Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible re...Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease.展开更多
Cerebral malaria and dengue are the common infections which cause higher mortality and morbidities in every part of the world especially in India.Concurrent infection of cerebral malaria and dengue is rare entity due ...Cerebral malaria and dengue are the common infections which cause higher mortality and morbidities in every part of the world especially in India.Concurrent infection of cerebral malaria and dengue is rare entity due to different habitat of vectors and it was reported rarely from Southeast Asia.In this case report,the authors reported a case of concurrent cerebral malaria and dengue which was recovered after eight days of admission with increase in morbidity.展开更多
Concurrent infections of malaria and dengue are when both of these mosquito-borne diseases occur simultaneously in an individual. In this review, reported cases with these co-infections in Asia are discussed. The focu...Concurrent infections of malaria and dengue are when both of these mosquito-borne diseases occur simultaneously in an individual. In this review, reported cases with these co-infections in Asia are discussed. The focus is on the overlapping clinical presentations and the difficulties encountered in differential diagnosis. Also, cases reported in some special conditions, viz., pregnancy, foetal infections, and co-infections with one or more other infectious agents are highlighted. Due to similar clinical presentations of malaria and dengue, these co-infections may give rise to an incorrect diagnosis. Moreover, the treatment regimens for these co-infections are not the same as those for mono-infections.Hence, a delay in implementing the appropriate treatment regimen for these concurrent infections due to poor diagnosis can be fatal. The present review is intended to increase awareness about the clinical significance and the importance of these co-infections among clinicians, public health workers and health authorities in the Asian region. Though malaria-dengue concurrent infections are seldom reported from the Asian region, it is probably increasing particularly in the countries known to be endemic for both of the above diseases. A compulsory reporting of the incidences of malaria-dengue concurrent infections is recommended.展开更多
Objective:To establish the nature and extent of dual dengue and malaria infections in an endemic area through a longitudinal study.Methods:A prospective study was conducted from August 2005 to December 2010 to documen...Objective:To establish the nature and extent of dual dengue and malaria infections in an endemic area through a longitudinal study.Methods:A prospective study was conducted from August 2005 to December 2010 to document the nature and extent of concurrent dengue and malaria infections in an area in central Kolkata,endemic both for dengue and malaria.Results: Of 2 971 suspected cases of dengue fever,in 605(20.36%) persons dengue infection was detected, of whom 46(7.60%,46/605) patients(40 and 6 suffered from secondary and primary dengue fever respectively) were simultaneously suffering from malaria(28 and 18 were infected with Plasmodium vivax(P.vivax) and Plasmodium falciparum(P.falciparum) respectively,such dual infections of dengue and malaria were detected in all the years of the study period,except 2007,indicating intense transmission of both dengue and malaria in the study area,and the phenomenon was not an isolated one,the rate of concomitant infections ranged from 25%in 2009 to 4.9%in 2005.Out of total population surveyed,1.54%(46/2 971) had concurrent dengue and malaria infection.Conclusions:These findings added a new dimension in diagnosis,treatment, epidemiology and control of dengue and malaria.The possible risk of concurrent dengue and malaria infectioas should always be kept in mind in endemic areas for early diagnosis employing modern technology and prompt and effective treatment to avoid serious complications.展开更多
Fasciolosis and hydatidosis are the world’s most common zoonotic major parasitic ailments of domesticated animals with financial and public health implications.A cross-sectional study was conducted on 384 randomly se...Fasciolosis and hydatidosis are the world’s most common zoonotic major parasitic ailments of domesticated animals with financial and public health implications.A cross-sectional study was conducted on 384 randomly selected cattle slaughtered at Wolaita Sodo municipal abattoir to estimate the prevalence and associated risk factors for co-infection of hydatidosis and fasciolosis using the ante-and postmortem examination techniques.Of the 384 examined cattle,4.17%were found to harbor co-infections of hydatidosis and fasciolosis.Similarly,the prevalence of concurrent fasciolosis and hydatidosis infections was 76.56%and 23.44%in local and crossbred animals,respectively.The current study took into account risk factors such as age,breed,origin,and body condition