TLC Identification of Yao Medicine Pileostegia tomentellal and Extraction Technology and Content Determination of Umbelliferone

[Objectives]To establish a TLC and content determination method of Pileostegia tomentellal,with umbelliferone as the indicator component.[Methods]TLC identification was performed by silica gel G thin layer plate with n-hexane-ethyl acetate(4:3)as the developing agent,and the plate was examined by UV lamp(365 nm).The umbelliferone content was determined by HPLC:Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm);mobile phase acetonitrile-0.2%phosphoric acid gradient elution;detection wavelength 320 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The chromatogram of P.tomentellal showed the same color spot in the same position as that of reference medicinal material,and the spot was clear with good specificity.Umbelliferone showed a good linear relationship when the injection volume was 2.63-131.27μg/mL(R^(2)=0.9997).The average recovery of umbelliferone in the low,middle and high adding groups of P.tomentellal was 99.57%and the RSD was 2.15%.[Conclusions]The method can effectively identify Yao medicine P.tomentellal and accurately determine the content of umbelliferone in medicinal materials,which will provide a scientific basis for the development and utilization of medicinal resources of Yao medicine P.tomentellal.

AHFO-based soil water content sensing technology considering soil-sensor thermal contact resistance

The actively heated fiber-optic(AHFO)technology has become emerged as a research focus due to its advantages of distributed,real-time measurement and good durability.These attributes have led to the gradual application of AHFO technology to the water content measurement of in situ soil.However,all existing in situ applications of AHFO technology fail to consider the effect of soilesensor contact quality on water content measurements,limiting potential for the wider application of AHFO technology.To address this issue,the authors propose a method for determining the soilesensor thermal contact resistance based on the principle of an infinite cylindrical heat source.This is then used to establish an AHFO water content measurement technology that considers the thermal contact resistance.The reliability and validity of the new measurement technology are explored through a laboratory test and a field case study,and the spatial-temporal evolution of the soil water content in the case is revealed.The results demonstrate that method for determining the soilesensor thermal contact resistance is highly effective and applicable to all types of soils.This method requires only the moisture content,dry density,and thermal response of the in situ soil to be obtained.In the field case,the measurement error of soil water content between the AHFO method,which takes into account the thermal contact resistance,and the neutron scattering method is only 0.011.The water content of in situ soil exhibits a seasonal variation,with an increase in spring and autumn and a decrease in summer and winter.Furthermore,the response of shallow soils to precipitation and evaporation is significant.These findings contribute to the enhancement of the accuracy of the AHFO technology in the measurement of the water content of in situ soils,thereby facilitating the dissemination and utilization of this technology.

Exploration of the efficacy and mechanism of treating head wind disease with the combination change of ginger volatile oil and gingerol by using content-weighted network pharmacology technology

Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content weight.Methods:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:0.The relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were considered.To assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was calculated.Subsequently,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different targets.Key targets with A≥1000 were identified.To predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://ctdbase.org/),Gene Cards(https://www.genecards.org/),and Disgenet database(https://www.disgenet.org/)were utilized.The key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted targets.This facilitated network pharmacological analysis and verification of the efficacy.Results:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil group.Each specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in content.Experimental testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in rats.Conclusion:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginger's volatile oil and gingerol leads to variations in potential targets and pathways,consequently impacting its efficacy.

基于注意力机制LSTM的电离层TEC预测

电离层总电子含量(Total Electron Content,TEC)的监测与预报是空间环境研究的重要内容,对卫星通讯和导航定位等有重要意义.TEC值影响因素较多,很难确定精确物理模型来对其进行预测.本文设计了基于注意力机制的LSTM模型(Att-LSTM),采用过去24小时TEC观测数据对未来TEC进行预测.选择北半球东经100°上,每2.5°纬度选择一个位置,共计36个位置来验证本文提出模型的性能,并与主流的深度学习模型如DNN、RNN、LSTM进行对比实验.取得了如下成果:(1)在选定的36个地区未来2小时单点预测上,基于本文的Att-LSTM模型的TEC预测性能明显优于其他对比模型;(2)讨论了纬度对Att-LSTM预测未来2小时TEC值时性能的影响,发现在北纬0°到60°之间,Att-LSTM预测性能随着纬度的升高而略有降低,在北纬62.5°~87.5°之间,模型预测性能出现扰动,预测效果略差;(3)讨论了磁暴期和磁静期模型的预测性能,发现无论是磁暴期还是磁静期,本文模型预测性能均较好;(4)还讨论了对未来多时点预测效果,实验结果表明,本文所提出的模型对未来2、4个小时的预测拟合度R-Square均超过0.95,预测结果比较可靠,对未来6、8、10个小时预测拟合度最高为0.7934,预测拟合度R-Square下降迅速,预测结果不可靠.

