MEDICINAL PLANTS OF THE GENUS LEONURUS AND SEVENTEEN OF THEIR ISOLATED CONSTITUENTS SCREENED FOR EFFECTS ON PPARa,β/δ, and γ IN AN IN VITRO LUCIFERASE REPORTER GENE ASSAY

Leonurus japonicus Houtt.is used in TCM to treat the metabolic syndrome.However,up to now,no active constituents could be identified.Here we describe the isolation of 17 dominant constituents of L.japonicus and the related European herb Leonurus cardiaca L.-namely7R-chloro-6-desoxy-harpagide,ajugol,campneoside II,chicoric acid,ferulic acid,harpagide,isoacteoside,