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Conotruncal heart malformations in Egypt: An epidemiological study
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作者 Doa’a A. Saleh Sameera Ezzat +3 位作者 Hala Hamza Mohamed Abdel-Hamid Karen S. Kuehl Christopher A. Loffredo 《Open Journal of Epidemiology》 2013年第4期169-176,共8页
Conotruncal malformations of the heart are a major category of birth defects. No previous epidemiological studies on these malformations have been carried out in Egypt;therefore our study aimed to describe association... Conotruncal malformations of the heart are a major category of birth defects. No previous epidemiological studies on these malformations have been carried out in Egypt;therefore our study aimed to describe associations with maternal and infant factors in order to identify possible risk factors. Cases (N = 255) were children up to two years of age whose heart malformations were confirmed by echocardiography;they were enrolled at the Cardiology Department of the Pediatric Hospital of Cairo University. Controls (N = 155) were free of congenital heart malformations, matched to the cases by age, and recruited from outpatients of the same hospital. Mothers of cases (97%) and controls (89%) provided consent to participate in an interview about their medical, familial, and occupational histories. Odds ratios (OR) and exact 95% confidence intervals (CI) assessed the magnitude and statistical significance of case-control differences. Cases were divided into two groups based on the presence of d-transposition of the great arteries (TGA): there were 139 with TGA and 116 with normally-related great arteries (NGA). Maternal diabetes prevalence was elevated in both the TGA (OR = 3.4) and NGA (OR = 5.5) subgroups. Several agricultural factors were associated with increased risk: raising animals (for TGA: OR = 2.4, 95% CI 1.2-4.6), raising poultry (for NGA: OR = 1.8, 95% CI 1.1-3.2), and using chemical rodenticides (for all conotruncal cases: OR = 3.2, 95% CI 1.1-13.2). These results are consistent with previous studies of associations of maternal diabetes and pesticide exposure with conotruncal malformations. Further research is warranted to explore such associations and determine avenues for prevention. 展开更多
关键词 CONGENITAL HEART Disease CARDIOVASCULAR MALFORMATIONS conotruncal MALFORMATIONS EPIDEMIOLOGY Environmental Factors Diabetes
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Etiopathogenesis research of tetralogy of Fallot
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作者 齐霄 陈寄梅 +1 位作者 庄建 朱平 《South China Journal of Cardiology》 CAS 2014年第1期84-92,共9页
Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital cardiac disease in humans. With recent advances in corrective surgery early lethality from TOF is rare but long-term sequelae, including arrhy... Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital cardiac disease in humans. With recent advances in corrective surgery early lethality from TOF is rare but long-term sequelae, including arrhythmia, ventricular dysfunction and often life-long disability. Now attention has shifted from immediate outcomes to understanding causation. This review summarizes current knowledge regarding the embryonic and molecular mechanisms involved in cardiac development, with particular attention paid to the role of transcription factors and to their potential usefulness in order to clarify the genetic basis of TOF. 展开更多
关键词 congenital heart disease tetralogy-of-Fallot conotruncal defect transcription factor gene mutation.
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