Toward high-sulfur-content,high-performance lithium-sulfur batteries:Review of materials and technologies

Lithium sulfur batteries(LSBs)are recognized as promising devices for developing next-generation energy storage systems.In addition,they are attractive rechargeable battery systems for replacing lithium-ion batteries(LIBs)for commercial use owing to their higher theoretical energy density and lower cost compared to those of LIBs.However,LSBs are still beset with some persistent issues that prevent them from being used industrially,such as the unavoidable dissolution of lithium polysulfide intermediates during electrochemical reactions and large volume expansion(up to 80%)upon the formation of Li_(2)S,resulting in serious battery life and safety limitations.In the process of solving these problems,it is necessary to maintain a high sulfur content in the cathode materials to ensure that the LSBs have high energy densities and excellent cycle performance.In this review,the novel preparation methods and cathode materials used for preparing LSBs in recent years are reviewed considering the sulfur content and cycle performance.In addition,the problems and difficulties in practically applying cathode materials are described,and the development trend is discussed.

基于北斗GEO卫星观测的桂林地区TEC空间梯度研究

小尺度的总电子含量(TEC)梯度异常会显著影响区域电离层模型以及地基增强系统(GBAS)的精度。因此,为了提高区域电离层模型的准确性和GBAS导航定位的精度,深入研究小尺度的TEC空间梯度显得尤为重要。为了研究中小尺度的空间梯度,利用2019—2022年间桂林地区全球卫星导航系统(GNSS)接收机的北斗地球静止轨道(GEO)卫星数据,对中国低纬地区(23°N 107.9°~113.1°E)电离层的TEC空间梯度进行研究分析。根据3颗北斗GEO卫星对地形成的3个相邻穿刺点(从西至东,依次编号为C02,C03,C01)的TEC观测值,构成C02-C03与C03-C01两个约为300 km尺度区域(107.9°~110.3°E,110.3°~113.1°E)的TEC梯度观测。统计结果显示,C02-C03区域的空间梯度基本为西向;而C03-C01区域的空间梯度在1~4月与9~12月为东向,5~8月为西向。这表明2个相邻区域的空间梯度在季节变化上存在差异,揭示了中小尺度空间梯度具有显著的局地效应。此外,地方时差并非空间梯度事件的主要原因。在太阳活动高年,背景TEC较高,空间梯度事件更易发生。梯度事件发生率的半年变化是TEC半年异常的体现。空间梯度事件在不同地磁条件下的发生率相似。

子午工程二期GNSS电离层TEC与闪烁监测仪样机测试及数据对比分析

子午工程二期电离层TEC与闪烁接收机布网采用国产设备.经过连续3天的运行测试,本文以同台站同天线的国外对比设备PolaRx5数据为参考,对样机的数据进行质量评估.对于科学研究,数据的连续性和有效性,VTEC、幅度闪烁指数、相位闪烁指数这三项数据的精度是最重要的指标.本文根据科研场景设计了这些方面的数据比较标准,评估样机的数据质量,并对两种设备探测结果特征的原因进行了分析,为数据准确性的评估提供参考和借鉴.

2015年3月特大磁暴期间中国区域电离层TEC NeuralProphet预报模型研究

延迟是全球卫星导航定位中重要的误差源之一,提高电离层TEC建模和预报精度对改善卫星导航定位精度至关重要.本文构建了以太阳辐射通量指数F_(10.7)、地磁活动指数Dst、地理坐标和中国科学院(Chinese Academy of Sciences,CAS)GIM数据为输入参数的NeuralProphet神经网络模型(NP模型),实现在2015年3月特大磁暴期中国区域电离层TEC短期预报.为验证NP模型的预报精度,本文同时构建了长短期记忆神经网络(Long Short-term Memory Neural Network,LSTM)模型进行对比分析.结果统计分析表明,NP模型在磁暴期(2015年DOY076-078)TEC预报值RMSE和RD分别为0.83 TECU和3.13%,绝对和相对精度较LSTM模型分别提高1.49 TECU和10.25%;且NP模型RMSE优于1.5 TECU的比例达97.24%,远高于LSTM模型.NP模型预报值与CAS具有较好一致性和无偏性,偏差均值仅为-0.01 TECU,而LSTM模型预报值的均值偏大,偏差均值为1.49 TECU.从低纬到中纬度的三个纬度带内,NP模型RMSE分别为1.12、0.83和0.44 TECU,精度比LSTM模型提高1.94、1.56和1.23 TECU.整体上,在磁暴期NP模型预报性能明显优于LSTM模型,能够精细描述中国区域电离层TEC时空变化.

QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

基于GPS TEC的2022年1月15日汤加火山喷发激起的电离层行扰分析

2022年1月15日南太平洋汤加海底火山发生剧烈喷发,是近30年来最大规模的火山爆发,产生的强烈大气波动为开展火山喷发电离层扰动研究提供了难得的机会。本文利用GPS数据探测火山附近、新西兰、澳大利亚和中国地区的电离层扰动,从波形、频率、传播速度和时空分布等角度分析汤加火山喷发电离层行扰(TIDs)的特征,并利用电离层测高站、海平面监测站和大气压监测站的观测数据进一步验证TIDs的传播特征。研究结果发现,汤加火山喷发在其附近区域、新西兰、澳大利亚和中国地区引起了3类TIDs。在火山附近东、西、南、北方向上均探测到第一类TIDs, TIDs的传播速度为617~972 m/s,该类TIDs极有可能由火山喷发产生的声波引起。汤加火山喷发仅在火山附近东、西方向引起第二类TIDs,其传播速度分别为472 m/s和418 m/s,可能由声波传播过程中衍生的声重力波或者混合波引起,形成机理有待进一步研究。汤加火山喷发在新西兰、澳大利亚和中国地区引发了第三类TIDs,其传播速度为328~352 m/s,该类TIDs与Lamb波密切相关。

Feasibility of measuring moisture content of green sand by a low frequency multiprobe detector based on dielectric characteristics

Green sand is a mixture of silica sand,bentonite,water and coal powder,and other additives.Moisture content is an important index to characterize the properties of green sand.Based on the dielectric characteristics of green sand and transmission line theory,a method for rapidly measuring the moisture content of green sand by means of a low frequency multiprobe detector was proposed.A system was constructed,where six detectors with different arrangements and probes were designed.The experimental results showed that the voltage difference of transmission line increases with the increasing frequency before 29 MHz while decreases after 35 MHz.A voltage difference platform occurs in the range of 29-35 MHz,which is suitable for measuring the moisture content due to its insensitivity to frequency.The electric field intensity gradually decreases with the increase of the probe depth,and the intensity of central probe is always greater than that of the edge probe.When the distance of the probe away from the sand sample surface is 80 mm,the electric field intensity of the edge probe is found to be very weak.The optimal excitation frequency for measuring the moisture content of green sand is 29-33 MHz.The optimal detector is the one with one center probe and three edge probes,and their lengths are 80 mm and 60 mm,respectively.The distance between the center and edge probes is 25 mm,and the diameter of probes is 5 mm.Taking the voltage difference of transmission line,bentonite content,coal powder content and compactability as parameters of the input layer,and the moisture content as a parameter of the output layer,a three-layer BP artificial neural network model for predicting the moisture content of green sand was constructed according to the experimental results at 33 MHz.The prediction error of the model is not higher than 3.3% when the moisture content of green sand is within the range of 3wt.%-7wt.%.

京津冀区域电离层TEC多参数融合预测模型

本文利用中国地壳观测网络(陆态网络)GPS站点实测总电子含量(Total Electron Content, TEC)数据,建立了京津冀区域电离层经验模型,并通过引入太阳通量和地磁活动数据来提高模型的性能。本文研究了电离层TEC的日变化、季节变化和地磁影响分量的函数模型,采用非线性最小二乘法拟合待定系数,提出了一种多参数经验融合模型——电离层TEC京津冀区域模型(Multi-Parameter Empirical Fusion Model-Ionospheric TEC Beijing-Tianjin-Hebei Region, MEFM-ITBTHR)——来预测京津冀区域电离层TEC。结果表明,MEFM-ITBTHR模型能够很好地拟合建模数据集。本文还对MEFM-ITBTHR模型的性能进行了地理位置变化分析、季节变化分析和地磁扰动分析。结果表明,在京津冀区域,MEFM-ITBTHR模型在不同经纬度、不同季节、不同地磁扰动下与实测TEC的预测效果、线性相关性、模型精度都优于IRI2020和NeQuick2模型。本文构建的区域TEC经验模型可为GNSS单频用户提供新的电离层延迟改正方法,同时对建立其他新的和改进现有的电离层经验模型具有重要的参考意义。

