Lateral deflection formulas are presented for analysis of the strengthened story applied to flame-core structures. For the framecore structures with top outriggers and with middle outriggers, the relationship between ...Lateral deflection formulas are presented for analysis of the strengthened story applied to flame-core structures. For the framecore structures with top outriggers and with middle outriggers, the relationship between stiffness characteristic parameters of frame and outriggers and the top drift of structures under different loads is analyzed. It is indicated that when stiffness characteristic parameter of frame is large, outrigger efficiency for top drift reduction is low, and the mutation of internal forces occurs; when the stiffness characteristic parameter of frame is less than 3, installing the strengthened story is advantageous to frame-core structures.展开更多
Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes mellitus.HCV...Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes mellitus.HCV,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a polyprotein.The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various mechanisms.The peptide(a.a.178-191)may play a role in the immune response.The polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis development.In addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron metabolism.In this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.展开更多
基金The Natural Science Foundation of China(No.50708041)
文摘Lateral deflection formulas are presented for analysis of the strengthened story applied to flame-core structures. For the framecore structures with top outriggers and with middle outriggers, the relationship between stiffness characteristic parameters of frame and outriggers and the top drift of structures under different loads is analyzed. It is indicated that when stiffness characteristic parameter of frame is large, outrigger efficiency for top drift reduction is low, and the mutation of internal forces occurs; when the stiffness characteristic parameter of frame is less than 3, installing the strengthened story is advantageous to frame-core structures.
基金Supported by Grants from the National Science Council of Taiwan,NSC 101-2320-B-320-011 to Lo SYfrom the Tzu Chi University,TCMRC-P-101015 and TCRPP101017 to Li HC and Lo SY
文摘Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcinoma,and its infection is also associated with insulin resistance and type 2 diabetes mellitus.HCV,belonging to the Flaviviridae family,is a small enveloped virus whose positive-stranded RNA genome encoding a polyprotein.The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein(a.a.1-177)and the cleaved peptide(a.a.178-191).Core protein could induce insulin resistance,steatosis and even hepatocellular carcinoma through various mechanisms.The peptide(a.a.178-191)may play a role in the immune response.The polymorphism of this peptide is associated with the cellular lipid drop accumulation,contributing to steatosis development.In addition to the conventional open reading frame(ORF),in the+1 frame,an ORF overlaps with the core proteincoding sequence and encodes the alternative reading frame proteins(ARFP or core+1).ARFP/core+1/F protein could enhance hepatocyte growth and may regulate iron metabolism.In this review,we briefly summarized the current knowledge regarding the production of different core gene products and their roles in viral pathogenesis.
