Clinical Observation on Treatment of 78 Patients of B-Thalassemla with Bushen Ylsul (补肾益髓) Method and Study on Its Molecular Mechanism

Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with BSYS recipe (consisted of 11 Chinese herbal drugs as Dogwood fruit, Fleeceflower root, prepared Rehmannia root and turtle shell, etc.) orally taken, 3 times per day, 10 g/time, 3 months as one therapeutic course. Hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were checked every month. At the same time, PAGE, PVR, PCR-SSCP, RT-PCR, DNA series analysis, mRNA gene expression analysis techniques were used to conduct the systematic gene analysis in patients to study the molecular mechanism of TCM treatment from aspects of gene mutation, gene expression and control-regulation. Results: All the blood criteria in patients after BSYS treatment were improved significantly with clinical symptoms

TCM Stage Differentiation Treatment of Diabetic Gangrene——An Observation on Microcirculatory Changes

Microcirculatory changes and therapeutic effects in 39 non-insulin dependent diabetes mellitus (NIDDM) cases were evaluated. Under the same basic treatment in both groups, the treatment group (21 cases) was treated with TCM drugs according to its stages and compared with the control group (18 cases, treated with 654-2). The results showed that the microcirculatory cumulative scores were significantly decreased in both groups (P<0.05), but the decrease in the treatment group was more marked (P<0.05). In the treatment group, 15 cases were cured, 3 markedly effective, 2 effective and 1 ineffective; while in the control group, 13 cases were cured, 1 markedly effective and 4 ineffective. Statistically, there is no significant difference between the 2 groups (P>0.05) in therapeutic effects.

Clinical Observation on Treatment of 50 Patients with Candidal Vaginitis by Chinese Herbal Medicine Combined with Canesten

From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 patients treated with Canesten alone. The therapeutic results were satisfactory and reported as follows.

Usefulness of contrast enhanced ultrasound in monitoring therapeutic response after hepatocellular carcinoma treatment

In the last years, the development in the oncology field has been huge and rapid. In particular, the evaluation of response to anti-tumour treatments has been being object of intense research, producing significant changes. Response assessment after therapy in solid neoplasias has always used radiological imaging techniques, with tumour size reduction representing a presumed therapeutic efficacy. However, with the introduction of anti-angiogenetic drugs the evaluation of tumour size has become unsuitable because some tumours, under treatment, show only tumour perfusion changes rather than lesion shrinkage. Between different imaging techniques with contrast-enhancement, contrastenhanced ultrasound(CEUS) and, in particular, dynamic CEUS have arisen as a promising and non-invasive device for monitoring cancer treatments. Moreover, the introduction of perfusion software has even more refined the technique since it is able to provide quantitative parameters related to blood flow and blood volume that can be associated with tumour response and clinical outcome such as the progression free survival and the overall survival. Here, we give an overview of the current status of CEUS in monitoring hepatocellular carcinoma response to different kind of treatments.

Unilateral contrast-induced encephalopathy with contrast medium exudation:A case report

BACKGROUND Contrast-induced encephalopathy(CIE)is a rare transient,reversible abnormality in the structure or function of the nervous system caused by the intravascular use of contrast agents.CIE can present with a range of neurological manifestations,including focal neurological deficits(hemiplegia,hemianopia,cortical blindness,aphasia,and parkinsonism)and systemic symptoms(confusion,seizures,and coma).However,if not accurately diagnosed and treated in a timely manner,CIE can cause irreversible damage to patients,especially critically ill patients.CASE SUMMARY A male in his 50 s,2 h after digital subtraction angiography,had a progressive disorder of consciousness,mixed aphasia,bilateral pupillary sluggish light reflex,and right limb weakness.Seven hours after the procedure,he developed unconsciousness,high fever(39.5°C),seizures,hemiplegia,neck stiffness(+),and right Babinski signs(+).computed tomography(CT)findings 2 h postprocedure were very confusing and led us to misdiagnose the patient with subarachnoid hemorrhage.Brain CT was performed again 7 h after the procedure.Compared with the CT 2 h after the procedure,the CT 7 h after the procedure showed that the manifestations of subarachnoid hemorrhage in the left cerebral hemisphere had disappeared and were replaced by brain tissue swelling,and the cerebral sulci had disappeared.Combined with the clinical manifestations of the patient and after the exclusion of subarachnoid hemorrhage and cerebrovascular embolism,we diagnosed the patient with CIE,and intravenous fluids were given for adequate hydration,as well as mannitol,albumin dehydration,furosemide and the glucocorticoid methylprednisolone.After 17 d of active treatment,the patient was discharged with no sequelae.CONCLUSION CIE should be taken seriously,but it is easily misdiagnosed,and once CIE is diagnosed,rapid,accurate diagnosis and treatment are critical steps.Whether a follow-up examination using a contrast agent can be performed should be closely evaluated,and the patient should be fully informed of the associated risks.

