal damage of magnetic hyperthermia
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作者 汤云东 陈鸣 +1 位作者 Rodolfo C.C.Flesch 金涛 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第9期304-311,共8页
Magnetic particle imaging(MPI)technology can generate a real-time magnetic nanoparticle(MNP)distribution image for biological tissues,and its use can overcome the limitations imposed in magnetic hyperthermia treatment... Magnetic particle imaging(MPI)technology can generate a real-time magnetic nanoparticle(MNP)distribution image for biological tissues,and its use can overcome the limitations imposed in magnetic hyperthermia treatments by the unpredictable MNP distribution after the intratumoral injection of nanofluid.However,the MNP concentration distribution is generally difficult to be extracted from MPI images.This study proposes an approach to extract the corresponding concentration value of each pixel from an MPI image by a least squares method(LSM),which is then translated as MNP concentration distribution by an interpolation function.The resulting MPI-based concentration distribution is used to evaluate the treatment effect and the results are compared with the ones of two baseline cases under the same dose:uniform distribution and MPI-based distribution considering diffusion.Additionally,the treatment effect for all these cases is affected by the blood perfusion rate,which is also investigated deeply in this study.The results demonstrate that the proposed method can be used to effectively reconstruct the concentration distribution from MPI images,and that the weighted LSM considering a quartic polynomial for interpolation provides the best results with respect to other cases considered.Furthermore,the results show that the uniformity of MNP distribution has a positive correlation with both therapeutic temperature distribution and thermal damage degree for the same dose and a critical power dissipation value in the MNPs.The MNPs uniformity inside biological tissue can be improved by the diffusion behavior after the nanofluid injection,which can ultimately reflect as an improvement of treatment effect.In addition,the blood perfusion rate considering local temperature can have a positive effect on the treatment compared to the case which considers a constant value during magnetic hyperthermia. 展开更多
关键词 magnetic hyperthermia magnetic nanoparticles distribution thermal damage blood perfusion rate
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Integrative biogeography: Validating hypotheses of species distribution 被引量:1
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作者 Zhong-E Hou Shu-Qiang Li 《Zoological Research(Diversity and Conservation)》 2024年第1期86-88,共3页
DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&... DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&Moore,2005).However,the majority of conclusions drawn within the field of biogeography are hypothetical.Rigorous testing of these biogeographic hypotheses remains a considerable challenge.This paper presents the concept of“integrative biogeography”,which emphasizes the experimental testing of biogeographic hypotheses through studies on geological history,as well as biotic and abiotic factors(Figure 1). 展开更多
关键词 BIOGEOGRAPHY distribution DATING
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GIS Mapping, Biomonitoring and Distribution of Heavy Metal Concentrations Using Neem (Azadirachta indica) Bark in Makurdi Town, Benue State, Nigeria
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作者 Ada Florence Ogli Mohammed Ahmed +2 位作者 Adams Udoji Itodo Raymond Ahulle Wuana Rufus Sha’Ato 《Journal of Geoscience and Environment Protection》 2023年第7期213-226,共14页
The present work determined the concentration and spatial distribution of heavy metals (As, Hg, Cr, Cd and Pb) in soil samples from Makurdi and its environs using geographic information system (GIS). The specific obje... The present work determined the concentration and spatial distribution of heavy metals (As, Hg, Cr, Cd and Pb) in soil samples from Makurdi and its environs using geographic information system (GIS). The specific objective is to produce the spatial distribution maps showing the spatial distribution of toxic heavy metals in the study area. Inverse Distance Weighting (IDW), a GIS technique was used to produce dotted maps showing the spatial distribution of heavy metals in neem bark for better visualization of contamination zones and non-contamination zones. The map reveals few hotspot areas showing areas of high concentrations of the heavy metals investigated which were identified in red colours, the following concentration ranges were obtained;As (4.71 - 6.43 mg/kg), Cd (13.9 - 16.84 mg/kg), Cr (46.3 - 60.84 mg/kg), Hg (3.70 - 5.05 mg/kg) and Pb (24.02 - 31.34 mg/kg). These hotspot areas were found close to business outlets, fuel filling and service stations, farm sites where the application of fertilizers and pesticides were persistent coupled with heavy traffic of vehicles and other machinery which was associated with As, Hg, Cd, Pb and Cr been released into the environment thus, suggesting anthropogenic activities controlling the concentration of these heavy metals in the study areas. The cumulative effect of these heavy metals into the barks of neem could pose as danger, because this plant is used as herbs in folk medicine. 展开更多