FY-3E掩星反演电离层foF2、hmF2和TEC参数精度评估

在分析FY-3E提供的每日掩星数据数量及其全球分布特征基础上,利用电离层垂测仪数据获取的F2层临界频率值(foF2)和F2层峰值高度(hmF2)、高精度全球电离层格网(GIM)及国际参考电离层模型(IRI2016)提供的总电子含量(TEC)对FY-3E掩星反演的foF2、hmF2和TEC精度进行评估。结果表明,电离层垂测仪和FY-3E反演的foF2和hmF2数据的相关系数分别为0.86和0.75,RMSE分别为0.99 MHz和19.26 km。以GIM数据获取的TEC为参考,FY-3E GPS和北斗(BDS)数据反演的TEC精度大致相当。FY-3E TEC精度与太阳活动呈负相关;FY-3E TEC与GIM TEC的相关系数为0.90,RMSE为5.23 TECu。FY-3E TEC与同高度范围的IRI2016 TEC的相关系数为0.88,RMSE为3.70 TECu。

Mechanical properties and acoustic emission characteristics of soft rock with different water contents under dynamic disturbance

Uniaxial compression tests and cyclic loading acoustic emission tests were conducted on 20%,40%,60%,80%,dry and saturated muddy sandstone by using a creep impact loading system to investigate the mechanical properties and acoustic emission characteristics of soft rocks with different water contents under dynamic disturbance.The mechanical properties and acoustic emission characteristics of muddy sandstones at different water contents were analysed.Results of experimental studies show that water is a key factor in the mechanical properties of rocks,softening them,increasing their porosity,reducing their brittleness and increasing their plasticity.Under uniaxial compression,the macroscopic damage characteristics of the muddy sandstone change from mono-bevel shear damage and‘X’type conjugate bevel shear damage to a roadway bottom-drum type damage as the water content increases.Dynamic perturbation has a strengthening effect on the mechanical properties of samples with 60%and less water content,and a weakening effect on samples with 80%and more water content,but the weakening effect is not obvious.Macroscopic damage characteristics of dry samples remain unchanged,water samples from shear damage and tensile–shear composite damage gradually transformed into cleavage damage,until saturation transformation monoclinic shear damage.The evolution of acoustic emission energy and event number is mainly divided into four stages:loading stage(Ⅰ),dynamic loading stage(Ⅱ),yield failure stage(Ⅲ),and post-peak stage(Ⅳ),the acoustic emission characteristics of the stages were different for different water contents.The characteristic value of acoustic emission key point frequency gradually decreases,and the damage degree of the specimen increases,corresponding to low water content—high main frequency—low damage and high water content—low main frequency—high damage.

A Novel Method for the Quantitative Detection of Sericin Content in Silk Fiber Based on the Ratio of Aspartate to Alanine

The development of a method for the quantitative determination of the sericin content ratio(SCR)is urgently needed for silk refining and the purification of silk fibroin for biomedical applications.In this work,a series of sericin/fibroin mixed samples with known SCRs were prepared by mixing initial samples of extracted sericin and fibroin from Bombyx mori silk.Significant differences were found in the contents of characteristic hydrophilic amino acids abundant in sericin and hydrophobic amino acids abundant in fibroin,and several linear relation-ships of SCR associated with the content ratios of Ser/Ala,Asp/Ala,Lys/Ala,Asp/Gly and Ser/Gly were estab-lished by amino acid analysis.Subsequently,the linear equation expressing SCR(%)as a function of the Asp to Ala content ratio X(%)was established as SCR=2.5634X−12.5587(R 2=0.9972).The results indicated that the SCR of degummed silks calculated by the equation is more objective and effective than the results obtained by the traditional weight loss method.Our study provides a novel approach for the sensitive and quantitative detection of the sericin content within the detection limit in unknown silks,which can contribute to quality control in the silk production process.