Contrastive Analysis of the Observation Data of Pressure and Temperature in Qingxian Weather Station

[Objective] The research aimed to contrast parallel observation data of pressure and temperature in Qingxian station. [Method] By u- sing pressure and temperature observed by automatic station and artificial station in Qingxian from January of 2009 to December of 2010, compara- tive analysis of observation data was conducted, and formation reason of difference value was discussed. E Resultl Monthly average pressure differ- ence between automatic station and artificial observation value was from -0.7 to 0.1 hPa. Difference value of monthly average maximum pressure was from -0.5 to 0.4 hPa, while difference value of monthly average minimum pressure was from -0.7 to 0.2 hPa. Difference value of monthly extremely maximum pressure was from -0.3 to 0.6 hPa, while difference value of monthly extremely minimum pressure was from -1.1 to 0.1 hPa. Monthly average temperature difference value was from -2.0 to 0 ℃. Difference value of monthly average maximum temperature was from -0.4 to 0 ℃, while difference value of monthly average minimum temperature was from -0.1 to 0.2 ℃. Difference value of monthly extremely maximum temperature was from -0.3 to 0.3 ℃, while difference value of monthly extremely minimum temperature was from -0.3 to 0.3 ℃. [ Conclusion] Generation reason of observation difference mainly included differences of observation instrument and principle, differences of data collection time and method, different sensor installation positions and environments, manual intervention and observation error.

Clinical Observation on Treatment of Hemiplegia with Galvanoacupuncture and Massotherapy．

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Clinical Observation on Treatment of Sequelae of Apoplexy With Eye and Body Acupuncture

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Clinical Observation on Acupuncture Treatment of 36 Cases of Pseudobutbar Paralysis Syndrome Caused by Apoplexy

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Clinical Observation on Scalp Acupuncture Treatment in 50 Cases of Headache

Headache is frequently encountered in clinic, including vascular headache, cervical headache, traumatic cerebral headache, and tonic headache, which may be seenin many acute or chronic diseases. During the period from Aug. 1996 - Apr. 2000, the author had treated 50 cases of headache by scalp acupuncture therapy and got quite satisfactory therapeutic results as reported in the following. ……

Clinical Observation on Effect of Xuesaitong Injection (血塞通注射液) as Auxiliary Treatment of Severe Craniocerebral Injury

Objective To evaluate the effect of Xuesai-tong injection (XSTI, 血塞通注射液 , a preparation of Panax Notoginseng) as auxilliary treatment of severe craniocerebral injury. Methods Eighty-seven patients with severe craniocerebral injury were selected and randomly divided into the treated group (n=44) and the control group (n = 43), they were treated with conventional treatment, and XSTI was given additionally to the treated group. Intracranial pressure (ICP) and Glasgow coma score (GCS) of all patients were measuredafter 1 or 2-week treatment, and Glasgow outcome scale (GOS) of them was determined 3 months later. Then the therapeutic effect in the two groups were compared. Results After treatment, the ICP was lower, GCS higher and GOS better in the treated group than those in the control group significantly, all showing statistical significance (P<0.05). Conclusion XSTI has marked clinical therapeutic effect in treating patients with severe craniocerebral injury.Original article on CJITWM (Chin) 2004 ;23 (3): 213

