Mechanism of traditional Chinese medicine in the treatment of psoriasis with depression:A review

Psoriasis is a kind of immune-mediated, chronic, inflammatory skin disease, which is often associated with different degrees of psychological disorders. Specifically, there is a significant correlation between psoriasis and depression, and they show the relationships of reciprocal causation and mutual promotion. Psoriasis with depression is more harmful than simple psoriasis, and its prognosis is worse, which brings a huge burden to the family and society and is worthy of clinical attention. Based on the pathogenic factors of western medicine and pathogenesis of traditional Chinese medicine in psoriasis with depression, the paper summarized and elaborated the research progress on the mechanism of traditional Chinese medicine in the treatment of psoriasis with depression, in order to provide new ideas for clinical treatment.

Application and Practice of Traditional Chinese Medicine Characteristic Technology Inheritance in Research and Development of Traditional Chinese Medicine Preparations in Medical Institutions

Medical institution preparations play an important role in the development of hospitals,being one of the main forms of traditional Chinese medicine clinical characteristic medication,as well as an important carrier for the inheritance and innovation of traditional Chinese medicine.In recent years,the research and development of traditional Chinese medicine preparations has become a hot spot in the research and development of preparations by medical institutions.Traditional Chinese medicine preparations prepared by traditional processes and their entrusted preparation matters have changed from the current licensing management to filing management.The registration model of traditional Chinese medicine preparations has undergone significant changes,emphasizing more on real data and evaluation results from the objective world,respecting traditional medication experience,and emphasizing the inheritance and innovative development of traditional technological experience.In the process of following teachers in the inheritance project of traditional Chinese medicine,we combined the inheritance of traditional Chinese medicine characteristic technology with the research and development practice of traditional Chinese medicine preparations in medical institutions,and focused on the analysis and discussion of technical problems such as prescription screening,dosage form selection,process route design and clinical observation of traditional Chinese medicine preparations,hoping to provide reference for scholars in the same field of traditional Chinese medicine.

Traditional Chinese Medicine in Malaysia: A Brief Historical Overview of the Institutions

Traditional Chinese Medicine(TCM)in British Malaya developed concurrently with the influx of Chinese immigrants.To cater for tins growing community,Chinese medical halls which sell Chinese herbs were established in major townships.Consultation and various TCM treatments were also offered by contract TCM practitioners in some of these medical halls.As the needs for TCM services continued to grow,dedicated TCM institutions were set up subsequently.The establishment of these institutions marked the beginning of professional TCM services in the history of Malaysia.

Through a Century: Traditional Chinese Medicine Since 1912

Since 1912,traditional Chinese medicine(TCM)went through the stages of the struggle,foundation,and growth.The all-round developing TCM is academically progressing and promoted worldwide.Characteristics of the centennial development of TCM have cultural relevance,policy pertinency,mutual supplement between Chinese and western medicine and TCM is treatment directed by pattern diagnosis.Researches show that the historical inevitable development of TCM will benefit the people for generations to come when taken as a national strategy.

Unique Traditional Chinese Medicine Therapy for Painful Diabetic Peripheral Neuropathy

Painful diabetic peripheral neuropathy is one of the common chronic complications of diabetes."Pain"is the most typical symptom in patients,which seriously affects their quality of life.Traditional Chinese medicine(TCM)treatment of the disease includes oral administration of Chinese medicine,TCM fumigation and acupuncture,etc.,which can significantly reduce the pain of patients and reduce the frequency of disease.Chinese decoctions regulate the imbalance of yin and yang in the human body through syndrome differentiation,so as to achieve the balance of yin and yang,which will then eliminate the disease.Chinese medicine fumigation make the medicine seep into the body from the skin to exert the medical effects,and nourish and dredge the meridians.There is no pain if the meridians are smooth flowing,there will be pain if the meridians are blocked,fumigation can be used alone or assisted by other treatment methods to enhance the efficacy.The characteristics of acupuncture are rapid painrelief,economic and convenient,and can quickly relieve pain for patients with low tolerance.

Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma

Objective:To analyze the syndrome characteristics in patients with chronic persistent asthma.Methods:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional study.The information of syndrome,symptoms,signs,tongue coating and pulse were collected from all patients.The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square test.Results:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney.