基于新型Contention网络的滚动轴承早期故障诊断方法研究

针对滚动轴承早期故障诊断问题,为了同时建模振动信号中的高频和低频特征,实现高精度诊断,提出了一种新的模型Contention。它以一种互补的方式集成了空洞卷积和自注意力机制的优点,具有同时捕捉高频和低频信息的能力。为了验证其诊断能力,首先,在完整信息原则下将振动信号连续构造成数据集;其次,搭建Contention网络并训练,其最终测试集准确度可达100%,t-SNE显示随网络层次的深入特征被明显聚类;最后,设置对照实验,将该模型与传统RNN、CNN、Transformer模型对比,证明该模型具备突出的诊断能力。

Shared Cache Based on Content Addressable Memory in a Multi-Core Architecture

Modern shared-memory multi-core processors typically have shared Level 2(L2)or Level 3(L3)caches.Cache bottlenecks and replacement strategies are the main problems of such architectures,where multiple cores try to access the shared cache simultaneously.The main problem in improving memory performance is the shared cache architecture and cache replacement.This paper documents the implementation of a Dual-Port Content Addressable Memory(DPCAM)and a modified Near-Far Access Replacement Algorithm(NFRA),which was previously proposed as a shared L2 cache layer in a multi-core processor.Standard Performance Evaluation Corporation(SPEC)Central Processing Unit(CPU)2006 benchmark workloads are used to evaluate the benefit of the shared L2 cache layer.Results show improved performance of the multicore processor’s DPCAM and NFRA algorithms,corresponding to a higher number of concurrent accesses to shared memory.The new architecture significantly increases system throughput and records performance improvements of up to 8.7%on various types of SPEC 2006 benchmarks.The miss rate is also improved by about 13%,with some exceptions in the sphinx3 and bzip2 benchmarks.These results could open a new window for solving the long-standing problems with shared cache in multi-core processors.

基于SSA-PSO-LSTM模型的电离层TEC预报

受多种因素影响,电离层电子总含量(TEC)时间序列具有非线性、非平稳性特征,为提升长短期记忆(LSTM)神经网络模型在电离层TEC预报中的精度,本文在该神经网络模型的基础上,引入奇异谱分析(SSA)与粒子群优化(PSO)算法,构建了新的SSA-PSO-LSTM模型。一方面,利用了SSA对TEC时间序列进行数据预处理;另一方面,利用粒子群优化算法改进LSTM神经网络模型参数。选用欧洲地球参考框架(EUREF)提供的格网点电离层TEC时间序列数据进行实验,实验结果表明,在磁平静期与磁暴期,该组合模型的TEC预报结果均方根误差分别为0.28个总电子含量单位(TECu)、0.83个TECu,平均相对精度分别为96.35%、91.33%,均优于对比模型,验证了本文提出的组合预报模型的有效性与优越性。平均相对精度分别为96.35%、91.33%,均优于对比模型,验证了本文提出的组合预报模型的有效性与优越性。

宝鸡地区电离层TEC的变化特征研究

目的 分析宝鸡地区电离层TEC的日变化和季节变化特征。方法 通过统计太阳极大年(2014年)和极小年(2019年)的GNSS TEC数据,以及与IRI 2016模型对比,分析宝鸡地区电离层TEC的变化特征。结果 除了极大年的夏季,其他季节的日变化都类似正弦变化,在太阳极大年,电离层TEC随季节单调下降,而在太阳极小年,电离层TEC夏季最大,冬季最小。结论 宝鸡地区电离层TEC存在显著的日变化和季节变化特征,可为电波信号通过电离层的时间延迟修正提供一定的参考。

电离层层析辅助等离子体泡的TEC空间梯度研究

在严重的电离层活动时,发生的极端电离层扰动会对GNSS地基增强系统(Ground-based Augmentation Systems, GBAS)的用户构成完好性威胁,例如中国低纬地区出现的等离子体泡现象。本文针对等离子体泡造成的TEC空间梯度展开研究,提出了一种电离层层析辅助研究等离子体泡造成的TEC空间梯度的方法。首先,通过多分辨率电离层层析成像技术重构中国及周边中低纬地区在2017-09-08T12:00—17:00UT扰动最强烈时段的电离层层析图像,发现该时段内中国低纬地区出现电子密度耗竭的等离子体泡现象;其次,利用短基线双站法和时间步长法两种方法计算等离子体泡附近区域TEC空间梯度;最后,结合两者进行比较研究,验证了较大的TEC空间梯度往往存在于等离子体泡的侧壁周围,如本文在14:06UT出现在香港空域附近的最大TEC空间梯度为133.16 mm/km。同时还可以看出:层析反演的电离层图像不仅能直观地分析等离子体泡的三维电子密度分布,还可以帮助发现TEC空间大梯度产生的原因。