关键词 Heavy Metal Contamination Spatial distribution Inverse Distance Weighting Folk Medicine Makurdi
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Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
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作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging
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Influence of Topography on the Distribution and Structure of Woody Plants in the Senegalese Sahel (Sandy Ferlo)
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作者 Moustapha Bassimbe Sagna Aïssatou Ndong Thiam +5 位作者 Khoudia Niang Oumar Sarr Aly Diallo Sekouna Diatta Daouda Ngom Aliou Guissé 《American Journal of Plant Sciences》 CAS 2024年第1期14-28,共15页
This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considerin... This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considering the different relief units was adopted. Woody vegetation was surveyed using a dendrometric approach. The results obtained show that the flora is dominated by a few species adapted to drought, such as Balanites aegyptiaca (L.) Del., Calotropis procera Ait. and Boscia senegalensis (Pers.). The distribution of this flora and the structure of the ligneous plants are linked to the topography. In the lowlands, the flora is more diversified and the ligneous plants reach their optimum level of development compared with the higher relief areas. In the lowlands, there are a few woody species which, in the past, were indicative of better climatic conditions. These are Anogeissus leiocarpus (DC.), Commiphora africana (A. Rich.), Feretia apodanthera Del., Loeseneriella africana (A. Smith), Mitragyna inermis (Willd.) and Sclerocarya birrea (A. Rich). It is important that their reintroduction into reforestation projects takes account of their edaphic preference. 展开更多
关键词 Woody Plants distribution TOPOGRAPHY Ferlo Senegal
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Boosting Adversarial Training with Learnable Distribution
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作者 Kai Chen Jinwei Wang +2 位作者 James Msughter Adeke Guangjie Liu Yuewei Dai 《Computers, Materials & Continua》 SCIE EI 2024年第3期3247-3265,共19页
In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.How... In recent years,various adversarial defense methods have been proposed to improve the robustness of deep neural networks.Adversarial training is one of the most potent methods to defend against adversarial attacks.However,the difference in the feature space between natural and adversarial examples hinders the accuracy and robustness of the model in adversarial training.This paper proposes a learnable distribution adversarial training method,aiming to construct the same distribution for training data utilizing the Gaussian mixture model.The distribution centroid is built to classify samples and constrain the distribution of the sample features.The natural and adversarial examples are pushed to the same distribution centroid to improve the accuracy and robustness of the model.The proposed method generates adversarial examples to close the distribution gap between the natural and adversarial examples through an attack algorithm explicitly designed for adversarial training.This algorithm gradually increases the accuracy and robustness of the model by scaling perturbation.Finally,the proposed method outputs the predicted labels and the distance between the sample and the distribution centroid.The distribution characteristics of the samples can be utilized to detect adversarial cases that can potentially evade the model defense.The effectiveness of the proposed method is demonstrated through comprehensive experiments. 展开更多
关键词 Adversarial training feature space learnable distribution distribution centroid
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Diversity of Orchids in Terms of Their Distribution, Uses and Conservation in Annapurna Conservation Area of Nepal
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作者 Babu Lal Tiruwa Basu Dev Neupane +2 位作者 Rabin Kadariya Chiranjibi Prasad Pokheral Bijaya Pant 《American Journal of Plant Sciences》 CAS 2024年第6期422-440,共19页