score;however,there is a statistically insignificant association between the risk factors and the prevalence of concurrent fasciolosis and hydatidosis infection.In this study,overall fasciolosis was recorded at a rate of 9.38%,with the highest prevalence of F.hepatica at 8.59%,followed by unidentified flukes at 4.17%and F.gigantica at 0.78%.Likewise,the single prevalence of hydatidosis was recorded at 10.94%.Of the 142 examined cysts,the liver alone harbors 54 cysts,and the lung alone harbors 88 cysts,with a total of 43 calcified,21 sterile,56 viable,9 nonviable,and 13 mixed cysts.The predicted yearly financial loss from organ condemnation was 15,436,142.00 ETB Birr.This study demonstrated that hydatidosis and fasciolosis are two relatively widespread parasite diseases of cattle in Ethiopia,causing significant economic loss attributable to organ rejection and indirect weight loss.Thus,awareness of the impact of the disease on the community could disrupt the parasite’s life cycle,and its economic significance was forwarded to other points.展开更多
BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver disease.Some studies have shown that comorbidities may have important effects on WD.Data on hepatitis B virus(HBV)infection in patients with WD a...BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver disease.Some studies have shown that comorbidities may have important effects on WD.Data on hepatitis B virus(HBV)infection in patients with WD are limited.AIM To investigate the prevalence and clinical impact of HBV infection in patients with WD.METHODS The clinical data of patients with WD were analyzed retrospectively,and the data of patients with concurrent WD and HBV infection were compared with those of patients with isolated WD.RESULTS Among a total of 915 WD patients recruited,the total prevalence of current and previous HBV infection was 2.1%[95%confidence interval(CI):1.2%-3.0%]and 9.2%(95%CI:7.3%-11.1%),respectively.The main finding of this study was the identification of 19 patients with concurrent WD and chronic hepatitis B(CHB)infection.The diagnosis of WD was missed in all but two patients with CHB infection.The mean delay in the diagnosis of WD in patients with concurrent WD and CHB infection was 32.5 mo,which was significantly longer than that in patients with isolated WD(10.5 mo).The rates of severe liver disease and mortality in patients with concurrent WD and CHB infection were significantly higher than those in patients with isolated WD(63.1%vs 19.3%,P=0.000 and 36.8%vs 4.1%,P<0.001,respectively).Binary logistic regression analysis revealed a significantly higher risk of severe liver disease at the diagnosis of WD in patients with current HBV infection[odds ratio(OR)=7.748;95%CI:2.890-20.774;P=0.000)]or previous HBV infection(OR=5.525;95%CI:3.159-8.739;P=0.000)than in patients with isolated WD.CONCLUSION The total prevalence of current HBV infection in patients with WD was 2.1%.The diagnosis of WD in CHB patients is usually missed.HBV infection is an independent risk factor for severe liver disease in WD patients.The diagnosis of WD should be ruled out in some patients with CHB infection.展开更多
文摘Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease.
文摘Cerebral malaria and dengue are the common infections which cause higher mortality and morbidities in every part of the world especially in India.Concurrent infection of cerebral malaria and dengue is rare entity due to different habitat of vectors and it was reported rarely from Southeast Asia.In this case report,the authors reported a case of concurrent cerebral malaria and dengue which was recovered after eight days of admission with increase in morbidity.
文摘Concurrent infections of malaria and dengue are when both of these mosquito-borne diseases occur simultaneously in an individual. In this review, reported cases with these co-infections in Asia are discussed. The focus is on the overlapping clinical presentations and the difficulties encountered in differential diagnosis. Also, cases reported in some special conditions, viz., pregnancy, foetal infections, and co-infections with one or more other infectious agents are highlighted. Due to similar clinical presentations of malaria and dengue, these co-infections may give rise to an incorrect diagnosis. Moreover, the treatment regimens for these co-infections are not the same as those for mono-infections.Hence, a delay in implementing the appropriate treatment regimen for these concurrent infections due to poor diagnosis can be fatal. The present review is intended to increase awareness about the clinical significance and the importance of these co-infections among clinicians, public health workers and health authorities in the Asian region. Though malaria-dengue concurrent infections are seldom reported from the Asian region, it is probably increasing particularly in the countries known to be endemic for both of the above diseases. A compulsory reporting of the incidences of malaria-dengue concurrent infections is recommended.