Comparison of intestinal absorption characteristics between rhubarb traditional Chinese medicine preparation and activity ingredients using in situ and in vitro model

Objective: The intestinal absorption characteristics of active ingredients are very important for oral administration of traditional Chinese medicine(TCM) to achieve the desired therapeutic effect.However, a deeper understanding about active ingredients absorption characteristics is still lack. The aim of this study was to investigate the absorption properties and mechanism of rhubarb active ingredients in TCM preparation and pure form.Methods: The intestinal absorption behavior of active ingredients in Shenkang extract(SKE) and rhubarb anthraquinone ingredients(RAI) were investigated by in situ single-pass intestinal perfusion model. And the bidirectional transport characteristics of these active ingredients were assessed by in vitro Caco-2 cell monolayer model.Results: In situ experiment on Sprague-Dawley rats, the effective permeability coefficient values of aloeemodin, emodin and chrysophanol in RAI were higher than those in SKE, and the value of rhein in RAI was lower than that in SKE. But the easily absorbed segments of intestine were consistent for all ingredients,whether in SKE or in RAI. In vitro experiment, the apparent permeability coefficient values of rhein, emodin and chrysophanol in RAI were higher than those in SKE, and this value of aloe-emodin in RAI was lower than that in SKE. But their efflux ratio(ER) values in SKE and RAI were all similar.Conclusion: Four rhubarb anthraquinone ingredients in SKE and RAI have similar absorption mechanism and different absorption behavior, and the microenvironment of the study models influenced their absorption behavior. The results may provide an aid for understanding of the absorption characteristics of the TCM active ingredients in complex environments and the complementarities of different research models.

基于PubMed和Web of Science数据平台的中医药网络药理学论文特征分析

目的:基于PubMed和Web of Science两大外文数据库,运用文献计量学的方法对中医药网络药理学的相关论文进行特征分析,以期评价目前国内外中医网络药理学的科研水平,总结研究热点,预判研究趋势。方法:以"network pharmacology"和"中医药"为并列主题词,在PubMed和Web of Science中检索2008-2018年的相关论文,并对年发文数,发表地区分布,研究内容,期刊分布,参考文献引用等内容进行描述性统计分析。对参考文献的篇引用数和普赖斯指数以中英文进行独立样本t检验。结果:研究共纳入447篇论文。中医药网络药理学的发文数量逐年上升,至今仍处于上升期。论文作者的单位以国内占据多数。从研究内容来看,以复方的网络药理学研究为主,而复方中又以自拟方占据一半之多。研究方向主要涉及循环系统疾病、肿瘤、消化系统疾病和神经系统疾病。从期刊来看,高影响因子的论文较少,青睐发Scientific Reports,Frontiers in Pharmacology和Journal of Ethnopharmacology等。再者,从参考文献的引用情况分析,中英文刊的参考文献篇引用数具有显著差异(P<0.001),而普赖斯指数没有差异。结论:中医药网络药理学的发展仍处于上升期,近些年来,对所得虚拟网络要求进行验证的期刊越来越多。高影响因子中医药网络药理学的论文仍是短板。

Effect of traditional Chinese medicine compounds on rumen fermentation, methanogenesis and microbial flora in vitro

This study was conducted to investigate the effects of traditional Chinese medicine compounds(TCMC)on rumen fermentation, methane emission and populations of ruminal microbes using an in vitro gas production technique. Cablin patchouli herb(CPH), Atractylodes rhizome(AR), Amur Cork-tree(AC) and Cypsum were mixed with the weight ratios of 1:1:1:0.5 and 1:1:1:1 to make up TCMC1 and TCMC2,respectively. Both TCMC were added at level of 25 g/kg of substrate dry matter. In vitro gas production was recorded and methane concentration was determined at 12 and 24 h of incubation. After 24 h, the incubation was terminated and the inoculants were measured for pH, ammonia nitrogen, volatile fatty acids(VFA). Total deoxyribonucleic acid of ruminal microbes was extracted from the inocula, and populations were determined by a real-time quantitative polymerase chain reaction. Populations of total rumen methanogens, protozoa, total fungi, Ruminococcus albus, Fibrobacter succinogenes and Ruminococcus flavefaciens were expressed as a proportion of total rumen bacterial 16 S ribosomal deoxyribonucleic acid. Compared with the control, the 2 TCMC decreased(P < 0.05) total VFA concentration,acetate molar proportion, acetate to propionate ratio, gas and methane productions at 12 and 24 h,hydrogen(H) produced and consumed, and methanogens and total fungi populations, while the 2 TCMC increased(P < 0.05) propionate molar proportion. Traditional Chinese medicine compound 1 also decreased(P ≤ 0.05) R. flavefaciens population. From the present study, it is inferred that there is an effect of the TCMC in suppressing methanogenesis, probably mediated via indirect mode by channeling H2 utilized for methanogenesis to synthesis of propionate and direct action against the rumen microbes involved in methane formation. In addition, the relative methane reduction potential(RMRP) of TCMC2 was superior to that of TCMC1.

