We create and analyze a mathematical model to understand the impact of condom-use and sexual behavior on the prevalence and spread of Sexually Transmitted Infections(STIs).STIs remain significant public health challen...We create and analyze a mathematical model to understand the impact of condom-use and sexual behavior on the prevalence and spread of Sexually Transmitted Infections(STIs).STIs remain significant public health challenges globally with a high burden of some Sexually Transmitted Diseases(STDs)in both developed and undeveloped countries.Although condom-use is known to reduce the transmission of STIs,there are a few quantitative population-based studies on the protective role of condom-use in reducing the incidence of STIs.The number of concurrent partners is correlated with their risk of being infectious by an STI such as chlamydia,gonorrhea,or syphilis.We develop a Susceptible-Infectious-Susceptible(SIS)model that stratifies the population based on the number of concurrent partners.The model captures the multi-level heterogeneous mixing through a combination of biased(preferential)and random(proportional)mixing processes between individuals with distinct risk levels,and accounts for differences in condom-use in the low-and high-risk populations.We use sensitivity analysis to assess the relative impact of high-risk people using condom as a prophylactic intervention to reduce their chance of being infectious,or infecting others.The model predicts the STI prevalence as a function of the number of partners of an individual,and quantifies how this distribution of effective partners changes as a function of condom-use.Our results show that when the mixing is random,then increasing the condom-use in the high-risk population is more effective in reducing the prevalence than when many of the partners of high-risk people have high risk.The model quantifies how the risk of being infected increases for people who have more partners,and the need for high-risk people to consistently use condoms to reduce their risk of infection.展开更多
基金This project has been partially supported by National Institute of Child Health and Human Development of the National Institutes of Health under award number R01HD086794by grants from the National Science Foundation(DMS1263374)the Office of the President of ASU,and the Office of the Provost at ASU.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
文摘We create and analyze a mathematical model to understand the impact of condom-use and sexual behavior on the prevalence and spread of Sexually Transmitted Infections(STIs).STIs remain significant public health challenges globally with a high burden of some Sexually Transmitted Diseases(STDs)in both developed and undeveloped countries.Although condom-use is known to reduce the transmission of STIs,there are a few quantitative population-based studies on the protective role of condom-use in reducing the incidence of STIs.The number of concurrent partners is correlated with their risk of being infectious by an STI such as chlamydia,gonorrhea,or syphilis.We develop a Susceptible-Infectious-Susceptible(SIS)model that stratifies the population based on the number of concurrent partners.The model captures the multi-level heterogeneous mixing through a combination of biased(preferential)and random(proportional)mixing processes between individuals with distinct risk levels,and accounts for differences in condom-use in the low-and high-risk populations.We use sensitivity analysis to assess the relative impact of high-risk people using condom as a prophylactic intervention to reduce their chance of being infectious,or infecting others.The model predicts the STI prevalence as a function of the number of partners of an individual,and quantifies how this distribution of effective partners changes as a function of condom-use.Our results show that when the mixing is random,then increasing the condom-use in the high-risk population is more effective in reducing the prevalence than when many of the partners of high-risk people have high risk.The model quantifies how the risk of being infected increases for people who have more partners,and the need for high-risk people to consistently use condoms to reduce their risk of infection.
