BACKGROUND： The study aimed to investigate the clinical characteristics of acute renal failure（ARF） caused by oral acyclovir.METHODS： A 45-year-old Chinese male patient with acyclovir-induced ARF suffered fromabdo...BACKGROUND： The study aimed to investigate the clinical characteristics of acute renal failure（ARF） caused by oral acyclovir.METHODS： A 45-year-old Chinese male patient with acyclovir-induced ARF suffered fromabdominal pain for one day. The pain was extended to the epigastric area from the right lowerquadrant. Transient oliguria was seen in addition to microscopic hematuria and proteinuria. Theserum creatinine concentration was 304 !mol/L. Eight days before the occurrence of ARF, the patienttook oral acyclovir for facial neuritis.RESULTS： His renal function was restored completely following the discontinuation of acyclovir,with continuous renal replacement therapy for 54 hours and some symptomatic treatment.CONCLUSION： The presentation of acute renal failure caused by acyclovir can be diverse, butthe prognosis is good after active treatment.展开更多
Renal dysfunction is common in liver diseases,either as part of multiorgan involvement in acute illness or secondary to advanced liver disease.The presence of renal impairment in both groups is a poor prognostic indic...Renal dysfunction is common in liver diseases,either as part of multiorgan involvement in acute illness or secondary to advanced liver disease.The presence of renal impairment in both groups is a poor prognostic indicator.Renal failure is often multifactorial and can present as pre-renal or intrinsic renal dysfunction.Obstructive or post renal dysfunction only rarely complicates liver disease.Hepatorenal syndrome(HRS)is a unique form of renal failure associated with advanced liver disease or cirrhosis,and is characterized by functional renal impairment without significant changes in renal histology.Irrespective of the type of renal failure,renal hypoperfusion is the central pathogenetic mechanism,due either to reduced perfusion pressure or increased renal vascular resistance.Volume expansion,avoidance of precipitating factors and treatment of underlying liver disease constitute the mainstay of therapy to prevent and reverse renal impairment.Splanchnic vasoconstrictor agents,such as terlipressin,along with volume expansion,and early placement of transjugular intrahepatic portosystemic shunt(TIPS)may be effective in improving renal function in HRS.Continuous renal replacement therapy(CRRT)and molecular absorbent recirculating system(MARS)in selected patients may be life saving while awaiting liver transplantation.展开更多
文摘BACKGROUND： The study aimed to investigate the clinical characteristics of acute renal failure（ARF） caused by oral acyclovir.METHODS： A 45-year-old Chinese male patient with acyclovir-induced ARF suffered fromabdominal pain for one day. The pain was extended to the epigastric area from the right lowerquadrant. Transient oliguria was seen in addition to microscopic hematuria and proteinuria. Theserum creatinine concentration was 304 !mol/L. Eight days before the occurrence of ARF, the patienttook oral acyclovir for facial neuritis.RESULTS： His renal function was restored completely following the discontinuation of acyclovir,with continuous renal replacement therapy for 54 hours and some symptomatic treatment.CONCLUSION： The presentation of acute renal failure caused by acyclovir can be diverse, butthe prognosis is good after active treatment.
文摘Renal dysfunction is common in liver diseases,either as part of multiorgan involvement in acute illness or secondary to advanced liver disease.The presence of renal impairment in both groups is a poor prognostic indicator.Renal failure is often multifactorial and can present as pre-renal or intrinsic renal dysfunction.Obstructive or post renal dysfunction only rarely complicates liver disease.Hepatorenal syndrome(HRS)is a unique form of renal failure associated with advanced liver disease or cirrhosis,and is characterized by functional renal impairment without significant changes in renal histology.Irrespective of the type of renal failure,renal hypoperfusion is the central pathogenetic mechanism,due either to reduced perfusion pressure or increased renal vascular resistance.Volume expansion,avoidance of precipitating factors and treatment of underlying liver disease constitute the mainstay of therapy to prevent and reverse renal impairment.Splanchnic vasoconstrictor agents,such as terlipressin,along with volume expansion,and early placement of transjugular intrahepatic portosystemic shunt(TIPS)may be effective in improving renal function in HRS.Continuous renal replacement therapy(CRRT)and molecular absorbent recirculating system(MARS)in selected patients may be life saving while awaiting liver transplantation.