Contrastive Observation of Solar Thermal and Photovoltaic Resource

Solar thermal and photovoltaic applications are the most w idely used and the most successful w ay of commercial development in solar energy applications. Observation and assessment of solar thermal and photovoltaic resources are the basis and key of their large-scale development and utilization. Using the observational data carried out from Beijing southern suburbs observation station of China M eteorological Administration in summer of 2009,preliminary solar thermal and photovoltaic resources characteristics for different w eather conditions,different angle and different directions are analyzed. The results show that:(1) In sunny,cloudy or rainy w eather conditions,both of solar thermal and photovoltaic sensors daily irradiance have consistent change in trend. Solar thermal irradiance is larger than photovoltaic. Under sunny conditions,solar thermal global radiation has about 2.7%higher than the photovoltaic global radiation. Under cloudy w eather conditions,solar thermal global radiation has about 3. 9%higher than the photovoltaic. Under rainy w eather conditions,solar thermal global radiation has about 20% higher than the photovoltaic.(2) For different inclined plane daily global radiation,southern latitude-15 °incline is the maximum and southern vertical surface is the minimum. The order from large to small is southern latitude-15 ° incline,southern latitude incline,southern latitude+15 °incline,horizontal surface and southern vertical surface. Southern latitude-15 °incline global radiation has about 41% higher than the southern vertical surface.(3) For different orientation vertical surface daily global radiation,southern vertical surface is the maximum and w estern vertical surface is the minimum,w hich eastern vertical surface is in the middle. Southern vertical surface global radiation has about 20% higher than the w estern vertical surface.

Prescription of Cancer Treatment Modalities in Developing Countries:Results from a Multi-Centre Observational Study

Background: Treatment is an important component of a comprehensive cancer control approach and its outcomes strongly depend on infrastructure, equipment, human and financial resources available. Therefore it is imperative to generate evidence-based tools to assist health policy makers from low resourced countries in planning efficient and equitable treatment services for a defined population based on what it is feasible to these settings. Methods: The intended cancer spe-cific treatment planned and written in the patients’ medical record (treatment prescription) of untreated adult cancer cases (≥18 years of age), excluding non-melanoma skin cancer, was recorded in a chronological way from 1 January 2012 onwards in a group of eight comprehensive cancer centres located in middle income countries and offering the main modalities of cancer treatment (surgery, medical oncology and radiotherapy). Results: A total of 17,713 medical records were reviewed, of which 7106 (54.2%) met the eligibility criteria. Prescription of main cancer treatment modalities were distributed as follows: 57.6% for chemotherapy (n = 4093), 56.8% for surgery (n = 4038), and 46.8% for radiotherapy (n = 3327). There was a predominance of plans consisting of combined treatment modalities over monotherapy (55.2% versus 44.8%). At the time of diagnosis 54.3% of the cancer cases had disease that had spread beyond the primary site, 41.2% were considered as having local disease and in 4.5% of the cases the information on disease extension was unknown. Conclusions: The results obtained should be seen as an approximation of cancer treatment service demand based on what it is currently practiced and therefore feasible in developing countries, particularly in middle income countries.

Evaluation of the Therapeutic Effect of Contrast-Enhanced Ultrasound on Different Types of Knee Osteoarthritis in the Elderly

Objective: To evaluate the curative effect of the Traditional Chinese Medicine (TCM) external therapy on knee osteoarthritis patients with different TCM constitutions using musculoskeletal ultrasonography and contrast-enhanced ultrasonography, and to explore the application value of contrast-enhanced ultrasonography in knee joint diseases. Methods: A total of 57 patients diagnosed with knee osteoarthritis in Shaanxi University of Traditional Chinese Medicine from December 2019 to May 2021 were collected, and they were divided into qi stagnation and blood stasis type group (23 cases) and cold-dampness obstruction type group (34 cases) according to the traditional Chinese medicine method. All patients were given acupuncture combined with TCM fumigation and washing. All patients underwent musculoskeletal ultrasonography and contrast-enhanced ultrasonography before and after treatment, observed and recorded relevant data, and compared the treatment effects between the two groups. Results: 85.96% (49/57) of knee osteoarthritis (KOA) patients had suprapatellar bursa effusion, 42.1% (24/57) had iliotibial band bursae effusion, some of which had poor sound transmission, and thickened synovium was seen in most effusions, 33.33% (19/57) had osteophyte formation. Compared with before treatment, the depth of suprapatellar sac effusion in the Qi stagnation and blood stasis type group decreased after treatment (P Conclusion: Musculoskeletal contrast-enhanced ultrasonography was used to quantitatively evaluate the efficacy of TCM external therapy on KOA for different TCM constitutions. Dynamic observation of synovial lesions of knee osteoarthritis provides a valuable imaging method for evaluating the efficacy of traditional Chinese medicine.

