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黄连对大肠杆菌R质粒消除作用的实验研究 被引量:27
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作者 陈群 陈南菊 王胜春 《中国中西医结合杂志》 CAS CSCD 北大核心 1996年第1期37-38,共2页
本研究以中药黄连的提取物为质粒消除剂,用携带R质粒的多重耐药性大肠杆菌E.102株为靶细菌,进行了体外R质粒消除作用的实验研究。同时观察了黄连作用不同时间,对大肠杆菌R质粒消除作用的影响。实验结果表明:黄连具有消除R... 本研究以中药黄连的提取物为质粒消除剂,用携带R质粒的多重耐药性大肠杆菌E.102株为靶细菌,进行了体外R质粒消除作用的实验研究。同时观察了黄连作用不同时间,对大肠杆菌R质粒消除作用的影响。实验结果表明:黄连具有消除R质粒的作用。经黄连作用24h,消除率为2.42%,延长作用时间至48h,其消除率提高为22.57%。细菌丢失的耐药性可以表现为单一或两种耐药性的丧失。 展开更多
关键词 黄连 大肠杆菌 r 实验
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ExperimentalStudyofRPlasmidEliminatingActionofRhizomaCoptidisonE.Coli
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作者 陈群 陈南菊 王胜春 《Chinese Journal of Integrative Medicine》 SCIE CAS 1996年第3期222-224,共3页
The R plasmid curing experiment was performed in vitro with E. coli strain E. 102 bearing Rplasmid with multiple drug resistance as target bacteria and Rhizoma Coptidis as elimination agent, and theinfluence at differ... The R plasmid curing experiment was performed in vitro with E. coli strain E. 102 bearing Rplasmid with multiple drug resistance as target bacteria and Rhizoma Coptidis as elimination agent, and theinfluence at different acting time of it on R plasmid elimination was also observed. Results showed that whenthe acting time was 24 hours, the cure rate of R plasmid was 2 . 42 % and when the action time increased to 48hours, the cure rate was elevated to 22. 57% . The missing pattern s of R plasmid might occur in diap-pearence of either multiple or single resistance. 展开更多
关键词 rhizoma Coptidis E. coli r plasmid elimination
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