The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enou... The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enough yet thus making the need for ambitious research to be carried out. Previous study only included 81 species of orchids within ACA. This study aims to update the record of species and genera richness in the ACA. In total 198 species of orchids, belonging to 67 genera (40% and 62% of the total recorded orchid species and genera in Nepal) has been recorded in ACA. This represents an increase of 144% in species and 56% in genera over the previous data. Out of the 198 species, 99 were epiphytes, 6 were holomycotrophic and 93 were terrestrial. Among the 67 genera, Bulbophyllum (17) species were dominant, followed by Dendrobium (16), Herminium (10), Coelogyne, Plantanthera (9 each), Eria, Habenaria, Oberonia (8 each), Calanthe (7), and Liparis (6). Fifty-six species were found to be ornamentally significant and 85 species medicinally significant. 展开更多
关键词 ORCHIDS Annapurna Conservation Area DIVERSITY distribution USES
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Different concentrations of hyaluronic acid eye drops for dry eye syndrome: a systematic review and Meta-analysis
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作者 Xiao-Wei Ouyang Sheng Fang +5 位作者 Yun-Min Yi Shi-Peng Zou Qi-Yu Hu Zi-Xuan Huang Qing-Xia Li Jin-Yan Luo 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第6期1110-1119,共10页
AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web o... AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July 2023.Pooled standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were calculated.Sensitivity analysis,Egger’s test and Meta-regression analysis were performed for all indicators.RESULTS:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 cases.High-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and OSDI.CONCLUSION:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes. 展开更多
关键词 dry eye hyaluronic acid concentration META-ANALYSIS
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Achievable hole concentration at room temperature as a function of Mg concentration for MOCVD-grown p-GaN after sufficient annealing
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作者 Siyi Huang Masao Ikeda +4 位作者 Feng Zhang Minglong Zhang Jianjun Zhu Shuming Zhang Jianping Liu 《Journal of Semiconductors》 EI CAS CSCD 2024年第8期67-73,共7页
Relationship between the hole concentration at room temperature and the Mg doping concentration in p-GaN grown by MOCVD after sufficient annealing was studied in this paper.Different annealing conditions were applied ... Relationship between the hole concentration at room temperature and the Mg doping concentration in p-GaN grown by MOCVD after sufficient annealing was studied in this paper.Different annealing conditions were applied to obtain sufficient activation for p-GaN samples with different Mg doping ranges.Hole concentration,resistivity and mobility were characterized by room-temperature Hall measurements.The Mg doping concentration and the residual impurities such as H,C,O and Si were measured by secondary ion mass spectroscopy,confirming negligible compensations by the impurities.The hole concentration,resistivity and mobility data are presented as a function of Mg concentration,and are compared with literature data.The appropriate curve relating the Mg doping concentration to the hole concentration is derived using a charge neutrality equation and the ionized-acceptor-density[N-(A)^(-)](cm^(−3))dependent ionization energy of Mg acceptor was determined asE_(A)^(Mg)=184−2.66×10^(−5)×[N_(A)^(-)]1/3 meV. 展开更多
关键词 P-GAN hole concentration electrical properties ANNEALING ionization energy
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Effects of Different Concentrations of Sulfate Ions on Carbonate Crude Oil Desorption:Experimental Analysis and Molecular Simulation
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作者 Nannan Liu Hengchen Qi +1 位作者 Hui Xu Yanfeng He 《Fluid Dynamics & Materials Processing》 EI 2024年第8期1731-1741,共11页
Low salinity water containing sulfate ions can significantly alter the surface wettability of carbonate rocks.Nevertheless,the impact of sulfate concentration on the desorption of oil film on the surface of carbonate ... Low salinity water containing sulfate ions can significantly alter the surface wettability of carbonate rocks.Nevertheless,the impact of sulfate concentration on the desorption of oil film on the surface of carbonate rock is still unknown.This study examines the variations in the wettability of the surface of carbonate rocks in solutions containing varying amounts of sodium sulfate and pure water.The problem is addressed in the framework of molecular dynamics simulation(Material Studio software)and experiments.The experiment’s findings demonstrate that sodium sulfate can increase the rate at which oil moisture is turned into water moisture.The final contact angle is smaller than that of pure water.The results of the simulations show that many water molecules travel down the water channel under the influence of several powerful forces,including the electrostatic force,the van der Waals force and hydrogen bond,crowding out the oil molecules on the calcite’s surface and causing the oil film to separate.The relative concentration curve of water and oil molecules indicates that the separation rate of the oil film on the surface of calcite increases with the number of sulfate ions. 展开更多
