In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast...In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions.展开更多
Among five types of pulmonary hypertension,chronic thromboembolic pulmonary hypertension(CTEPH)is the only curable form,but prompt and accurate diagnosis can be challenging.Computed tomography and nuclear medicine-bas...Among five types of pulmonary hypertension,chronic thromboembolic pulmonary hypertension(CTEPH)is the only curable form,but prompt and accurate diagnosis can be challenging.Computed tomography and nuclear medicine-based techniques are standard imaging modalities to non-invasively diagnose CTEPH,however these are limited by radiation exposure,subjective qualitative bias,and lack of cardiac functional assessment.This review aims to assess the methodology,diagnostic accuracy of pulmonary perfusion imaging in the current literature and discuss its advantages,limitations and future research scope.展开更多
目的探讨盆腔无对比剂磁共振血管造影技术(Non-Contrast Enhanced Magnetic Resonance Angiography,NCEMRA)在髂静脉压迫综合征(Iliac Vein Compression Syndrome,IVCS)诊断及腔内介入指导的应用价值。方法进行了NCE-MRA[包括无对比剂...目的探讨盆腔无对比剂磁共振血管造影技术(Non-Contrast Enhanced Magnetic Resonance Angiography,NCEMRA)在髂静脉压迫综合征(Iliac Vein Compression Syndrome,IVCS)诊断及腔内介入指导的应用价值。方法进行了NCE-MRA[包括无对比剂和心电、呼吸门控触发的血管造影技术(Relaxation-Enhanced MR Angiography Without Contrast and Triggering,REACT)、平衡快速场回波技术(Balance Turbo Field Echo Magnetic Resonance Venogram,B-TFE MRV)、时间飞跃法技术(Time of Flight Magnetic Resonance Venogram,TOF-MRV)]及DSA检查且髂静脉受压部位和数量完全一致的38例下肢静脉疾病患者被纳入此研究,进行狭窄率的相关性分析。结果采用REACT、B-TFE MRV、TOF-MRV得到的狭窄率数据分别与DSA相比均无明显差异(t=-0.421、1.365、-0.941,P>0.05),但REACT的狭窄率与DSA相比差异最小(Cohen’s d值=0.060);REACT、B-TFE MRV及TOF-MRV两两之间的狭窄率相比,REACT的狭窄率与B-TFE MRV、TOF-MRV相比均无明显差异(t=-1.375、0.284,P>0.05),但REACT的狭窄率与TOF-MRV相比差异更小(Cohen’sd值=0.040),B-TFE的狭窄率与TOF-MRV相比差异较大(t=2.211,P=0.032)。结论NCE-MRA有助于提高IVCS的诊断率,进而能够进一步指导髂静脉腔内介入治疗。展开更多
目的探讨透视跟踪技术三维动态增强磁共振血管造影(3DCE-MRA)在下肢动脉病变中的临床应用价值。方法在161例疑有下肢血管病变做下肢3 D CE-MRA的患者中随机抽取50例,对其成像表现及均值曲线(mean curve)进行回顾性分析。结果当靶血管感...目的探讨透视跟踪技术三维动态增强磁共振血管造影(3DCE-MRA)在下肢动脉病变中的临床应用价值。方法在161例疑有下肢血管病变做下肢3 D CE-MRA的患者中随机抽取50例,对其成像表现及均值曲线(mean curve)进行回顾性分析。结果当靶血管感兴趣区(腹主动脉腹腔干水平)对比剂信号强度mean值上升到40～60范围内开始触发扫描,也就是感兴趣区有造影剂显影第4～6s触发扫描能准确地观察3段(下腹及盆腔、大腿、小腿)动脉血管,3段血管充盈饱满并且静脉干扰少。结论透视跟踪技术3 DCE-MRA能较好地显示下肢动脉病变的范围和程度,具有操作简便、快捷、节省造影剂用量等优点,而触发扫描时间点的正确选择更有利于动脉病变的检出,可为临床诊断提供更准确的信息。展开更多
基金supported by the Natural Science Foundation of Jiangsu University(14KJB320003)
文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions.
文摘Among five types of pulmonary hypertension,chronic thromboembolic pulmonary hypertension(CTEPH)is the only curable form,but prompt and accurate diagnosis can be challenging.Computed tomography and nuclear medicine-based techniques are standard imaging modalities to non-invasively diagnose CTEPH,however these are limited by radiation exposure,subjective qualitative bias,and lack of cardiac functional assessment.This review aims to assess the methodology,diagnostic accuracy of pulmonary perfusion imaging in the current literature and discuss its advantages,limitations and future research scope.
文摘目的探讨盆腔无对比剂磁共振血管造影技术(Non-Contrast Enhanced Magnetic Resonance Angiography,NCEMRA)在髂静脉压迫综合征(Iliac Vein Compression Syndrome,IVCS)诊断及腔内介入指导的应用价值。方法进行了NCE-MRA[包括无对比剂和心电、呼吸门控触发的血管造影技术(Relaxation-Enhanced MR Angiography Without Contrast and Triggering,REACT)、平衡快速场回波技术(Balance Turbo Field Echo Magnetic Resonance Venogram,B-TFE MRV)、时间飞跃法技术(Time of Flight Magnetic Resonance Venogram,TOF-MRV)]及DSA检查且髂静脉受压部位和数量完全一致的38例下肢静脉疾病患者被纳入此研究,进行狭窄率的相关性分析。结果采用REACT、B-TFE MRV、TOF-MRV得到的狭窄率数据分别与DSA相比均无明显差异(t=-0.421、1.365、-0.941,P>0.05),但REACT的狭窄率与DSA相比差异最小(Cohen’s d值=0.060);REACT、B-TFE MRV及TOF-MRV两两之间的狭窄率相比,REACT的狭窄率与B-TFE MRV、TOF-MRV相比均无明显差异(t=-1.375、0.284,P>0.05),但REACT的狭窄率与TOF-MRV相比差异更小(Cohen’sd值=0.040),B-TFE的狭窄率与TOF-MRV相比差异较大(t=2.211,P=0.032)。结论NCE-MRA有助于提高IVCS的诊断率,进而能够进一步指导髂静脉腔内介入治疗。
文摘目的探讨透视跟踪技术三维动态增强磁共振血管造影(3DCE-MRA)在下肢动脉病变中的临床应用价值。方法在161例疑有下肢血管病变做下肢3 D CE-MRA的患者中随机抽取50例,对其成像表现及均值曲线(mean curve)进行回顾性分析。结果当靶血管感兴趣区(腹主动脉腹腔干水平)对比剂信号强度mean值上升到40～60范围内开始触发扫描,也就是感兴趣区有造影剂显影第4～6s触发扫描能准确地观察3段(下腹及盆腔、大腿、小腿)动脉血管,3段血管充盈饱满并且静脉干扰少。结论透视跟踪技术3 DCE-MRA能较好地显示下肢动脉病变的范围和程度,具有操作简便、快捷、节省造影剂用量等优点,而触发扫描时间点的正确选择更有利于动脉病变的检出,可为临床诊断提供更准确的信息。