基金supported by grants from Department of Science and Technology,Government of West Bengal, India
文摘Objective:To establish the nature and extent of dual dengue and malaria infections in an endemic area through a longitudinal study.Methods:A prospective study was conducted from August 2005 to December 2010 to document the nature and extent of concurrent dengue and malaria infections in an area in central Kolkata,endemic both for dengue and malaria.Results: Of 2 971 suspected cases of dengue fever,in 605(20.36%) persons dengue infection was detected, of whom 46(7.60%,46/605) patients(40 and 6 suffered from secondary and primary dengue fever respectively) were simultaneously suffering from malaria(28 and 18 were infected with Plasmodium vivax(P.vivax) and Plasmodium falciparum(P.falciparum) respectively,such dual infections of dengue and malaria were detected in all the years of the study period,except 2007,indicating intense transmission of both dengue and malaria in the study area,and the phenomenon was not an isolated one,the rate of concomitant infections ranged from 25%in 2009 to 4.9%in 2005.Out of total population surveyed,1.54%(46/2 971) had concurrent dengue and malaria infection.Conclusions:These findings added a new dimension in diagnosis,treatment, epidemiology and control of dengue and malaria.The possible risk of concurrent dengue and malaria infectioas should always be kept in mind in endemic areas for early diagnosis employing modern technology and prompt and effective treatment to avoid serious complications.
文摘Fasciolosis and hydatidosis are the world’s most common zoonotic major parasitic ailments of domesticated animals with financial and public health implications.A cross-sectional study was conducted on 384 randomly selected cattle slaughtered at Wolaita Sodo municipal abattoir to estimate the prevalence and associated risk factors for co-infection of hydatidosis and fasciolosis using the ante-and postmortem examination techniques.Of the 384 examined cattle,4.17%were found to harbor co-infections of hydatidosis and fasciolosis.Similarly,the prevalence of concurrent fasciolosis and hydatidosis infections was 76.56%and 23.44%in local and crossbred animals,respectively.The current study took into account risk factors such as age,breed,origin,and body condition score;however,there is a statistically insignificant association between the risk factors and the prevalence of concurrent fasciolosis and hydatidosis infection.In this study,overall fasciolosis was recorded at a rate of 9.38%,with the highest prevalence of F.hepatica at 8.59%,followed by unidentified flukes at 4.17%and F.gigantica at 0.78%.Likewise,the single prevalence of hydatidosis was recorded at 10.94%.Of the 142 examined cysts,the liver alone harbors 54 cysts,and the lung alone harbors 88 cysts,with a total of 43 calcified,21 sterile,56 viable,9 nonviable,and 13 mixed cysts.The predicted yearly financial loss from organ condemnation was 15,436,142.00 ETB Birr.This study demonstrated that hydatidosis and fasciolosis are two relatively widespread parasite diseases of cattle in Ethiopia,causing significant economic loss attributable to organ rejection and indirect weight loss.Thus,awareness of the impact of the disease on the community could disrupt the parasite’s life cycle,and its economic significance was forwarded to other points.
文摘BACKGROUND Wilson disease(WD)is the most common genetic metabolic liver disease.Some studies have shown that comorbidities may have important effects on WD.Data on hepatitis B virus(HBV)infection in patients with WD are limited.AIM To investigate the prevalence and clinical impact of HBV infection in patients with WD.METHODS The clinical data of patients with WD were analyzed retrospectively,and the data of patients with concurrent WD and HBV infection were compared with those of patients with isolated WD.RESULTS Among a total of 915 WD patients recruited,the total prevalence of current and previous HBV infection was 2.1%[95%confidence interval(CI):1.2%-3.0%]and 9.2%(95%CI:7.3%-11.1%),respectively.The main finding of this study was the identification of 19 patients with concurrent WD and chronic hepatitis B(CHB)infection.The diagnosis of WD was missed in all but two patients with CHB infection.The mean delay in the diagnosis of WD in patients with concurrent WD and CHB infection was 32.5 mo,which was significantly longer than that in patients with isolated WD(10.5 mo).The rates of severe liver disease and mortality in patients with concurrent WD and CHB infection were significantly higher than those in patients with isolated WD(63.1%vs 19.3%,P=0.000 and 36.8%vs 4.1%,P<0.001,respectively).Binary logistic regression analysis revealed a significantly higher risk of severe liver disease at the diagnosis of WD in patients with current HBV infection[odds ratio(OR)=7.748;95%CI:2.890-20.774;P=0.000)]or previous HBV infection(OR=5.525;95%CI:3.159-8.739;P=0.000)than in patients with isolated WD.CONCLUSION The total prevalence of current HBV infection in patients with WD was 2.1%.The diagnosis of WD in CHB patients is usually missed.HBV infection is an independent risk factor for severe liver disease in WD patients.The diagnosis of WD should be ruled out in some patients with CHB infection.