关键词 Carbonate rocks WETTABILITY sulfate ions concentration molecular simulation DESORPTION
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Simulation of Haloxylon Ammodendron Stand Basic Diameter Structure Based on Fuzzy Distribution Function
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作者 Shaohua Wang Chuanqiang Liu Ting Yang 《Agricultural Sciences》 2024年第1期132-145,共14页
Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting ac... Based on the investigation data of 12 Haloxylon ammodendron plots in the south edge of Gurbantunggut Desert, Fuzzy distribution was introduced into the study of Haloxylon ammodendron base diameter structure fitting according to the consistency between the characteristics of Fuzzy distribution function and the distribution series of cumulative percentage of stand base diameter, and the fitting precision and effect of Fuzzy distribution function were discussed. The root mean square error RMSE and determination coefficient R<sup>2</sup> values showed that Fuzzy-Γ<sub>1</sub>, Fuzzy-Γ<sub>2</sub>, Fuzzy-Γ<sub>3</sub>, Fuzzy-Γ<sub>4</sub> had good fitting performance, among which Fuzzy-Γ<sub>1</sub> had relatively high fitting precision, and its parameters were closely related to stand age and density, Fuzzy-Γ<sub>2</sub> distribution function was the second, and Fuzzy-Γ<sub>4</sub> distribution function had the worst fitting effect. By introducing a parameter c from the similarity of four distribution function formulas, a generalized Fuzzy distribution function Fuzzy-Γ<sub>5</sub> is obtained. This function shows the highest fitting accuracy. Most of the values of parameter c are near 1 or 2, which shows that the diameter distribution is mainly approximate to Fuzzy-Γ<sub>1</sub> and Fuzzy-Γ<sub>2</sub>. 展开更多
关键词 Fuzzy distribution Function Haloxylon Ammodendron Base Diameter distribution Stand Factor
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Dynamics and genetic regulation of macronutrient concentrations during grain development in maize
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作者 Pengcheng Li Shuangyi Yin +7 位作者 Yunyun Wang Tianze Zhu Xinjie Zhu Minggang Ji Wenye Rui Houmiao Wang Chenwu Xu Zefeng Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期781-794,共14页
Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics an... Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize. 展开更多
关键词 MAIZE nutrient concentration unconditional QTL mapping conditional QTL mapping dynamic trait
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Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
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作者 Yan Ren Yan-Ni Cui Hong-Wei Wang 《World Journal of Stem Cells》 SCIE 2024年第2期163-175,共13页
BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect... BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cells(HSCs)in cord blood could improve clinical efficacy of this vital resource.Nicotinamide(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cells(HSPCs,CD34^(+)CD38)and functional subtypes of HSCs-shortterm repopulating HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and long-term repopulating HSCs(LT-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet known.As a sirtuin 1(SIRT1)inhibitor,NAM participates in regulating cell adhesion,polarity,migration,proliferation,and differentiation.However,SIRT1 exhibits dual effects by promoting or inhibiting differentiation in different tissues or cells.We propose that the concentration of NAM may influence proliferation,differentiation,and SIRT1 signaling of HSCs.AIM To evaluate the effects and underlying mechanisms of action of different concentrations of NAM on HSC proliferation and differentiation.METHODS CD34^(+)cells were purified from umbilical cord blood using MacsCD34 beads,and cultured for 10-12 d in a serum-free medium supplemented with cytokines,with different concentrations of NAM added according to experimental requirements.Flow cytometry was used to detect phenotype,cell cycle distribution,and apoptosis of the cultured cells.Real-time polymerase chain reaction was used to detect the transcription levels of target genes encoding stemness-related factors,che mokines,components of hypoxia pathways,and antioxidant enzymes.Dichloro-dihydro-fluorescein diacetate probes were used to evaluate intracellular production