Biomechanical analysis of optic nerve injury treated by compound light granules and ciliary neurotrophic factor

In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone.

Morphological and microscopic characterization of five commonly-used testacean traditional Chinese medicines

Testacean traditional Chinese medicine(TTCM), derived from the outer shell of sea or freshwater mollusks, is a special and important category of Chinese medicinal materials. To ensure the effective use of TTCM, a comparative identification study was performed on five commonly-used testacean drugs, including Haliotidis Concha, Arcae Concha, Meretricis Concha, Ostreae Concha and Margaritifera Concha(Shijueming, Walengzi, Geqiao, Muli and Zhenzhumu in Chinese, respectively).Typical morphological photographs of the crude drugs were acquired, and the key microscopic characteristics of the derived powders under normal light microscope and polarized light microscope were summarized. The major results can be concluded as follows:(1) the original species involved in the five TTCMs could be distinguished by their respective interspecies morphological characteristics;(2) the key identification characteristics of the five powdered crude drugs were mainly crystal fragments, with the fragment features under both normal light and polarized light microscope providing powerful points for differentiating the five commonly-used testacean drugs. This study demonstrated that it is feasible to provide authentication for these five kinds of TTCMs by the combination of morphology with microscopy.

Perspective on the Development of Traditional Chinese Medicine and World Medicine

Following the spirit of Central Committee about the Opinions on Promoting the Inheritance, Innovation and Development of Traditional Chinese Medicine, professor Kai-Xian Chen, from Shanghai University of Traditional Chinese Medicine, delivered a comprehensive lecture on the development of traditional Chinese medicine (TCM) and world medicine. The lecture deeply elaborated on five aspects:the characteristics and advantages of TCM, the challenges faced by contemporary medicine, the status and role of TCM in the contemporary era, the inheritance and innovation of TCM, and the cooperation and development of "Belt and Road".

退变性腰椎管狭窄Coflex装置内固定术后的中医特色护理

[目的]探讨退变性腰椎管狭窄症(degenerative lumbar spinal stenosis,DLSS)行Coflex装置内固定术后中医特色护理的体会。[方法]84例肾阳虚型DLSS患者行Coflex装置内固定术,术后患者被随机分为观察组(n=42)和对照组(n=42)两组,对照组给予常规护理,观察组在对照组基础上给予中医特色护理,在术后第1d、第15d、第90d进行Oswestry功能障碍指数(oswestry disability index,ODI)及日本骨科协会评估治疗(Japanese orthopaedic association scores,JOA)评分,比较两组护理效果。[结果]两组患者术后第1d ODI及JOA评分比较差异均无统计学意义(P>0.05)。观察组患者术后第15d、第90dODI评分及JOA评分明显优于对照组,差异均有统计学意义(P<0.05)。[结论]对DLSS术后患者在常规护理的基础上采取中医特色护理,能明显减轻症状,降低疼痛,巩固手术疗效,促进患者全面康复。

中医师承教育在西医院校中医课程教学中的意义及作用

中医药师承教育是中医教育人才培养的重要途径。院校教育与师承教育相结合的模式被认为是当前最符合中医药教育自身规律的教育模式,西医院校的中医教育现状及存在的主要问题是中西医思维方式的切换难度大、中医临床见习课时有限。文化传承、经典传承、名师传授、实践导向、个性化教育,是中医师承教育的优势与特点。因此,将中医师承教育融入中医临床见习,是西医学生学习中医一种新型的教育模式,为培养中西医结合高级别人才做出探索与尝试。