加味二陈汤治疗顽固性呃逆临床观察

目的:观察加味二陈汤治疗顽固性呃逆的临床效果。方法:126例按照随机数字表法分为试验组和对照组各63例。试验组用加味二陈汤治疗,对照组用甲氧氯普胺治疗。结果:试验组起效时间短于对照组,症状改善优于对照组,总有效率高于对照组,两组比较差异均有统计学意义(P<0.05)。结论:加味二陈汤治疗顽固性呃逆效果较好。

垃圾渗滤液污水处理设备的臭氧投加复合抗扰控制

垃圾渗滤液污水处理设备中的臭氧投加系统具有大时滞、大惯性和多扰动的特点,导致难以实时调整臭氧投加量,从而影响后续设备出水水质。针对以上问题,在水流量比例的控制方面提出一种基于扰动观测器的改进型Smith预估器与滑模控制相结合的复合抗扰控制。其中,滑模控制为主控制器,扰动观测器用于估计出系统的集总扰动并反馈至前向通道消除扰动的不利影响,以便于Smith预估器更好地进行时滞补偿。仿真和实验结果表明,复合抗扰控制相较于PID控制和自抗扰控制具有更好的控制性能和抑制扰动的能力,能够有效提高垃圾渗滤液污水处理设备的出水水质。

经直肠超声造影评估前列腺癌新辅助内分泌治疗反应的价值

目的:探讨经直肠超声造影(contrast-enhanced transrectal ultrasound)时间-强度曲线(time-intensity curve,TIC)参数评估前列腺癌(prostate cancer,PCa)患者对新辅助内分泌治疗(neoadjuvant hormonal therapy,NHT)的反应程度。方法:纳入27例接受NHT的PCa患者的临床资料,根据术后病理学检查结果分为有效组(n=16)和无效组(n=11)。对比两组患者临床病理学特征、治疗前后血清前列腺特异性抗原(prostate-specific antigen,PSA)和CETRUS检查指标及其变化率,以筛选与NHT反应性有关的潜在指标。进一步采用相关性分析评价其在评估患者对NHT反应方面的价值。结果:有效组和无效组在临床病理学特征、治疗前的血清PSA和C E T R U S检查指标方面的差异无统计学意义(均P>0.05)。治疗后,仅有效组的TIC曲线下面积(area under curve,AUC)低于无效组(560 dB·s vs 710 dB·s),其变化率大于无效组(-27.1%vs-5.3%)(均P<0.05)。相关性分析显示AUC变化率与组织学反应评分之间的相关性略高于治疗后AUC(r为-0.690 vs-0.630)。结论:CETRUS TIC参数中,NHT后的AUC及其变化率在评估PCa患者对NHT反应方面具有较好的价值。其中,AUC变化率可能与治疗反应程度更相关。

基于CT平扫的急性缺血性卒中血管内治疗术前影像学评估的研究进展

急性缺血性卒中治疗的关键在于尽早开通阻塞血管,挽救缺血半暗带。DAWN和/或DEFUSE-3试验将急性缺血性卒中血管内治疗的时间窗从6 h延长至24 h,然而资源要求高、高辐射、造影剂引起的肾损伤和较长的检查时间使得多模态影像筛选方案的实际应用有限。越来越多的证据表明,基于CT平扫的影像标准在选择缺血性卒中合并大血管闭塞患者进行血管内治疗可能是安全有效的。本文将根据血管内治疗的时间窗与梗死核心,从早期时间窗、延长时间窗、超时间窗、大梗死核心血管内治疗4个方面对基于CT平扫的急性缺血性卒中血管内治疗术前影像学评估的研究进展进行综述。