of reactive oxygen species(ROS).Determination of the effect of different culture conditions on the balance of cytokine by cytometric bead array.RESULTS Compared with the control group,the proportion and expansion folds of HSPCs(CD34^(+)CD38)incubated with 5 mmol/L or 10 mmol/L NAM were significantly increased(all P<0.05).The ST-HSCs ratio and fold expansion of the 5 mmol/L NAM group were significantly higher than those of the control and 10 mmol/L NAM groups(all P<0.001),whereas the LT-HSCs ratio and fold expansion of the 10 mmol/L NAM group were significantly higher than those of the other two groups(all P<0.05).When the NAM concentration was>10 mmol/L,cell viability significantly decreased.In addition,compared with the 5 mmol/L NAM group,the proportion of apoptotic cells in the 10 mmol/L NAM group increased and the proportion of cells in S and G2 phase decreased.Compared with the 5 mmol/L NAM group,the HSCs incubated with 10 mmol/L NAM exhibited significantly inhibited SIRT1 expression,increased intracellular ROS content,and downregulated expression of genes encoding antioxidant enzymes(superoxide dismutase 1,peroxiredoxin 1).CONCLUSION Low concentrations(5 mmol/L)of NAM can better regulate the balance between proliferation and differentiation,thereby promoting expansion of HSCs.These findings allow adjustment of NAM concentrations according to expansion needs. 展开更多
关键词 Hematopoietic stem cells NICOTINAMIDE concentration PROLIFERATION DIFFERENTIATION Sirtuin 1
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Effects of Serum Concentration, Synchronization Time and Confluence on the Cell-Cycle Synchronization Efficiency of Goat Fibroblasts
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作者 Van Khanh Nguyen Huong Thu Thi Vu +4 位作者 Au Thi Hoang Yen Kim Thi Pham Giang Thi Thanh Nhan Hung Phu Lai Lan Doan Pham 《Open Journal of Animal Sciences》 2024年第3期194-203,共10页
This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference... This study aims to evaluate the effect of serum concentration, synchronization time, and confluence degree on the synchronisation efficiency of goat fibroblast cycle. The results indicated that there was no difference in the percentage of nucleated fibroblasts in the G0/G1 stage between serum concentrations of 0.3% and 0.4% (83.89% and 82.69%, respectively, P > 0.05) as well as between serum concentrations of 0.2% and 0.5% (76.95% and 75.46%, respectively, P > 0.05). The percentage of nucleated fibroblasts in the G0/G1 stage was highest at the concentration of 0.3% and lowest in the control group (83.89% vs. 62.67%, P 0.05). The beneficial effect of high confluence was confirmed by the large percentage of nucleated fibroblasts at the G0/G1 stage. The 60% confluency was significantly lower than the 80% and 100% confluency (73.44%, 86.63%, and 87.17%, respectively, P < 0.05). The results indicate that the goat fibroblast cycle synchronization is the most effective at the serum concentration of 0.3%, 72 hours of synchronization and 100% confluency. 展开更多
关键词 Goat Fibroblast Cycle Synchronisation Serum concentration Synchronization Time CONFLUENCE
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Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear
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作者 Aixiang Wu Zhenqi Wang +3 位作者 Zhuen Ruan Raimund Bürger Shaoyong Wang Yi Mo 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第5期862-876,共15页
Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations o... Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed. 展开更多
关键词 thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration
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Evaluation of Multi-Temporal-Spatial Scale Adjustment Capability and Cluster Optimization Operation Method for Distribution Networks with Distributed Photovoltaics
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作者 Jiaxin Qiao Yuchen Hao +2 位作者 Yingqi Liao Fang Liang Jing Bian 《Energy Engineering》 EI 2024年第9期2655-2680,共26页
Themassive integration of high-proportioned distributed photovoltaics into distribution networks poses significant challenges to the flexible regulation capabilities of distribution stations.To accurately assess the f... Themassive integration of high-proportioned distributed photovoltaics into distribution networks poses significant challenges to the flexible regulation capabilities of distribution stations.To accurately assess the flexible regulation capabilities of distribution stations,amulti-temporal and spatial scale regulation capability assessment technique is proposed for distribution station areas with distributed photovoltaics,considering different geographical locations,coverage areas,and response capabilities.Firstly,the multi-temporal scale regulation characteristics and response capabilities of different