岭南中医妇科课程标准化教学改革

地域特色课程是中医药院校的新兴课程,是我国发展中医药事业和高等中医药教育教学改革的重要组成部分,课程质量是培育人才的基石。文章基于岭南中医妇科课程标准化建设研究,通过分析目前的中医人才的培育要求及中医院校课程标准化的现状,指出该课程教学改革的必要性,从教材编写、教学设计、教学比例、教师队伍、教学形式、教学方法及考评方式等方面提出思考及实践总结,强调思政立德树人,跟师守正创新。以期为同类课程设置及教学实践提供参考。

泰国孔子学院中医药文化传播研究

2003年以来泰国中医药发展迅速,泰国高校与中国医学院建立紧密的合作关系,如东方大学孔子学院和华侨崇圣大学中医孔子学院,这对于泰国中医药文化的传播具有里程碑式的意义。在梳理泰国孔子学院发展概况的基础上,旨在对两所孔子学院——东方大学孔子学院、华侨崇圣大学中医孔子学院的中医药文化传播方式、特点及影响因素进行深入讨论。通过探究以上问题,提出三点对策:其一,提升师资力量,保证优质教学;其二,完善教学资源,编写本土化的中医汉语教材;其三,多样化推广中医药文化,拓宽中医药文化传播途径,以期为中医孔子学院实现可持续发展提供参考。

湖湘古代中医药文献的类型与特点述略

湖湘中医药文献既是湖湘先人认识疾病的重要途径,又是湖湘地区中医药知识的重要宝库。从早期的口头传承到简帛、竹木简牍,再到纸质文献,湖湘中医药文献呈现了丰富多样的类型和独特的发展轨迹。周秦两汉时期,湖湘中医药文献开始萌芽,主要以简帛文献为主;魏晋隋唐时期,文献载体逐渐向竹木简牍转变,且养生文献得到发展;宋金元时期,方书集合文献占据主导地位,中医药知识体系更趋完善;明清时期,见证了湖湘中医药文献的鼎盛,特别是处理时疫的文献得到广泛流传。通过厘清湖湘古代中医药文献的类型与特点,展示和挖掘湖湘中医药知识和理论的构建历程,从而促进湖湘中医药及其文献的研究利用。

中医治疗银屑病伴抑郁症的机制研究进展

银屑病是由免疫介导的慢性、炎症性皮肤病,常伴不同程度的心理障碍,其中,银屑病与抑郁症具有显著的关联性,呈现互为因果、互相促进的紧密关系。银屑病伴抑郁症较单纯银屑病危害更大,预后更差,给家庭及社会带来巨大负担,值得临床关注。本文基于银屑病伴抑郁症的西医发病因素及中医病机认识,总结阐述中医治疗银屑病抑郁机制的研究进展,以期为临床诊疗提供新的思路。

《中华中医药学刊》刊文特征与热点分析

目的 系统总结和分析《中华中医药学刊》2007—2022年所刊文的内容特征与热点,以期为《中华中医药学刊》的发展提供参考。方法 综合运用CiteSpace、VOSviewer等文献计量工具,从刊文量、研究者、研究机构、刊文主要关键词、刊文热点主题、刊文研究趋势等,进行多维视角的可视化分析。结果 年刊文数量呈下降趋势,但刊文质量显著提升;研究者之间连线较为密集;研究者群体相对稳定。结论 刊文研究者合作关系相对紧密;呈现以高校及其附属医院为核心研究者群体特征;中西医结合、中药现代化和针灸治疗现代化三大主题,是《中华中医药学刊》2007—2022年的研究热点。

浅析天津中药炮制技术的形成、发展与特色

天津中药饮片炮制起源于明代,成于清代,独具地方特色。为了传承与发扬天津中药炮制特色,文章通过整理文献书籍和《天津中药饮片炮制规范》2022版,分析了天津中药炮制技术的形成、发展与特色。天津中药炮制优选道地药材;修治与软化药材技术多样;切制技术兼容并蓄;辅料使用丰富多彩,重用醋与黄酒,善用甘草水炮制解毒;炮炙技术丰富,醋煮技术独具特色,通过比较《中国药典》2020版与其他地方中药材与饮片标准,挖掘出一些特色炮制品种。经过本文的挖掘与分析,可以为天津中药炮制的继承、发展与推广提供参考。