regulation resources in distribution station areas are analyzed,and a resource regulation capability model is established to quantify the adjustable range of different regulation resources.On this basis,considering the limitations of line transmission capacity,a regulation capability assessment index for distribution stations is proposed to evaluate their regulation capabilities.Secondly,considering different geographical locations and coverage areas,a comprehensive performance index based on electrical distance modularity and active power balance is established,and a cluster division method based on genetic algorithms is proposed to fully leverage the coordination and complementarity among nodes and improve the active power matching degree within clusters.Simultaneously,an economic optimization model with the objective of minimizing the economic cost of the distribution station is established,comprehensively considering the safety constraints of the distribution network and the regulation constraints of resources.This model can provide scientific guidance for the economic dispatch of the distribution station area.Finally,case studies demonstrate that the proposed assessment and optimization methods effectively evaluate the regulation capabilities of distribution stations,facilitate the consumption of distributed photovoltaics,and enhance the economic efficiency of the distribution station area. 展开更多
关键词 Distributed photovoltaic distribution station area assessment of adjustment capacity line transmission capacity economic optimization
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An Algorithm for Short-Circuit Current Interval in Distribution Networks with Inverter Type Distributed Generation Based on Affine Arithmetic
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作者 Yan Zhang Bowen Du +3 位作者 Benren Pan GuannanWang Guoqiang Xie Tong Jiang 《Energy Engineering》 EI 2024年第7期1903-1920,共18页
During faults in a distribution network,the output power of a distributed generation(DG)may be uncertain.Moreover,the output currents of distributed power sources are also affected by the output power,resulting in unc... During faults in a distribution network,the output power of a distributed generation(DG)may be uncertain.Moreover,the output currents of distributed power sources are also affected by the output power,resulting in uncertainties in the calculation of the short-circuit current at the time of a fault.Additionally,the impacts of such uncertainties around short-circuit currents will increase with the increase of distributed power sources.Thus,it is very important to develop a method for calculating the short-circuit current while considering the uncertainties in a distribution network.In this study,an affine arithmetic algorithm for calculating short-circuit current intervals in distribution networks with distributed power sources while considering power fluctuations is presented.The proposed algorithm includes two stages.In the first stage,normal operations are considered to establish a conservative interval affine optimization model of injection currents in distributed power sources.Constrained by the fluctuation range of distributed generation power at the moment of fault occurrence,the model can then be used to solve for the fluctuation range of injected current amplitudes in distributed power sources.The second stage is implemented after a malfunction occurs.In this stage,an affine optimization model is first established.This model is developed to characterizes the short-circuit current interval of a transmission line,and is constrained by the fluctuation range of the injected current amplitude of DG during normal operations.Finally,the range of the short-circuit current amplitudes of distribution network lines after a short-circuit fault occurs is predicted.The algorithm proposed in this article obtains an interval range containing accurate results through interval operation.Compared with traditional point value calculation methods,interval calculation methods can provide more reliable analysis and calculation results.The range of short-circuit current amplitude obtained by this algorithm is slightly larger than those obtained using the Monte Carlo algorithm and the Latin hypercube sampling algorithm.Therefore,the proposed algorithm has good suitability and does not require iterative calculations,resulting in a significant improvement in computational speed compared to the Monte Carlo algorithm and the Latin hypercube sampling algorithm.Furthermore,the proposed algorithm can provide more reliable analysis and calculation results,improving the safety and stability of power systems. 展开更多
关键词 Short circuit calculation inverter type distributed power supplies affine arithmetic distribution network
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